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Protein

Histone H2A

Gene

HIST1H2AB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:HIST1H2ABImported
Synonyms:HIST1H2AEImported
ORF Names:hCG_1640984Imported, hCG_1787383Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000277075.2
HostDB:ENSG00000278463.1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29111

Expressioni

Gene expression databases

BgeeiENSG00000277075 Expressed in 129 organ(s), highest expression level in stomach

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 89HistoneInterPro annotationAdd BLAST85
Domaini92 – 126Histone_H2A_CInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
HOVERGENiHBG009342
KOiK11251
OMAiANEMFIN
OrthoDBiEOG091G0XGD

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequencei

Sequence statusi: Complete.

Q08AJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV
60 70 80 90 100
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGR
110 120 130
VTIAQGGVLP NIQAVLLPKK TESHHKAKGK
Length:130
Mass (Da):14,135
Last modified:October 31, 2006 - v1
Checksum:i9CFE6184B2CC89F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125140 mRNA Translation: AAI25141.1
AK311785 mRNA Translation: BAG34728.1
AK311824 mRNA Translation: BAG34766.1
CH471087 Genomic DNA Translation: EAW55512.1
CH471087 Genomic DNA Translation: EAW55546.1
RefSeqiNP_003504.2, NM_003513.2
NP_066390.1, NM_021052.2
UniGeneiHs.121017
Hs.248174
Hs.709162

Genome annotation databases

GeneIDi3012
8335
KEGGihsa:3012
hsa:8335
UCSCiuc003nft.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125140 mRNA Translation: AAI25141.1
AK311785 mRNA Translation: BAG34728.1
AK311824 mRNA Translation: BAG34766.1
CH471087 Genomic DNA Translation: EAW55512.1
CH471087 Genomic DNA Translation: EAW55546.1
RefSeqiNP_003504.2, NM_003513.2
NP_066390.1, NM_021052.2
UniGeneiHs.121017
Hs.248174
Hs.709162

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi3012
8335
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3012
8335
KEGGihsa:3012
hsa:8335
UCSCiuc003nft.2 human

Organism-specific databases

CTDi3012
8335
EuPathDBiHostDB:ENSG00000277075.2
HostDB:ENSG00000278463.1
PharmGKBiPA29111

Phylogenomic databases

eggNOGiKOG1756 Eukaryota
COG5262 LUCA
HOVERGENiHBG009342
KOiK11251
OMAiANEMFIN
OrthoDBiEOG091G0XGD

Gene expression databases

BgeeiENSG00000277075 Expressed in 129 organ(s), highest expression level in stomach

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ08AJ9_HUMAN
AccessioniPrimary (citable) accession number: Q08AJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 10, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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