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Entry version 114 (13 Feb 2019)
Sequence version 3 (28 Nov 2012)
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Protein

Protein spire homolog 1

Gene

SPIRE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein spire homolog 1
Short name:
Spir-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPIRE1Imported
Synonyms:KIAA1135, SPIR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134278.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30622 SPIRE1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609216 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08AE8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131I → K: Strongly reduces interaction with FMN2. 1 Publication1
Mutagenesisi134Y → K: Abolishes interaction with FMN2. 1 Publication1
Mutagenesisi138D → N: Abolishes interaction with FMN2. 2 Publications1
Mutagenesisi146E → A or K: Abolishes interaction with FMN2. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
56907

Open Targets

More...
OpenTargetsi
ENSG00000134278

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134895885

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPIRE1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
425906061

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003095692 – 756Protein spire homolog 1Add BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei406PhosphoserineBy similarity1
Modified residuei464PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei509PhosphothreonineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei682PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q08AE8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08AE8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08AE8

PeptideAtlas

More...
PeptideAtlasi
Q08AE8

PRoteomics IDEntifications database

More...
PRIDEi
Q08AE8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58658
58659 [Q08AE8-2]
58660 [Q08AE8-3]
58661 [Q08AE8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08AE8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08AE8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134278 Expressed in 204 organ(s), highest expression level in medial globus pallidus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q08AE8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08AE8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040737
HPA040942

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FMN2.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121237, 10 interactors

Database of interacting proteins

More...
DIPi
DIP-42378N

Protein interaction database and analysis system

More...
IntActi
Q08AE8, 6 interactors

Molecular INTeraction database

More...
MINTi
Q08AE8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387266

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1756
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YLEX-ray1.80A36-236[»]
2YLFX-ray2.05A36-236[»]
3R7GX-ray2.20A20-237[»]
3RBWX-ray3.20A/B/C/D20-237[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q08AE8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q08AE8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 231KINDPROSITE-ProRule annotationAdd BLAST192
Domaini305 – 323WH2 1Add BLAST19
Domaini369 – 386WH2 2Add BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni131 – 138Important for interaction with FMN28
Regioni556 – 576Spir-boxAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili229 – 257Sequence analysisAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds to actin monomers via the WH2 domain.By similarity
The Spir-box targets binding to intracellular membrane structures.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spire family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK9H Eukaryota
ENOG4111E0J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003058

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013039

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058898

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08AE8

KEGG Orthology (KO)

More...
KOi
K02098

Identification of Orthologs from Complete Genome Data

More...
OMAi
TMELYTF

Database of Orthologous Groups

More...
OrthoDBi
560461at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08AE8

TreeFam database of animal gene trees

More...
TreeFami
TF326239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011019 KIND_dom
IPR029901 Spire
IPR029905 Spire1
IPR011011 Znf_FYVE_PHD

The PANTHER Classification System

More...
PANTHERi
PTHR21345 PTHR21345, 1 hit
PTHR21345:SF3 PTHR21345:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16474 KIND, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00750 KIND, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51377 KIND, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q08AE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQAAGPAGG GEPRTEAVGG EGPREPGAAG GAAGGSRDAL SLEEILRLYN
60 70 80 90 100
QPINEEQAWA VCYQCCGSLR AAARRRQPRH RVRSAAQIRV WRDGAVTLAP
110 120 130 140 150
AADDAGEPPP VAGKLGYSQC METEVIESLG IIIYKALDYG LKENEERELS
160 170 180 190 200
PPLEQLIDHM ANTVEADGSN DEGYEAAEEG LGDEDEKRKI SAIRSYRDVM
210 220 230 240 250
KLCAAHLPTE SDAPNHYQAV CRALFAETME LHTFLTKIKS AKENLKKIQE
260 270 280 290 300
MEKSDESSTD LEELKNADWA RFWVQVMRDL RNGVKLKKVQ ERQYNPLPIE
310 320 330 340 350
YQLTPYEMLM DDIRCKRYTL RKVMVNGDIP PRLKKSAHEI ILDFIRSRPP
360 370 380 390 400
LNPVSARKLK PTPPRPRSLH ERILEEIKAE RKLRPVSPEE IRRSRLAMRP
410 420 430 440 450
LSMSYSFDLS DVTTPESTKN LVESSMVNGG LTSQTKENGL STSQQVPAQR
460 470 480 490 500
KKLLRAPTLA ELDSSESEEE TLHKSTSSSS VSPSFPEEPV LEAVSTRKKP
510 520 530 540 550
PKFLPISSTP QPERRQPPQR RHSIEKETPT NVRQFLPPSR QSSRSLEEFC
560 570 580 590 600
YPVECLALTV EEVMHIRQVL VKAELEKYQQ YKDIYTALKK GKLCFCCRTR
610 620 630 640 650
RFSFFTWSYT CQFCKRPVCS QCCKKMRLPS KPYSTLPIFS LGPSALQRGE
660 670 680 690 700
SSMRSEKPST AHHRPLRSIA RFSSKSKSMD KSDEELQFPK ELMEDWSTME
710 720 730 740 750
VCVDCKKFIS EIISSSRRSL VLANKRARLK RKTQSFYMSS PGPSEYCPSE

RTISEI
Note: No experimental confirmation available.Curated
Length:756
Mass (Da):85,544
Last modified:November 28, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1379B39C8CA9DDB3
GO
Isoform 5 (identifier: Q08AE8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     397-410: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:622
Mass (Da):71,568
Checksum:iD4DF3C072A295F96
GO
Isoform 22 Publications (identifier: Q08AE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-410: Missing.

Show »
Length:742
Mass (Da):83,957
Checksum:iF76F168197958220
GO
Isoform 3 (identifier: Q08AE8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     397-410: Missing.

Show »
Length:583
Mass (Da):67,057
Checksum:i89163C062A16AB3D
GO
Isoform 4 (identifier: Q08AE8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     397-410: Missing.
     616-756: RPVCSQCCKK...CPSERTISEI → SDCLFNGTAHCQFYLG

Note: No experimental confirmation available.
Show »
Length:458
Mass (Da):52,747
Checksum:iBCE16535DEA4326C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNG6J3KNG6_HUMAN
Protein spire homolog 1
SPIRE1
545Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYR7C9JYR7_HUMAN
Protein spire homolog 1
SPIRE1
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENV1K7ENV1_HUMAN
Protein spire homolog 1
SPIRE1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQR2K7EQR2_HUMAN
Protein spire homolog 1
SPIRE1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMJ7K7EMJ7_HUMAN
Protein spire homolog 1
SPIRE1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI15006 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI25207 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI25208 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA86449 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058695249Q → P. Corresponds to variant dbSNP:rs1785296Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0379251 – 159Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST159
Alternative sequenceiVSP_0544641 – 120Missing in isoform 5. CuratedAdd BLAST120
Alternative sequenceiVSP_052595397 – 410Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 4 PublicationsAdd BLAST14
Alternative sequenceiVSP_037926616 – 756RPVCS…TISEI → SDCLFNGTAHCQFYLG in isoform 4. 1 PublicationAdd BLAST141

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB032961 mRNA Translation: BAA86449.2 Different initiation.
AK290180 mRNA Translation: BAF82869.1
AL833817 mRNA Translation: CAD38680.1
AP001028 Genomic DNA No translation available.
AP001029 Genomic DNA No translation available.
AP005482 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01546.1
BC115005 mRNA Translation: AAI15006.1 Different initiation.
BC125206 mRNA Translation: AAI25207.1 Different initiation.
BC125207 mRNA Translation: AAI25208.1 Different initiation.
AJ277587 mRNA Translation: CAB96370.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32790.2 [Q08AE8-2]
CCDS45829.1 [Q08AE8-1]
CCDS45830.1 [Q08AE8-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001122098.1, NM_001128626.1 [Q08AE8-1]
NP_001122099.1, NM_001128627.1 [Q08AE8-5]
NP_064533.3, NM_020148.2 [Q08AE8-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.515283

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409402; ENSP00000387266; ENSG00000134278 [Q08AE8-1]
ENST00000410092; ENSP00000387226; ENSG00000134278 [Q08AE8-2]
ENST00000440472; ENSP00000404752; ENSG00000134278 [Q08AE8-4]
ENST00000453447; ENSP00000407050; ENSG00000134278 [Q08AE8-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56907

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56907

UCSC genome browser

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UCSCi
uc002kre.4 human [Q08AE8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032961 mRNA Translation: BAA86449.2 Different initiation.
AK290180 mRNA Translation: BAF82869.1
AL833817 mRNA Translation: CAD38680.1
AP001028 Genomic DNA No translation available.
AP001029 Genomic DNA No translation available.
AP005482 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01546.1
BC115005 mRNA Translation: AAI15006.1 Different initiation.
BC125206 mRNA Translation: AAI25207.1 Different initiation.
BC125207 mRNA Translation: AAI25208.1 Different initiation.
AJ277587 mRNA Translation: CAB96370.1
CCDSiCCDS32790.2 [Q08AE8-2]
CCDS45829.1 [Q08AE8-1]
CCDS45830.1 [Q08AE8-5]
RefSeqiNP_001122098.1, NM_001128626.1 [Q08AE8-1]
NP_001122099.1, NM_001128627.1 [Q08AE8-5]
NP_064533.3, NM_020148.2 [Q08AE8-2]
UniGeneiHs.515283

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YLEX-ray1.80A36-236[»]
2YLFX-ray2.05A36-236[»]
3R7GX-ray2.20A20-237[»]
3RBWX-ray3.20A/B/C/D20-237[»]
ProteinModelPortaliQ08AE8
SMRiQ08AE8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121237, 10 interactors
DIPiDIP-42378N
IntActiQ08AE8, 6 interactors
MINTiQ08AE8
STRINGi9606.ENSP00000387266

PTM databases

iPTMnetiQ08AE8
PhosphoSitePlusiQ08AE8

Polymorphism and mutation databases

BioMutaiSPIRE1
DMDMi425906061

Proteomic databases

jPOSTiQ08AE8
MaxQBiQ08AE8
PaxDbiQ08AE8
PeptideAtlasiQ08AE8
PRIDEiQ08AE8
ProteomicsDBi58658
58659 [Q08AE8-2]
58660 [Q08AE8-3]
58661 [Q08AE8-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409402; ENSP00000387266; ENSG00000134278 [Q08AE8-1]
ENST00000410092; ENSP00000387226; ENSG00000134278 [Q08AE8-2]
ENST00000440472; ENSP00000404752; ENSG00000134278 [Q08AE8-4]
ENST00000453447; ENSP00000407050; ENSG00000134278 [Q08AE8-5]
GeneIDi56907
KEGGihsa:56907
UCSCiuc002kre.4 human [Q08AE8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56907
DisGeNETi56907
EuPathDBiHostDB:ENSG00000134278.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPIRE1
HGNCiHGNC:30622 SPIRE1
HPAiHPA040737
HPA040942
MIMi609216 gene
neXtProtiNX_Q08AE8
OpenTargetsiENSG00000134278
PharmGKBiPA134895885

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK9H Eukaryota
ENOG4111E0J LUCA
GeneTreeiENSGT00390000003058
HOGENOMiHOG000013039
HOVERGENiHBG058898
InParanoidiQ08AE8
KOiK02098
OMAiTMELYTF
OrthoDBi560461at2759
PhylomeDBiQ08AE8
TreeFamiTF326239

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPIRE1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56907

Protein Ontology

More...
PROi
PR:Q08AE8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134278 Expressed in 204 organ(s), highest expression level in medial globus pallidus
ExpressionAtlasiQ08AE8 baseline and differential
GenevisibleiQ08AE8 HS

Family and domain databases

InterProiView protein in InterPro
IPR011019 KIND_dom
IPR029901 Spire
IPR029905 Spire1
IPR011011 Znf_FYVE_PHD
PANTHERiPTHR21345 PTHR21345, 1 hit
PTHR21345:SF3 PTHR21345:SF3, 1 hit
PfamiView protein in Pfam
PF16474 KIND, 1 hit
SMARTiView protein in SMART
SM00750 KIND, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51377 KIND, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPIR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08AE8
Secondary accession number(s): A8K2B5
, J3KQ50, J3KQR5, Q1RMD4, Q8NDP1, Q9NQ71, Q9ULT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 28, 2012
Last modified: February 13, 2019
This is version 114 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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