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Protein

Argininosuccinate synthase

Gene

argG

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei96CitrullineUniRule annotation1
Binding sitei101CitrullineUniRule annotation1
Binding sitei126ATP; via amide nitrogenUniRule annotation1
Binding sitei128AspartateUniRule annotation1
Binding sitei132AspartateUniRule annotation1
Binding sitei132CitrullineUniRule annotation1
Binding sitei133AspartateUniRule annotation1
Binding sitei136CitrullineUniRule annotation1
Binding sitei185CitrullineUniRule annotation1
Binding sitei194CitrullineUniRule annotation1
Binding sitei270CitrullineUniRule annotation1
Binding sitei282CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Sfri_0194
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000000684 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002639701 – 407Argininosuccinate synthaseAdd BLAST407

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi318167.Sfri_0194

Structurei

3D structure databases

ProteinModelPortaliQ089K8
SMRiQ089K8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q089K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNAVKKTGV KKVVLAYSGG LDTSAIIPWL KETYDDCEII AFCADVGQGE
60 70 80 90 100
EELVGLTEKA LASGASECHI VDLKEEFVAD YIYPTIATGA IYEGTYLLGT
110 120 130 140 150
SMARPIIAKA QVEVARKVGA DAVCHGCTGK GNDQVRFEGC FAALAPDLKV
160 170 180 190 200
IAPWREWEMR SREDLLAYLA ERDIKTSASA TKIYSRDANA WHISHEGGEL
210 220 230 240 250
EDPWNEPSKG VWTLTVAPED APNEPEYVSL AVKHGRVTHV NDEALSPYAA
260 270 280 290 300
LMKLNDIAGK HGVGRIDITE NRLVGMKSRG CYETPGGTVM FAGLRAIEEL
310 320 330 340 350
VLDKTSRTWR EQIAGQMSHL VYDGRWFTPL CKSLIAASES LAESVNGDVV
360 370 380 390 400
IKLYKGQATA VKKRSPNSLY SESFATFGED DVYDQKHAEG FIRLYSLASR

IRALNTK
Length:407
Mass (Da):44,566
Last modified:October 31, 2006 - v1
Checksum:iC6746BFC717F4912
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA Translation: ABI70057.1
RefSeqiWP_011635684.1, NC_008345.1

Genome annotation databases

EnsemblBacteriaiABI70057; ABI70057; Sfri_0194
KEGGisfr:Sfri_0194

Similar proteinsi

Entry informationi

Entry nameiASSY_SHEFN
AccessioniPrimary (citable) accession number: Q089K8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 31, 2006
Last modified: February 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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