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UniProtKB - Q08879 (FBLN1_MOUSE)

Protein

Fibulin-1

Gene

Fbln1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
Fibulin-1
Short name:
FIBL-1
Alternative name(s):
Basement-membrane protein 90
Short name:
BM-90
Gene namesi
Name:Fbln1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:95487 Fbln1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000000756430 – 705Fibulin-1Add BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 61By similarity
Disulfide bondi37 ↔ 68By similarity
Disulfide bondi50 ↔ 69By similarity
Disulfide bondi78 ↔ 109By similarity
Disulfide bondi91 ↔ 110By similarity
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 136By similarity
Disulfide bondi113 ↔ 143By similarity
Disulfide bondi126 ↔ 144By similarity
Disulfide bondi182 ↔ 192By similarity
Disulfide bondi188 ↔ 201By similarity
Disulfide bondi203 ↔ 216By similarity
Disulfide bondi222 ↔ 235By similarity
Disulfide bondi229 ↔ 244By similarity
Disulfide bondi250 ↔ 262By similarity
Disulfide bondi268 ↔ 281By similarity
Disulfide bondi275 ↔ 290By similarity
Disulfide bondi296 ↔ 308By similarity
Disulfide bondi314 ↔ 327By similarity
Disulfide bondi321 ↔ 336By similarity
Disulfide bondi343 ↔ 356By similarity
Disulfide bondi362 ↔ 375By similarity
Disulfide bondi369 ↔ 384By similarity
Disulfide bondi386 ↔ 399By similarity
Disulfide bondi405 ↔ 417By similarity
Disulfide bondi413 ↔ 426By similarity
Disulfide bondi428 ↔ 441By similarity
Disulfide bondi447 ↔ 456By similarity
Disulfide bondi452 ↔ 465By similarity
Disulfide bondi467 ↔ 481By similarity
Disulfide bondi487 ↔ 500By similarity
Disulfide bondi496 ↔ 509By similarity
Disulfide bondi511 ↔ 525By similarity
Disulfide bondi531 ↔ 544By similarity
Glycosylationi537N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi538 ↔ 553By similarity
Glycosylationi541N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi558 ↔ 579By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ08879
PeptideAtlasiQ08879
PRIDEiQ08879

PTM databases

PhosphoSitePlusiQ08879

Expressioni

Tissue specificityi

Detected in most organs (brain, heart, lung, spleen, liver and kidney). Neurons are the predominant source of production in the brain. Not expressed significantly by astrocytes or microglia.1 Publication

Developmental stagei

The differential expression of the fibulin family contributes to the formation of molecularly distinct extracellular matrices already during early developmental stages of a large number of tissues. Increase expression at neonate stage in the brain. Expressed in interdigital regions of the handplate of a 12 dpc embryo and in the lateral perichondrial region. Similar expression persists in the 13 dpc handplate particularly in the perichondrial regions and apical aspects of the developing digits.3 Publications

Inductioni

Glucocorticoids suppressed mRNA expression and protein synthesis.

Gene expression databases

BgeeiENSMUSG00000006369 Expressed in 297 organ(s), highest expression level in ear vesicle
CleanExiMM_FBLN1
ExpressionAtlasiQ08879 baseline and differential
GenevisibleiQ08879 MM

Interactioni

Subunit structurei

Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LMA2, NID, ACAN, CSPG2 and type IV collagen. Binding analysis demonstrated for isoform C a 100-fold stronger binding to the basement membrane protein NID than for isoform D. Interacts with FBLN7.4 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi199605, 1 interactor
IntActiQ08879, 2 interactors
MINTiQ08879
STRINGi10090.ENSMUSP00000054583

Structurei

3D structure databases

ProteinModelPortaliQ08879
SMRiQ08879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 76Anaphylatoxin-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini77 – 111Anaphylatoxin-like 2PROSITE-ProRule annotationAdd BLAST35
Domaini112 – 144Anaphylatoxin-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini178 – 217EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini218 – 263EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST46
Domaini264 – 309EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST46
Domaini310 – 357EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST48
Domaini358 – 400EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini401 – 442EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini443 – 482EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini483 – 526EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini527 – 580EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni358 – 442Self-association and FN1-bindingBy similarityAdd BLAST85

Sequence similaritiesi

Belongs to the fibulin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR7F Eukaryota
ENOG410Y194 LUCA
GeneTreeiENSGT00760000118806
HOGENOMiHOG000007079
HOVERGENiHBG051559
InParanoidiQ08879
KOiK17307
OMAiGHLCVNS
OrthoDBiEOG091G02LJ
PhylomeDBiQ08879
TreeFamiTF317514

Family and domain databases

CDDicd00017 ANATO, 2 hits
InterProiView protein in InterPro
IPR000020 Anaphylatoxin/fibulin
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR017048 Fibulin-1
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF12662 cEGF, 3 hits
PF07645 EGF_CA, 4 hits
PIRSFiPIRSF036313 Fibulin-1, 1 hit
SMARTiView protein in SMART
SM00104 ANATO, 3 hits
SM00181 EGF, 9 hits
SM00179 EGF_CA, 8 hits
SUPFAMiSSF57184 SSF57184, 4 hits
PROSITEiView protein in PROSITE
PS01177 ANAPHYLATOXIN_1, 3 hits
PS01178 ANAPHYLATOXIN_2, 3 hits
PS00010 ASX_HYDROXYL, 4 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 8 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform D (identifier: Q08879-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERPVPSRLV PLPLLLLSSL SLLAARANAD ISMEACCTDG NQMANQHRDC 
        60         70         80         90        100
SLPYTSESKE CRMVQEQCCH NQLEELHCAT GINLASEPEG CASLHSYNSS 
       110        120        130        140        150
LETIFIKRCC HCCMLGKASL ARDQTCEPIV MISYQCGLVF RACCVKAREN 
       160        170        180        190        200
SDFVQGNGAD LQDPAKIPDE EDQEDPYLND RCRGGGPCKQ QCRDTGDEVI 
       210        220        230        240        250
CSCFVGYQLQ SDGVSCEDIN ECITGSHNCR LGESCINTVG SFRCQRDSSC 
       260        270        280        290        300
GTGYELTEDN NCKDIDECET GIHNCPPDFI CQNTLGSFRC RPKLQCKSGF 
       310        320        330        340        350
IQDALGNCID INECLSISAP CPVGQTCINT EGSYTCQKNV PNCGRGYHLN 
       360        370        380        390        400
EEGTRCVDVD ECSPPAEPCG KGHHCLNSPG SFRCECKAGF YFDGISRTCV 
       410        420        430        440        450
DINECQRYPG RLCGHKCENT PGSFHCSCSA GFRLSVDGRS CEDVNECLNS 
       460        470        480        490        500
PCSQECANVY GSYQCYCRRG YQLSDVDGVT CEDIDECALP TGGHICSYRC 
       510        520        530        540        550
INIPGSFQCS CPSSGYRLAP NGRNCQDIDE CVTGIHNCSI NETCFNIQGS 
       560        570        580        590        600
FRCLSFECPE NYRRSADTFR QEKTDTVRCI KSCRPNDEAC VRDPVHTVSH 
       610        620        630        640        650
TVISLPTFRE FTRPEEIIFL RAVTPLYPAN QADIIFDITE GNLRDSFDII 
       660        670        680        690        700
KRYEDGMTVG VVRQVRPIVG PFYAVLKLEM NYVLGGVVSH RNVVNVHIFV 

SEYWF
Length:705
Mass (Da):78,033
Last modified:May 9, 2003 - v2
Checksum:i76C527A12E97D0E1
GO
Isoform A (identifier: Q08879-3)
Sequence is not available
Length:–
Mass (Da):–
Isoform B (identifier: Q08879-4)
Sequence is not available
Length:–
Mass (Da):–
Isoform C (identifier: Q08879-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-705: FRQEKTDTVR...VHIFVSEYWF → RCERLPCHEN...KLFIFVSAEL

Show »
Length:685
Mass (Da):75,284
Checksum:iEF0D77D7F66B73B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30D → N AA sequence (PubMed:2249686).Curated1
Sequence conflicti40G → P in CAA50207 (PubMed:8354280).Curated1
Sequence conflicti363S → A in CAA50207 (PubMed:8354280).Curated1
Sequence conflicti385E → K in BAC39669 (PubMed:16141072).Curated1
Sequence conflicti553C → Q AA sequence (PubMed:2249686).Curated1
Sequence conflicti558C → Q AA sequence (PubMed:2249686).Curated1
Isoform C (identifier: Q08879-2)
Sequence conflicti571E → A in CAA50206 (PubMed:8354280).1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001386569 – 705FRQEK…SEYWF → RCERLPCHENQECPRLPLRI TYYHLSFPTNIQVPAVVFRM GPSSAVPGDSMQLAITAGNE EGFFTTRKVSHHSGVVALTK PIPEPRDLLLTVKMDLYRHG TVSSFVAKLFIFVSAEL in isoform C. 3 PublicationsAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70854 mRNA Translation: CAA50207.1
X70853 mRNA Translation: CAA50206.1
AK086451 mRNA Translation: BAC39669.1
AK035388 mRNA Translation: BAC29054.1
BC007140 mRNA Translation: AAH07140.1
AY040588 Genomic DNA Translation: AAK82944.1
CCDSiCCDS27719.1 [Q08879-1]
CCDS84186.1 [Q08879-2]
PIRiS34968
S78040
RefSeqiNP_001334017.1, NM_001347088.1 [Q08879-2]
NP_034310.2, NM_010180.2 [Q08879-1]
UniGeneiMm.297992

Genome annotation databases

EnsembliENSMUST00000057410; ENSMUSP00000054583; ENSMUSG00000006369 [Q08879-1]
ENSMUST00000109432; ENSMUSP00000105058; ENSMUSG00000006369 [Q08879-2]
GeneIDi14114
KEGGimmu:14114
UCSCiuc007xdb.2 mouse [Q08879-2]
uc011zxk.1 mouse [Q08879-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFBLN1_MOUSE
AccessioniPrimary (citable) accession number: Q08879
Secondary accession number(s): Q08878
, Q8C3B1, Q91ZC9, Q922K8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 9, 2003
Last modified: September 12, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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