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Entry version 114 (17 Jun 2020)
Sequence version 1 (31 Oct 2006)
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Protein

Acyl-coenzyme A synthetase ACSM1, mitochondrial

Gene

ACSM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10434065). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by monovalent cations, such as potassium, rubidium or ammonium.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=21 µM for benzoate1 Publication
  2. KM=570 µM for butyrate1 Publication
  3. KM=20 µM for decanoate1 Publication
  4. KM=34 µM for hexanoate1 Publication
  5. KM=24 µM for laurate1 Publication
  6. KM=143 µM for phenylacetate1 Publication
  7. KM=25 µM for salicylate1 Publication
  1. Vmax=9 nmol/min/mg enzyme for benzoate1 Publication
  2. Vmax=24 nmol/min/mg enzyme for butyrate1 Publication
  3. Vmax=8 nmol/min/mg enzyme for decanoate1 Publication
  4. Vmax=118 nmol/min/mg enzyme for hexanoate1 Publication
  5. Vmax=0.15 nmol/min/mg enzyme for laurate1 Publication
  6. Vmax=2 nmol/min/mg enzyme for phenylacetate1 Publication

pH dependencei

Optimum pH is 8.8.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei452ATPBy similarity1
Binding sitei467ATPBy similarity1
Binding sitei563ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi226 – 234ATPBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-177135 Conjugation of benzoate with glycine
R-HSA-177162 Conjugation of phenylacetate with glutamine

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000449

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-coenzyme A synthetase ACSM1, mitochondrial (EC:6.2.1.21 Publication)
Alternative name(s):
Acyl-CoA synthetase medium-chain family member 1
Benzoate--CoA ligase (EC:6.2.1.251 Publication)
Butyrate--CoA ligase 1
Butyryl-coenzyme A synthetase 1
Lipoate-activating enzymeBy similarity
Middle-chain acyl-CoA synthetase 1
Xenobiotic/medium-chain fatty acid-CoA ligase HXM-B1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACSM1
Synonyms:BUCS1, LAEBy similarity, MACS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166743.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18049 ACSM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614357 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08AH1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
116285

Open Targets

More...
OpenTargetsi
ENSG00000166743

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25468

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q08AH1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACSM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121940002

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 31MitochondrionBy similarityAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030609132 – 577Acyl-coenzyme A synthetase ACSM1, mitochondrialAdd BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei85N6-succinyllysineBy similarity1
Modified residuei146N6-acetyllysine; alternateBy similarity1
Modified residuei146N6-succinyllysine; alternateBy similarity1
Modified residuei183N6-succinyllysineBy similarity1
Modified residuei204N6-acetyllysine; alternateBy similarity1
Modified residuei204N6-succinyllysine; alternateBy similarity1
Modified residuei214N6-acetyllysineBy similarity1
Modified residuei237N6-succinyllysineBy similarity1
Modified residuei356N6-acetyllysine; alternateBy similarity1
Modified residuei356N6-succinyllysine; alternateBy similarity1
Modified residuei391N6-acetyllysine; alternateBy similarity1
Modified residuei391N6-succinyllysine; alternateBy similarity1
Modified residuei531N6-acetyllysineBy similarity1
Modified residuei538N6-acetyllysine; alternateBy similarity1
Modified residuei538N6-succinyllysine; alternateBy similarity1
Modified residuei549N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q08AH1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q08AH1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08AH1

PeptideAtlas

More...
PeptideAtlasi
Q08AH1

PRoteomics IDEntifications database

More...
PRIDEi
Q08AH1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58670 [Q08AH1-1]
58671 [Q08AH1-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q08AH1-1 [Q08AH1-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08AH1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08AH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166743 Expressed in left ovary and 96 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q08AH1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08AH1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166743 Tissue enriched (breast)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125496, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q08AH1, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301956

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q08AH1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q08AH1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1175 Eukaryota
COG0365 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161138

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_59_10_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08AH1

KEGG Orthology (KO)

More...
KOi
K23756

Identification of Orthologs from Complete Genome Data

More...
OMAi
TMDPMVI

Database of Orthologous Groups

More...
OrthoDBi
683933at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08AH1

TreeFam database of animal gene trees

More...
TreeFami
TF354287

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08AH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQWLMRFRTL WGIHKSFHNI HPAPSQLRCR SLSEFGAPRW NDYEVPEEFN
60 70 80 90 100
FASYVLDYWA QKEKEGKRGP NPAFWWVNGQ GDEVKWSFRE MGDLTRRVAN
110 120 130 140 150
VFTQTCGLQQ GDHLALMLPR VPEWWLVAVG CMRTGIIFIP ATILLKAKDI
160 170 180 190 200
LYRLQLSKAK GIVTIDALAS EVDSIASQCP SLKTKLLVSD HSREGWLDFR
210 220 230 240 250
SLVKSASPEH TCVKSKTLDP MVIFFTSGTT GFPKMAKHSH GLALQPSFPG
260 270 280 290 300
SRKLRSLKTS DVSWCLSDSG WIVATIWTLV EPWTAGCTVF IHHLPQFDTK
310 320 330 340 350
VIIQTLLKYP INHFWGVSSI YRMILQQDFT SIRFPALEHC YTGGEVVLPK
360 370 380 390 400
DQEEWKRRTG LLLYENYGQS ETGLICATYW GMKIKPGFMG KATPPYDVQV
410 420 430 440 450
IDDKGSILPP NTEGNIGIRI KPVRPVSLFM CYEGDPEKTA KVECGDFYNT
460 470 480 490 500
GDRGKMDEEG YICFLGRSDD IINASGYRIG PAEVESALVE HPAVAESAVV
510 520 530 540 550
GSPDPIRGEV VKAFIVLTPQ FLSHDKDQLT KELQQHVKSV TAPYKYPRKV
560 570
EFVSELPKTI TGKIERKELR KKETGQM
Length:577
Mass (Da):65,273
Last modified:October 31, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i380BF4B8944B0E34
GO
Isoform 2 (identifier: Q08AH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-577: Missing.

Show »
Length:204
Mass (Da):23,538
Checksum:i6C7EAEA423A0D790
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFK0E5RFK0_HUMAN
Acyl-coenzyme A synthetase ACSM1, m...
ACSM1
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAU5H0YAU5_HUMAN
Acyl-coenzyme A synthetase ACSM1, m...
ACSM1
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti549K → N in BAB64535 (PubMed:11470804).Curated1
Sequence conflicti549K → N in BAB68363 (PubMed:11470804).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048238272I → M. Corresponds to variant dbSNP:rs16970511Ensembl.1
Natural variantiVAR_035245479I → V. Corresponds to variant dbSNP:rs8056709Ensembl.1
Natural variantiVAR_035246515I → T. Corresponds to variant dbSNP:rs16970453Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028391205 – 577Missing in isoform 2. 1 PublicationAdd BLAST373

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB059429 mRNA Translation: BAB64535.1
AB062503 Genomic DNA Translation: BAB68363.1
BC125177 mRNA Translation: AAI25178.1
BC125178 mRNA Translation: AAI25179.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10587.1 [Q08AH1-1]

NCBI Reference Sequences

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RefSeqi
NP_001305819.1, NM_001318890.1 [Q08AH1-1]
NP_443188.2, NM_052956.2 [Q08AH1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000307493; ENSP00000301956; ENSG00000166743 [Q08AH1-1]
ENST00000519745; ENSP00000428650; ENSG00000166743 [Q08AH1-2]
ENST00000520010; ENSP00000428047; ENSG00000166743 [Q08AH1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
116285

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:116285

UCSC genome browser

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UCSCi
uc002dhm.1 human [Q08AH1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB059429 mRNA Translation: BAB64535.1
AB062503 Genomic DNA Translation: BAB68363.1
BC125177 mRNA Translation: AAI25178.1
BC125178 mRNA Translation: AAI25179.1
CCDSiCCDS10587.1 [Q08AH1-1]
RefSeqiNP_001305819.1, NM_001318890.1 [Q08AH1-1]
NP_443188.2, NM_052956.2 [Q08AH1-1]

3D structure databases

SMRiQ08AH1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125496, 4 interactors
IntActiQ08AH1, 9 interactors
STRINGi9606.ENSP00000301956

Chemistry databases

SwissLipidsiSLP:000000449

PTM databases

iPTMnetiQ08AH1
PhosphoSitePlusiQ08AH1

Polymorphism and mutation databases

BioMutaiACSM1
DMDMi121940002

Proteomic databases

jPOSTiQ08AH1
MassIVEiQ08AH1
PaxDbiQ08AH1
PeptideAtlasiQ08AH1
PRIDEiQ08AH1
ProteomicsDBi58670 [Q08AH1-1]
58671 [Q08AH1-2]
TopDownProteomicsiQ08AH1-1 [Q08AH1-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
49877 67 antibodies

Genome annotation databases

EnsembliENST00000307493; ENSP00000301956; ENSG00000166743 [Q08AH1-1]
ENST00000519745; ENSP00000428650; ENSG00000166743 [Q08AH1-2]
ENST00000520010; ENSP00000428047; ENSG00000166743 [Q08AH1-1]
GeneIDi116285
KEGGihsa:116285
UCSCiuc002dhm.1 human [Q08AH1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
116285
DisGeNETi116285
EuPathDBiHostDB:ENSG00000166743.9

GeneCards: human genes, protein and diseases

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GeneCardsi
ACSM1
HGNCiHGNC:18049 ACSM1
HPAiENSG00000166743 Tissue enriched (breast)
MIMi614357 gene
neXtProtiNX_Q08AH1
OpenTargetsiENSG00000166743
PharmGKBiPA25468

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00940000161138
HOGENOMiCLU_000022_59_10_1
InParanoidiQ08AH1
KOiK23756
OMAiTMDPMVI
OrthoDBi683933at2759
PhylomeDBiQ08AH1
TreeFamiTF354287

Enzyme and pathway databases

ReactomeiR-HSA-177135 Conjugation of benzoate with glycine
R-HSA-177162 Conjugation of phenylacetate with glutamine

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
116285 6 hits in 789 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ACSM1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
116285
PharosiQ08AH1 Tbio

Protein Ontology

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PROi
PR:Q08AH1
RNActiQ08AH1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166743 Expressed in left ovary and 96 other tissues
ExpressionAtlasiQ08AH1 baseline and differential
GenevisibleiQ08AH1 HS

Family and domain databases

Gene3Di3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACSM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08AH1
Secondary accession number(s): Q08AH2, Q96A20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 31, 2006
Last modified: June 17, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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