Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

APC/C-CDH1 modulator 1

Gene

ACM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of GDH1, the activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C), and which is required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.1 Publication

Miscellaneous

Present with 688 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ubiquitin-protein transferase inhibitor activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processCell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34150-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
APC/C-CDH1 modulator 1
Gene namesi
Name:ACM1
Ordered Locus Names:YPL267W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL267W
SGDiS000006188 ACM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002681741 – 209APC/C-CDH1 modulator 1Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphoserineCombined sources1
Modified residuei161PhosphothreonineCombined sources1
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ08981
PRIDEiQ08981

PTM databases

iPTMnetiQ08981

Expressioni

Inductioni

Expressed very quickly after G1 release, just prior to initiation of DNA replication.1 Publication

Interactioni

Subunit structurei

Interacts with CDH1, BMH1 and BMH2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35946, 78 interactors
DIPiDIP-8871N
ELMiQ08981
IntActiQ08981, 7 interactors
MINTiQ08981
STRINGi4932.YPL267W

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi68 – 84Combined sources17
Helixi95 – 100Combined sources6
Helixi103 – 106Combined sources4

3D structure databases

ProteinModelPortaliQ08981
SMRiQ08981
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000033782
InParanoidiQ08981
OMAiHETHVND
OrthoDBiEOG092C5CYT

Sequencei

Sequence statusi: Complete.

Q08981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPSKKRTI LSSKNINQKP RAVVKGNELR SPSKRRSQID TDYALRRSPI
60 70 80 90 100
KTIQISKAAQ FMLYEETAEE RNIAVHRHNE IYNNNNSVSN ENNPSQVKEN
110 120 130 140 150
LSPAKICPYE RAFLREGGRI ALKDLSVDEF KGYIQDPLTD ETIPLTLPLG
160 170 180 190 200
DKKISLPSFI TPPRNSKISI FFTSKHQGQN PETKISRSTD DVSEKKVVRK

LSFHVYEDE
Length:209
Mass (Da):23,870
Last modified:November 1, 1996 - v1
Checksum:i0646D4E3AD41758C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73623 Genomic DNA Translation: CAA98002.1
AY558139 Genomic DNA Translation: AAS56465.1
BK006949 Genomic DNA Translation: DAA11169.1
PIRiS65300
RefSeqiNP_015056.1, NM_001184081.1

Genome annotation databases

EnsemblFungiiYPL267W; YPL267W; YPL267W
GeneIDi855861
KEGGisce:YPL267W

Similar proteinsi

Entry informationi

Entry nameiACM1_YEAST
AccessioniPrimary (citable) accession number: Q08981
Secondary accession number(s): D6W3A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health