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Protein

Putative golgin subfamily A member 8F/8G

Gene

GOLGA8F

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene. A family of highly similar proteins (GOLGA8A, GOLGA8B, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G) are encoded by a repeated region on chromosome 15q11-15q13. Our sequences are in agreement with HGNC nomenclature.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Putative golgin subfamily A member 8F/8G
Gene namesi
Name:GOLGA8F
AND
Name:GOLGA8G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000153684.14
HGNCiHGNC:32378 GOLGA8F
HGNC:25328 GOLGA8G
neXtProtiNX_Q08AF8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153684

Polymorphism and mutation databases

DMDMi121939991

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003149681 – 430Putative golgin subfamily A member 8F/8GAdd BLAST430

Proteomic databases

PaxDbiQ08AF8
PeptideAtlasiQ08AF8
PRIDEiQ08AF8
ProteomicsDBi58665
58666 [Q08AF8-2]
58667 [Q08AF8-3]

Expressioni

Gene expression databases

BgeeiENSG00000153684 Expressed in 50 organ(s), highest expression level in testis
CleanExiHS_GOLGA8G
ExpressionAtlasiQ08AF8 baseline and differential
GenevisibleiQ08AF8 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

IntActiQ08AF8, 24 interactors
STRINGi9606.ENSP00000458130

Structurei

3D structure databases

ProteinModelPortaliQ08AF8
SMRiQ08AF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2 – 217Sequence analysisAdd BLAST216

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi427 – 430Poly-Arg4

Sequence similaritiesi

Belongs to the GOLGA8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00530000062932
HOGENOMiHOG000218631
InParanoidiQ08AF8
OrthoDBiEOG091G0DDT
PhylomeDBiQ08AF8

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PfamiView protein in Pfam
PF15070 GOLGA2L5, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q08AF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEWKLEQSMR EQALLKAQLT QLKESLKEVQ LERDEYAEHL KGERARWQQR
60 70 80 90 100
MRKMSQEVCS LKKEKKHDKY RVEKLERSLS KLKHQMAEPL PPEPPAVPSE
110 120 130 140 150
VELQHLRKEL ERVAGELQAQ VEYNQRISLL NEGQKERLRE QEERLQEQQE
160 170 180 190 200
RLPEQEERLQ QLAEPQNSFK ELNNENKSVL QLEQQVKELQ EKLGKERLEA
210 220 230 240 250
ASQQKQQLTA QLSLMALPGE GDGGGHLDSE GEEAPRPIPS IPQDLESREA
260 270 280 290 300
MSGFMDHLEE KADLSELVEK EELGFFQYYR ERCHQKVYHP ITKPGGSAKD
310 320 330 340 350
AAPGGGHHQA GPGQGGDEGE AAGAAGDGVA AGGDYKGHSK FLVTAQNPAH
360 370 380 390 400
EPSPGAPAPQ ELGAAHKHGD LCEVSLTDSV EPVQGEAREG SPHDNPTAQP
410 420 430
IVQDHQEHPG LGSNCCVPFF CWAWLPRRRR
Length:430
Mass (Da):48,405
Last modified:October 31, 2006 - v1
Checksum:iC758D5AF42EC4171
GO
Isoform 2 (identifier: Q08AF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-267: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,550
Checksum:i008A9E2F67385718
GO
Isoform 3 (identifier: Q08AF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-195: K → KVKET

Show »
Length:434
Mass (Da):48,863
Checksum:i1307A908C841659E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMC3H3BMC3_HUMAN
Putative golgin subfamily A member ...
GOLGA8G GOLGA8F
648Annotation score:
A0A0G2JPF6A0A0G2JPF6_HUMAN
Putative golgin subfamily A member ...
GOLGA8F
648Annotation score:
A0A0G2JP71A0A0G2JP71_HUMAN
Putative golgin subfamily A member ...
GOLGA8F
430Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232E → K in BC066774 (PubMed:15489334).Curated1
Sequence conflicti391S → P in AAH99913 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035081121 – 267Missing in isoform 2. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_037944195K → KVKET in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ309038 mRNA Translation: ABD73922.1
AC138749 Genomic DNA No translation available.
BC066774 mRNA No translation available.
BC099913 mRNA Translation: AAH99913.1
BC125193 mRNA Translation: AAI25194.1
BC125194 mRNA Translation: AAI25195.1
BC150302 mRNA Translation: AAI50303.1
AL833871 mRNA Translation: CAD38728.1
UniGeneiHs.169639
Hs.510812
Hs.592025

Genome annotation databases

EnsembliENST00000329523; ENSP00000457934; ENSG00000183629
ENST00000526619; ENSP00000456138; ENSG00000153684 [Q08AF8-1]
ENST00000612831; ENSP00000481013; ENSG00000277090
UCSCiuc001zbp.4 human [Q08AF8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ309038 mRNA Translation: ABD73922.1
AC138749 Genomic DNA No translation available.
BC066774 mRNA No translation available.
BC099913 mRNA Translation: AAH99913.1
BC125193 mRNA Translation: AAI25194.1
BC125194 mRNA Translation: AAI25195.1
BC150302 mRNA Translation: AAI50303.1
AL833871 mRNA Translation: CAD38728.1
UniGeneiHs.169639
Hs.510812
Hs.592025

3D structure databases

ProteinModelPortaliQ08AF8
SMRiQ08AF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ08AF8, 24 interactors
STRINGi9606.ENSP00000458130

Polymorphism and mutation databases

DMDMi121939991

Proteomic databases

PaxDbiQ08AF8
PeptideAtlasiQ08AF8
PRIDEiQ08AF8
ProteomicsDBi58665
58666 [Q08AF8-2]
58667 [Q08AF8-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329523; ENSP00000457934; ENSG00000183629
ENST00000526619; ENSP00000456138; ENSG00000153684 [Q08AF8-1]
ENST00000612831; ENSP00000481013; ENSG00000277090
UCSCiuc001zbp.4 human [Q08AF8-1]

Organism-specific databases

EuPathDBiHostDB:ENSG00000153684.14
GeneCardsiGOLGA8F
GOLGA8G
HGNCiHGNC:32378 GOLGA8F
HGNC:25328 GOLGA8G
neXtProtiNX_Q08AF8
OpenTargetsiENSG00000153684
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00530000062932
HOGENOMiHOG000218631
InParanoidiQ08AF8
OrthoDBiEOG091G0DDT
PhylomeDBiQ08AF8

Gene expression databases

BgeeiENSG00000153684 Expressed in 50 organ(s), highest expression level in testis
CleanExiHS_GOLGA8G
ExpressionAtlasiQ08AF8 baseline and differential
GenevisibleiQ08AF8 HS

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PfamiView protein in Pfam
PF15070 GOLGA2L5, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGOG8F_HUMAN
AccessioniPrimary (citable) accession number: Q08AF8
Secondary accession number(s): A4FTY1, Q1A5X9, Q8NDK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: September 12, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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