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Entry version 106 (18 Sep 2019)
Sequence version 1 (31 Oct 2006)
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Protein

Schlafen family member 5

Gene

SLFN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a role in hematopoietic cell differentiation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi578 – 585ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Schlafen family member 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLFN5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28286 SLFN5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614952 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08AF3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
162394

Open Targets

More...
OpenTargetsi
ENSG00000166750

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596357

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLFN5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121939987

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002829821 – 891Schlafen family member 5Add BLAST891

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki59Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q08AF3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q08AF3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q08AF3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08AF3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08AF3

PeptideAtlas

More...
PeptideAtlasi
Q08AF3

PRoteomics IDEntifications database

More...
PRIDEi
Q08AF3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58663 [Q08AF3-1]
58664 [Q08AF3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08AF3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08AF3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q08AF3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166750 Expressed in 212 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q08AF3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08AF3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017760

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127815, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q08AF3, 7 interactors

Molecular INTeraction database

More...
MINTi
Q08AF3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299977

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q08AF3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Schlafen family. Subgroup III subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJEW Eukaryota
ENOG410Z5MV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00410000025651

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049135

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08AF3

Identification of Orthologs from Complete Genome Data

More...
OMAi
NVFHCEP

Database of Orthologous Groups

More...
OrthoDBi
211385at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08AF3

TreeFam database of animal gene trees

More...
TreeFami
TF337168

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.950.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018647 DUF2075
IPR027417 P-loop_NTPase
IPR029684 Schlafen
IPR007421 Schlafen_AlbA_2_dom
IPR038461 Schlafen_AlbA_2_dom_sf
IPR029671 Slfn5

The PANTHER Classification System

More...
PANTHERi
PTHR12155 PTHR12155, 1 hit
PTHR12155:SF26 PTHR12155:SF26, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04326 AlbA_2, 1 hit
PF09848 DUF2075, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08AF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLRIDVDTN FPECVVDAGK VTLGTQQRQE MDPRLREKQN EIILRAVCAL
60 70 80 90 100
LNSGGGIIKA EIENKGYNYE RHGVGLDVPP IFRSHLDKMQ KENHFLIFVK
110 120 130 140 150
SWNTEAGVPL ATLCSNLYHR ERTSTDVMDS QEALAFLKCR TQTPTNINVS
160 170 180 190 200
NSLGPQAAQG SVQYEGNINV SAAALFDRKR LQYLEKLNLP ESTHVEFVMF
210 220 230 240 250
STDVSHCVKD RLPKCVSAFA NTEGGYVFFG VHDETCQVIG CEKEKIDLTS
260 270 280 290 300
LRASIDGCIK KLPVHHFCTQ RPEIKYVLNF LEVHDKGALR GYVCAIKVEK
310 320 330 340 350
FCCAVFAKVP SSWQVKDNRV RQLPTREWTA WMMEADPDLS RCPEMVLQLS
360 370 380 390 400
LSSATPRSKP VCIHKNSECL KEQQKRYFPV FSDRVVYTPE SLYKELFSQH
410 420 430 440 450
KGLRDLINTE MRPFSQGILI FSQSWAVDLG LQEKQGVICD ALLISQNNTP
460 470 480 490 500
ILYTIFSKWD AGCKGYSMIV AYSLKQKLVN KGGYTGRLCI TPLVCVLNSD
510 520 530 540 550
RKAQSVYSSY LQIYPESYNF MTPQHMEALL QSLVIVLLGF KSFLSEELGS
560 570 580 590 600
EVLNLLTNKQ YELLSKNLRK TRELFVHGLP GSGKTILALR IMEKIRNVFH
610 620 630 640 650
CEPANILYIC ENQPLKKLVS FSKKNICQPV TRKTFMKNNF EHIQHIIIDD
660 670 680 690 700
AQNFRTEDGD WYGKAKFITQ TARDGPGVLW IFLDYFQTYH LSCSGLPPPS
710 720 730 740 750
DQYPREEINR VVRNAGPIAN YLQQVMQEAR QNPPPNLPPG SLVMLYEPKW
760 770 780 790 800
AQGVPGNLEI IEDLNLEEIL IYVANKCRFL LRNGYSPKDI AVLFTKASEV
810 820 830 840 850
EKYKDRLLTA MRKRKLSQLH EESDLLLQIG DASDVLTDHI VLDSVCRFSG
860 870 880 890
LERNIVFGIN PGVAPPAGAY NLLLCLASRA KRHLYILKAS V
Length:891
Mass (Da):101,055
Last modified:October 31, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52F2AC3259251AB5
GO
Isoform 2 (identifier: Q08AF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: D → G
     339-891: Missing.

Note: No experimental confirmation available.
Show »
Length:338
Mass (Da):38,103
Checksum:iF321EDDA06C592FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4E128B4E128_HUMAN
Schlafen family member 5
SLFN5
389Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti183Y → H in AAI25202 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053876754V → L. Corresponds to variant dbSNP:rs16970806Ensembl.1
Natural variantiVAR_031445787P → L1 PublicationCorresponds to variant dbSNP:rs11651240Ensembl.1
Natural variantiVAR_031446797A → V. Corresponds to variant dbSNP:rs2291189Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024271338D → G in isoform 2. 1 Publication1
Alternative sequenceiVSP_024272339 – 891Missing in isoform 2. 1 PublicationAdd BLAST553

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC021238 mRNA Translation: AAH21238.1
BC125200 mRNA Translation: AAI25201.1
BC125201 mRNA Translation: AAI25202.1
AK054668 mRNA Translation: BAB70788.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32619.1 [Q08AF3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_659412.3, NM_144975.3 [Q08AF3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299977; ENSP00000299977; ENSG00000166750 [Q08AF3-1]
ENST00000592325; ENSP00000466984; ENSG00000166750 [Q08AF3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
162394

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:162394

UCSC genome browser

More...
UCSCi
uc002hje.4 human [Q08AF3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021238 mRNA Translation: AAH21238.1
BC125200 mRNA Translation: AAI25201.1
BC125201 mRNA Translation: AAI25202.1
AK054668 mRNA Translation: BAB70788.1
CCDSiCCDS32619.1 [Q08AF3-1]
RefSeqiNP_659412.3, NM_144975.3 [Q08AF3-1]

3D structure databases

SMRiQ08AF3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127815, 7 interactors
IntActiQ08AF3, 7 interactors
MINTiQ08AF3
STRINGi9606.ENSP00000299977

PTM databases

iPTMnetiQ08AF3
PhosphoSitePlusiQ08AF3
SwissPalmiQ08AF3

Polymorphism and mutation databases

BioMutaiSLFN5
DMDMi121939987

Proteomic databases

EPDiQ08AF3
jPOSTiQ08AF3
MassIVEiQ08AF3
MaxQBiQ08AF3
PaxDbiQ08AF3
PeptideAtlasiQ08AF3
PRIDEiQ08AF3
ProteomicsDBi58663 [Q08AF3-1]
58664 [Q08AF3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299977; ENSP00000299977; ENSG00000166750 [Q08AF3-1]
ENST00000592325; ENSP00000466984; ENSG00000166750 [Q08AF3-2]
GeneIDi162394
KEGGihsa:162394
UCSCiuc002hje.4 human [Q08AF3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
162394
DisGeNETi162394

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLFN5
HGNCiHGNC:28286 SLFN5
HPAiHPA017760
MIMi614952 gene
neXtProtiNX_Q08AF3
OpenTargetsiENSG00000166750
PharmGKBiPA144596357

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJEW Eukaryota
ENOG410Z5MV LUCA
GeneTreeiENSGT00410000025651
HOGENOMiHOG000049135
InParanoidiQ08AF3
OMAiNVFHCEP
OrthoDBi211385at2759
PhylomeDBiQ08AF3
TreeFamiTF337168

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
162394

Pharos

More...
Pharosi
Q08AF3

Protein Ontology

More...
PROi
PR:Q08AF3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166750 Expressed in 212 organ(s), highest expression level in blood
ExpressionAtlasiQ08AF3 baseline and differential
GenevisibleiQ08AF3 HS

Family and domain databases

Gene3Di3.30.950.30, 1 hit
InterProiView protein in InterPro
IPR018647 DUF2075
IPR027417 P-loop_NTPase
IPR029684 Schlafen
IPR007421 Schlafen_AlbA_2_dom
IPR038461 Schlafen_AlbA_2_dom_sf
IPR029671 Slfn5
PANTHERiPTHR12155 PTHR12155, 1 hit
PTHR12155:SF26 PTHR12155:SF26, 1 hit
PfamiView protein in Pfam
PF04326 AlbA_2, 1 hit
PF09848 DUF2075, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLFN5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08AF3
Secondary accession number(s): Q08AF2, Q8WU54, Q96A82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 31, 2006
Last modified: September 18, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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