UniProtKB - Q08853 (ATC_PLAFK)
Protein
Calcium-transporting ATPase
Gene
ATP6
Organism
Plasmodium falciparum (isolate K1 / Thailand)
Status
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Catalytic activityi
- EC:7.2.2.10
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 358 | 4-aspartylphosphate intermediate | 1 | |
Binding sitei | 716 | ATPBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium transmembrane transporter activity, phosphorylative mechanism Source: UniProtKB-EC
Keywordsi
Molecular function | Translocase |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Magnesium, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.3.8, 4889 |
Protein family/group databases
TCDBi | 3.A.3.2.31, the p-type atpase (p-atpase) superfamily |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ATP6 |
Organismi | Plasmodium falciparum (isolate K1 / Thailand) |
Taxonomic identifieri | 5839 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Subcellular locationi
Other locations
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 63 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 64 – 81 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 82 – 92 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 93 – 112 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 113 – 270 | CytoplasmicSequence analysisAdd BLAST | 158 | |
Transmembranei | 271 – 291 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 292 – 300 | ExtracellularSequence analysis | 9 | |
Transmembranei | 301 – 321 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 322 – 974 | CytoplasmicSequence analysisAdd BLAST | 653 | |
Transmembranei | 975 – 994 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 995 – 1000 | ExtracellularSequence analysis | 6 | |
Transmembranei | 1001 – 1021 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1022 – 1042 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 1043 – 1067 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 1068 – 1118 | ExtracellularSequence analysisAdd BLAST | 51 | |
Transmembranei | 1119 – 1140 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 1141 – 1151 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 1152 – 1172 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1173 – 1185 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 1186 – 1206 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1207 – 1228 | CytoplasmicSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046227 | 1 – 1228 | Calcium-transporting ATPaseAdd BLAST | 1228 |
Keywords - PTMi
PhosphoproteinStructurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 457 – 465 | Poly-Asn | 9 | |
Compositional biasi | 661 – 671 | Poly-AsnAdd BLAST | 11 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 3.40.1110.10, 3 hits 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08853-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEVIKNAHT YDVEDVLKFL DVNKDNGLKN EELDDRRLKY GLNELEVEKK
60 70 80 90 100
KSIFELILNQ FDDLLVKILL LAAFISFVLT LLDMKHKKIE ICDFIEPLVI
110 120 130 140 150
VLILILNAAV GVWQECNAEK SLEALKELQP TKAKVLRDGK WEIIDSKYLY
160 170 180 190 200
VGDIIELSVG NKTPADARII KIYSTSLKVE QSMLTGESCS VDKYAEKMED
210 220 230 240 250
SYKNCEIQLK KNILFSSTAI VCGRCIAVVI NIGMKTEIGH IQHAVIESNS
260 270 280 290 300
EDTQTPLQIK IDLFGQQLSK IIFVICVTVW IINFKHFSDP IHGSFLYGCL
310 320 330 340 350
YYFKISVALA VAAIPEGLPA VITTCLALGT RRMVKKNAIV RKLQSVETLG
360 370 380 390 400
CTTVICSDKT GTLTTNQMTT TVFHLFRESD SLTEYQLCQK GDTYYFYESS
410 420 430 440 450
NLTNDIYAGE SSFFNKLKDE GNVEALTDDG EEGSIDEADP YSDYFSSDSK
460 470 480 490 500
KMKNDLNNNN NNNNNSSRSG AKRNIPLKEM KSNENTIISR GSKILEDKIN
510 520 530 540 550
KYCYSEYDYN FYMCLVNCNE ANIFCNDNSQ IVKKFGDSTE LALLHFVHNF
560 570 580 590 600
DILPTFSKNN KMPAEYEKNT TPVQSSNKKD KSPRGINKFF SSKNDNSHIT
610 620 630 640 650
STLNENDKNL KNANHSNYTT AQATTNGYEA IGENTFEHGT SFENCFHSKL
660 670 680 690 700
GNKINTTSTH NNNNNNNNNS NSVPSECISS WRNECKQIKI IEFTRERKLM
710 720 730 740 750
SVIVENKKKE IILYCKGAPE NIIKNCKYYL TKNDIRPLNE TLKNEIHNKI
760 770 780 790 800
QNMGKRALRT LSFAYKKLSS KDLNIKNTDD YYKLEQDLIY LGGLGIIDPP
810 820 830 840 850
RKYVGRAIRL CHMAGIRVFM ITGDNINTAR AIAKEINILN KNEGDDEKDN
860 870 880 890 900
YTNNKNTQIC CYNGREFEDF SLEKQKHILK NTPRIVFCRT EPKHKKQIVK
910 920 930 940 950
VLKDLGETVA MTGDGVNDAP ALKSADIGIA MGINGTEVAK EASDIVLADD
960 970 980 990 1000
NFNTIVEAIK EGRCIYNNMK AFIRYLISSN IGEVASIFIT ALLGIPDSLA
1010 1020 1030 1040 1050
PVQLLWVNLV TDGLPATALG FNPPEHDVMK CKPRHKNDNL INGLTLLRYI
1060 1070 1080 1090 1100
IIGTYVGIAT VSIFVYWFLF YPDSDMHTLI NFYQLSHYNQ CKAWNNFRVN
1110 1120 1130 1140 1150
KVYDMSEDHC SYFSAGKIKA STLSLSVLVL IEMFNALNAL SEYNSLFEIP
1160 1170 1180 1190 1200
PWRNMYLVLA TIGSLLLHVL ILYIPPLARI FGVVPLSAYD WFLVFLWSFP
1210 1220
VIILDEIIKF YAKRKLKEEQ RTKKIKID
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71765 Genomic DNA Translation: CAA50664.1 |
PIRi | S37621 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71765 Genomic DNA Translation: CAA50664.1 |
PIRi | S37621 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1U5N | model | - | A | 1-1228 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Chemistry databases
DrugBanki | DB11638, Artenimol |
Protein family/group databases
TCDBi | 3.A.3.2.31, the p-type atpase (p-atpase) superfamily |
Enzyme and pathway databases
BRENDAi | 3.6.3.8, 4889 |
Family and domain databases
Gene3Di | 3.40.1110.10, 3 hits 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATC_PLAFK | |
Accessioni | Q08853Primary (citable) accession number: Q08853 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families