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Protein

Nuclear division defective protein 1

Gene

NDD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription activator involved in G2/M transcription through its association with FKH2.7 Publications

Miscellaneous

Present with 779 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • transcription coactivator activity Source: SGD

GO - Biological processi

  • positive regulation of transcription involved in G2/M transition of mitotic cell cycle Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33840-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear division defective protein 1
Gene namesi
Name:NDD1
Ordered Locus Names:YOR372C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR372C
SGDiS000005899 NDD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi319T → A: Growth delay. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686861 – 554Nuclear division defective protein 1Add BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319Phosphothreonine; by CDC28Combined sources1 Publication1

Post-translational modificationi

Phosphorylation of Thr-319 by CDC28 is required for the interaction with FKH2 and recruitment to promoters.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ08887
PaxDbiQ08887
PRIDEiQ08887

PTM databases

iPTMnetiQ08887

Expressioni

Inductioni

During S phase of the cell cycle. Expression is cell cycle regulated by HCM1.2 Publications

Interactioni

Subunit structurei

Forms an activator complex with FKH2.

Protein-protein interaction databases

BioGridi34755, 27 interactors
DIPiDIP-1806N
IntActiQ08887, 5 interactors
MINTiQ08887
STRINGi4932.YOR372C

Structurei

3D structure databases

ProteinModelPortaliQ08887
SMRiQ08887
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 113Gln-richAdd BLAST18
Compositional biasi493 – 546Ser-richAdd BLAST54

Phylogenomic databases

HOGENOMiHOG000066011
InParanoidiQ08887
OMAiFQIIVAN
OrthoDBiEOG092C4W8U

Sequencei

Sequence statusi: Complete.

Q08887-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRDISYQQN YTSTGATATS SRQPSTDNNA DTNFLKVMSE FKYNFNSPLP
60 70 80 90 100
TTTQFPTPYS SNQYQQTQDH FANTDAHNSS SNESSLVENS ILPHHQQIQQ
110 120 130 140 150
QQQQQQQQQQ QQQALGSLVP PAVTRTDTSE TLDDINVQPS SVLQFGNSLP
160 170 180 190 200
SEFLVASPEQ FKEFLLDSPS TNFNFFHKTP AKTPLRFVTD SNGAQQSTTE
210 220 230 240 250
NPGQQQNVFS NVDLNNLLKS NGKTPSSSCT GAFSRTPLSK IDMNLMFNQP
260 270 280 290 300
LPTSPSKRFS SLSLTPYGRK ILNDVGTPYA KALISSNSAL VDFQKARKDI
310 320 330 340 350
TTNATSIGLE NANNILQRTP LRSNNKKLFI KTPQDTINST STLTKDNENK
360 370 380 390 400
QDIYGSSPTT IQLNSSITKS ISKLDNSRIP LLASRSDNIL DSNVDDQLFD
410 420 430 440 450
LGLTRLPLSP TPNCNSLHST TTGTSALQIP ELPKMGSFRS DTGINPISSS
460 470 480 490 500
NTVSFKSKSG NNNSKGRIKK NGKKPSKFQI IVANIDQFNQ DTSSSSLSSS
510 520 530 540 550
LNASSSAGNS NSNVTKKRAS KLKRSQSLLS DSGSKSQARK SCNSKSNGNL

FNSQ
Length:554
Mass (Da):60,523
Last modified:November 1, 1996 - v1
Checksum:i1CF99115F2B1F23D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75280 Genomic DNA Translation: CAA99703.1
BK006948 Genomic DNA Translation: DAA11131.1
PIRiS67284
RefSeqiNP_015017.1, NM_001183792.1

Genome annotation databases

EnsemblFungiiYOR372C; YOR372C; YOR372C
GeneIDi854554
KEGGisce:YOR372C

Similar proteinsi

Entry informationi

Entry nameiNDD1_YEAST
AccessioniPrimary (citable) accession number: Q08887
Secondary accession number(s): D6W365
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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