UniProtKB - Q08881 (ITK_HUMAN)
Tyrosine-protein kinase ITK/TSK
ITK
Functioni
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281).
Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity).
Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity).
By similarity3 PublicationsCatalytic activityi
- EC:2.7.10.2PROSITE-ProRule annotation
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 121 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 132 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 133 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 143 | ZincPROSITE-ProRule annotation | 1 | |
Binding sitei | 391 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 482 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 113 – 149 | Btk-typePROSITE-ProRule annotationAdd BLAST | 37 | |
Nucleotide bindingi | 369 – 377 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- activation of phospholipase C activity Source: UniProtKB
- adaptive immune response Source: UniProtKB
- B cell receptor signaling pathway Source: GO_Central
- cellular defense response Source: ProtInc
- gamma-delta T cell activation Source: UniProtKB
- intracellular signal transduction Source: InterPro
- NK T cell differentiation Source: GO_Central
- peptidyl-tyrosine autophosphorylation Source: GO_Central
- positive regulation of cytokine production Source: UniProtKB
- signal transduction Source: ProtInc
- T cell activation Source: UniProtKB
- T cell receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Adaptive immunity, Immunity |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | Q08881 |
Reactomei | R-HSA-202433, Generation of second messenger molecules R-HSA-2871809, FCERI mediated Ca+2 mobilization |
SignaLinki | Q08881 |
SIGNORi | Q08881 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase ITK/TSK (EC:2.7.10.2)Alternative name(s): Interleukin-2-inducible T-cell kinase Short name: IL-2-inducible T-cell kinase Kinase EMT T-cell-specific kinase Tyrosine-protein kinase Lyk |
Gene namesi | Name:ITK Synonyms:EMT, LYK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6171, ITK |
MIMi | 186973, gene |
neXtProti | NX_Q08881 |
VEuPathDBi | HostDB:ENSG00000113263 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cell-cell junction Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Lymphoproliferative syndrome 1 (LPFS1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063424 | 335 | R → W in LPFS1; shows nearly undetectable mutant ITK protein consistent with severe protein instability. 1 PublicationCorresponds to variant dbSNP:rs121908191EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 288 | P → G: Complete loss of interaction with PPIA/CYPA. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 3702 |
MalaCardsi | ITK |
MIMi | 613011, phenotype |
OpenTargetsi | ENSG00000113263 |
Orphaneti | 538963, Combined immunodeficiency due to ITK deficiency |
PharmGKBi | PA29968 |
Miscellaneous databases
Pharosi | Q08881, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2959 |
DrugBanki | DB12010, Fostamatinib DB06589, Pazopanib DB02010, Staurosporine DB15035, Zanubrutinib |
DrugCentrali | Q08881 |
GuidetoPHARMACOLOGYi | 2046 |
Genetic variation databases
BioMutai | ITK |
DMDMi | 585361 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088106 | 1 – 620 | Tyrosine-protein kinase ITK/TSKAdd BLAST | 620 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 180 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 512 | Phosphotyrosine; by LCKCombined sources | 1 | |
Modified residuei | 565 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q08881 |
MassIVEi | Q08881 |
MaxQBi | Q08881 |
PaxDbi | Q08881 |
PeptideAtlasi | Q08881 |
PRIDEi | Q08881 |
ProteomicsDBi | 58650 |
PTM databases
iPTMneti | Q08881 |
PhosphoSitePlusi | Q08881 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000113263, Expressed in mononuclear cell and 152 other tissues |
ExpressionAtlasi | Q08881, baseline and differential |
Genevisiblei | Q08881, HS |
Organism-specific databases
HPAi | ENSG00000113263, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Homooligomerizes; this association negatively regulates kinase activity (By similarity).
Interacts with PPIA/CYPA; this interaction regulates TCR signal strength via a proline-directed conformational switch in ITK.
Interacts with THEMIS (By similarity).
Interacts with FASLG.
Interacts with VAV1; this interaction is important for VAV1 localization and TCR-induced actin polarization.
Interacts with TBX21 (By similarity).
By similarity3 PublicationsBinary interactionsi
Q08881
Protein-protein interaction databases
BioGRIDi | 109907, 44 interactors |
CORUMi | Q08881 |
DIPi | DIP-29974N |
IntActi | Q08881, 25 interactors |
MINTi | Q08881 |
STRINGi | 9606.ENSP00000398655 |
Chemistry databases
BindingDBi | Q08881 |
Miscellaneous databases
RNActi | Q08881, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q08881 |
SMRi | Q08881 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q08881 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 111 | PHPROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 171 – 231 | SH3PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 239 – 338 | SH2PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 363 – 615 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 253 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 113 – 149 | Btk-typePROSITE-ProRule annotationAdd BLAST | 37 |
Keywords - Domaini
SH2 domain, SH3 domain, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000158850 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | Q08881 |
OMAi | IQDKNGH |
OrthoDBi | 1047190at2759 |
PhylomeDBi | Q08881 |
TreeFami | TF351634 |
Family and domain databases
CDDi | cd05112, PTKc_Itk, 1 hit cd11908, SH3_ITK, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR042785, ITK_PTKc IPR035583, ITK_SH3 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001562, Znf_Btk_motif |
Pfami | View protein in Pfam PF00779, BTK, 1 hit PF00169, PH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00107, BTK, 1 hit SM00233, PH, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit PS51113, ZF_BTK, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT
60 70 80 90 100
LKGSIELSRI KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ
110 120 130 140 150
RWVLALKEET RNNNSLVPKY HPNFWMDGKW RCCSQLEKLA TGCAQYDPTK
160 170 180 190 200
NASKKPLPPT PEDNRRPLWE PEETVVIALY DYQTNDPQEL ALRRNEEYCL
210 220 230 240 250
LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY NKSISRDKAE
260 270 280 290 300
KLLLDTGKEG AFMVRDSRTA GTYTVSVFTK AVVSENNPCI KHYHIKETND
310 320 330 340 350
NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCF GRQKAPVTAG
360 370 380 390 400
LRYGKWVIDP SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIREGAMSE
410 420 430 440 450
EDFIEEAEVM MKLSHPKLVQ LYGVCLEQAP ICLVFEFMEH GCLSDYLRTQ
460 470 480 490 500
RGLFAAETLL GMCLDVCEGM AYLEEACVIH RDLAARNCLV GENQVIKVSD
510 520 530 540 550
FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD VWSFGVLMWE
560 570 580 590 600
VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASTHVYQI MNHCWKERPE
610 620
DRPAFSRLLR QLAEIAESGL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RFR5 | E5RFR5_HUMAN | Tyrosine-protein kinase ITK/TSK | ITK | 73 | Annotation score: | ||
E5RJY4 | E5RJY4_HUMAN | Tyrosine-protein kinase ITK/TSK | ITK | 116 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 171 – 172 | PE → GS AA sequence (PubMed:12573241).Curated | 2 | |
Sequence conflicti | 331 | V → W in AAB28072 (PubMed:8364206).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041710 | 19 | R → K in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041711 | 23 | P → L in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_051696 | 193 | R → Q. Corresponds to variant dbSNP:rs17054374EnsemblClinVar. | 1 | |
Natural variantiVAR_063424 | 335 | R → W in LPFS1; shows nearly undetectable mutant ITK protein consistent with severe protein instability. 1 PublicationCorresponds to variant dbSNP:rs121908191EnsemblClinVar. | 1 | |
Natural variantiVAR_041712 | 451 | R → Q in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs779372373Ensembl. | 1 | |
Natural variantiVAR_041713 | 581 | R → W1 PublicationCorresponds to variant dbSNP:rs34482255EnsemblClinVar. | 1 | |
Natural variantiVAR_041714 | 587 | V → I1 PublicationCorresponds to variant dbSNP:rs56005928EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13720 mRNA Translation: BAA02873.1 L10717 mRNA Translation: AAA36748.1 S65186 mRNA Translation: AAB28072.2 AK312846 mRNA Translation: BAG35699.1 CH471062 Genomic DNA Translation: EAW61608.1 BC109077 mRNA Translation: AAI09078.1 BC109078 mRNA Translation: AAI09079.1 |
CCDSi | CCDS4336.1 |
PIRi | S33253 |
RefSeqi | NP_005537.3, NM_005546.3 |
Genome annotation databases
Ensembli | ENST00000422843; ENSP00000398655; ENSG00000113263 |
GeneIDi | 3702 |
KEGGi | hsa:3702 |
MANE-Selecti | ENST00000422843.8; ENSP00000398655.4; NM_005546.4; NP_005537.3 |
UCSCi | uc003lwo.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13720 mRNA Translation: BAA02873.1 L10717 mRNA Translation: AAA36748.1 S65186 mRNA Translation: AAB28072.2 AK312846 mRNA Translation: BAG35699.1 CH471062 Genomic DNA Translation: EAW61608.1 BC109077 mRNA Translation: AAI09078.1 BC109078 mRNA Translation: AAI09079.1 |
CCDSi | CCDS4336.1 |
PIRi | S33253 |
RefSeqi | NP_005537.3, NM_005546.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SM2 | X-ray | 2.30 | A/B | 357-620 | [»] | |
1SNU | X-ray | 2.50 | A/B | 357-620 | [»] | |
1SNX | X-ray | 3.20 | A/B | 357-620 | [»] | |
2E6I | NMR | - | A | 113-169 | [»] | |
2LMJ | NMR | - | A | 171-231 | [»] | |
2YUQ | NMR | - | A | 162-239 | [»] | |
3MIY | X-ray | 1.67 | A/B | 357-620 | [»] | |
3MJ1 | X-ray | 1.72 | A | 357-620 | [»] | |
3MJ2 | X-ray | 1.90 | A | 357-620 | [»] | |
3QGW | X-ray | 2.10 | A/B | 357-620 | [»] | |
3QGY | X-ray | 2.10 | A/B | 357-620 | [»] | |
3T9T | X-ray | 1.65 | A | 354-620 | [»] | |
3V5J | X-ray | 2.59 | A/B | 357-620 | [»] | |
3V5L | X-ray | 1.86 | A/B/C/D | 357-620 | [»] | |
3V8T | X-ray | 2.00 | A/B | 357-620 | [»] | |
3V8W | X-ray | 2.27 | A/B | 357-620 | [»] | |
4HCT | X-ray | 1.48 | A | 354-620 | [»] | |
4HCU | X-ray | 1.43 | A | 354-620 | [»] | |
4HCV | X-ray | 1.48 | A | 354-620 | [»] | |
4KIO | X-ray | 2.18 | A/B/C/D | 357-620 | [»] | |
4L7S | X-ray | 2.03 | A/B | 357-620 | [»] | |
4M0Y | X-ray | 1.70 | A | 354-620 | [»] | |
4M0Z | X-ray | 2.00 | A | 354-620 | [»] | |
4M12 | X-ray | 2.15 | A | 354-620 | [»] | |
4M13 | X-ray | 1.85 | A | 354-620 | [»] | |
4M14 | X-ray | 1.55 | A | 354-620 | [»] | |
4M15 | X-ray | 1.52 | A | 354-620 | [»] | |
4MF0 | X-ray | 2.67 | A/B | 357-620 | [»] | |
4MF1 | X-ray | 2.11 | A/B | 357-620 | [»] | |
4PP9 | X-ray | 2.58 | A/B | 357-620 | [»] | |
4PPA | X-ray | 2.67 | A/B | 357-620 | [»] | |
4PPB | X-ray | 2.82 | A/B | 357-620 | [»] | |
4PPC | X-ray | 2.95 | A/B | 357-620 | [»] | |
4PQN | X-ray | 1.71 | A | 357-620 | [»] | |
4QD6 | X-ray | 2.45 | A/B | 357-620 | [»] | |
4RFM | X-ray | 2.10 | A | 357-620 | [»] | |
BMRBi | Q08881 | |||||
SMRi | Q08881 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109907, 44 interactors |
CORUMi | Q08881 |
DIPi | DIP-29974N |
IntActi | Q08881, 25 interactors |
MINTi | Q08881 |
STRINGi | 9606.ENSP00000398655 |
Chemistry databases
BindingDBi | Q08881 |
ChEMBLi | CHEMBL2959 |
DrugBanki | DB12010, Fostamatinib DB06589, Pazopanib DB02010, Staurosporine DB15035, Zanubrutinib |
DrugCentrali | Q08881 |
GuidetoPHARMACOLOGYi | 2046 |
PTM databases
iPTMneti | Q08881 |
PhosphoSitePlusi | Q08881 |
Genetic variation databases
BioMutai | ITK |
DMDMi | 585361 |
Proteomic databases
jPOSTi | Q08881 |
MassIVEi | Q08881 |
MaxQBi | Q08881 |
PaxDbi | Q08881 |
PeptideAtlasi | Q08881 |
PRIDEi | Q08881 |
ProteomicsDBi | 58650 |
Protocols and materials databases
ABCDi | Q08881, 4 sequenced antibodies |
Antibodypediai | 16533, 503 antibodies from 42 providers |
DNASUi | 3702 |
Genome annotation databases
Ensembli | ENST00000422843; ENSP00000398655; ENSG00000113263 |
GeneIDi | 3702 |
KEGGi | hsa:3702 |
MANE-Selecti | ENST00000422843.8; ENSP00000398655.4; NM_005546.4; NP_005537.3 |
UCSCi | uc003lwo.2, human |
Organism-specific databases
CTDi | 3702 |
DisGeNETi | 3702 |
GeneCardsi | ITK |
HGNCi | HGNC:6171, ITK |
HPAi | ENSG00000113263, Tissue enriched (lymphoid) |
MalaCardsi | ITK |
MIMi | 186973, gene 613011, phenotype |
neXtProti | NX_Q08881 |
OpenTargetsi | ENSG00000113263 |
Orphaneti | 538963, Combined immunodeficiency due to ITK deficiency |
PharmGKBi | PA29968 |
VEuPathDBi | HostDB:ENSG00000113263 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000158850 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | Q08881 |
OMAi | IQDKNGH |
OrthoDBi | 1047190at2759 |
PhylomeDBi | Q08881 |
TreeFami | TF351634 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | Q08881 |
Reactomei | R-HSA-202433, Generation of second messenger molecules R-HSA-2871809, FCERI mediated Ca+2 mobilization |
SignaLinki | Q08881 |
SIGNORi | Q08881 |
Miscellaneous databases
BioGRID-ORCSi | 3702, 8 hits in 1068 CRISPR screens |
ChiTaRSi | ITK, human |
EvolutionaryTracei | Q08881 |
GeneWikii | ITK_(gene) |
GenomeRNAii | 3702 |
Pharosi | Q08881, Tclin |
PROi | PR:Q08881 |
RNActi | Q08881, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113263, Expressed in mononuclear cell and 152 other tissues |
ExpressionAtlasi | Q08881, baseline and differential |
Genevisiblei | Q08881, HS |
Family and domain databases
CDDi | cd05112, PTKc_Itk, 1 hit cd11908, SH3_ITK, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR042785, ITK_PTKc IPR035583, ITK_SH3 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001562, Znf_Btk_motif |
Pfami | View protein in Pfam PF00779, BTK, 1 hit PF00169, PH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00107, BTK, 1 hit SM00233, PH, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit PS51113, ZF_BTK, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ITK_HUMAN | |
Accessioni | Q08881Primary (citable) accession number: Q08881 Secondary accession number(s): B2R752, Q32ML7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 220 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families