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Entry version 126 (17 Jun 2020)
Sequence version 3 (05 Oct 2010)
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Protein

Calmodulin-regulated spectrin-associated protein 2

Gene

CAMSAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242).6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin-regulated spectrin-associated protein 2Curated
Alternative name(s):
Calmodulin-regulated spectrin-associated protein 1-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAMSAP2Imported
Synonyms:CAMSAP1L1Imported, KIAA10781 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000118200.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29188 CAMSAP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613775 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08AD1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in CAMSAP2 may be a cause of susceptibility to epilepsy in the Chinese population.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
23271

Open Targets

More...
OpenTargetsi
ENSG00000118200

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672206

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q08AD1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAMSAP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153626

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003168321 – 1489Calmodulin-regulated spectrin-associated protein 2Add BLAST1489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei416PhosphoserineCombined sources1
Modified residuei418PhosphoserineBy similarity1
Modified residuei426PhosphothreonineBy similarity1
Modified residuei464PhosphoserineCombined sources1
Modified residuei598PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei611PhosphoserineBy similarity1
Modified residuei673PhosphoserineCombined sources1
Modified residuei678PhosphothreonineBy similarity1
Modified residuei680PhosphoserineBy similarity1
Modified residuei862PhosphoserineCombined sources1
Modified residuei931PhosphoserineCombined sources1
Modified residuei936PhosphoserineCombined sources1
Modified residuei997PhosphothreonineCombined sources1
Modified residuei1002PhosphothreonineCombined sources1
Modified residuei1004PhosphothreonineCombined sources1
Modified residuei1008PhosphoserineCombined sources1
Modified residuei1019PhosphoserineCombined sources1
Modified residuei1148PhosphoserineCombined sources1
Modified residuei1313PhosphoserineCombined sources1
Modified residuei1319PhosphoserineCombined sources1
Modified residuei1321PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q08AD1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q08AD1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q08AD1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q08AD1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08AD1

PeptideAtlas

More...
PeptideAtlasi
Q08AD1

PRoteomics IDEntifications database

More...
PRIDEi
Q08AD1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58654 [Q08AD1-1]
58655 [Q08AD1-2]
58656 [Q08AD1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08AD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q08AD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118200 Expressed in forebrain and 232 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q08AD1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08AD1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000118200 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CAMSAP3 (By similarity).

Interacts with KATNA1 and KATNB1; leading to regulate the length of CAMSAP2-decorated microtubule stretches (PubMed:24486153).

Interacts with a complex formed by AKAP9 and PDE4DIP isoform 13/MMG8/SMYLE, which recruits CAMSAP2 to the Golgi (PubMed:27666745, PubMed:28814570).

Interacts with MAPRE1/EB1 (PubMed:28726242, PubMed:28814570).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116872, 78 interactors

Protein interaction database and analysis system

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IntActi
Q08AD1, 33 interactors

Molecular INTeraction database

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MINTi
Q08AD1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000236925

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q08AD1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q08AD1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini222 – 335Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST114
Domaini1349 – 1483CKKPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni922 – 1034MBD region1 PublicationAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili756 – 793Sequence analysisAdd BLAST38
Coiled coili887 – 926Sequence analysisAdd BLAST40
Coiled coili1166 – 1238Sequence analysisAdd BLAST73

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CKK domain binds microtubules and specifically recognizes the minus-end of microtubules (PubMed:24486153).PROSITE-ProRule annotation1 Publication
The MBD (microtubule-binding domain) region can recognize some features of the microtubule lattice, which might contribute to the specific decoration of growing microtubule minus-ends by CAMSAP2.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IU7J Eukaryota
ENOG411033G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004833_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08AD1

KEGG Orthology (KO)

More...
KOi
K17493

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQPVNGT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08AD1

TreeFam database of animal gene trees

More...
TreeFami
TF315529

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.360, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032940 CAMSAP
IPR031372 CAMSAP_CC1
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR038209 CKK_dom_sf
IPR014797 CKK_domain
IPR011033 PRC_barrel-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21595 PTHR21595, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17095 CAMSAP_CC1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF08683 CAMSAP_CKK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01051 CAMSAP_CKK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF50346 SSF50346, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS51508 CKK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08AD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDAADPREM RKTFIVPAIK PFDHYDFSRA KIACNLAWLV AKAFGTENVP
60 70 80 90 100
EELQEPFYTD QYDQEHIKPP VVNLLLSAEL YCRAGSLILK SDAAKPLLGH
110 120 130 140 150
DAVIQALAQK GLYVTDQEKL VTERDLHKKP IQMSAHLAMI DTLMMAYTVE
160 170 180 190 200
MVSIEKVIAC AQQYSAFFQA TDLPYDIEDA VMYWINKVNE HLKDIMEQEQ
210 220 230 240 250
KLKEHHTVEA PGGQKSPSKW FWKLVPARYR KEQTLLKQLP CIPLVENLLK
260 270 280 290 300
DGTDGCALAA LIHFYCPDVV RLEDICLKET MSLADSLYNL QLIQEFCQEY
310 320 330 340 350
LNQCCHFTLE DMLYAASSIK SNYLVFMAEL FWWFEVVKPS FVQPRVVRPQ
360 370 380 390 400
GAEPVKDMPS IPVLNAAKRN VLDSSSDFPS SGEGATFTQS HHHLPSRYSR
410 420 430 440 450
PQAHSSASGG IRRSSSMSYV DGFIGTWPKE KRSSVHGVSF DISFDKEDSV
460 470 480 490 500
QRSTPNRGIT RSISNEGLTL NNSHVSKHIR KNLSFKPING EEEAESIEEE
510 520 530 540 550
LNIDSHSDLK SCVPLNTNEL NSNENIHYKL PNGALQNRIL LDEFGNQIET
560 570 580 590 600
PSIEEALQII HDTEKSPHTP QPDQIANGFF LHSQEMSILN SNIKLNQSSP
610 620 630 640 650
DNVTDTKGAL SPITDNTEVD TGIHVPSEDI PETMDEDSSL RDYTVSLDSD
660 670 680 690 700
MDDASKFLQD YDIRTGNTRE ALSPCPSTVS TKSQPGSSAS SSSGVKMTSF
710 720 730 740 750
AEQKFRKLNH TDGKSSGSSS QKTTPEGSEL NIPHVVAWAQ IPEETGLPQG
760 770 780 790 800
RDTTQLLASE MVHLRMKLEE KRRAIEAQKK KMEAAFTKQR QKMGRTAFLT
810 820 830 840 850
VVKKKGDGIS PLREEAAGAE DEKVYTDRAK EKESQKTDGQ RSKSLADIKE
860 870 880 890 900
SMENPQAKWL KSPTTPIDPE KQWNLASPSE ETLNEGEILE YTKSIEKLNS
910 920 930 940 950
SLHFLQQEMQ RLSLQQEMLM QMREQQSWVI SPPQPSPQKQ IRDFKPSKQA
960 970 980 990 1000
GLSSAIAPFS SDSPRPTHPS PQSSNRKSAS FSVKSQRTPR PNELKITPLN
1010 1020 1030 1040 1050
RTLTPPRSVD SLPRLRRFSP SQVPIQTRSF VCFGDDGEPQ LKESKPKEEV
1060 1070 1080 1090 1100
KKEELESKGT LEQRGHNPEE KEIKPFESTV SEVLSLPVTE TVCLTPNEDQ
1110 1120 1130 1140 1150
LNQPTEPPPK PVFPPTAPKN VNLIEVSLSD LKPPEKADVP VEKYDGESDK
1160 1170 1180 1190 1200
EQFDDDQKVC CGFFFKDDQK AENDMAMKRA ALLEKRLRRE KETQLRKQQL
1210 1220 1230 1240 1250
EAEMEHKKEE TRRKTEEERQ KKEDERARRE FIRQEYMRRK QLKLMEDMDT
1260 1270 1280 1290 1300
VIKPRPQVVK QKKQRPKSIH RDHIESPKTP IKGPPVSSLS LASLNTGDNE
1310 1320 1330 1340 1350
SVHSGKRTPR SESVEGFLSP SRCGSRNGEK DWENASTTSS VASGTEYTGP
1360 1370 1380 1390 1400
KLYKEPSAKS NKHIIQNALA HCCLAGKVNE GQKKKILEEM EKSDANNFLI
1410 1420 1430 1440 1450
LFRDSGCQFR SLYTYCPETE EINKLTGIGP KSITKKMIEG LYKYNSDRKQ
1460 1470 1480
FSHIPAKTLS ASVDAITIHS HLWQTKRPVT PKKLLPTKA
Length:1,489
Mass (Da):168,089
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E20A240E2691027
GO
Isoform 2 (identifier: Q08AD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-226: Missing.
     380-395: Missing.

Show »
Length:1,462
Mass (Da):165,058
Checksum:iE036B5F830A186F1
GO
Isoform 3 (identifier: Q08AD1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-226: Missing.

Show »
Length:1,478
Mass (Da):166,732
Checksum:iD2979D7D328FB53D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YE13H0YE13_HUMAN
Calmodulin-regulated spectrin-assoc...
CAMSAP2
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4Z1H0Y4Z1_HUMAN
Calmodulin-regulated spectrin-assoc...
CAMSAP2
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH56910 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150E → K in BAA83030 (PubMed:10470851).Curated1
Sequence conflicti1261Q → K in AAH56910 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038399361I → L in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_038400958P → L. Corresponds to variant dbSNP:rs3753952Ensembl.1
Natural variantiVAR_057796969P → L. Corresponds to variant dbSNP:rs3753952Ensembl.1
Natural variantiVAR_0384011028R → P. Corresponds to variant dbSNP:rs6674599Ensembl.1
Natural variantiVAR_0577971039P → R. Corresponds to variant dbSNP:rs6674599Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030805216 – 226Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_030806380 – 395Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL450104 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91320.1
BC011385 mRNA Translation: AAH11385.1
BC056910 mRNA Translation: AAH56910.1 Different initiation.
BC125229 mRNA Translation: AAI25230.1
BC125230 mRNA Translation: AAI25231.1
AB029001 mRNA Translation: BAA83030.2
AL110158 mRNA Translation: CAB53664.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1404.1 [Q08AD1-3]
CCDS72998.1 [Q08AD1-1]
CCDS72999.1 [Q08AD1-2]

Protein sequence database of the Protein Information Resource

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PIRi
T14744

NCBI Reference Sequences

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RefSeqi
NP_001284636.1, NM_001297707.1 [Q08AD1-1]
NP_001284637.1, NM_001297708.1 [Q08AD1-2]
NP_982284.1, NM_203459.2 [Q08AD1-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000236925; ENSP00000236925; ENSG00000118200 [Q08AD1-1]
ENST00000358823; ENSP00000351684; ENSG00000118200 [Q08AD1-3]
ENST00000413307; ENSP00000416800; ENSG00000118200 [Q08AD1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23271

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23271

UCSC genome browser

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UCSCi
uc001gvk.4 human [Q08AD1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450104 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91320.1
BC011385 mRNA Translation: AAH11385.1
BC056910 mRNA Translation: AAH56910.1 Different initiation.
BC125229 mRNA Translation: AAI25230.1
BC125230 mRNA Translation: AAI25231.1
AB029001 mRNA Translation: BAA83030.2
AL110158 mRNA Translation: CAB53664.2
CCDSiCCDS1404.1 [Q08AD1-3]
CCDS72998.1 [Q08AD1-1]
CCDS72999.1 [Q08AD1-2]
PIRiT14744
RefSeqiNP_001284636.1, NM_001297707.1 [Q08AD1-1]
NP_001284637.1, NM_001297708.1 [Q08AD1-2]
NP_982284.1, NM_203459.2 [Q08AD1-3]

3D structure databases

SMRiQ08AD1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116872, 78 interactors
IntActiQ08AD1, 33 interactors
MINTiQ08AD1
STRINGi9606.ENSP00000236925

PTM databases

iPTMnetiQ08AD1
PhosphoSitePlusiQ08AD1

Polymorphism and mutation databases

BioMutaiCAMSAP2
DMDMi308153626

Proteomic databases

EPDiQ08AD1
jPOSTiQ08AD1
MassIVEiQ08AD1
MaxQBiQ08AD1
PaxDbiQ08AD1
PeptideAtlasiQ08AD1
PRIDEiQ08AD1
ProteomicsDBi58654 [Q08AD1-1]
58655 [Q08AD1-2]
58656 [Q08AD1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20635 67 antibodies

The DNASU plasmid repository

More...
DNASUi
23271

Genome annotation databases

EnsembliENST00000236925; ENSP00000236925; ENSG00000118200 [Q08AD1-1]
ENST00000358823; ENSP00000351684; ENSG00000118200 [Q08AD1-3]
ENST00000413307; ENSP00000416800; ENSG00000118200 [Q08AD1-2]
GeneIDi23271
KEGGihsa:23271
UCSCiuc001gvk.4 human [Q08AD1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23271
DisGeNETi23271
EuPathDBiHostDB:ENSG00000118200.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CAMSAP2
HGNCiHGNC:29188 CAMSAP2
HPAiENSG00000118200 Low tissue specificity
MIMi613775 gene
neXtProtiNX_Q08AD1
OpenTargetsiENSG00000118200
PharmGKBiPA142672206

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IU7J Eukaryota
ENOG411033G LUCA
GeneTreeiENSGT00950000182975
HOGENOMiCLU_004833_1_0_1
InParanoidiQ08AD1
KOiK17493
OMAiFQPVNGT
PhylomeDBiQ08AD1
TreeFamiTF315529

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23271 19 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CAMSAP2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23271
PharosiQ08AD1 Tbio

Protein Ontology

More...
PROi
PR:Q08AD1
RNActiQ08AD1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118200 Expressed in forebrain and 232 other tissues
ExpressionAtlasiQ08AD1 baseline and differential
GenevisibleiQ08AD1 HS

Family and domain databases

Gene3Di3.10.20.360, 1 hit
InterProiView protein in InterPro
IPR032940 CAMSAP
IPR031372 CAMSAP_CC1
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR038209 CKK_dom_sf
IPR014797 CKK_domain
IPR011033 PRC_barrel-like_sf
PANTHERiPTHR21595 PTHR21595, 1 hit
PfamiView protein in Pfam
PF17095 CAMSAP_CC1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF08683 CAMSAP_CKK, 1 hit
SMARTiView protein in SMART
SM01051 CAMSAP_CKK, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF50346 SSF50346, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51508 CKK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAMP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08AD1
Secondary accession number(s): B1APG6
, Q08AD2, Q6PGN8, Q96FB3, Q9UG20, Q9UPS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 5, 2010
Last modified: June 17, 2020
This is version 126 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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