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UniProtKB - Q08874 (MITF_MOUSE)

Protein

Microphthalmia-associated transcription factor

Gene

Mitf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR) (PubMed:23207919). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.By similarity1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3232118 SUMOylation of transcription factors

Names & Taxonomyi

Protein namesi
Recommended name:
Microphthalmia-associated transcription factor
Gene namesi
Name:Mitf
Synonyms:Bw, Mi, Vit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104554 Mitf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Mitf are the cause of microphthalmia (mi), a condition characterized by loss of pigmentation; reduced eye size; failure of secondary bone resorption; reduced numbers of mast cells; early onset of deafness, and which gives rise to a number of different phenotypes. Among them, microphthalmia-eyeless white (mi-ew) has a normal appearance at the heterozygous state, but shows white coat; eyes almost absent and eyelids never open at homozygosity. Microphthalmia-black and white spot (mi-bws) is normal at heterozygosity, and presents white spots and black eyes at homozygous state. Microphthalmia-white (mi-wh) has reduced coat color and eye pigmentation; spots on toes, tail and belly; inner ear defects at heterozygosity, and at homozygosity shows white coat; eyes small and inner iris slightly pigmented; spinal ganglia, adrenal medulla and dermis smaller than normal, and inner ear defects. Microphthalmia-vitiligo (mi-vi) has normal phenotype at heterozygosity, but shows gradual depigmentation of coat, skin and eyes; and retinal degeneration at homozygosity. Microphthalmia-spotted (mi-sp) shows normal phenotype; at homozygosity, however, tyrosinase activity in skin is reduced. Microphthalmia-defective irism (mi-di) has reduced retinal pigmentation at heterozygosity and shows white coat; eyes of reduced sized and possible mild osteoporosis at homozygosity. Microphthalmia-cloudy eyed (mi-ce) has a normal appearance at the heterozygous state, but shows white coat; eyes of reduced size and unpigmented at homozygosity. Microphthalmia-red-eyed white (mi-rw) has a normal appearance at the homozygous state, but shows white coat with one or more pigmented spots around the head/and or tail; eyes are small and red at heterozygosity. Microphthalmia-black-eyed white (mi-bw) shows a white coat but normal sized eyes which reamin black at homozygosity.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi367 – 369EQQ → AAA: Changes the structure of the leucine zipper and thereby confers the ability to form heterodimers with MAX. 1 Publication3

Keywords - Diseasei

Deafness, Disease mutation

Chemistry databases

ChEMBLiCHEMBL1075142

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272771 – 526Microphthalmia-associated transcription factorAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei180Phosphoserine; by MAPKBy similarity1
Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei405Phosphoserine; by GSK3By similarity1
Modified residuei414PhosphoserineCombined sources1
Cross-linki423Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei491PhosphoserineBy similarity1
Modified residuei516Phosphoserine; by RPS6KA1By similarity1

Post-translational modificationi

Phosphorylation at Ser-405 significantly enhances the ability to bind the tyrosinase promoter. Phosphorylated at Ser-180 and Ser-516 following KIT signaling, trigerring a short live activation: Phosphorylation at Ser-180 and Ser-516 by MAPK and RPS6KA1, respectively, activate the transcription factor activity but also promote ubiquitination and subsequent degradation by the proteasome (By similarity).By similarity
Ubiquitinated following phosphorylation at Ser-180, leading to subsequent degradation by the proteasome. Deubiquitinated by USP13, preventing its degradation (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ08874
PeptideAtlasiQ08874
PRIDEiQ08874

PTM databases

iPTMnetiQ08874
PhosphoSitePlusiQ08874

Expressioni

Tissue specificityi

In the adult, expressed at high levels in the heart, skin, skeletal muscle, intestine, stomach, kidney, ovary, lung, spleen and brain. In the embryo, expressed in developing eye, ear, skin and heart. Isoform M is expressed in melanocytes and also in the embryonic and adult heart while isoform A and isoform H are more widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000035158 Expressed in 261 organ(s), highest expression level in pineal body
CleanExiMM_MITF
MM_VIT
ExpressionAtlasiQ08874 baseline and differential
GenevisibleiQ08874 MM

Interactioni

Subunit structurei

Homodimer or heterodimer; dimerization is mediated via the coiled coil region (PubMed:23207919). Efficient DNA binding requires dimerization with another bHLH protein (PubMed:23207919). Binds DNA in the form of homodimer or heterodimer with either TFE3, TFEB or TFEC (By similarity). Binds DNA as a homodimer (in vitro) (PubMed:23207919). Interacts with KARS (PubMed:14975237). Identified in a complex with HINT1 and CTNNB1 (By similarity).By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi201427, 8 interactors
IntActiQ08874, 1 interactor
MINTiQ08874
STRINGi10090.ENSMUSP00000044938

Structurei

Secondary structure

1526
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ08874
SMRiQ08874
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini311 – 364bHLHPROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 291TransactivationBy similarityAdd BLAST68
Regioni374 – 395Leucine-zipper1 PublicationAdd BLAST22
Regioni401 – 431DNA binding regulationBy similarityAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili355 – 401Sequence analysisAdd BLAST47

Domaini

The leucine zipper region is part of a larger coiled coil.1 Publication

Sequence similaritiesi

Belongs to the MiT/TFE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1318 Eukaryota
ENOG4110SME LUCA
GeneTreeiENSGT00390000004402
HOVERGENiHBG006768
InParanoidiQ08874
KOiK09455
OMAiMEDTDHA
OrthoDBiEOG091G0QCO
PhylomeDBiQ08874
TreeFamiTF317174

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR031867 MiT/TFE_N
IPR030532 MITF
PANTHERiPTHR12565 PTHR12565, 2 hits
PTHR12565:SF91 PTHR12565:SF91, 2 hits
PfamiView protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit
PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequences (9+)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q08874-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSESGIVAD FEVGEEFHEE PKTYYELKSQ PLKSSSSAEH SGASKPPLSS 
        60         70         80         90        100
STMTSRILLR QQLMREQMQE QERREQQQKL QAAQFMQQRV AVSQTPAINV 
       110        120        130        140        150
SVPTTLPSAT QVPMEVLKVQ THLENPTKYH IQQAQRHQVK QYLSTTLANK 
       160        170        180        190        200
HASQVLSSPC PNQPGDHAMP PVPGSSAPNS PMAMLTLNSN CEKEAFYKFE 
       210        220        230        240        250
EQSRAESECP GMNTHSRASC MQMDDVIDDI ISLESSYNEE ILGLMDPALQ 
       260        270        280        290        300
MANTLPVSGN LIDLYSNQGL PPPGLTISNS CPANLPNIKR ELTACIFPTE 
       310        320        330        340        350
SEARALAKER QKKDNHNLIE RRRRFNINDR IKELGTLIPK SNDPDMRWNK 
       360        370        380        390        400
GTILKASVDY IRKLQREQQR AKDLENRQKK LEHANRHLLL RVQELEMQAR 
       410        420        430        440        450
AHGLSLIPST GLCSPDLVNR IIKQEPVLEN CSQELVQHQA DLTCTTTLDL 
       460        470        480        490        500
TDGTITFTNN LGTMPESSPA YSIPRKMGSN LEDILMDDAL SPVGVTDPLL 
       510        520 
SSVSPGASKT SSRRSSMSAE ETEHAC
Length:526
Mass (Da):58,605
Last modified:July 5, 2017 - v4
Checksum:iA3CB0E4F27C8DCDB
GO
Isoform A1 (identifier: Q08874-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-194: Missing.

Show »
Length:470
Mass (Da):52,746
Checksum:i7026C08084259180
GO
Isoform A2 (identifier: Q08874-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-222: Missing.
     294-299: Missing.
     318-319: LI → LSKFV

Show »
Length:419
Mass (Da):46,815
Checksum:i22F23451EE2F989B
GO
Isoform H (identifier: Q08874-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSS → MEALRFEMLIPCSFESLCL

Show »
Length:510
Mass (Da):56,818
Checksum:i47CD5802DDA9686D
GO
Isoform H1 (identifier: Q08874-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSS → MEALRFEMLIPCSFESLCL
     119-254: Missing.

Show »
Length:374
Mass (Da):41,773
Checksum:iD86B5FC7B42F1E1D
GO
Isoform H2 (identifier: Q08874-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSS → MEALRFEMLIPCSFESLCL
     119-254: Missing.
     294-319: ACIFPTESEARALAKERQKKDNHNLI → V

Show »
Length:349
Mass (Da):38,906
Checksum:i950EA84CF9E74FD0
GO
Isoform H3 (identifier: Q08874-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSS → MEALRFEMLIPCSFESLCL
     139-194: Missing.

Show »
Length:454
Mass (Da):50,958
Checksum:i47A5D6D453DC69CB
GO
Isoform M (identifier: Q08874-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: MQSESGIVAD...ATQVPMEVLK → MLEMLEYSHYQ

Show »
Length:419
Mass (Da):46,769
Checksum:i2620A6F93CDED178
GO
Isoform M1 (identifier: Q08874-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: MQSESGIVAD...ATQVPMEVLK → MLEMLEYSHYQ
     294-299: Missing.

Show »
Length:413
Mass (Da):46,136
Checksum:iC1A44A4D643E435B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZ28E9PZ28_MOUSE
Microphthalmia-associated transcrip...
Mitf
501Annotation score:
A0A0N4SV79A0A0N4SV79_MOUSE
Microphthalmia-associated transcrip...
Mitf
357Annotation score:
D6RCW2D6RCW2_MOUSE
Microphthalmia-associated transcrip...
Mitf
105Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9A → P in AAF81266 (PubMed:10790403).1
Sequence conflicti9A → P in AAF81267 (PubMed:10790403).1
Sequence conflicti9A → P in AAF81268 (PubMed:10790403).1
Sequence conflicti9A → P in AAF81269 (PubMed:10790403).1
Sequence conflicti9A → P in AAF81270 (PubMed:10790403).1
Sequence conflicti9A → P in AAF81271 (PubMed:10790403).1
Sequence conflicti9A → P in AAF81272 (PubMed:10790403).1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti36 – 118Missing in microphthalmia-red-eyed white/mi-rw. Add BLAST83
Natural varianti119 – 254Missing in microphthalmia-white spot/mi-ws. 1 PublicationAdd BLAST136
Natural varianti139 – 194Missing in microphthalmia-black and white spot/mi-bws. Add BLAST56
Natural varianti294 – 319ACIFP…NHNLI → V in microphthalmia-eyeless-white/mi-ew. Add BLAST26
Natural varianti294 – 299Missing in microphthalmia-spotted/mi-sp. 6
Natural varianti319I → N in microphthalmia-white/mi-wh. 1
Natural varianti323Missing in microphthalmia/mi. 1 Publication1
Natural varianti329D → N in microphthalmia-vitiligo/mi-vi. 1
Natural varianti370 – 526Missing in microphthalmia-cloudy-eyed/mi-ce and microphthalmia-defective iris/mi-di. Add BLAST157

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0021301 – 118MQSES…MEVLK → MLEMLEYSHYQ in isoform M and isoform M1. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_0021291 – 35MQSES…PLKSS → MEALRFEMLIPCSFESLCL in isoform H, isoform H1, isoform H2 and isoform H3. CuratedAdd BLAST35
Alternative sequenceiVSP_002132119 – 254Missing in isoform H1 and isoform H2. CuratedAdd BLAST136
Alternative sequenceiVSP_002131119 – 222Missing in isoform A2. CuratedAdd BLAST104
Alternative sequenceiVSP_002133139 – 194Missing in isoform A1 and isoform H3. CuratedAdd BLAST56
Alternative sequenceiVSP_002135294 – 319ACIFP…NHNLI → V in isoform H2. CuratedAdd BLAST26
Alternative sequenceiVSP_002134294 – 299Missing in isoform A2 and isoform M1. 1 Publication6
Alternative sequenceiVSP_002136318 – 319LI → LSKFV in isoform A2. Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23066 mRNA Translation: CAA80600.1
AF222344 Genomic DNA Translation: AAF63466.1
AF222959
, AF222949, AF222951, AF222953, AF222954, AF222955, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81266.2
AF222959
, AF222950, AF222951, AF222953, AF222954, AF222955, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81267.2
AF222959
, AF222950, AF222951, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81268.2
AF222959
, AF222950, AF222951, AF222956, AF222958 Genomic DNA Translation: AAF81269.2
AF222959
, AF222950, AF222951, AF222953, AF222954, AF222955, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81270.2
AF222959
, AF222949, AF222951, AF222953, AF222954, AF222955, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81271.2
AF222959
, AF222949, AF222951, AF222955, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81272.2
AF222952 Genomic DNA No translation available.
AK155350 mRNA Translation: BAE33209.1
AC131676 Genomic DNA No translation available.
AC157098 Genomic DNA No translation available.
AC158650 Genomic DNA No translation available.
U19874 mRNA Translation: AAC52155.1
U19875 mRNA Translation: AAC52156.1
L22958 mRNA Translation: AAB47773.1
AB009397 mRNA Translation: BAA32329.1
CCDSiCCDS20385.1 [Q08874-8]
CCDS51861.1 [Q08874-1]
CCDS51862.1 [Q08874-4]
PIRiA40728
I49244
PD0026
RefSeqiNP_001106669.1, NM_001113198.1 [Q08874-1]
NP_032627.1, NM_008601.3 [Q08874-8]
XP_006505758.1, XM_006505695.3 [Q08874-9]
UniGeneiMm.333284
Mm.454504

Genome annotation databases

EnsembliENSMUST00000043628; ENSMUSP00000044459; ENSMUSG00000035158 [Q08874-8]
ENSMUST00000043637; ENSMUSP00000044938; ENSMUSG00000035158 [Q08874-1]
ENSMUST00000101123; ENSMUSP00000098683; ENSMUSG00000035158 [Q08874-4]
GeneIDi17342
KEGGimmu:17342
UCSCiuc009daz.2 mouse

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23066 mRNA Translation: CAA80600.1
AF222344 Genomic DNA Translation: AAF63466.1
AF222959
, AF222949, AF222951, AF222953, AF222954, AF222955, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81266.2
AF222959
, AF222950, AF222951, AF222953, AF222954, AF222955, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81267.2
AF222959
, AF222950, AF222951, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81268.2
AF222959
, AF222950, AF222951, AF222956, AF222958 Genomic DNA Translation: AAF81269.2
AF222959
, AF222950, AF222951, AF222953, AF222954, AF222955, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81270.2
AF222959
, AF222949, AF222951, AF222953, AF222954, AF222955, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81271.2
AF222959
, AF222949, AF222951, AF222955, AF222956, AF222957, AF222958 Genomic DNA Translation: AAF81272.2
AF222952 Genomic DNA No translation available.
AK155350 mRNA Translation: BAE33209.1
AC131676 Genomic DNA No translation available.
AC157098 Genomic DNA No translation available.
AC158650 Genomic DNA No translation available.
U19874 mRNA Translation: AAC52155.1
U19875 mRNA Translation: AAC52156.1
L22958 mRNA Translation: AAB47773.1
AB009397 mRNA Translation: BAA32329.1
CCDSiCCDS20385.1 [Q08874-8]
CCDS51861.1 [Q08874-1]
CCDS51862.1 [Q08874-4]
PIRiA40728
I49244
PD0026
RefSeqiNP_001106669.1, NM_001113198.1 [Q08874-1]
NP_032627.1, NM_008601.3 [Q08874-8]
XP_006505758.1, XM_006505695.3 [Q08874-9]
UniGeneiMm.333284
Mm.454504

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ATHX-ray1.95A/B324-403[»]
4ATIX-ray2.60A/B287-403[»]
4ATKX-ray2.95A/B287-403[»]
ProteinModelPortaliQ08874
SMRiQ08874
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201427, 8 interactors
IntActiQ08874, 1 interactor
MINTiQ08874
STRINGi10090.ENSMUSP00000044938

Chemistry databases

ChEMBLiCHEMBL1075142

PTM databases

iPTMnetiQ08874
PhosphoSitePlusiQ08874

Proteomic databases

PaxDbiQ08874
PeptideAtlasiQ08874
PRIDEiQ08874

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043628; ENSMUSP00000044459; ENSMUSG00000035158 [Q08874-8]
ENSMUST00000043637; ENSMUSP00000044938; ENSMUSG00000035158 [Q08874-1]
ENSMUST00000101123; ENSMUSP00000098683; ENSMUSG00000035158 [Q08874-4]
GeneIDi17342
KEGGimmu:17342
UCSCiuc009daz.2 mouse

Organism-specific databases

CTDi4286
MGIiMGI:104554 Mitf

Phylogenomic databases

eggNOGiKOG1318 Eukaryota
ENOG4110SME LUCA
GeneTreeiENSGT00390000004402
HOVERGENiHBG006768
InParanoidiQ08874
KOiK09455
OMAiMEDTDHA
OrthoDBiEOG091G0QCO
PhylomeDBiQ08874
TreeFamiTF317174

Enzyme and pathway databases

ReactomeiR-MMU-3232118 SUMOylation of transcription factors

Miscellaneous databases

ChiTaRSiMitf mouse
PROiPR:Q08874
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035158 Expressed in 261 organ(s), highest expression level in pineal body
CleanExiMM_MITF
MM_VIT
ExpressionAtlasiQ08874 baseline and differential
GenevisibleiQ08874 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR031867 MiT/TFE_N
IPR030532 MITF
PANTHERiPTHR12565 PTHR12565, 2 hits
PTHR12565:SF91 PTHR12565:SF91, 2 hits
PfamiView protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit
PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMITF_MOUSE
AccessioniPrimary (citable) accession number: Q08874
Secondary accession number(s): A0A0N4SVJ5
, O08885, O88203, Q08843, Q3U2D2, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 5, 2017
Last modified: November 7, 2018
This is version 180 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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