Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Iron-regulated transcriptional activator AFT2

Gene

AFT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor required for iron homeostasis and resistance to oxidative stress. With RCS1, activates the gene expression in response to low-iron conditions, also called iron regulon.5 Publications

Miscellaneous

The transcription activation by RCS1 and AST2 depends on the mitochondrial iron-sulfur protein biosynthesis pathway.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandIron

Enzyme and pathway databases

BioCyciYEAST:G3O-34094-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-regulated transcriptional activator AFT2
Alternative name(s):
Activator of iron transcription protein 2
Gene namesi
Name:AFT2
Ordered Locus Names:YPL202C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL202C
SGDiS000006123 AFT2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275991 – 416Iron-regulated transcriptional activator AFT2Add BLAST416

Proteomic databases

MaxQBiQ08957
PaxDbiQ08957
PRIDEiQ08957

Interactioni

Protein-protein interaction databases

BioGridi35982, 61 interactors
MINTiQ08957
STRINGi4932.YPL202C

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ08957
SMRiQ08957
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000069471
InParanoidiQ08957
OrthoDBiEOG092C52YQ

Family and domain databases

InterProiView protein in InterPro
IPR014842 AFT
PfamiView protein in Pfam
PF08731 AFT, 2 hits

Sequencei

Sequence statusi: Complete.

Q08957-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAKSMKSII SVPISVSKTG KMKLTASPDN LASMMSKDQN KLIHLDPVPS
60 70 80 90 100
FEDRHEIKPW LQKIFYPQGI DIVIERSDSS KVTFKCRSVR SKVGLNPKSK
110 120 130 140 150
GSSSRSHACP FRIRAAYSVR LQKWNVVVMN NIHSHELRFD LITKTDDYKK
160 170 180 190 200
FKENLRQKND EKAIKTFDEL EYKASLNLPL VTPIISCDCG LTKEIEAFNN
210 220 230 240 250
IFLPLSNPPL TSKKNLLKTN KNSVSKIKSR QMDNSKPRPR LKTKLDADLH
260 270 280 290 300
DTGFLDNFKT RNSCVKIEKE DSLTNLNEID FTNMFCNDNF IQNYNQGLME
310 320 330 340 350
LLTEPTPGPS SSSCILPSTP TRPLSQSKMD IALSESTTSS PNFMETDAPY
360 370 380 390 400
GDEIIKVSKD TKSNAPTADT DIATNLGKER NENFGMLNYN YEALLHFNDE
410
HFNELNSIDP ALISKY
Length:416
Mass (Da):47,105
Last modified:November 1, 1996 - v1
Checksum:i0DAC56291EE56EFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73558 Genomic DNA Translation: CAA97916.1
BK006949 Genomic DNA Translation: DAA11233.1
PIRiS65221
RefSeqiNP_015122.1, NM_001184016.1

Genome annotation databases

EnsemblFungiiYPL202C; YPL202C; YPL202C
GeneIDi855899
KEGGisce:YPL202C

Similar proteinsi

Entry informationi

Entry nameiAFT2_YEAST
AccessioniPrimary (citable) accession number: Q08957
Secondary accession number(s): D6W3G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again