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Entry version 124 (12 Aug 2020)
Sequence version 2 (01 Sep 2009)
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Protein

Zinc finger protein 616

Gene

ZNF616

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri185 – 207C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri689 – 711C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri717 – 739C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri745 – 767C2H2-type 21PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q08AN1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 616
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF616
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204611.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28062, ZNF616

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08AN1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000204611

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134978923

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q08AN1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF616

Domain mapping of disease mutations (DMDM)

More...
DMDMi
257050983

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804241 – 781Zinc finger protein 616Add BLAST781

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q08AN1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q08AN1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q08AN1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08AN1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08AN1

PeptideAtlas

More...
PeptideAtlasi
Q08AN1

PRoteomics IDEntifications database

More...
PRIDEi
Q08AN1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58682

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08AN1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08AN1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q08AN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204611, Expressed in sural nerve and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q08AN1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08AN1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204611, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124691, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q08AN1, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000471000

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q08AN1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q08AN1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 84KRABPROSITE-ProRule annotationAdd BLAST78

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri185 – 207C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 291C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri689 – 711C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri717 – 739C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri745 – 767C2H2-type 21PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164749

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_17_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08AN1

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
KAYVCNE

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08AN1

TreeFam database of animal gene trees

More...
TreeFami
TF341892

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 21 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 21 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 21 hits
PS50157, ZINC_FINGER_C2H2_2, 21 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q08AN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATQGHLTFK DVAIEFSQEE WKCLEPVQKA LYKDVMLENY RNLVFLGISP
60 70 80 90 100
KCVIKELPPT ENSNTGERFQ TVALERHQSY DIENLYFREI QKHLHDLEFQ
110 120 130 140 150
WKDGETNDKE VPVPHENNLT GKRDQHSQGD VENNHIENQL TSNFESRLAE
160 170 180 190 200
LQKVQTEGRL YECNETEKTG NNGCLVSPHI REKTYVCNEC GKAFKASSSL
210 220 230 240 250
INHQRIHTTE KPYKCNECGK AFHRASLLTV HKVVHTRGKS YQCDVCGKIF
260 270 280 290 300
RKNSYFVRHQ RSHTGQKPYI CNECGKSFSK SSHLAVHQRI HTGEKPYKCN
310 320 330 340 350
LCGKSFSQRV HLRLHQTVHT GERPFKCNEC GKTFKRSSNL TVHQVIHAGK
360 370 380 390 400
KPYKCDVCGK AFRHRSNLVC HRRIHSGEKQ YKCNECGKVF SKRSSLAVHR
410 420 430 440 450
RIHTVEKPCK CNECGKVFSK RSSLAVHQRI HTGQKTYKCN KCGKVYSKHS
460 470 480 490 500
HLAVHWRIHT GEKAYKCNEC GKVFSIHSRL AAHQRIHTGE KPYKCNECGK
510 520 530 540 550
VFSQHSRLAV HRRIHTGEKP YKCKECGKVF SDRSAFARHR RIHTGEKPYK
560 570 580 590 600
CKECGKVFSQ CSRLTVHRRI HSGEKPYKCN ECGKVYSQYS HLVGHRRVHT
610 620 630 640 650
GEKPYKCHEC GKAFNQGSTL NRHQRIHTGE KPYKCNQCGN SFSQRVHLRL
660 670 680 690 700
HQTVHTGDRP YKCNECGKTF KRSSNLTAHQ IIHAGKKPYK CDECGKVFRH
710 720 730 740 750
SSHLVSHQRI HTGEKRYKCI ECGKAFGRLF SLSKHQRIHS GKKPYKCNEC
760 770 780
GKSFICRSGL TKHRIRHTGE SLTTKLNVTR P
Length:781
Mass (Da):90,273
Last modified:September 1, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i487A86A65B70CE10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYU5M0QYU5_HUMAN
Zinc finger protein 616
ZNF616
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXF0M0QXF0_HUMAN
Zinc finger protein 616
ZNF616
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0C2M0R0C2_HUMAN
Zinc finger protein 616
ZNF616
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06196050P → S2 PublicationsCorresponds to variant dbSNP:rs35582075Ensembl.1
Natural variantiVAR_031149451H → R. Corresponds to variant dbSNP:rs3764537Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK092266 mRNA Translation: BAG52513.1
BC033199 mRNA Translation: AAH33199.1
BC125099 mRNA Translation: AAI25100.1
AL832969 mRNA Translation: CAH56353.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33090.1

NCBI Reference Sequences

More...
RefSeqi
NP_848618.2, NM_178523.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000600228; ENSP00000471000; ENSG00000204611

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
90317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90317

UCSC genome browser

More...
UCSCi
uc002pym.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092266 mRNA Translation: BAG52513.1
BC033199 mRNA Translation: AAH33199.1
BC125099 mRNA Translation: AAI25100.1
AL832969 mRNA Translation: CAH56353.1
CCDSiCCDS33090.1
RefSeqiNP_848618.2, NM_178523.4

3D structure databases

SMRiQ08AN1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124691, 7 interactors
IntActiQ08AN1, 6 interactors
STRINGi9606.ENSP00000471000

PTM databases

iPTMnetiQ08AN1
PhosphoSitePlusiQ08AN1
SwissPalmiQ08AN1

Polymorphism and mutation databases

BioMutaiZNF616
DMDMi257050983

Proteomic databases

EPDiQ08AN1
jPOSTiQ08AN1
MassIVEiQ08AN1
MaxQBiQ08AN1
PaxDbiQ08AN1
PeptideAtlasiQ08AN1
PRIDEiQ08AN1
ProteomicsDBi58682

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
76364, 8 antibodies

Genome annotation databases

EnsembliENST00000600228; ENSP00000471000; ENSG00000204611
GeneIDi90317
KEGGihsa:90317
UCSCiuc002pym.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90317
EuPathDBiHostDB:ENSG00000204611.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF616
HGNCiHGNC:28062, ZNF616
HPAiENSG00000204611, Low tissue specificity
neXtProtiNX_Q08AN1
OpenTargetsiENSG00000204611
PharmGKBiPA134978923

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000164749
HOGENOMiCLU_002678_17_1_1
InParanoidiQ08AN1
KOiK09228
OMAiKAYVCNE
OrthoDBi1318335at2759
PhylomeDBiQ08AN1
TreeFamiTF341892

Enzyme and pathway databases

PathwayCommonsiQ08AN1
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
90317, 4 hits in 894 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
90317
PharosiQ08AN1, Tdark

Protein Ontology

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PROi
PR:Q08AN1
RNActiQ08AN1, protein

Gene expression databases

BgeeiENSG00000204611, Expressed in sural nerve and 168 other tissues
ExpressionAtlasiQ08AN1, baseline and differential
GenevisibleiQ08AN1, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 21 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 21 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 21 hits
PS50157, ZINC_FINGER_C2H2_2, 21 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN616_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08AN1
Secondary accession number(s): B3KRV1, Q0P658, Q658V7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: September 1, 2009
Last modified: August 12, 2020
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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