UniProtKB - Q08879 (FBLN1_MOUSE)
Fibulin-1
Fbln1
Functioni
GO - Molecular functioni
- calcium ion binding Source: MGI
- extracellular matrix structural constituent Source: MGI
- fibrinogen binding Source: MGI
- fibronectin binding Source: MGI
- identical protein binding Source: MGI
- integrin binding Source: MGI
- peptidase activator activity Source: MGI
- protein-containing complex binding Source: MGI
- protein C-terminus binding Source: MGI
GO - Biological processi
- blood coagulation, fibrin clot formation Source: MGI
- embryo implantation Source: Ensembl
- extracellular matrix organization Source: MGI
- negative regulation of cell adhesion Source: MGI
- negative regulation of cell motility Source: MGI
- negative regulation of ERK1 and ERK2 cascade Source: MGI
- negative regulation of protein phosphorylation Source: MGI
- negative regulation of stem cell proliferation Source: MGI
- negative regulation of substrate adhesion-dependent cell spreading Source: MGI
- negative regulation of transformation of host cell by virus Source: MGI
- negative regulation of transforming growth factor beta production Source: MGI
- positive regulation of fibroblast proliferation Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of substrate-dependent cell migration, cell attachment to substrate Source: MGI
Keywordsi
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Fibulin-1Short name: FIBL-1 Alternative name(s): Basement-membrane protein 90 Short name: BM-90 |
Gene namesi | Name:Fbln1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95487, Fbln1 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- basement membrane Source: MGI
- collagen-containing extracellular matrix Source: BHF-UCL
- elastic fiber Source: MGI
- extracellular matrix Source: MGI
- extracellular space Source: BHF-UCL
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | 1 PublicationAdd BLAST | 29 | |
ChainiPRO_0000007564 | 30 – 705 | Fibulin-1Add BLAST | 676 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 61 | By similarity | ||
Disulfide bondi | 37 ↔ 68 | By similarity | ||
Disulfide bondi | 50 ↔ 69 | By similarity | ||
Disulfide bondi | 78 ↔ 109 | By similarity | ||
Disulfide bondi | 91 ↔ 110 | By similarity | ||
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 112 ↔ 136 | By similarity | ||
Disulfide bondi | 113 ↔ 143 | By similarity | ||
Disulfide bondi | 126 ↔ 144 | By similarity | ||
Disulfide bondi | 182 ↔ 192 | By similarity | ||
Disulfide bondi | 188 ↔ 201 | By similarity | ||
Disulfide bondi | 203 ↔ 216 | By similarity | ||
Disulfide bondi | 222 ↔ 235 | By similarity | ||
Disulfide bondi | 229 ↔ 244 | By similarity | ||
Disulfide bondi | 250 ↔ 262 | By similarity | ||
Disulfide bondi | 268 ↔ 281 | By similarity | ||
Disulfide bondi | 275 ↔ 290 | By similarity | ||
Disulfide bondi | 296 ↔ 308 | By similarity | ||
Disulfide bondi | 314 ↔ 327 | By similarity | ||
Disulfide bondi | 321 ↔ 336 | By similarity | ||
Disulfide bondi | 343 ↔ 356 | By similarity | ||
Disulfide bondi | 362 ↔ 375 | By similarity | ||
Disulfide bondi | 369 ↔ 384 | By similarity | ||
Disulfide bondi | 386 ↔ 399 | By similarity | ||
Disulfide bondi | 405 ↔ 417 | By similarity | ||
Disulfide bondi | 413 ↔ 426 | By similarity | ||
Disulfide bondi | 428 ↔ 441 | By similarity | ||
Disulfide bondi | 447 ↔ 456 | By similarity | ||
Disulfide bondi | 452 ↔ 465 | By similarity | ||
Disulfide bondi | 467 ↔ 481 | By similarity | ||
Disulfide bondi | 487 ↔ 500 | By similarity | ||
Disulfide bondi | 496 ↔ 509 | By similarity | ||
Disulfide bondi | 511 ↔ 525 | By similarity | ||
Disulfide bondi | 531 ↔ 544 | By similarity | ||
Glycosylationi | 537 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 538 ↔ 553 | By similarity | ||
Glycosylationi | 541 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 558 ↔ 579 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q08879 |
PeptideAtlasi | Q08879 |
PRIDEi | Q08879 |
PTM databases
GlyGeni | Q08879, 3 sites |
PhosphoSitePlusi | Q08879 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000006369, Expressed in ear vesicle and 313 other tissues |
ExpressionAtlasi | Q08879, baseline and differential |
Genevisiblei | Q08879, MM |
Interactioni
Subunit structurei
Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LMA2, NID, ACAN, CSPG2 and type IV collagen. Binding analysis demonstrated for isoform C a 100-fold stronger binding to the basement membrane protein NID than for isoform D.
Interacts with FBLN7.
Interacts with CCN3 (By similarity).
By similarity4 PublicationsGO - Molecular functioni
- fibronectin binding Source: MGI
- identical protein binding Source: MGI
- integrin binding Source: MGI
- protein C-terminus binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199605, 7 interactors |
IntActi | Q08879, 2 interactors |
MINTi | Q08879 |
STRINGi | 10090.ENSMUSP00000054583 |
Miscellaneous databases
RNActi | Q08879, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 76 | Anaphylatoxin-like 1PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 77 – 111 | Anaphylatoxin-like 2PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 112 – 144 | Anaphylatoxin-like 3PROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 178 – 217 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 218 – 263 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 264 – 309 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 310 – 357 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 358 – 400 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 401 – 442 | EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 443 – 482 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 483 – 526 | EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 527 – 580 | EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 358 – 442 | Self-association and FN1-bindingBy similarityAdd BLAST | 85 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000156642 |
HOGENOMi | CLU_004826_1_1_1 |
InParanoidi | Q08879 |
OMAi | ITYYHLT |
PhylomeDBi | Q08879 |
TreeFami | TF317514 |
Family and domain databases
CDDi | cd00017, ANATO, 2 hits |
InterProi | View protein in InterPro IPR000020, Anaphylatoxin/fibulin IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR017048, Fibulin-1 IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF12662, cEGF, 3 hits PF07645, EGF_CA, 4 hits |
PIRSFi | PIRSF036313, Fibulin-1, 1 hit |
SMARTi | View protein in SMART SM00104, ANATO, 3 hits SM00181, EGF, 9 hits SM00179, EGF_CA, 8 hits |
SUPFAMi | SSF57184, SSF57184, 3 hits |
PROSITEi | View protein in PROSITE PS01177, ANAPHYLATOXIN_1, 3 hits PS01178, ANAPHYLATOXIN_2, 3 hits PS00010, ASX_HYDROXYL, 4 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 4 hits PS01187, EGF_CA, 8 hits |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERPVPSRLV PLPLLLLSSL SLLAARANAD ISMEACCTDG NQMANQHRDC
60 70 80 90 100
SLPYTSESKE CRMVQEQCCH NQLEELHCAT GINLASEPEG CASLHSYNSS
110 120 130 140 150
LETIFIKRCC HCCMLGKASL ARDQTCEPIV MISYQCGLVF RACCVKAREN
160 170 180 190 200
SDFVQGNGAD LQDPAKIPDE EDQEDPYLND RCRGGGPCKQ QCRDTGDEVI
210 220 230 240 250
CSCFVGYQLQ SDGVSCEDIN ECITGSHNCR LGESCINTVG SFRCQRDSSC
260 270 280 290 300
GTGYELTEDN NCKDIDECET GIHNCPPDFI CQNTLGSFRC RPKLQCKSGF
310 320 330 340 350
IQDALGNCID INECLSISAP CPVGQTCINT EGSYTCQKNV PNCGRGYHLN
360 370 380 390 400
EEGTRCVDVD ECSPPAEPCG KGHHCLNSPG SFRCECKAGF YFDGISRTCV
410 420 430 440 450
DINECQRYPG RLCGHKCENT PGSFHCSCSA GFRLSVDGRS CEDVNECLNS
460 470 480 490 500
PCSQECANVY GSYQCYCRRG YQLSDVDGVT CEDIDECALP TGGHICSYRC
510 520 530 540 550
INIPGSFQCS CPSSGYRLAP NGRNCQDIDE CVTGIHNCSI NETCFNIQGS
560 570 580 590 600
FRCLSFECPE NYRRSADTFR QEKTDTVRCI KSCRPNDEAC VRDPVHTVSH
610 620 630 640 650
TVISLPTFRE FTRPEEIIFL RAVTPLYPAN QADIIFDITE GNLRDSFDII
660 670 680 690 700
KRYEDGMTVG VVRQVRPIVG PFYAVLKLEM NYVLGGVVSH RNVVNVHIFV
SEYWF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 30 | D → N AA sequence (PubMed:2249686).Curated | 1 | ||
Sequence conflicti | 40 | G → P in CAA50207 (PubMed:8354280).Curated | 1 | ||
Sequence conflicti | 363 | S → A in CAA50207 (PubMed:8354280).Curated | 1 | ||
Sequence conflicti | 385 | E → K in BAC39669 (PubMed:16141072).Curated | 1 | ||
Sequence conflicti | 553 | C → Q AA sequence (PubMed:2249686).Curated | 1 | ||
Sequence conflicti | 558 | C → Q AA sequence (PubMed:2249686).Curated | 1 | ||
Isoform C (identifier: Q08879-2) | |||||
Sequence conflicti | 571 | E → A in CAA50206 (PubMed:8354280).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001386 | 569 – 705 | FRQEK…SEYWF → RCERLPCHENQECPRLPLRI TYYHLSFPTNIQVPAVVFRM GPSSAVPGDSMQLAITAGNE EGFFTTRKVSHHSGVVALTK PIPEPRDLLLTVKMDLYRHG TVSSFVAKLFIFVSAEL in isoform C. 3 PublicationsAdd BLAST | 137 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70854 mRNA Translation: CAA50207.1 X70853 mRNA Translation: CAA50206.1 AK086451 mRNA Translation: BAC39669.1 AK035388 mRNA Translation: BAC29054.1 BC007140 mRNA Translation: AAH07140.1 AY040588 Genomic DNA Translation: AAK82944.1 |
CCDSi | CCDS27719.1 [Q08879-1] CCDS84186.1 [Q08879-2] |
PIRi | S34968 S78040 |
RefSeqi | NP_001334017.1, NM_001347088.1 [Q08879-2] NP_034310.2, NM_010180.2 [Q08879-1] |
Genome annotation databases
Ensembli | ENSMUST00000057410; ENSMUSP00000054583; ENSMUSG00000006369 [Q08879-1] ENSMUST00000109432; ENSMUSP00000105058; ENSMUSG00000006369 [Q08879-2] |
GeneIDi | 14114 |
KEGGi | mmu:14114 |
UCSCi | uc007xdb.2, mouse [Q08879-2] uc011zxk.1, mouse [Q08879-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70854 mRNA Translation: CAA50207.1 X70853 mRNA Translation: CAA50206.1 AK086451 mRNA Translation: BAC39669.1 AK035388 mRNA Translation: BAC29054.1 BC007140 mRNA Translation: AAH07140.1 AY040588 Genomic DNA Translation: AAK82944.1 |
CCDSi | CCDS27719.1 [Q08879-1] CCDS84186.1 [Q08879-2] |
PIRi | S34968 S78040 |
RefSeqi | NP_001334017.1, NM_001347088.1 [Q08879-2] NP_034310.2, NM_010180.2 [Q08879-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 199605, 7 interactors |
IntActi | Q08879, 2 interactors |
MINTi | Q08879 |
STRINGi | 10090.ENSMUSP00000054583 |
PTM databases
GlyGeni | Q08879, 3 sites |
PhosphoSitePlusi | Q08879 |
Proteomic databases
PaxDbi | Q08879 |
PeptideAtlasi | Q08879 |
PRIDEi | Q08879 |
Protocols and materials databases
Antibodypediai | 886, 307 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000057410; ENSMUSP00000054583; ENSMUSG00000006369 [Q08879-1] ENSMUST00000109432; ENSMUSP00000105058; ENSMUSG00000006369 [Q08879-2] |
GeneIDi | 14114 |
KEGGi | mmu:14114 |
UCSCi | uc007xdb.2, mouse [Q08879-2] uc011zxk.1, mouse [Q08879-1] |
Organism-specific databases
CTDi | 2192 |
MGIi | MGI:95487, Fbln1 |
Phylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000156642 |
HOGENOMi | CLU_004826_1_1_1 |
InParanoidi | Q08879 |
OMAi | ITYYHLT |
PhylomeDBi | Q08879 |
TreeFami | TF317514 |
Miscellaneous databases
BioGRID-ORCSi | 14114, 0 hits in 17 CRISPR screens |
ChiTaRSi | Fbln1, mouse |
PROi | PR:Q08879 |
RNActi | Q08879, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000006369, Expressed in ear vesicle and 313 other tissues |
ExpressionAtlasi | Q08879, baseline and differential |
Genevisiblei | Q08879, MM |
Family and domain databases
CDDi | cd00017, ANATO, 2 hits |
InterProi | View protein in InterPro IPR000020, Anaphylatoxin/fibulin IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR017048, Fibulin-1 IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF12662, cEGF, 3 hits PF07645, EGF_CA, 4 hits |
PIRSFi | PIRSF036313, Fibulin-1, 1 hit |
SMARTi | View protein in SMART SM00104, ANATO, 3 hits SM00181, EGF, 9 hits SM00179, EGF_CA, 8 hits |
SUPFAMi | SSF57184, SSF57184, 3 hits |
PROSITEi | View protein in PROSITE PS01177, ANAPHYLATOXIN_1, 3 hits PS01178, ANAPHYLATOXIN_2, 3 hits PS00010, ASX_HYDROXYL, 4 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 4 hits PS01187, EGF_CA, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBLN1_MOUSE | |
Accessioni | Q08879Primary (citable) accession number: Q08879 Secondary accession number(s): Q08878 Q922K8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | May 9, 2003 | |
Last modified: | February 10, 2021 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families