UniProtKB - Q08877 (DYN3_RAT)
Dynamin-3
Dnm3
Functioni
Catalytic activityi
- EC:3.6.5.5
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 38 – 46 | GTPBy similarity | 9 | |
Nucleotide bindingi | 205 – 211 | GTPBy similarity | 7 | |
Nucleotide bindingi | 236 – 239 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB-KW
- microtubule binding Source: GO_Central
- nitric-oxide synthase binding Source: RGD
- structural constituent of postsynapse Source: SynGO
- type 1 metabotropic glutamate receptor binding Source: RGD
- type 5 metabotropic glutamate receptor binding Source: RGD
GO - Biological processi
- dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
- endocytosis Source: UniProtKB
- filopodium assembly Source: UniProtKB
- membrane fusion Source: GO_Central
- mitochondrial fission Source: GO_Central
- negative regulation of dendritic spine morphogenesis Source: RGD
- positive regulation of filopodium assembly Source: RGD
- positive regulation of synaptic vesicle recycling Source: RGD
- postsynaptic neurotransmitter receptor internalization Source: SynGO
- receptor internalization Source: GO_Central
- regulation of dendritic spine morphogenesis Source: RGD
- regulation of synapse structure or activity Source: GO_Central
- sperm ejaculation Source: UniProtKB
- synapse assembly Source: UniProtKB
- synaptic vesicle budding from presynaptic endocytic zone membrane Source: RGD
- synaptic vesicle endocytosis Source: RGD
Keywordsi
Molecular function | Hydrolase, Motor protein |
Biological process | Endocytosis |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.5.5, 5301 |
Reactomei | R-RNO-2132295, MHC class II antigen presentation R-RNO-437239, Recycling pathway of L1 R-RNO-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Dnm3 Synonyms:Dyn3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 727949, Dnm3 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Microtubule-associated. Isoform-specific localization.1 Publication
Other locations
- Cytoplasmic vesicle 1 Publication
Cytoplasm and Cytosol
Golgi apparatus
- Golgi apparatus 1 Publication
Cytoskeleton
- microtubule Source: UniProtKB-KW
- microtubule cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- synaptic cleft Source: RGD
Golgi apparatus
- Golgi apparatus Source: RGD
Mitochondrion
- mitochondrial membrane Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
- postsynaptic endocytic zone membrane Source: SynGO
Other locations
- apical tubulobulbar complex Source: RGD
- axon Source: RGD
- basal tubulobulbar complex Source: RGD
- cytoplasm Source: RGD
- cytoplasmic vesicle Source: GO_Central
- dendritic spine Source: UniProtKB
- dendritic spine head Source: RGD
- glutamatergic synapse Source: SynGO
- membrane Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB
- photoreceptor inner segment Source: RGD
- postsynaptic density Source: UniProtKB
- presynapse Source: RGD
- synapse Source: RGD
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206574 | 1 – 869 | Dynamin-3Add BLAST | 869 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 231 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 299 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 603 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 604 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 769 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 773 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 853 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q08877 |
PaxDbi | Q08877 |
PRIDEi | Q08877 |
PTM databases
iPTMneti | Q08877 |
PhosphoSitePlusi | Q08877 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSRNOG00000026490, Expressed in testis and 19 other tissues |
Genevisiblei | Q08877, RN |
Interactioni
GO - Molecular functioni
- microtubule binding Source: GO_Central
- nitric-oxide synthase binding Source: RGD
- type 1 metabotropic glutamate receptor binding Source: RGD
- type 5 metabotropic glutamate receptor binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 251309, 3 interactors |
ELMi | Q08877 |
IntActi | Q08877, 3 interactors |
STRINGi | 10116.ENSRNOP00000063767 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 294 | Dynamin-type GPROSITE-ProRule annotationAdd BLAST | 267 | |
Domaini | 525 – 631 | PHPROSITE-ProRule annotationAdd BLAST | 107 | |
Domaini | 659 – 750 | GEDPROSITE-ProRule annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 38 – 45 | G1 motifPROSITE-ProRule annotation | 8 | |
Regioni | 64 – 66 | G2 motifPROSITE-ProRule annotation | 3 | |
Regioni | 136 – 139 | G3 motifPROSITE-ProRule annotation | 4 | |
Regioni | 205 – 208 | G4 motifPROSITE-ProRule annotation | 4 | |
Regioni | 235 – 238 | G5 motifPROSITE-ProRule annotation | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 753 – 862 | Pro-richAdd BLAST | 110 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0446, Eukaryota |
GeneTreei | ENSGT00940000158056 |
HOGENOMi | CLU_008964_1_1_1 |
InParanoidi | Q08877 |
OMAi | MILQFIT |
OrthoDBi | 264244at2759 |
PhylomeDBi | Q08877 |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR022812, Dynamin_SF IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR11566, PTHR11566, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit PS50003, PH_DOMAIN, 1 hit |
s (13)i Sequence
Sequence statusi: Complete.
This entry describes 13 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRHE
110 120 130 140 150
IEAETDRVTG MNKGISSVPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP
160 170 180 190 200
DIEYQIRDMI MQFITRENCL ILAVTPANTD LANSDALKLA KEVDPQGLRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK DIDGKKDIKA
260 270 280 290 300
AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL
310 320 330 340 350
QGQLLSIEHE VEAFKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ
360 370 380 390 400
VDTLELSGGA KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT
410 420 430 440 450
GLFTPDMAFE AIVKKQIVKL KGPSLKSVDL VMQELINTVK KCTKRLANFP
460 470 480 490 500
RLCEETERIV ANHIREREGK TKDQVLLLID IQVSYINTNH EDFIGFANAQ
510 520 530 540 550
QRSSQVHKKS TIGNQGTNLP PSRQIVIRKG WLTVSNIGIM KGGSKGYWFV
560 570 580 590 600
LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKGFMSSKH VFALFNTEQR
610 620 630 640 650
NVYKDYRSLE LACDSQEDVD SWKASLLRAG VYPDKSFTEN DENGQAENFS
660 670 680 690 700
MDPQLERQVE TIRNLVDSYM SIINKCIRDL IPKTIMHLMI NNVKDFINSE
710 720 730 740 750
LLAQLYSSED QNTLMEESVE QAQRRDEMLR MYQALKEALA IIGDINTVTV
760 770 780 790 800
STPAPPPVDD SWLQHSRRSP PPSPTTQRRL TLSAPLPRPA SSRGPAPAIP
810 820 830 840 850
SPGPHSGAPP VPFRPGPLPP FPNSSDSYGA PPQVPSRPTR APPSVPSRRP
860
PPSPTRPTII RPLESSLLD
The sequence of this isoform differs from the canonical sequence as follows:
847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP
The sequence of this isoform differs from the canonical sequence as follows:
516-525: Missing.
847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP
The sequence of this isoform differs from the canonical sequence as follows:
516-525: Missing.
636-640: SFTEN → SFGSNKTEM
847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP
The sequence of this isoform differs from the canonical sequence as follows:
516-525: Missing.
636-640: SFTEN → DQAENEDGAQENTF
The sequence of this isoform differs from the canonical sequence as follows:
516-525: Missing.
636-640: SFTEN → DQAENEDGAQENTF
847-869: SRRPPPSPTRPTIIRPLESSLLD → RFGAVKEEAVEP
The sequence of this isoform differs from the canonical sequence as follows:
526-564: VIRKGWLTVS...SLSWYKDDEE → VRAKFCDSEG...CPHGRKLVLV
565-869: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034038 | 516 – 525 | Missing in isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. 1 Publication | 10 | |
Alternative sequenceiVSP_034039 | 526 – 564 | VIRKG…KDDEE → VRAKFCDSEGLADRQQHWHH ERRLEGLLVCPHGRKLVLV in isoform 13. CuratedAdd BLAST | 39 | |
Alternative sequenceiVSP_034040 | 565 – 869 | Missing in isoform 13. CuratedAdd BLAST | 305 | |
Alternative sequenceiVSP_034041 | 636 – 640 | SFTEN → SFGSNKTEM in isoform 3, isoform 4, isoform 9 and isoform 10. Curated | 5 | |
Alternative sequenceiVSP_034042 | 636 – 640 | SFTEN → DQAENEDGAQENTF in isoform 5, isoform 6, isoform 11 and isoform 12. Curated | 5 | |
Alternative sequenceiVSP_034043 | 847 – 869 | SRRPP…SSLLD → RFGAVKEEAVEP in isoform 2, isoform 4, isoform 6, isoform 8, isoform 10 and isoform 12. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14076 mRNA Translation: BAA03161.1 AF201839 mRNA Translation: AAF07848.1 |
PIRi | I55498 |
RefSeqi | NP_612547.1, NM_138538.1 [Q08877-1] XP_006250203.1, XM_006250141.3 [Q08877-7] XP_006250204.1, XM_006250142.3 [Q08877-9] |
Genome annotation databases
Ensembli | ENSRNOT00000067653; ENSRNOP00000063767; ENSRNOG00000026490 [Q08877-1] ENSRNOT00000075938; ENSRNOP00000068044; ENSRNOG00000026490 [Q08877-9] |
GeneIDi | 171574 |
KEGGi | rno:171574 |
UCSCi | RGD:727949, rat [Q08877-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14076 mRNA Translation: BAA03161.1 AF201839 mRNA Translation: AAF07848.1 |
PIRi | I55498 |
RefSeqi | NP_612547.1, NM_138538.1 [Q08877-1] XP_006250203.1, XM_006250141.3 [Q08877-7] XP_006250204.1, XM_006250142.3 [Q08877-9] |
3D structure databases
SMRi | Q08877 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 251309, 3 interactors |
ELMi | Q08877 |
IntActi | Q08877, 3 interactors |
STRINGi | 10116.ENSRNOP00000063767 |
PTM databases
iPTMneti | Q08877 |
PhosphoSitePlusi | Q08877 |
Proteomic databases
jPOSTi | Q08877 |
PaxDbi | Q08877 |
PRIDEi | Q08877 |
Genome annotation databases
Ensembli | ENSRNOT00000067653; ENSRNOP00000063767; ENSRNOG00000026490 [Q08877-1] ENSRNOT00000075938; ENSRNOP00000068044; ENSRNOG00000026490 [Q08877-9] |
GeneIDi | 171574 |
KEGGi | rno:171574 |
UCSCi | RGD:727949, rat [Q08877-1] |
Organism-specific databases
CTDi | 26052 |
RGDi | 727949, Dnm3 |
Phylogenomic databases
eggNOGi | KOG0446, Eukaryota |
GeneTreei | ENSGT00940000158056 |
HOGENOMi | CLU_008964_1_1_1 |
InParanoidi | Q08877 |
OMAi | MILQFIT |
OrthoDBi | 264244at2759 |
PhylomeDBi | Q08877 |
Enzyme and pathway databases
BRENDAi | 3.6.5.5, 5301 |
Reactomei | R-RNO-2132295, MHC class II antigen presentation R-RNO-437239, Recycling pathway of L1 R-RNO-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
PROi | PR:Q08877 |
Gene expression databases
Bgeei | ENSRNOG00000026490, Expressed in testis and 19 other tissues |
Genevisiblei | Q08877, RN |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR022812, Dynamin_SF IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR11566, PTHR11566, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DYN3_RAT | |
Accessioni | Q08877Primary (citable) accession number: Q08877 Secondary accession number(s): Q9QXL9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | June 10, 2008 | |
Last modified: | April 7, 2021 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families