S-adenosylmethionine permease SAM3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amino acid transmembrane transporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• putrescine transmembrane transporter activity Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae."
    Uemura T., Kashiwagi K., Igarashi K.
    J. Biol. Chem. 282:7733-7741(2007) [PubMed] [Europe PMC] [Abstract]
• S-adenosyl-L-methionine transmembrane transporter activity Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.3

    "Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae."
    Rouillon A., Surdin-Kerjan Y., Thomas D.
    J. Biol. Chem. 274:28096-28105(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• spermidine transmembrane transporter activity Source: SGDInferred from direct assayⁱ
  • "Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae."
    Uemura T., Kashiwagi K., Igarashi K.
    J. Biol. Chem. 282:7733-7741(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• amino acid transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• putrescine transport Source: SGDInferred from direct assayⁱ
  • "Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae."
    Uemura T., Kashiwagi K., Igarashi K.
    J. Biol. Chem. 282:7733-7741(2007) [PubMed] [Europe PMC] [Abstract]
• S-adenosyl-L-methionine transport Source: SGDInferred from mutant phenotypeⁱ
  • Ref.3

    "Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae."
    Rouillon A., Surdin-Kerjan Y., Thomas D.
    J. Biol. Chem. 274:28096-28105(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• spermidine transport Source: SGDInferred from direct assayⁱ
  • "Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae."
    Uemura T., Kashiwagi K., Igarashi K.
    J. Biol. Chem. 282:7733-7741(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDILKRGNES DKFTKIETES TTIPNDSDRS GSLIRRMKDS FKQSNLHVIP 
        60         70         80         90        100
EDLENSEQTE QEKIQWKLAS QPYQKVLSQR HLTMIAIGGT LGTGLFIGLG 
       110        120        130        140        150
YSLASGPAAL LIGFLLVGTS MFCVVQSAAE LSCQFPVSGS YATHVSRFID 
       160        170        180        190        200
ESVGFTVATN YALAWLISFP SELIGCALTI SYWNQTVNPA VWVAIFYVFI 
       210        220        230        240        250
MVLNLFGVRG FAETEFALSI IKVIAIFIFI IIGIVLIAGG GPNSTGYIGA 
       260        270        280        290        300
KYWHDPGAFA KPVFKNLCNT FVSAAFSFGG SELVLLTSTE SKNISAISRA 
       310        320        330        340        350
AKGTFWRIAI FYITTVVIIG CLVPYNDPRL LSGSNSEDVS ASPFVIALSN 
       360        370        380        390        400
TGSMGAKVSN FMNVVILVAV VSVCNSCVYA SSRLIQALGA SGQLPSVCSY 
       410        420        430        440        450
MDRKGRPLVG IGISGAFGLL GFLVASKKED EVFTWLFALC SISSFFTWFC 
       460        470        480        490        500
ICMSQIRFRM ALKAQGRSND EIAYKSILGV YGGILGCVLN ALLIAGEIYV 
       510        520        530        540        550
SAAPVGSPSS AEAFFEYCLS IPIMIVVYFA HRFYRRDWKH FYIKRSEIDL 
       560        570        580 
DTGCSVENLE LFKAQKEAEE QLIASKPFYY KIYRFWC               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
3. Yeast chromosome XVI
   Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names