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Protein

Retinoblastoma-like protein 2

Gene

RBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • promoter-specific chromatin binding Source: MGI
  • RNA polymerase II activating transcription factor binding Source: GO_Central
  • RNA polymerase II regulatory region DNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Repressor
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q08999

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retinoblastoma-like protein 2
Alternative name(s):
130 kDa retinoblastoma-associated protein
Short name:
p130
Retinoblastoma-related protein 2
Short name:
RBR-2
pRb2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBL2
Synonyms:RB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103479.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9894 RBL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
180203 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08999

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
5934

Open Targets

More...
OpenTargetsi
ENSG00000103479

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34258

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242746

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001678411 – 1139Retinoblastoma-like protein 2Add BLAST1139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei413PhosphoserineCombined sources1
Modified residuei417PhosphothreonineBy similarity1
Modified residuei639Phosphoserine1 Publication1
Modified residuei642PhosphothreonineBy similarity1
Modified residuei662PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1 Publication1
Modified residuei688PhosphoserineCombined sources1
Modified residuei948PhosphoserineBy similarity1
Modified residuei952Phosphoserine1 Publication1
Modified residuei966Phosphoserine1 Publication1
Modified residuei971Phosphoserine1 Publication1
Modified residuei972Phosphoserine1 Publication1
Modified residuei973Phosphoserine1 Publication1
Modified residuei974Phosphothreonine1 Publication1
Modified residuei981Phosphoserine1 Publication1
Modified residuei982Phosphoserine1 Publication1
Modified residuei986Phosphothreonine1 Publication1
Modified residuei1035PhosphoserineCombined sources1
Modified residuei1068PhosphoserineCombined sources1
Modified residuei1080PhosphoserineCombined sources1
Modified residuei1112PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q08999

MaxQB - The MaxQuant DataBase

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MaxQBi
Q08999

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q08999

PeptideAtlas

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PeptideAtlasi
Q08999

PRoteomics IDEntifications database

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PRIDEi
Q08999

ProteomicsDB human proteome resource

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ProteomicsDBi
58652

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q08999

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q08999

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

G0-restricted expression.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103479 Expressed in 237 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_RBL2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q08999 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q08999 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016547
HPA019703

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AATF. Interacts with KMT5B, KMT5C and USP4 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111869, 63 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q08999

Database of interacting proteins

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DIPi
DIP-425N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q08999

Protein interaction database and analysis system

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IntActi
Q08999, 41 interactors

Molecular INTeraction database

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MINTi
Q08999

STRING: functional protein association networks

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STRINGi
9606.ENSP00000262133

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q08999

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q08999

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni417 – 1024Pocket; binds E1AAdd BLAST608
Regioni417 – 616Domain AAdd BLAST200
Regioni617 – 827SpacerAdd BLAST211
Regioni828 – 1024Domain BAdd BLAST197

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 16Poly-Pro8
Compositional biasi17 – 20Poly-Ala4
Compositional biasi23 – 26Poly-Glu4
Compositional biasi998 – 1001Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the retinoblastoma protein (RB) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1010 Eukaryota
ENOG410XQF7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153871

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000273892

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG017710

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q08999

KEGG Orthology (KO)

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KOi
K16332

Identification of Orthologs from Complete Genome Data

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OMAi
EVFHFCW

Database of Orthologous Groups

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OrthoDBi
EOG091G0398

Database for complete collections of gene phylogenies

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PhylomeDBi
Q08999

TreeFam database of animal gene trees

More...
TreeFami
TF105568

Family and domain databases

Conserved Domains Database

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CDDi
cd00043 CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR028308 RB2
IPR002720 RB_A
IPR002719 RB_B
IPR015030 RB_C
IPR028309 RB_fam
IPR024599 RB_N

The PANTHER Classification System

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PANTHERi
PTHR13742 PTHR13742, 1 hit
PTHR13742:SF8 PTHR13742:SF8, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF11934 DUF3452, 1 hit
PF01858 RB_A, 1 hit
PF01857 RB_B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385 CYCLIN, 2 hits
SM01367 DUF3452, 1 hit
SM01368 RB_A, 1 hit
SM01369 Rb_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08999-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSGGDQSPP PPPPPPAAAA SDEEEEDDGE AEDAAPPAES PTPQIQQRFD
60 70 80 90 100
ELCSRLNMDE AARAEAWDSY RSMSESYTLE GNDLHWLACA LYVACRKSVP
110 120 130 140 150
TVSKGTVEGN YVSLTRILKC SEQSLIEFFN KMKKWEDMAN LPPHFRERTE
160 170 180 190 200
RLERNFTVSA VIFKKYEPIF QDIFKYPQEE QPRQQRGRKQ RRQPCTVSEI
210 220 230 240 250
FHFCWVLFIY AKGNFPMISD DLVNSYHLLL CALDLVYGNA LQCSNRKELV
260 270 280 290 300
NPNFKGLSED FHAKDSKPSS DPPCIIEKLC SLHDGLVLEA KGIKEHFWKP
310 320 330 340 350
YIRKLYEKKL LKGKEENLTG FLEPGNFGES FKAINKAYEE YVLSVGNLDE
360 370 380 390 400
RIFLGEDAEE EIGTLSRCLN AGSGTETAER VQMKNILQQH FDKSKALRIS
410 420 430 440 450
TPLTGVRYIK ENSPCVTPVS TATHSLSRLH TMLTGLRNAP SEKLEQILRT
460 470 480 490 500
CSRDPTQAIA NRLKEMFEIY SQHFQPDEDF SNCAKEIASK HFRFAEMLYY
510 520 530 540 550
KVLESVIEQE QKRLGDMDLS GILEQDAFHR SLLACCLEVV TFSYKPPGNF
560 570 580 590 600
PFITEIFDVP LYHFYKVIEV FIRAEDGLCR EVVKHLNQIE EQILDHLAWK
610 620 630 640 650
PESPLWEKIR DNENRVPTCE EVMPPQNLER ADEICIAGSP LTPRRVTEVR
660 670 680 690 700
ADTGGLGRSI TSPTTLYDRY SSPPASTTRR RLFVENDSPS DGGTPGRMPP
710 720 730 740 750
QPLVNAVPVQ NVSGETVSVT PVPGQTLVTM ATATVTANNG QTVTIPVQGI
760 770 780 790 800
ANENGGITFF PVQVNVGGQA QAVTGSIQPL SAQALAGSLS SQQVTGTTLQ
810 820 830 840 850
VPGQVAIQQI SPGGQQQKQG QSVTSSSNRP RKTSSLSLFF RKVYHLAAVR
860 870 880 890 900
LRDLCAKLDI SDELRKKIWT CFEFSIIQCP ELMMDRHLDQ LLMCAIYVMA
910 920 930 940 950
KVTKEDKSFQ NIMRCYRTQP QARSQVYRSV LIKGKRKRRN SGSSDSRSHQ
960 970 980 990 1000
NSPTELNKDR TSRDSSPVMR SSSTLPVPQP SSAPPTPTRL TGANSDMEEE
1010 1020 1030 1040 1050
ERGDLIQFYN NIYIKQIKTF AMKYSQANMD APPLSPYPFV RTGSPRRIQL
1060 1070 1080 1090 1100
SQNHPVYISP HKNETMLSPR EKIFYYFSNS PSKRLREINS MIRTGETPTK
1110 1120 1130
KRGILLEDGS ESPAKRICPE NHSALLRRLQ DVANDRGSH
Length:1,139
Mass (Da):128,367
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD129032FB1F383D4
GO
Isoform 2 (identifier: Q08999-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.
     638-1042: Missing.

Note: No experimental confirmation available.
Show »
Length:518
Mass (Da):59,349
Checksum:i12F3758A5A3AD0D1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H837F5H837_HUMAN
Retinoblastoma-like protein 2
RBL2
639Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSF7J3KSF7_HUMAN
Retinoblastoma-like protein 2
RBL2
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37P → S in CAA53661 (PubMed:8253383).Curated1
Sequence conflicti37P → S in AAC50479 (PubMed:8643454).Curated1
Sequence conflicti64A → P (PubMed:8253383).Curated1
Sequence conflicti64A → P (PubMed:8643454).Curated1
Sequence conflicti206V → M in CAA52671 (PubMed:8361765).Curated1
Sequence conflicti1093R → H in AAH34490 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06937799V → F1 Publication1
Natural variantiVAR_028437210Y → C. Corresponds to variant dbSNP:rs17800727Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0543281 – 216Missing in isoform 2. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_054329638 – 1042Missing in isoform 2. 1 PublicationAdd BLAST405

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X76061 mRNA Translation: CAA53661.1
S67171 mRNA Translation: AAB29227.1
AK304283 mRNA Translation: BAH14149.1
AC007342 Genomic DNA No translation available.
BC034490 mRNA Translation: AAH34490.1
X74594 mRNA Translation: CAA52671.1
U53220 Genomic DNA Translation: AAC50479.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10748.1 [Q08999-1]

Protein sequence database of the Protein Information Resource

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PIRi
A49370

NCBI Reference Sequences

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RefSeqi
NP_001310537.1, NM_001323608.1 [Q08999-1]
NP_005602.3, NM_005611.3 [Q08999-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.513609

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262133; ENSP00000262133; ENSG00000103479 [Q08999-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5934

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5934

UCSC genome browser

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UCSCi
uc002ehi.5 human [Q08999-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76061 mRNA Translation: CAA53661.1
S67171 mRNA Translation: AAB29227.1
AK304283 mRNA Translation: BAH14149.1
AC007342 Genomic DNA No translation available.
BC034490 mRNA Translation: AAH34490.1
X74594 mRNA Translation: CAA52671.1
U53220 Genomic DNA Translation: AAC50479.1
CCDSiCCDS10748.1 [Q08999-1]
PIRiA49370
RefSeqiNP_001310537.1, NM_001323608.1 [Q08999-1]
NP_005602.3, NM_005611.3 [Q08999-1]
UniGeneiHs.513609

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XI9X-ray3.10E/F/G/H416-422[»]
5C1DX-ray2.05C416-422[»]
ProteinModelPortaliQ08999
SMRiQ08999
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111869, 63 interactors
CORUMiQ08999
DIPiDIP-425N
ELMiQ08999
IntActiQ08999, 41 interactors
MINTiQ08999
STRINGi9606.ENSP00000262133

PTM databases

iPTMnetiQ08999
PhosphoSitePlusiQ08999

Polymorphism and mutation databases

BioMutaiRBL2
DMDMi116242746

Proteomic databases

EPDiQ08999
MaxQBiQ08999
PaxDbiQ08999
PeptideAtlasiQ08999
PRIDEiQ08999
ProteomicsDBi58652

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5934
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262133; ENSP00000262133; ENSG00000103479 [Q08999-1]
GeneIDi5934
KEGGihsa:5934
UCSCiuc002ehi.5 human [Q08999-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5934
DisGeNETi5934
EuPathDBiHostDB:ENSG00000103479.14

GeneCards: human genes, protein and diseases

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GeneCardsi
RBL2
HGNCiHGNC:9894 RBL2
HPAiCAB016547
HPA019703
MIMi180203 gene
neXtProtiNX_Q08999
OpenTargetsiENSG00000103479
PharmGKBiPA34258

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1010 Eukaryota
ENOG410XQF7 LUCA
GeneTreeiENSGT00940000153871
HOGENOMiHOG000273892
HOVERGENiHBG017710
InParanoidiQ08999
KOiK16332
OMAiEVFHFCW
OrthoDBiEOG091G0398
PhylomeDBiQ08999
TreeFamiTF105568

Enzyme and pathway databases

ReactomeiR-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
SIGNORiQ08999

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBL2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Retinoblastoma-like_protein_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5934

Protein Ontology

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PROi
PR:Q08999

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103479 Expressed in 237 organ(s), highest expression level in blood
CleanExiHS_RBL2
ExpressionAtlasiQ08999 baseline and differential
GenevisibleiQ08999 HS

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR028308 RB2
IPR002720 RB_A
IPR002719 RB_B
IPR015030 RB_C
IPR028309 RB_fam
IPR024599 RB_N
PANTHERiPTHR13742 PTHR13742, 1 hit
PTHR13742:SF8 PTHR13742:SF8, 1 hit
PfamiView protein in Pfam
PF11934 DUF3452, 1 hit
PF01858 RB_A, 1 hit
PF01857 RB_B, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01367 DUF3452, 1 hit
SM01368 RB_A, 1 hit
SM01369 Rb_C, 1 hit
SUPFAMiSSF47954 SSF47954, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08999
Secondary accession number(s): B7Z913
, Q15073, Q16084, Q8NE70, Q92812
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 17, 2006
Last modified: December 5, 2018
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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