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UniProtKB - Q08967 (FLC1_YEAST)
Protein
Flavin carrier protein 1
Gene
FLC1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.
1 PublicationGO - Molecular functioni
- FAD transmembrane transporter activity Source: SGD
GO - Biological processi
- FAD transport Source: SGD
- fungal-type cell wall biogenesis Source: SGD
- protein folding Source: SGD
- sphingolipid biosynthetic process Source: SGD
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 1.A.4.9.1, the transient receptor potential ca(2+) channel (trp-cc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Flavin carrier protein 1Alternative name(s): Bypass of PAM1 protein 1 FAD transporter 1 Heme utilization factor 1 TRP-like ion channel protein FLC1 |
Gene namesi | Name:FLC1 Synonyms:BOP1, HUF1 Ordered Locus Names:YPL221W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006142, FLC1 |
VEuPathDBi | FungiDB:YPL221W |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Vacuole
- fungal-type vacuole Source: SGD
Other locations
- cellular bud neck Source: SGD
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 163 | LumenalSequence analysisAdd BLAST | 142 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 194 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 195 – 215 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 216 – 223 | LumenalSequence analysis | 8 | |
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 245 – 249 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 250 – 272 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 273 – 317 | LumenalSequence analysisAdd BLAST | 45 | |
Transmembranei | 318 – 338 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 339 – 372 | CytoplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 373 – 393 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 394 – 397 | LumenalSequence analysis | 4 | |
Transmembranei | 398 – 418 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 419 – 461 | CytoplasmicSequence analysisAdd BLAST | 43 | |
Transmembranei | 462 – 482 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 483 – 484 | LumenalSequence analysis | 2 | |
Transmembranei | 485 – 505 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 506 – 516 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 517 – 537 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 538 – 551 | LumenalSequence analysisAdd BLAST | 14 | |
Transmembranei | 552 – 572 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 573 – 793 | CytoplasmicSequence analysisAdd BLAST | 221 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000252267 | 22 – 793 | Flavin carrier protein 1Add BLAST | 772 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 143 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 281 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 610 | PhosphoserineBy similarity | 1 | |
Modified residuei | 626 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 771 | PhosphoserineCombined sources | 1 | |
Modified residuei | 774 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q08967 |
PaxDbi | Q08967 |
PRIDEi | Q08967 |
PTM databases
iPTMneti | Q08967 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35964, 68 interactors |
DIPi | DIP-3965N |
IntActi | Q08967, 32 interactors |
MINTi | Q08967 |
STRINGi | 4932.YPL221W |
Miscellaneous databases
RNActi | Q08967, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q08967 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 649 – 674 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 689 – 731 | DisorderedSequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 658 – 674 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 697 – 731 | Polar residuesSequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the transient receptor potential (TRP) ion channel family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSVZ, Eukaryota |
GeneTreei | ENSGT00940000176312 |
HOGENOMi | CLU_010226_0_0_1 |
InParanoidi | Q08967 |
OMAi | YTIVKGM |
Family and domain databases
InterProi | View protein in InterPro IPR010308, TRP_C IPR040241, TRP_Flc/Pkd2-like IPR032800, TRP_N |
PANTHERi | PTHR31145, PTHR31145, 1 hit |
Pfami | View protein in Pfam PF06011, TRP, 1 hit PF14558, TRP_N, 1 hit |
SMARTi | View protein in SMART SM01320, TRP_N, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q08967-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVLVTLWCL ICTCLVLPVA AKKRTLTASS LVTCMENSQL SANSFDVSFS
60 70 80 90 100
PDDRSLHYDL DMTTQIDSYI YAYVDVYAYG FKIITENFDV CSMGWKQFCP
110 120 130 140 150
VHPGNIQIDS IEYIAQKYVK MIPGIAYQVP DIDAYVRLNI YNNVSENLAC
160 170 180 190 200
IQVFFSNGKT VSQIGVKWVT AVIAGIGLLT SAVLSTFGNS TAASHISANT
210 220 230 240 250
MSLFLYFQSV AVVAMQHVDS VPPIAAAWSE NLAWSMGLIR ITFMQKIFRW
260 270 280 290 300
YVEATGGSAS LYLTATTMSV LTQRGLDYLK NTSVYKRAEN VLYGNSNTLI
310 320 330 340 350
FRGIKRMGYR MKIENTAIVC TGFTFFVLCG YFLAGFIMAC KYSIELCIRC
360 370 380 390 400
GWMRSDRFYQ FRKNWRSVLK GSLLRYIYIG FTQLTILSFW EFTERDSAGV
410 420 430 440 450
IVIACLFIVL SCGLMAWAAY RTIFFASKSV EMYNNPAALL YGDEYVLNKY
460 470 480 490 500
GFFYTMFNAK HYWWNALLTT YILVKALFVG FAQASGKTQA LAIFIIDLAY
510 520 530 540 550
FVAIIRYKPY LDRPTNIVNI FICTVTLVNS FLFMFFSNLF NQKYAVSAIM
560 570 580 590 600
GWVFFIMNAA FSLLLLLMIL AFTTIILFSK NPDSRFKPAK DDRASFQKHA
610 620 630 640 650
IPHEGALNKS VANELMALGN VAKDHTENWE YELKSQEGKS EDNLFGVEYD
660 670 680 690 700
DEKTGTNSEN AESSSKETTR PTFSEKVLRS LSIKRNKSKL GSFKRSAPDK
710 720 730 740 750
ITQQEVSPDR ASSSPNSKSY PGVSHTRQES EANNGLINAY EDEQFSLMEP
760 770 780 790
SILEDAASST QMHAMPARDL SLSSVANAQD VTKKANILDP DYL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73577 Genomic DNA Translation: CAA97936.1 BK006949 Genomic DNA Translation: DAA11215.1 |
PIRi | S65240 |
RefSeqi | NP_015103.1, NM_001184035.1 |
Genome annotation databases
EnsemblFungii | YPL221W_mRNA; YPL221W; YPL221W |
GeneIDi | 855880 |
KEGGi | sce:YPL221W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73577 Genomic DNA Translation: CAA97936.1 BK006949 Genomic DNA Translation: DAA11215.1 |
PIRi | S65240 |
RefSeqi | NP_015103.1, NM_001184035.1 |
3D structure databases
AlphaFoldDBi | Q08967 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35964, 68 interactors |
DIPi | DIP-3965N |
IntActi | Q08967, 32 interactors |
MINTi | Q08967 |
STRINGi | 4932.YPL221W |
Protein family/group databases
TCDBi | 1.A.4.9.1, the transient receptor potential ca(2+) channel (trp-cc) family |
PTM databases
iPTMneti | Q08967 |
Proteomic databases
MaxQBi | Q08967 |
PaxDbi | Q08967 |
PRIDEi | Q08967 |
Genome annotation databases
EnsemblFungii | YPL221W_mRNA; YPL221W; YPL221W |
GeneIDi | 855880 |
KEGGi | sce:YPL221W |
Organism-specific databases
SGDi | S000006142, FLC1 |
VEuPathDBi | FungiDB:YPL221W |
Phylogenomic databases
eggNOGi | ENOG502QSVZ, Eukaryota |
GeneTreei | ENSGT00940000176312 |
HOGENOMi | CLU_010226_0_0_1 |
InParanoidi | Q08967 |
OMAi | YTIVKGM |
Miscellaneous databases
PROi | PR:Q08967 |
RNActi | Q08967, protein |
Family and domain databases
InterProi | View protein in InterPro IPR010308, TRP_C IPR040241, TRP_Flc/Pkd2-like IPR032800, TRP_N |
PANTHERi | PTHR31145, PTHR31145, 1 hit |
Pfami | View protein in Pfam PF06011, TRP, 1 hit PF14558, TRP_N, 1 hit |
SMARTi | View protein in SMART SM01320, TRP_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FLC1_YEAST | |
Accessioni | Q08967Primary (citable) accession number: Q08967 Secondary accession number(s): D6W3E9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - SIMILARITY comments
Index of protein domains and families