DNA damage checkpoint protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 3'-5' exonuclease activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: UniProtKB-KW
• protein kinase activator activity Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Mec1ATR Autophosphorylation and Ddc2ATRIP Phosphorylation Regulates DNA Damage Checkpoint Signaling."
    Memisoglu G., Lanz M.C., Eapen V.V., Jordan J.M., Lee K., Smolka M.B., Haber J.E.
    Cell Rep 28:1090-1102.e3(2019) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of protein kinase activity Source: SGDInferred from direct assayⁱ
  • "Mec1ATR Autophosphorylation and Ddc2ATRIP Phosphorylation Regulates DNA Damage Checkpoint Signaling."
    Memisoglu G., Lanz M.C., Eapen V.V., Jordan J.M., Lee K., Smolka M.B., Haber J.E.
    Cell Rep 28:1090-1102.e3(2019) [PubMed] [Europe PMC] [Abstract]
• cellular response to ionizing radiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA repair Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA replication checkpoint Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• intra-S DNA damage checkpoint Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.3

    "The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast."
    Longhese M.P., Paciotti V., Fraschini R., Zaccarini R., Plevani P., Lucchini G.
    EMBO J. 16:5216-5226(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, PHOSPHORYLATION.
• meiotic cell cycle Source: SGDInferred from mutant phenotypeⁱ
  • Ref.7

    "A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint."
    Hong E.-J.E., Roeder G.S.
    Genes Dev. 16:363-376(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION.
• meiotic recombination checkpoint Source: SGDInferred from mutant phenotypeⁱ
  • Ref.7

    "A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint."
    Hong E.-J.E., Roeder G.S.
    Genes Dev. 16:363-376(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION.
• mitotic cell cycle checkpoint Source: SGDInferred from mutant phenotypeⁱ
  • Ref.3

    "The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast."
    Longhese M.P., Paciotti V., Fraschini R., Zaccarini R., Plevani P., Lucchini G.
    EMBO J. 16:5216-5226(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, PHOSPHORYLATION.
• recombinational repair Source: SGDInferred from direct assayⁱ
  • "Dpb11, the budding yeast homolog of TopBP1, functions with the checkpoint clamp in recombination repair."
    Ogiwara H., Ui A., Onoda F., Tada S., Enomoto T., Seki M.
    Nucleic Acids Res. 34:3389-3398(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSFKATITES GKQNIWFRAI YVLSTIQDDI KITVTTNELI AWSMNETDTT 
        60         70         80         90        100
LCQVRFQKSF FEEYEFKPHE IVFGENGVQV IEDTYGNSHK LYSFRVNGRH 
       110        120        130        140        150
LTTISRKPDG DGIKSFTIAV NNTSTCPESL ANRLIVVIEM DSLIVKEYCP 
       160        170        180        190        200
QFQPIKYDPI IINLKYKRRF LDVFGTAASD RNPQEPLDPK LLDVFTNTER 
       210        220        230        240        250
ELTSALFNEE VESDIRKRNQ LTAADEINYI CCNSTLLKNF LDNCNVNVTD 
       260        270        280        290        300
EVKLEINVHR LSITAFTKAV YGKNNDLLRN ALSMSNTIST LDLEHYCLFT 
       310        320        330        340        350
TIEDEKQDKR SHSKRREHMK SIIFKLKDFK NFITIGPSWK TTQDGNDNIS 
       360        370        380        390        400
LWFCHPGDPI LMQMQKPGVK LELVEVTDSN INDDILEGKF IKTAISGSKE 
       410        420        430        440        450
EAGLKDNKES CESPLKSKTA LKRENLPHSV AGTRNSPLKV SYLTPDNGST 
       460        470        480        490        500
VAKTYRNNTA RKLFVEEQSQ STNYEQDKRF RQASSVHMNM NREQSFDIGT 
       510        520        530        540        550
THEVACPRNE SNSLKRSIAD ICNETEDPTQ QSTFAKRADT TVTWGKALPA 
       560        570        580        590        600
ADDEVSCSNI DRKGMLKKEK LKHMQGLLNS QNDTSNHKKQ DNKEMEDGLG 
       610 
LTQVEKPRGI FD                                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
3. Yeast chromosome XVI
   Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names