Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Schlafen family member 5

Gene

SLFN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a role in hematopoietic cell differentiation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi578 – 585ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Schlafen family member 5
Gene namesi
Name:SLFN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000166750.9
HGNCiHGNC:28286 SLFN5
MIMi614952 gene
neXtProtiNX_Q08AF3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi162394
OpenTargetsiENSG00000166750
PharmGKBiPA144596357

Polymorphism and mutation databases

BioMutaiSLFN5
DMDMi121939987

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002829821 – 891Schlafen family member 5Add BLAST891

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki59Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ08AF3
MaxQBiQ08AF3
PaxDbiQ08AF3
PeptideAtlasiQ08AF3
PRIDEiQ08AF3
ProteomicsDBi58663
58664 [Q08AF3-2]

PTM databases

iPTMnetiQ08AF3
PhosphoSitePlusiQ08AF3
SwissPalmiQ08AF3

Expressioni

Gene expression databases

BgeeiENSG00000166750 Expressed in 212 organ(s), highest expression level in blood
CleanExiHS_SLFN5
ExpressionAtlasiQ08AF3 baseline and differential
GenevisibleiQ08AF3 HS

Organism-specific databases

HPAiHPA017760

Interactioni

Protein-protein interaction databases

BioGridi127815, 5 interactors
IntActiQ08AF3, 7 interactors
MINTiQ08AF3

Structurei

3D structure databases

ProteinModelPortaliQ08AF3
SMRiQ08AF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Schlafen family. Subgroup III subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IJEW Eukaryota
ENOG410Z5MV LUCA
GeneTreeiENSGT00410000025651
HOGENOMiHOG000049135
HOVERGENiHBG056880
InParanoidiQ08AF3
OMAiQIYPESY
OrthoDBiEOG091G01HZ
PhylomeDBiQ08AF3
TreeFamiTF337168

Family and domain databases

Gene3Di3.30.950.30, 1 hit
InterProiView protein in InterPro
IPR018647 DUF2075
IPR027417 P-loop_NTPase
IPR029684 Schlafen
IPR007421 Schlafen_AAA_dom
IPR038461 Schlafen_AAA_dom_sf
IPR029671 Slfn5
PANTHERiPTHR12155 PTHR12155, 1 hit
PTHR12155:SF26 PTHR12155:SF26, 1 hit
PfamiView protein in Pfam
PF04326 AlbA_2, 1 hit
PF09848 DUF2075, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q08AF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLRIDVDTN FPECVVDAGK VTLGTQQRQE MDPRLREKQN EIILRAVCAL
60 70 80 90 100
LNSGGGIIKA EIENKGYNYE RHGVGLDVPP IFRSHLDKMQ KENHFLIFVK
110 120 130 140 150
SWNTEAGVPL ATLCSNLYHR ERTSTDVMDS QEALAFLKCR TQTPTNINVS
160 170 180 190 200
NSLGPQAAQG SVQYEGNINV SAAALFDRKR LQYLEKLNLP ESTHVEFVMF
210 220 230 240 250
STDVSHCVKD RLPKCVSAFA NTEGGYVFFG VHDETCQVIG CEKEKIDLTS
260 270 280 290 300
LRASIDGCIK KLPVHHFCTQ RPEIKYVLNF LEVHDKGALR GYVCAIKVEK
310 320 330 340 350
FCCAVFAKVP SSWQVKDNRV RQLPTREWTA WMMEADPDLS RCPEMVLQLS
360 370 380 390 400
LSSATPRSKP VCIHKNSECL KEQQKRYFPV FSDRVVYTPE SLYKELFSQH
410 420 430 440 450
KGLRDLINTE MRPFSQGILI FSQSWAVDLG LQEKQGVICD ALLISQNNTP
460 470 480 490 500
ILYTIFSKWD AGCKGYSMIV AYSLKQKLVN KGGYTGRLCI TPLVCVLNSD
510 520 530 540 550
RKAQSVYSSY LQIYPESYNF MTPQHMEALL QSLVIVLLGF KSFLSEELGS
560 570 580 590 600
EVLNLLTNKQ YELLSKNLRK TRELFVHGLP GSGKTILALR IMEKIRNVFH
610 620 630 640 650
CEPANILYIC ENQPLKKLVS FSKKNICQPV TRKTFMKNNF EHIQHIIIDD
660 670 680 690 700
AQNFRTEDGD WYGKAKFITQ TARDGPGVLW IFLDYFQTYH LSCSGLPPPS
710 720 730 740 750
DQYPREEINR VVRNAGPIAN YLQQVMQEAR QNPPPNLPPG SLVMLYEPKW
760 770 780 790 800
AQGVPGNLEI IEDLNLEEIL IYVANKCRFL LRNGYSPKDI AVLFTKASEV
810 820 830 840 850
EKYKDRLLTA MRKRKLSQLH EESDLLLQIG DASDVLTDHI VLDSVCRFSG
860 870 880 890
LERNIVFGIN PGVAPPAGAY NLLLCLASRA KRHLYILKAS V
Length:891
Mass (Da):101,055
Last modified:October 31, 2006 - v1
Checksum:i52F2AC3259251AB5
GO
Isoform 2 (identifier: Q08AF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: D → G
     339-891: Missing.

Note: No experimental confirmation available.
Show »
Length:338
Mass (Da):38,103
Checksum:iF321EDDA06C592FE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4E128B4E128_HUMAN
Schlafen family member 5
SLFN5
389Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183Y → H in AAI25202 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053876754V → L. Corresponds to variant dbSNP:rs16970806Ensembl.1
Natural variantiVAR_031445787P → L1 PublicationCorresponds to variant dbSNP:rs11651240Ensembl.1
Natural variantiVAR_031446797A → V. Corresponds to variant dbSNP:rs2291189Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024271338D → G in isoform 2. 1 Publication1
Alternative sequenceiVSP_024272339 – 891Missing in isoform 2. 1 PublicationAdd BLAST553

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021238 mRNA Translation: AAH21238.1
BC125200 mRNA Translation: AAI25201.1
BC125201 mRNA Translation: AAI25202.1
AK054668 mRNA Translation: BAB70788.1
CCDSiCCDS32619.1 [Q08AF3-1]
RefSeqiNP_659412.3, NM_144975.3 [Q08AF3-1]
UniGeneiHs.585792
Hs.709347

Genome annotation databases

EnsembliENST00000299977; ENSP00000299977; ENSG00000166750 [Q08AF3-1]
ENST00000592325; ENSP00000466984; ENSG00000166750 [Q08AF3-2]
GeneIDi162394
KEGGihsa:162394
UCSCiuc002hje.4 human [Q08AF3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSLFN5_HUMAN
AccessioniPrimary (citable) accession number: Q08AF3
Secondary accession number(s): Q08AF2, Q8WU54, Q96A82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 31, 2006
Last modified: September 12, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again