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Entry version 118 (10 Feb 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Fluoride export protein 1

Gene

FEX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.

2 Publications

Miscellaneous

Present with 220 molecules/cell in the plasma membrane.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • fluoride transmembrane transport Source: SGD

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.43.2.4, the camphor resistance or fluoride exporter (fluc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fluoride export protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FEX11 Publication
Ordered Locus Names:YOR390WImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005917, FEX1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YOR390W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11Cytoplasmic1 PublicationAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 34Extracellular1 Publication2
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 79Cytoplasmic1 PublicationAdd BLAST24
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 127Extracellular1 PublicationAdd BLAST27
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 213Cytoplasmic1 PublicationAdd BLAST65
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 241Extracellular1 Publication7
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 268Cytoplasmic1 Publication6
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 310Extracellular1 PublicationAdd BLAST21
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 338Cytoplasmic1 Publication7
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 375Extracellular1 PublicationAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Highly sensible to fluoride, but not to other halide salts. The growth of a double deletion of both FEX1 and FEX2 is inhibited at almost a 1000-fold lower fluoride concentration than in the wild-type. Has increased intracellular fluoride concentrations.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002416991 – 375Fluoride export protein 1Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi109N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi117N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi235N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08913

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08913

PRoteomics IDEntifications database

More...
PRIDEi
Q08913

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34771, 32 interactors

Database of interacting proteins

More...
DIPi
DIP-4815N

Protein interaction database and analysis system

More...
IntActi
Q08913, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YOR390W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q08913, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q08913

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fluoride exporter Fluc/FEX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT5F, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176800

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030507_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08913

Identification of Orthologs from Complete Genome Data

More...
OMAi
IWPPDRH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003691, CrcB

The PANTHER Classification System

More...
PANTHERi
PTHR28259, PTHR28259, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02537, CRCB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q08913-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIFNPVISNH KLSHYIHVFC TFTTFCILGT ETRQAITALS TYTPAFVTAP
60 70 80 90 100
TVLWSNCSSC MLMGIMQSLN AYTWMKDHQV LFLGVTTGYC GALSSFSSML
110 120 130 140 150
LEMFEHSTNL TNGNIANHTK LPNRAYGIME FLSVLLVHLM VSMGSLIFGR
160 170 180 190 200
QLGKEVIVAY GSSSFSKPYT PPSDTVKENA GDVDTQEMEK NILEFKFKTP
210 220 230 240 250
APFFKKFFDI VDKLAYALAF PLIILFVVLC AYYENYSRGK WTLPCLFGIF
260 270 280 290 300
AGFLRYWLAE MFNKTNKKFP LGTFLANVFA TLLIGIFTMV QRGKKHFSTD
310 320 330 340 350
VPIVNSLNSC HIVSALISGF CGTLSTISTF INEGYKLSFI NMLIYYTVSI
360 370
AISYCLLVIT LGSYAWTRGL TNPIC
Length:375
Mass (Da):41,985
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2852663384C72CE7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z75298 Genomic DNA Translation: CAA99722.1
BK006948 Genomic DNA Translation: DAA11149.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S67302

NCBI Reference Sequences

More...
RefSeqi
NP_015035.1, NM_001183810.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR390W_mRNA; YOR390W; YOR390W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854572

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR390W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75298 Genomic DNA Translation: CAA99722.1
BK006948 Genomic DNA Translation: DAA11149.1
PIRiS67302
RefSeqiNP_015035.1, NM_001183810.1

3D structure databases

SMRiQ08913
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi34771, 32 interactors
DIPiDIP-4815N
IntActiQ08913, 2 interactors
STRINGi4932.YOR390W

Protein family/group databases

TCDBi1.A.43.2.4, the camphor resistance or fluoride exporter (fluc) family

Proteomic databases

MaxQBiQ08913
PaxDbiQ08913
PRIDEiQ08913

Genome annotation databases

EnsemblFungiiYOR390W_mRNA; YOR390W; YOR390W
GeneIDi854572
KEGGisce:YOR390W

Organism-specific databases

SGDiS000005917, FEX1
VEuPathDBiFungiDB:YOR390W

Phylogenomic databases

eggNOGiENOG502QT5F, Eukaryota
GeneTreeiENSGT00940000176800
HOGENOMiCLU_030507_1_2_1
InParanoidiQ08913
OMAiIWPPDRH

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q08913
RNActiQ08913, protein

Family and domain databases

InterProiView protein in InterPro
IPR003691, CrcB
PANTHERiPTHR28259, PTHR28259, 1 hit
PfamiView protein in Pfam
PF02537, CRCB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFEX1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08913
Secondary accession number(s): D6W383
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: February 10, 2021
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. SIMILARITY comments
    Index of protein domains and families
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