UniProtKB - Q08BS4 (EZH2_DANRE)
Protein
Histone-lysine N-methyltransferase EZH2
Gene
ezh2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes.By similarity
Catalytic activityi
- L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteineBy similarityEC:2.1.1.356By similarity
GO - Molecular functioni
- histone-lysine N-methyltransferase activity Source: InterPro
- promoter-specific chromatin binding Source: UniProtKB
GO - Biological processi
- digestive tract development Source: ZFIN
- fin regeneration Source: ZFIN
- heart development Source: ZFIN
- histone H3-K27 methylation Source: ZFIN
- negative regulation of gene expression, epigenetic Source: UniProtKB
- rhythmic process Source: UniProtKB-KW
- tissue homeostasis Source: ZFIN
Keywordsi
Molecular function | Chromatin regulator, Methyltransferase, Repressor, Transferase |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
Reactomei | R-DRE-212300, PRC2 methylates histones and DNA R-DRE-2559580, Oxidative Stress Induced Senescence R-DRE-8943724, Regulation of PTEN gene transcription R-DRE-8953750, Transcriptional Regulation by E2F6 |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-lysine N-methyltransferase EZH2 (EC:2.1.1.356By similarity)Alternative name(s): Enhancer of zeste homolog 2 |
Gene namesi | Name:ezh2 Synonyms:zgc:152758 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-041111-259, ezh2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- ESC/E(Z) complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000345427 | 1 – 760 | Histone-lysine N-methyltransferase EZH2Add BLAST | 760 |
Proteomic databases
PaxDbi | Q08BS4 |
Interactioni
Subunit structurei
Component of the prc2/eed-ezh2 complex.
By similarityProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000023693 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 517 – 619 | CXCPROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 626 – 741 | SETPROSITE-ProRule annotationAdd BLAST | 116 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 537 – 602 | Cys-richAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG1079, Eukaryota |
InParanoidi | Q08BS4 |
OrthoDBi | 875190at2759 |
PhylomeDBi | Q08BS4 |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
InterProi | View protein in InterPro IPR026489, CXC_dom IPR021654, EZH1/EZH2 IPR041343, PRC2_HTH_1 IPR041355, Pre-SET_CXC IPR001005, SANT/Myb IPR001214, SET_dom IPR033467, Tesmin/TSO1-like_CXC |
Pfami | View protein in Pfam PF11616, EZH2_WD-Binding, 1 hit PF18118, PRC2_HTH_1, 1 hit PF18264, preSET_CXC, 1 hit PF00856, SET, 1 hit |
SMARTi | View protein in SMART SM01114, CXC, 1 hit SM00717, SANT, 2 hits SM00317, SET, 1 hit |
PROSITEi | View protein in PROSITE PS51633, CXC, 1 hit PS50280, SET, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q08BS4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLTGRKSEK GPVCWRRRVK SEYMRLRQLK RFRRADEVKS MFSSNRQKIL
60 70 80 90 100
ERTDILNQEW KLRRIQPVHI MTPVSSLRGT RECTVDSGFS EFSRQVIPLK
110 120 130 140 150
TLNAVASVPV MYSWSPLQQN FMVEDETVLH NIPYMGDEIL DQDGTFIEEL
160 170 180 190 200
IKNYDGKVHG DRECGFINDE IFVELVNALN QYSDNEEDDE EDDHHDYKFE
210 220 230 240 250
KMDLCDGKDD AEDHKEQLSS ESHNNDGSKK FPSDKIFEAI SSMFPDKGST
260 270 280 290 300
EELKEKYKEL TEQQLPGALP PECTPNIDGP NAKSVQREQS LHSFHTLFCR
310 320 330 340 350
RCFKYDCFLH PFQATPNTYK RKNMENLVDS KPCGIYCYMY MVQDGMVREY
360 370 380 390 400
PAGVVPERAK TPSKRSTGRR RGRLPNSNSR PSTPTVNSET KDTDSDREGG
410 420 430 440 450
ADGNDSNDKD DDDKKDETTS SSEANSRCQT PVKLKLSSEP PENVDWSGAE
460 470 480 490 500
ASLFRVLIGT YYDNFCAIAR LIGTKTCRQV YEFRVKESSI IARAPAVDEN
510 520 530 540 550
TPQRKKKRKH RLWATHCRKI QLKKDGSSNH VYNYQPCDHP RQPCDSSCPC
560 570 580 590 600
VTAQNFCEKF CQCSSECQNR FPGCRCKAQC NTKQCPCYLA VRECDPDLCL
610 620 630 640 650
TCGAAEHWDS KNVSCKNCSI QRGAKKHLLL APSDVAGWGI FIKEPVQKNE
660 670 680 690 700
FISEYCGEII SQDEADRRGK VYDKYMCSFL FNLNNDFVVD ATRKGNKIRF
710 720 730 740 750
ANHSVNPNCY AKVMMVNGDH RIGIFAKRAI QTGEELFFDY RYSQADALKY
760
VGIEREMEIP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1QQ58 | F1QQ58_DANRE | [Histone H3]-lysine(27) N-trimethyl... | ezh2 | 760 | Annotation score: | ||
A0A286Y9P9 | A0A286Y9P9_DANRE | [Histone H3]-lysine(27) N-trimethyl... | ezh2 | 770 | Annotation score: | ||
X1WHS1 | X1WHS1_DANRE | Histone-lysine N-methyltransferase ... | ezh2 | 126 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC124588 mRNA Translation: AAI24589.1 |
RefSeqi | NP_001070747.1, NM_001077279.1 |
Genome annotation databases
GeneIDi | 768133 |
KEGGi | dre:768133 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC124588 mRNA Translation: AAI24589.1 |
RefSeqi | NP_001070747.1, NM_001077279.1 |
3D structure databases
SMRi | Q08BS4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000023693 |
Proteomic databases
PaxDbi | Q08BS4 |
Genome annotation databases
GeneIDi | 768133 |
KEGGi | dre:768133 |
Organism-specific databases
CTDi | 2146 |
ZFINi | ZDB-GENE-041111-259, ezh2 |
Phylogenomic databases
eggNOGi | KOG1079, Eukaryota |
InParanoidi | Q08BS4 |
OrthoDBi | 875190at2759 |
PhylomeDBi | Q08BS4 |
Enzyme and pathway databases
Reactomei | R-DRE-212300, PRC2 methylates histones and DNA R-DRE-2559580, Oxidative Stress Induced Senescence R-DRE-8943724, Regulation of PTEN gene transcription R-DRE-8953750, Transcriptional Regulation by E2F6 |
Miscellaneous databases
PROi | PR:Q08BS4 |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
InterProi | View protein in InterPro IPR026489, CXC_dom IPR021654, EZH1/EZH2 IPR041343, PRC2_HTH_1 IPR041355, Pre-SET_CXC IPR001005, SANT/Myb IPR001214, SET_dom IPR033467, Tesmin/TSO1-like_CXC |
Pfami | View protein in Pfam PF11616, EZH2_WD-Binding, 1 hit PF18118, PRC2_HTH_1, 1 hit PF18264, preSET_CXC, 1 hit PF00856, SET, 1 hit |
SMARTi | View protein in SMART SM01114, CXC, 1 hit SM00717, SANT, 2 hits SM00317, SET, 1 hit |
PROSITEi | View protein in PROSITE PS51633, CXC, 1 hit PS50280, SET, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EZH2_DANRE | |
Accessioni | Q08BS4Primary (citable) accession number: Q08BS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | October 31, 2006 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families