UniProtKB - Q08924 (WDR6_YEAST)
Protein
Regulator of Ty1 transposition protein 10
Gene
RTT10
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in regulation of Ty1 transposition. Plays also a role in the regulation of the retromer complex and is required for the recycling from endosomes of plasma membrane proteins like CAN1 and MUP1. Required together with TRM7 for the methylation of the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)).3 Publications
Miscellaneous
Present with 3450 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- endocytic recycling Source: SGD
- wobble position ribose methylation Source: SGD
Keywordsi
Biological process | tRNA processing |
Names & Taxonomyi
Protein namesi | Recommended name: Regulator of Ty1 transposition protein 10Alternative name(s): Endosomal recycling protein 2 tRNA (guanosine(34)-2'-O)-methyltransferase non-catalytic subunit TRM734 |
Gene namesi | Name:RTT10 Synonyms:ERE2, TRM734 Ordered Locus Names:YPL183C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006104, RTT10 |
VEuPathDBi | FungiDB:YPL183C |
Pathology & Biotechi
Disruption phenotypei
Increases Ty1 mobility 31-fold.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234366 | 1 – 1013 | Regulator of Ty1 transposition protein 10Add BLAST | 1013 |
Proteomic databases
MaxQBi | Q08924 |
PaxDbi | Q08924 |
PRIDEi | Q08924 |
PTM databases
iPTMneti | Q08924 |
Interactioni
Subunit structurei
Interacts with RRT2.
Interacts with TRM7; for 2'-O-methylation of position 34 in substrate tRNAs.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 36000, 188 interactors |
IntActi | Q08924, 1 interactor |
MINTi | Q08924 |
STRINGi | 4932.YPL183C |
Miscellaneous databases
RNActi | Q08924, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SASBDBi | Q08924 |
SMRi | Q08924 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 5 – 41 | WD 1Add BLAST | 37 | |
Repeati | 45 – 84 | WD 2Add BLAST | 40 | |
Repeati | 132 – 174 | WD 3Add BLAST | 43 | |
Repeati | 177 – 216 | WD 4Add BLAST | 40 | |
Repeati | 219 – 258 | WD 5Add BLAST | 40 | |
Repeati | 269 – 308 | WD 6Add BLAST | 40 | |
Repeati | 465 – 504 | WD 7Add BLAST | 40 | |
Repeati | 586 – 625 | WD 8Add BLAST | 40 | |
Repeati | 652 – 702 | WD 9Add BLAST | 51 | |
Repeati | 709 – 747 | WD 10Add BLAST | 39 | |
Repeati | 761 – 804 | WD 11Add BLAST | 44 | |
Repeati | 811 – 852 | WD 12Add BLAST | 42 | |
Repeati | 880 – 928 | WD 13Add BLAST | 49 | |
Repeati | 934 – 973 | WD 14Add BLAST | 40 | |
Repeati | 975 – 1013 | WD 15Add BLAST | 39 |
Sequence similaritiesi
Belongs to the WD repeat WDR6 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0974, Eukaryota |
GeneTreei | ENSGT00420000029923 |
HOGENOMi | CLU_002615_0_1_1 |
InParanoidi | Q08924 |
OMAi | HFFTGHE |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 9 hits |
SUPFAMi | SSF50978, SSF50978, 3 hits |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08924-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDLSHYGPA LCVKFYNDYV LAGYGPFIHV YDYHSATLIN KCRLFHYNKV
60 70 80 90 100
HGLSLSSEGK ILAYGARSVT IVELEDVLKK ESLVDFERIN SDWITGATFS
110 120 130 140 150
FDNLQIYLLT CYNKVLICDL NCEVLFRKSL GGERSILYSG IIKVFGPDKV
160 170 180 190 200
YVNAGTVMGG VIIWDLFSET KIHNLLGHEG SIFYVNLSNN GRYVASCSDD
210 220 230 240 250
RSIRLWDLET GKQLSVGWSH TARIWNLMFF DNDSKLISVS EDCTCRVWNI
260 270 280 290 300
IESRENVAEL SISNVYEVHL IKSIWGVDVK DDEMIAVTSG NDGRLKLIDL
310 320 330 340 350
LQLKRHGDEE TSFSLDDIAK QCGDIFEKNE SIKGFQWFSF GVIAITSLGK
360 370 380 390 400
ILKYSDVTKQ WKLLLTNEKF NSYPITNGIQ TQNIAVFSNN KSDILLIKFS
410 420 430 440 450
KDSADIIETE EFHLDELSKT NNCLVTEYDD DSFLLTLQSP NPREKFVCLE
460 470 480 490 500
ISLQNLKIKS KHCFNKPENF SSSCLTSFRN HILVGSRFST LVIYNLLDES
510 520 530 540 550
EEPFIIRRLS PGDTTTSIEF VEDKDNSAVF SVTNRDGYYV FIELTKNSLE
560 570 580 590 600
EGPYRLSYKV LHSNKMMKGF LEGAFFNSKG EYITYGFKSS LFYLYNETNC
610 620 630 640 650
YELASEVCGG SHRLWNLAKI TDGHVLMYIK ASRFHLRKIY NSIVPETLEN
660 670 680 690 700
GVHGREIRDI SICPVSNTNT NDNFKDGHIF CTASEDTTIK LGYFNNRTGK
710 720 730 740 750
VQNFWTQRKH VSGLQRCQFI NHKLMISSSA REELFLWELN DKYNKRPYMT
760 770 780 790 800
IRQALPVSTN NSDLRIMDFD VKFISQSGDF LLVTVYSDST IKIWHYRENQ
810 820 830 840 850
NKFDLIMQGR YKTCCLFNVV FIALKEELLV VISPTDGHLV VYNITEYVPF
860 870 880 890 900
SVDPISGDLV DHKLDATISN LPAPVAQLPV HQSGVKSLDY VANATRTSAT
910 920 930 940 950
ILTGGDDNGL GLSNLKLDDS NKVTLKTSDF IAAAASSTIT SGMLINGGKE
960 970 980 990 1000
VITTSVDQVI RAWEITAGKL SLVDKKRTTV ADTGSLEIIS NDEDADSEKT
1010
LLIGGVGLSI WKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73539 Genomic DNA Translation: CAA97892.1 BK006949 Genomic DNA Translation: DAA11252.1 |
PIRi | S65195 |
RefSeqi | NP_015142.1, NM_001183997.1 |
Genome annotation databases
EnsemblFungii | YPL183C_mRNA; YPL183C; YPL183C |
GeneIDi | 855919 |
KEGGi | sce:YPL183C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z73539 Genomic DNA Translation: CAA97892.1 BK006949 Genomic DNA Translation: DAA11252.1 |
PIRi | S65195 |
RefSeqi | NP_015142.1, NM_001183997.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6JP6 | X-ray | 2.70 | A/C | 1-1013 | [»] | |
6JPL | X-ray | 2.32 | A/C | 1-1013 | [»] | |
SASBDBi | Q08924 | |||||
SMRi | Q08924 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 36000, 188 interactors |
IntActi | Q08924, 1 interactor |
MINTi | Q08924 |
STRINGi | 4932.YPL183C |
PTM databases
iPTMneti | Q08924 |
Proteomic databases
MaxQBi | Q08924 |
PaxDbi | Q08924 |
PRIDEi | Q08924 |
Genome annotation databases
EnsemblFungii | YPL183C_mRNA; YPL183C; YPL183C |
GeneIDi | 855919 |
KEGGi | sce:YPL183C |
Organism-specific databases
SGDi | S000006104, RTT10 |
VEuPathDBi | FungiDB:YPL183C |
Phylogenomic databases
eggNOGi | KOG0974, Eukaryota |
GeneTreei | ENSGT00420000029923 |
HOGENOMi | CLU_002615_0_1_1 |
InParanoidi | Q08924 |
OMAi | HFFTGHE |
Miscellaneous databases
PROi | PR:Q08924 |
RNActi | Q08924, protein |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 9 hits |
SUPFAMi | SSF50978, SSF50978, 3 hits |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR6_YEAST | |
Accessioni | Q08924Primary (citable) accession number: Q08924 Secondary accession number(s): D6W3I6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names