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UniProtKB - Q08967 (FLC1_YEAST)

Entry version 145 (25 May 2022)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Flavin carrier protein 1

Gene

FLC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • FAD transmembrane transporter activity Source: SGD
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.4.9.1, the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Flavin carrier protein 1
Alternative name(s):
Bypass of PAM1 protein 1
FAD transporter 1
Heme utilization factor 1
TRP-like ion channel protein FLC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FLC1
Synonyms:BOP1, HUF1
Ordered Locus Names:YPL221W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000006142, FLC1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YPL221W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 163LumenalSequence analysisAdd BLAST142
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 194CytoplasmicSequence analysis10
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 223LumenalSequence analysis8
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 249CytoplasmicSequence analysis5
Transmembranei250 – 272HelicalSequence analysisAdd BLAST23
Topological domaini273 – 317LumenalSequence analysisAdd BLAST45
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 372CytoplasmicSequence analysisAdd BLAST34
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 397LumenalSequence analysis4
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 461CytoplasmicSequence analysisAdd BLAST43
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 484LumenalSequence analysis2
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 516CytoplasmicSequence analysisAdd BLAST11
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21
Topological domaini538 – 551LumenalSequence analysisAdd BLAST14
Transmembranei552 – 572HelicalSequence analysisAdd BLAST21
Topological domaini573 – 793CytoplasmicSequence analysisAdd BLAST221

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025226722 – 793Flavin carrier protein 1Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei610PhosphoserineBy similarity1
Modified residuei626PhosphothreonineCombined sources1
Modified residuei771PhosphoserineCombined sources1
Modified residuei774PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q08967

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q08967

PRoteomics IDEntifications database

More...PRIDEi		Q08967

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q08967

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		35964, 68 interactors

Database of interacting proteins

More...DIPi		DIP-3965N

Protein interaction database and analysis system

More...IntActi		Q08967, 32 interactors

Molecular INTeraction database

More...MINTi		Q08967

STRING: functional protein association networks

More...STRINGi		4932.YPL221W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q08967, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q08967

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni649 – 674DisorderedSequence analysisAdd BLAST26
Regioni689 – 731DisorderedSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi658 – 674Polar residuesSequence analysisAdd BLAST17
Compositional biasi697 – 731Polar residuesSequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transient receptor potential (TRP) ion channel family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSVZ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000176312

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010226_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q08967

Identification of Orthologs from Complete Genome Data

More...OMAi		YTIVKGM

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010308, TRP_C
IPR040241, TRP_Flc/Pkd2-like
IPR032800, TRP_N

The PANTHER Classification System

More...PANTHERi		PTHR31145, PTHR31145, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06011, TRP, 1 hit
PF14558, TRP_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01320, TRP_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q08967-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVLVTLWCL ICTCLVLPVA AKKRTLTASS LVTCMENSQL SANSFDVSFS 
        60         70         80         90        100
PDDRSLHYDL DMTTQIDSYI YAYVDVYAYG FKIITENFDV CSMGWKQFCP 
       110        120        130        140        150
VHPGNIQIDS IEYIAQKYVK MIPGIAYQVP DIDAYVRLNI YNNVSENLAC 
       160        170        180        190        200
IQVFFSNGKT VSQIGVKWVT AVIAGIGLLT SAVLSTFGNS TAASHISANT 
       210        220        230        240        250
MSLFLYFQSV AVVAMQHVDS VPPIAAAWSE NLAWSMGLIR ITFMQKIFRW 
       260        270        280        290        300
YVEATGGSAS LYLTATTMSV LTQRGLDYLK NTSVYKRAEN VLYGNSNTLI 
       310        320        330        340        350
FRGIKRMGYR MKIENTAIVC TGFTFFVLCG YFLAGFIMAC KYSIELCIRC 
       360        370        380        390        400
GWMRSDRFYQ FRKNWRSVLK GSLLRYIYIG FTQLTILSFW EFTERDSAGV 
       410        420        430        440        450
IVIACLFIVL SCGLMAWAAY RTIFFASKSV EMYNNPAALL YGDEYVLNKY 
       460        470        480        490        500
GFFYTMFNAK HYWWNALLTT YILVKALFVG FAQASGKTQA LAIFIIDLAY 
       510        520        530        540        550
FVAIIRYKPY LDRPTNIVNI FICTVTLVNS FLFMFFSNLF NQKYAVSAIM 
       560        570        580        590        600
GWVFFIMNAA FSLLLLLMIL AFTTIILFSK NPDSRFKPAK DDRASFQKHA 
       610        620        630        640        650
IPHEGALNKS VANELMALGN VAKDHTENWE YELKSQEGKS EDNLFGVEYD 
       660        670        680        690        700
DEKTGTNSEN AESSSKETTR PTFSEKVLRS LSIKRNKSKL GSFKRSAPDK 
       710        720        730        740        750
ITQQEVSPDR ASSSPNSKSY PGVSHTRQES EANNGLINAY EDEQFSLMEP 
       760        770        780        790 
SILEDAASST QMHAMPARDL SLSSVANAQD VTKKANILDP DYL
Length:793
Mass (Da):89,291
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAB678C0038E2604
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z73577 Genomic DNA Translation: CAA97936.1
BK006949 Genomic DNA Translation: DAA11215.1

Protein sequence database of the Protein Information Resource

More...PIRi		S65240

NCBI Reference Sequences

More...RefSeqi		NP_015103.1, NM_001184035.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YPL221W_mRNA; YPL221W; YPL221W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		855880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YPL221W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73577 Genomic DNA Translation: CAA97936.1
BK006949 Genomic DNA Translation: DAA11215.1
PIRiS65240
RefSeqiNP_015103.1, NM_001184035.1

3D structure databases

AlphaFoldDBiQ08967
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi35964, 68 interactors
DIPiDIP-3965N
IntActiQ08967, 32 interactors
MINTiQ08967
STRINGi4932.YPL221W

Protein family/group databases

TCDBi1.A.4.9.1, the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiQ08967

Proteomic databases

MaxQBiQ08967
PaxDbiQ08967
PRIDEiQ08967

Genome annotation databases

EnsemblFungiiYPL221W_mRNA; YPL221W; YPL221W
GeneIDi855880
KEGGisce:YPL221W

Organism-specific databases

SGDiS000006142, FLC1
VEuPathDBiFungiDB:YPL221W

Phylogenomic databases

eggNOGiENOG502QSVZ, Eukaryota
GeneTreeiENSGT00940000176312
HOGENOMiCLU_010226_0_0_1
InParanoidiQ08967
OMAiYTIVKGM

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q08967
RNActiQ08967, protein

Family and domain databases

InterProiView protein in InterPro
IPR010308, TRP_C
IPR040241, TRP_Flc/Pkd2-like
IPR032800, TRP_N
PANTHERiPTHR31145, PTHR31145, 1 hit
PfamiView protein in Pfam
PF06011, TRP, 1 hit
PF14558, TRP_N, 1 hit
SMARTiView protein in SMART
SM01320, TRP_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLC1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08967
Secondary accession number(s): D6W3E9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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