Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).

UniProtKB - Q08877 (DYN3_RAT)

Entry version 171 (07 Apr 2021)
Sequence version 2 (10 Jun 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Dynamin-3

Gene

Dnm3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi38 – 46GTPBy similarity9
Nucleotide bindingi205 – 211GTPBy similarity7
Nucleotide bindingi236 – 239GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Motor protein
Biological processEndocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.5.5, 5301

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-2132295, MHC class II antigen presentation
R-RNO-437239, Recycling pathway of L1
R-RNO-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynamin-3 (EC:3.6.5.5)
Alternative name(s):
Dynamin, testicular
T-dynamin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnm3
Synonyms:Dyn3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Rat genome database

More...RGDi		727949, Dnm3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002065741 – 869Dynamin-3Add BLAST869

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei231PhosphotyrosineBy similarity1
Modified residuei299N6-acetyllysineBy similarity1
Modified residuei603PhosphotyrosineBy similarity1
Modified residuei604N6-acetyllysineBy similarity1
Modified residuei769PhosphoserineCombined sources1 Publication1
Modified residuei773PhosphoserineCombined sources1 Publication1
Modified residuei853Phosphoserine1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q08877

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q08877

PRoteomics IDEntifications database

More...PRIDEi		Q08877

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q08877

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q08877

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform-specific expression in germ-cell-depleted testis (Sertoli cells), brain (peripheral sensory neurons), lung and heart.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Up-regulated expression throughout development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000026490, Expressed in testis and 19 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q08877, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		251309, 3 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q08877

Protein interaction database and analysis system

More...IntActi		Q08877, 3 interactors

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000063767

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q08877

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 294Dynamin-type GPROSITE-ProRule annotationAdd BLAST267
Domaini525 – 631PHPROSITE-ProRule annotationAdd BLAST107
Domaini659 – 750GEDPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 45G1 motifPROSITE-ProRule annotation8
Regioni64 – 66G2 motifPROSITE-ProRule annotation3
Regioni136 – 139G3 motifPROSITE-ProRule annotation4
Regioni205 – 208G4 motifPROSITE-ProRule annotation4
Regioni235 – 238G5 motifPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi753 – 862Pro-richAdd BLAST110

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0446, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158056

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008964_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q08877

Identification of Orthologs from Complete Genome Data

More...OMAi		MILQFIT

Database of Orthologous Groups

More...OrthoDBi		264244at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q08877

Family and domain databases

Conserved Domains Database

More...CDDi		cd08771, DLP_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001401, Dynamin_GTPase
IPR019762, Dynamin_GTPase_CS
IPR022812, Dynamin_SF
IPR000375, Dynamin_stalk
IPR030381, G_DYNAMIN_dom
IPR003130, GED
IPR020850, GED_dom
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...PANTHERi		PTHR11566, PTHR11566, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01031, Dynamin_M, 1 hit
PF00350, Dynamin_N, 1 hit
PF02212, GED, 1 hit
PF00169, PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00195, DYNAMIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00053, DYNc, 1 hit
SM00302, GED, 1 hit
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00410, G_DYNAMIN_1, 1 hit
PS51718, G_DYNAMIN_2, 1 hit
PS51388, GED, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 13 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q08877-1) [UniParc]FASTAAdd to basket
Also known as: bab, DynIIIbb

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN 
        60         70         80         90        100
FVGRDFLPRG SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE 
       110        120        130        140        150
IEAETDRVTG MNKGISSVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP 
       160        170        180        190        200
DIEYQIRDMI MQFITRENCL ILAVTPANTD LANSDALKLA KEVDPQGLRT 
       210        220        230        240        250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK DIDGKKDIKA 
       260        270        280        290        300
AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 
       310        320        330        340        350
QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ 
       360        370        380        390        400
VDTLELSGGA KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT 
       410        420        430        440        450
GLFTPDMAFE AIVKKQIVKL KGPSLKSVDL VMQELINTVK KCTKRLANFP 
       460        470        480        490        500
RLCEETERIV ANHIREREGK TKDQVLLLID IQVSYINTNH EDFIGFANAQ 
       510        520        530        540        550
QRSSQVHKKS TIGNQGTNLP PSRQIVIRKG WLTVSNIGIM KGGSKGYWFV 
       560        570        580        590        600
LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR 
       610        620        630        640        650
NVYKDYRSLE LACDSQEDVD SWKASLLRAG VYPDKSFTEN DENGQAENFS 
       660        670        680        690        700
MDPQLERQVE TIRNLVDSYM SIINKCIRDL IPKTIMHLMI NNVKDFINSE 
       710        720        730        740        750
LLAQLYSSED QNTLMEESVE QAQRRDEMLR MYQALKEALA IIGDINTVTV 
       760        770        780        790        800
STPAPPPVDD SWLQHSRRSP PPSPTTQRRL TLSAPLPRPA SSRGPAPAIP 
       810        820        830        840        850
SPGPHSGAPP VPFRPGPLPP FPNSSDSYGA PPQVPSRPTR APPSVPSRRP 
       860 
PPSPTRPTII RPLESSLLD
Note: Expressed in lung, brain, heart.
Length:869
Mass (Da):97,914
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00B41E41E5425BAD
GO
Isoform 2 (identifier: Q08877-2) [UniParc]FASTAAdd to basket
Also known as: baa, DynIIIba

The sequence of this isoform differs from the canonical sequence as follows:
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung, brain, heart, testis. Localized to vesicular-like punctate spots, neither at the plasma membrane nor the Golgi area.Curated
Show »
Length:858
Mass (Da):96,660
Checksum:iA54B96E1388DD0CA
GO
Isoform 3 (identifier: Q08877-3) [UniParc]FASTAAdd to basket
Also known as: bbb

The sequence of this isoform differs from the canonical sequence as follows:
     636-640: SFTEN → SFGSNKTEM

Note: Expressed in lung, brain, heart, testis.Curated
Show »
Length:873
Mass (Da):98,318
Checksum:iB57DCEFF9E6696DA
GO
Isoform 4 (identifier: Q08877-4) [UniParc]FASTAAdd to basket
Also known as: bba

The sequence of this isoform differs from the canonical sequence as follows:
     636-640: SFTEN → SFGSNKTEM
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung, brain, heart.Curated
Show »
Length:862
Mass (Da):97,063
Checksum:i3AED72E98B90062E
GO
Isoform 5 (identifier: Q08877-5) [UniParc]FASTAAdd to basket
Also known as: bcb

The sequence of this isoform differs from the canonical sequence as follows:
     636-640: SFTEN → DQAENEDGAQENTF

Note: Expressed in lung.Curated
Show »
Length:878
Mass (Da):98,885
Checksum:iFD1BCCBFB42A2FD8
GO
Isoform 6 (identifier: Q08877-6) [UniParc]FASTAAdd to basket
Also known as: bca

The sequence of this isoform differs from the canonical sequence as follows:
     636-640: SFTEN → DQAENEDGAQENTF
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung.Curated
Show »
Length:867
Mass (Da):97,631
Checksum:iB1B5E94CDD159795
GO
Isoform 7 (identifier: Q08877-7) [UniParc]FASTAAdd to basket
Also known as: aab, DynIIIab

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.

Note: Expressed in lung, brain, heart, testis.Curated
Show »
Length:859
Mass (Da):96,850
Checksum:i43526CBCC8DCA610
GO
Isoform 8 (identifier: Q08877-9) [UniParc]FASTAAdd to basket
Also known as: aaa, DynIIIaa

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung, brain, heart, testis. Diffuse cytoplasmic distribution and some modest association with the Golgi apparatus.Curated
Show »
Length:848
Mass (Da):95,596
Checksum:i802E365FCFC685F6
GO
Isoform 9 (identifier: Q08877-10) [UniParc]FASTAAdd to basket
Also known as: abb

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     636-640: SFTEN → SFGSNKTEM

Note: Expressed in lung, brain, heart.Curated
Show »
Length:863
Mass (Da):97,254
Checksum:i89467DF02D80E427
GO
Isoform 10 (identifier: Q08877-11) [UniParc]FASTAAdd to basket
Also known as: aba

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     636-640: SFTEN → SFGSNKTEM
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung, brain, heart.Curated
Show »
Length:852
Mass (Da):95,999
Checksum:iA79E52BFEEF5A690
GO
Isoform 11 (identifier: Q08877-12) [UniParc]FASTAAdd to basket
Also known as: acb

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     636-640: SFTEN → DQAENEDGAQENTF

Note: Expressed in lung.Curated
Show »
Length:868
Mass (Da):97,821
Checksum:iF47C9B5D47E6146B
GO
Isoform 12 (identifier: Q08877-13) [UniParc]FASTAAdd to basket
Also known as: aca

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     636-640: SFTEN → DQAENEDGAQENTF
     847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP

Note: Expressed in lung.Curated
Show »
Length:857
Mass (Da):96,566
Checksum:iC348C4D220A8E4B5
GO
Isoform 13 (identifier: Q08877-8) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     526-564: VIRKGWLTVS...SLSWYKDDEE → VRAKFCDSEG...CPHGRKLVLV
     565-869: Missing.

Note: Expressed in lung, brain, heart, testis.Curated
Show »
Length:564
Mass (Da):63,927
Checksum:i2EE4B6A6D27E35CB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034038516 – 525Missing in isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. 1 Publication10
Alternative sequenceiVSP_034039526 – 564VIRKG…KDDEE → VRAKFCDSEGLADRQQHWHH ERRLEGLLVCPHGRKLVLV in isoform 13. CuratedAdd BLAST39
Alternative sequenceiVSP_034040565 – 869Missing in isoform 13. CuratedAdd BLAST305
Alternative sequenceiVSP_034041636 – 640SFTEN → SFGSNKTEM in isoform 3, isoform 4, isoform 9 and isoform 10. Curated5
Alternative sequenceiVSP_034042636 – 640SFTEN → DQAENEDGAQENTF in isoform 5, isoform 6, isoform 11 and isoform 12. Curated5
Alternative sequenceiVSP_034043847 – 869SRRPP…SSLLD → RFGAVKEEAVEP in isoform 2, isoform 4, isoform 6, isoform 8, isoform 10 and isoform 12. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D14076 mRNA Translation: BAA03161.1
AF201839 mRNA Translation: AAF07848.1

Protein sequence database of the Protein Information Resource

More...PIRi		I55498

NCBI Reference Sequences

More...RefSeqi		NP_612547.1, NM_138538.1 [Q08877-1]
XP_006250203.1, XM_006250141.3 [Q08877-7]
XP_006250204.1, XM_006250142.3 [Q08877-9]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000067653; ENSRNOP00000063767; ENSRNOG00000026490 [Q08877-1]
ENSRNOT00000075938; ENSRNOP00000068044; ENSRNOG00000026490 [Q08877-9]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		171574

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:171574

UCSC genome browser

More...UCSCi		RGD:727949, rat [Q08877-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14076 mRNA Translation: BAA03161.1
AF201839 mRNA Translation: AAF07848.1
PIRiI55498
RefSeqiNP_612547.1, NM_138538.1 [Q08877-1]
XP_006250203.1, XM_006250141.3 [Q08877-7]
XP_006250204.1, XM_006250142.3 [Q08877-9]

3D structure databases

SMRiQ08877
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi251309, 3 interactors
ELMiQ08877
IntActiQ08877, 3 interactors
STRINGi10116.ENSRNOP00000063767

PTM databases

iPTMnetiQ08877
PhosphoSitePlusiQ08877

Proteomic databases

jPOSTiQ08877
PaxDbiQ08877
PRIDEiQ08877

Genome annotation databases

EnsembliENSRNOT00000067653; ENSRNOP00000063767; ENSRNOG00000026490 [Q08877-1]
ENSRNOT00000075938; ENSRNOP00000068044; ENSRNOG00000026490 [Q08877-9]
GeneIDi171574
KEGGirno:171574
UCSCiRGD:727949, rat [Q08877-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26052
RGDi727949, Dnm3

Phylogenomic databases

eggNOGiKOG0446, Eukaryota
GeneTreeiENSGT00940000158056
HOGENOMiCLU_008964_1_1_1
InParanoidiQ08877
OMAiMILQFIT
OrthoDBi264244at2759
PhylomeDBiQ08877

Enzyme and pathway databases

BRENDAi3.6.5.5, 5301
ReactomeiR-RNO-2132295, MHC class II antigen presentation
R-RNO-437239, Recycling pathway of L1
R-RNO-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q08877

Gene expression databases

BgeeiENSRNOG00000026490, Expressed in testis and 19 other tissues
GenevisibleiQ08877, RN

Family and domain databases

CDDicd08771, DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001401, Dynamin_GTPase
IPR019762, Dynamin_GTPase_CS
IPR022812, Dynamin_SF
IPR000375, Dynamin_stalk
IPR030381, G_DYNAMIN_dom
IPR003130, GED
IPR020850, GED_dom
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR11566, PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031, Dynamin_M, 1 hit
PF00350, Dynamin_N, 1 hit
PF02212, GED, 1 hit
PF00169, PH, 1 hit
PRINTSiPR00195, DYNAMIN
SMARTiView protein in SMART
SM00053, DYNc, 1 hit
SM00302, GED, 1 hit
SM00233, PH, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410, G_DYNAMIN_1, 1 hit
PS51718, G_DYNAMIN_2, 1 hit
PS51388, GED, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYN3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08877
Secondary accession number(s): Q9QXL9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: June 10, 2008
Last modified: April 7, 2021
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again