UniProtKB - Q08BG4 (Q08BG4_DANRE)
Protein
Submitted name:
Lysophosphatidic acid receptor 6a
Gene
lpar6a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- lysophosphatidic acid receptor activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: UniProtKB
- angiogenesis Source: ZFIN
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: GO_Central
- positive regulation of Rho protein signal transduction Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-DRE-416476 G alpha (q) signalling events R-DRE-417957 P2Y receptors |
Names & Taxonomyi
Protein namesi | Submitted name: Lysophosphatidic acid receptor 6aImportedSubmitted name: Zgc:153784ImportedSubmitted name: Zgc:153784 proteinImported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-061013-343 lpar6a |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 29 – 53 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 65 – 88 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 110 – 133 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 145 – 165 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 194 – 218 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 238 – 263 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 283 – 305 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 99 ↔ 178 | Combined sources |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000062552 Expressed in 15 organ(s), highest expression level in heart |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5XSZ | X-ray | 3.20 | A | 1-227 | [»] | |
A | 233-312 | [»] | ||||
SMRi | Q08BG4 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 302 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 259 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG410IFM0 Eukaryota ENOG41115C6 LUCA |
GeneTreei | ENSGT00940000159959 |
HOGENOMi | HOG000231307 |
HOVERGENi | HBG101917 |
KOi | K04273 |
OMAi | FRIFYFA |
OrthoDBi | 840755at2759 |
TreeFami | TF350009 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08BG4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYNTSLEMEM LNVSNVTHCP KNDNFKYPLY SMVFSIVFMV GLITNVAAMY
60 70 80 90 100
IFMCSLKLRN ETTTYMMNLV VSDLLFVLTL PLRVFYFVQQ NWPFGSLLCK
110 120 130 140 150
LSVSLFYTNM YGSILFLTCI SVDRFLAIVY PFRSRGLRTK RNAKIVCAAV
160 170 180 190 200
WVLVLSGSLP TGFMLNSTNK LENNSISCFE NFSSKEWKSH LSKVVIFIET
210 220 230 240 250
VGFLIPLMLN VVCSAMVLQT LRRPNTVSRG GKLNKKKILR MIIVHLFIFC
260 270 280 290 300
FCFIPYNVNL VFYSLVRTNT LKGCAAESVV RTIYPIALCI AVSNCCFDPI
310 320 330 340 350
VYYFTSETIQ NSIKRKTQTG HSIDVKFSEA LQSETSSTLQ FSLRSIKNKM
FHNESHV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABZ01040554 Genomic DNA No translation available. CABZ01040555 Genomic DNA No translation available. CABZ01040556 Genomic DNA No translation available. CABZ01040557 Genomic DNA No translation available. CABZ01040558 Genomic DNA No translation available. CABZ01040559 Genomic DNA No translation available. CABZ01061587 Genomic DNA No translation available. CABZ01081365 Genomic DNA No translation available. BC124734 mRNA Translation: AAI24735.1 BC165329 mRNA Translation: AAI65329.1 |
RefSeqi | NP_001073524.1, NM_001080055.2 |
UniGenei | Dr.84125 |
Genome annotation databases
Ensembli | ENSDART00000090624; ENSDARP00000085057; ENSDARG00000062552 ENSDART00000182986; ENSDARP00000155212; ENSDARG00000062552 |
GeneIDi | 571773 |
KEGGi | dre:571773 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABZ01040554 Genomic DNA No translation available. CABZ01040555 Genomic DNA No translation available. CABZ01040556 Genomic DNA No translation available. CABZ01040557 Genomic DNA No translation available. CABZ01040558 Genomic DNA No translation available. CABZ01040559 Genomic DNA No translation available. CABZ01061587 Genomic DNA No translation available. CABZ01081365 Genomic DNA No translation available. BC124734 mRNA Translation: AAI24735.1 BC165329 mRNA Translation: AAI65329.1 |
RefSeqi | NP_001073524.1, NM_001080055.2 |
UniGenei | Dr.84125 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5XSZ | X-ray | 3.20 | A | 1-227 | [»] | |
A | 233-312 | [»] | ||||
SMRi | Q08BG4 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000085057 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSDART00000090624; ENSDARP00000085057; ENSDARG00000062552 ENSDART00000182986; ENSDARP00000155212; ENSDARG00000062552 |
GeneIDi | 571773 |
KEGGi | dre:571773 |
Organism-specific databases
CTDi | 571773 |
ZFINi | ZDB-GENE-061013-343 lpar6a |
Phylogenomic databases
eggNOGi | ENOG410IFM0 Eukaryota ENOG41115C6 LUCA |
GeneTreei | ENSGT00940000159959 |
HOGENOMi | HOG000231307 |
HOVERGENi | HBG101917 |
KOi | K04273 |
OMAi | FRIFYFA |
OrthoDBi | 840755at2759 |
TreeFami | TF350009 |
Enzyme and pathway databases
Reactomei | R-DRE-416476 G alpha (q) signalling events R-DRE-417957 P2Y receptors |
Gene expression databases
Bgeei | ENSDARG00000062552 Expressed in 15 organ(s), highest expression level in heart |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | Q08BG4_DANRE | |
Accessioni | Q08BG4Primary (citable) accession number: Q08BG4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 31, 2006 |
Last sequence update: | October 31, 2006 | |
Last modified: | February 13, 2019 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |