UniProtKB - Q08986 (SAM3_YEAST)
Protein
S-adenosylmethionine permease SAM3
Gene
SAM3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source.1 Publication
Miscellaneous
Present with 1300 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: GO_Central
- putrescine transmembrane transporter activity Source: SGD
- S-adenosyl-L-methionine transmembrane transporter activity Source: SGD
- spermidine transmembrane transporter activity Source: SGD
GO - Biological processi
- amino acid transmembrane transport Source: GO_Central
- putrescine transport Source: SGD
- S-adenosyl-L-methionine transport Source: SGD
- spermidine transport Source: SGD
Keywordsi
Biological process | Amino-acid transport, Transport |
Protein family/group databases
TCDBi | 2.A.3.10.15, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: S-adenosylmethionine permease SAM3Alternative name(s): S-adenosylmethionine metabolism protein 3 |
Gene namesi | Name:SAM3 Ordered Locus Names:YPL274W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006195, SAM3 |
VEuPathDBi | FungiDB:YPL274W |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Other locations
- Membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
Plasma Membrane
- plasma membrane Source: SGD
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 80 | CytoplasmicSequence analysisAdd BLAST | 80 | |
Transmembranei | 81 – 103 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 104 – 109 | ExtracellularSequence analysis | 6 | |
Transmembranei | 110 – 129 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 130 – 162 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 163 – 183 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 184 – 186 | ExtracellularSequence analysis | 3 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 208 – 219 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 220 – 240 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 241 – 266 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 267 – 287 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 288 – 302 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 303 – 323 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 324 – 360 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 361 – 381 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 382 – 406 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 407 – 427 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 428 – 431 | ExtracellularSequence analysis | 4 | |
Transmembranei | 432 – 452 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 453 – 475 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 476 – 496 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 497 – 509 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 510 – 530 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 531 – 587 | CytoplasmicSequence analysisAdd BLAST | 57 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054163 | 1 – 587 | S-adenosylmethionine permease SAM3Add BLAST | 587 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Modified residuei | 44 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 184 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 243 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q08986 |
PaxDbi | Q08986 |
PRIDEi | Q08986 |
PTM databases
iPTMneti | Q08986 |
SwissPalmi | Q08986 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35939, 72 interactors |
DIPi | DIP-8874N |
STRINGi | 4932.YPL274W |
Miscellaneous databases
RNActi | Q08986, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000176823 |
HOGENOMi | CLU_007946_12_0_1 |
InParanoidi | Q08986 |
OMAi | ISSFFTW |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004762, Amino_acid_permease_fungi IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
TIGRFAMsi | TIGR00913, 2A0310, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08986-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDILKRGNES DKFTKIETES TTIPNDSDRS GSLIRRMKDS FKQSNLHVIP
60 70 80 90 100
EDLENSEQTE QEKIQWKLAS QPYQKVLSQR HLTMIAIGGT LGTGLFIGLG
110 120 130 140 150
YSLASGPAAL LIGFLLVGTS MFCVVQSAAE LSCQFPVSGS YATHVSRFID
160 170 180 190 200
ESVGFTVATN YALAWLISFP SELIGCALTI SYWNQTVNPA VWVAIFYVFI
210 220 230 240 250
MVLNLFGVRG FAETEFALSI IKVIAIFIFI IIGIVLIAGG GPNSTGYIGA
260 270 280 290 300
KYWHDPGAFA KPVFKNLCNT FVSAAFSFGG SELVLLTSTE SKNISAISRA
310 320 330 340 350
AKGTFWRIAI FYITTVVIIG CLVPYNDPRL LSGSNSEDVS ASPFVIALSN
360 370 380 390 400
TGSMGAKVSN FMNVVILVAV VSVCNSCVYA SSRLIQALGA SGQLPSVCSY
410 420 430 440 450
MDRKGRPLVG IGISGAFGLL GFLVASKKED EVFTWLFALC SISSFFTWFC
460 470 480 490 500
ICMSQIRFRM ALKAQGRSND EIAYKSILGV YGGILGCVLN ALLIAGEIYV
510 520 530 540 550
SAAPVGSPSS AEAFFEYCLS IPIMIVVYFA HRFYRRDWKH FYIKRSEIDL
560 570 580
DTGCSVENLE LFKAQKEAEE QLIASKPFYY KIYRFWC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73629 Genomic DNA Translation: CAA98010.1 Z73630 Genomic DNA Translation: CAA98011.1 BK006949 Genomic DNA Translation: DAA11162.1 |
PIRi | S65307 |
RefSeqi | NP_015049.1, NM_001184088.1 |
Genome annotation databases
EnsemblFungii | YPL274W_mRNA; YPL274W; YPL274W |
GeneIDi | 855854 |
KEGGi | sce:YPL274W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73629 Genomic DNA Translation: CAA98010.1 Z73630 Genomic DNA Translation: CAA98011.1 BK006949 Genomic DNA Translation: DAA11162.1 |
PIRi | S65307 |
RefSeqi | NP_015049.1, NM_001184088.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35939, 72 interactors |
DIPi | DIP-8874N |
STRINGi | 4932.YPL274W |
Protein family/group databases
TCDBi | 2.A.3.10.15, the amino acid-polyamine-organocation (apc) family |
PTM databases
iPTMneti | Q08986 |
SwissPalmi | Q08986 |
Proteomic databases
MaxQBi | Q08986 |
PaxDbi | Q08986 |
PRIDEi | Q08986 |
Genome annotation databases
EnsemblFungii | YPL274W_mRNA; YPL274W; YPL274W |
GeneIDi | 855854 |
KEGGi | sce:YPL274W |
Organism-specific databases
SGDi | S000006195, SAM3 |
VEuPathDBi | FungiDB:YPL274W |
Phylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000176823 |
HOGENOMi | CLU_007946_12_0_1 |
InParanoidi | Q08986 |
OMAi | ISSFFTW |
Miscellaneous databases
PROi | PR:Q08986 |
RNActi | Q08986, protein |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004762, Amino_acid_permease_fungi IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
TIGRFAMsi | TIGR00913, 2A0310, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SAM3_YEAST | |
Accessioni | Q08986Primary (citable) accession number: Q08986 Secondary accession number(s): D6W396, Q7LGU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - SIMILARITY comments
Index of protein domains and families