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Protein

Ribosome biogenesis protein BMS1

Gene

BMS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus. The depletion of BMS1 interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi76 – 83ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • GTPase activity Source: SGD
  • GTP binding Source: SGD
  • U3 snoRNA binding Source: SGD

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34106-MONOMER
ReactomeiR-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BMS1
Gene namesi
Name:BMS1
Ordered Locus Names:YPL217C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

SGDiS000006138 BMS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001950061 – 1183Ribosome biogenesis protein BMS1Add BLAST1183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei438PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei504PhosphothreonineCombined sources1
Modified residuei516PhosphothreonineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08965
PaxDbiQ08965
PRIDEiQ08965

PTM databases

iPTMnetiQ08965

Interactioni

Subunit structurei

Associates with RCL1.

Binary interactionsi

WithEntry#Exp.IntActNotes
RCL1Q080964EBI-3683,EBI-14892

Protein-protein interaction databases

BioGridi35968, 441 interactors
ComplexPortaliCPX-1606 RCL1-BMS1 40S ribosomal subunit maturation complex
DIPiDIP-6562N
IntActiQ08965, 22 interactors
MINTiQ08965
STRINGi4932.YPL217C

Structurei

Secondary structure

11183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ08965
SMRiQ08965
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 234Bms1-type GAdd BLAST167

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074774
HOGENOMiHOG000166882
InParanoidiQ08965
KOiK14569
OMAiGMPKIMG
OrthoDBiEOG092C16GO

Family and domain databases

CDDicd01882 BMS1, 1 hit
InterProiView protein in InterPro
IPR012948 AARP2CN
IPR003959 ATPase_AAA_core
IPR039761 Bms1/Tsr1
IPR037875 Bms1_N
IPR007034 BMS1_TSR1_C
IPR030387 G_Bms1/Tsr1_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR12858 PTHR12858, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF08142 AARP2CN, 1 hit
PF04950 RIBIOP_C, 1 hit
SMARTiView protein in SMART
SM00785 AARP2CN, 1 hit
SM01362 DUF663, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51714 G_BMS1, 1 hit

Sequencei

Sequence statusi: Complete.

Q08965-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQSNKQHRK AKEKNTAKKK LHTQGHNAKA FAVAAPGKMA RTMQRSSDVN
60 70 80 90 100
ERKLHVPMVD RTPEDDPPPF IVAVVGPPGT GKTTLIRSLV RRMTKSTLND
110 120 130 140 150
IQGPITVVSG KHRRLTFLEC PADDLNAMID IAKIADLVLL LIDGNFGFEM
160 170 180 190 200
ETMEFLNIAQ HHGMPRVLGV ATHLDLFKSQ STLRASKKRL KHRFWTEVYQ
210 220 230 240 250
GAKLFYLSGV INGRYPDREI LNLSRFISVM KFRPLKWRNE HPYMLADRFT
260 270 280 290 300
DLTHPELIET QGLQIDRKVA IYGYLHGTPL PSAPGTRVHI AGVGDFSVAQ
310 320 330 340 350
IEKLPDPCPT PFYQQKLDDF EREKMKEEAK ANGEITTAST TRRRKRLDDK
360 370 380 390 400
DKLIYAPMSD VGGVLMDKDA VYIDIGKKNE EPSFVPGQER GEGEKLMTGL
410 420 430 440 450
QSVEQSIAEK FDGVGLQLFS NGTELHEVAD HEGMDVESGE ESIEDDEGKS
460 470 480 490 500
KGRTSLRKPR IYGKPVQEED ADIDNLPSDE EPYTNDDDVQ DSEPRMVEID
510 520 530 540 550
FNNTGEQGAE KLALETDSEF EESEDEFSWE RTAANKLKKT ESKKRTWNIG
560 570 580 590 600
KLIYMDNISP EECIRRWRGE DDDSKDESDI EEDVDDDFFR KKDGTVTKEG
610 620 630 640 650
NKDHAVDLEK FVPYFDTFEK LAKKWKSVDA IKERFLGAGI LGNDNKTKSD
660 670 680 690 700
SNEGGEELYG DFEDLEDGNP SEQAEDNSDK ESEDEDENED TNGDDDNSFT
710 720 730 740 750
NFDAEEKKDL TMEQEREMNA AKKEKLRAQF EIEEGENFKE DDENNEYDTW
760 770 780 790 800
YELQKAKISK QLEINNIEYQ EMTPEQRQRI EGFKAGSYVR IVFEKVPMEF
810 820 830 840 850
VKNFNPKFPI VMGGLLPTEI KFGIVKARLR RHRWHKKILK TNDPLVLSLG
860 870 880 890 900
WRRFQTLPIY TTTDSRTRTR MLKYTPEHTY CNAAFYGPLC SPNTPFCGVQ
910 920 930 940 950
IVANSDTGNG FRIAATGIVE EIDVNIEIVK KLKLVGFPYK IFKNTAFIKD
960 970 980 990 1000
MFSSAMEVAR FEGAQIKTVS GIRGEIKRAL SKPEGHYRAA FEDKILMSDI
1010 1020 1030 1040 1050
VILRSWYPVR VKKFYNPVTS LLLKEKTEWK GLRLTGQIRA AMNLETPSNP
1060 1070 1080 1090 1100
DSAYHKIERV ERHFNGLKVP KAVQKELPFK SQIHQMKPQK KKTYMAKRAV
1110 1120 1130 1140 1150
VLGGDEKKAR SFIQKVLTIS KAKDSKRKEQ KASQRKERLK KLAKMEEEKS
1160 1170 1180
QRDKEKKKEY FAQNGKRTTM GGDDESRPRK MRR
Length:1,183
Mass (Da):135,571
Last modified:November 1, 1996 - v1
Checksum:i9A337F1EE0B0F21D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73573 Genomic DNA Translation: CAA97932.1
BK006949 Genomic DNA Translation: DAA11219.1
PIRiS65236
RefSeqiNP_015107.1, NM_001184031.1

Genome annotation databases

EnsemblFungiiYPL217C; YPL217C; YPL217C
GeneIDi855884
KEGGisce:YPL217C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73573 Genomic DNA Translation: CAA97932.1
BK006949 Genomic DNA Translation: DAA11219.1
PIRiS65236
RefSeqiNP_015107.1, NM_001184031.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CLQX-ray2.02B547-636[»]
5JPQelectron microscopy7.30a1-1183[»]
5TZSelectron microscopy5.10i547-636[»]
5WLCelectron microscopy3.80SI1-1183[»]
5WYJelectron microscopy8.70B11-1183[»]
5WYKelectron microscopy4.50B11-1183[»]
ProteinModelPortaliQ08965
SMRiQ08965
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35968, 441 interactors
ComplexPortaliCPX-1606 RCL1-BMS1 40S ribosomal subunit maturation complex
DIPiDIP-6562N
IntActiQ08965, 22 interactors
MINTiQ08965
STRINGi4932.YPL217C

PTM databases

iPTMnetiQ08965

Proteomic databases

MaxQBiQ08965
PaxDbiQ08965
PRIDEiQ08965

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL217C; YPL217C; YPL217C
GeneIDi855884
KEGGisce:YPL217C

Organism-specific databases

SGDiS000006138 BMS1

Phylogenomic databases

GeneTreeiENSGT00550000074774
HOGENOMiHOG000166882
InParanoidiQ08965
KOiK14569
OMAiGMPKIMG
OrthoDBiEOG092C16GO

Enzyme and pathway databases

BioCyciYEAST:G3O-34106-MONOMER
ReactomeiR-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PROiPR:Q08965

Family and domain databases

CDDicd01882 BMS1, 1 hit
InterProiView protein in InterPro
IPR012948 AARP2CN
IPR003959 ATPase_AAA_core
IPR039761 Bms1/Tsr1
IPR037875 Bms1_N
IPR007034 BMS1_TSR1_C
IPR030387 G_Bms1/Tsr1_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR12858 PTHR12858, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF08142 AARP2CN, 1 hit
PF04950 RIBIOP_C, 1 hit
SMARTiView protein in SMART
SM00785 AARP2CN, 1 hit
SM01362 DUF663, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51714 G_BMS1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBMS1_YEAST
AccessioniPrimary (citable) accession number: Q08965
Secondary accession number(s): D6W3F3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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