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Protein

Arylsulfatase K

Gene

arsk

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi35CalciumBy similarity1
Active sitei75NucleophileBy similarity1
Metal bindingi75Calcium; via 3-oxoalanineBy similarity1
Binding sitei123SubstrateBy similarity1
Binding sitei246SubstrateBy similarity1
Metal bindingi308CalciumBy similarity1
Metal bindingi309CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase K (EC:3.1.6.-)
Short name:
ASK
Gene namesi
Name:arsk
ORF Names:zgc:153019
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-060929-332 arsk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000035628917 – 523Arylsulfatase KAdd BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei753-oxoalanine (Cys)By similarity1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ08CJ7
PRIDEiQ08CJ7

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000077752

Structurei

3D structure databases

ProteinModelPortaliQ08CJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3731 Eukaryota
COG3119 LUCA
HOGENOMiHOG000034080
HOVERGENiHBG054703
InParanoidiQ08CJ7
KOiK12376
PhylomeDBiQ08CJ7

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08CJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVFVLLIF NVNAYCMYLN WTSHDRPNIV MIMSDAFDGR LTFQPGNKVV
60 70 80 90 100
QLPYINYMRE LGSVFLNSYT NSPICCPSRA AMWSGQFVHL TQSWNNNKCL
110 120 130 140 150
HPNATTWMDD LRKSGYHTHS MGKLDYTSGH HSVSNRVEAW TRDVPFLLRQ
160 170 180 190 200
EGRPVTDLVG DASTKRVMIK DWTITDAAVQ WIRNTTASLT QPFALYLGLN
210 220 230 240 250
LPHPYRTDSL GPTAGGSTFR TSPYWLNKVS YNQVSVPKWL RFKDMHPVDY
260 270 280 290 300
YSTVTKNCSG HFTEEEIRNI RAFYYAMCAE TDGMLGEVMA ALRDTGSLNK
310 320 330 340 350
TVVLFTSDHG DLAMEHRQFY KMSMFEGSSH VPLLIMGPGV KSGFEVSLPV
360 370 380 390 400
SLVDIYPTVL DLAGVPQTGG LSGHSLIPLI SRVSIHSAEP HPAWAFSEYH
410 420 430 440 450
GCNANTSTYM LRIAEWKYIA YADGLNVPPQ LFNLSKDESE LRNIASQFPD
460 470 480 490 500
VCQDLDKLLR SIVDYPSVSK SVHRYNKQQF LEWKQSLGDS YSQVIASLRW
510 520
HVDWKKDAKS YERDIDEWLL GLD
Length:523
Mass (Da):59,499
Last modified:October 31, 2006 - v1
Checksum:i16C87DCE83BCB0FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC124212 mRNA Translation: AAI24213.1
RefSeqiNP_001070625.1, NM_001077157.1
UniGeneiDr.90831

Genome annotation databases

GeneIDi562412
KEGGidre:562412

Similar proteinsi

Entry informationi

Entry nameiARSK_DANRE
AccessioniPrimary (citable) accession number: Q08CJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 31, 2006
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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