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Protein

Syntaxin-5

Gene

Stx5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates endoplasmic reticulum to Golgi transport (PubMed:10930451, PubMed:14742712, PubMed:9506515). Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus (PubMed:18167358).4 Publications

GO - Molecular functioni

  • protein N-terminus binding Source: Ensembl
  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-204005 COPII-mediated vesicle transport
R-RNO-5694530 Cargo concentration in the ER
R-RNO-6807878 COPI-mediated anterograde transport
R-RNO-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-5
Gene namesi
Name:Stx5
Synonyms:Stx5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi68426 Stx5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 333CytoplasmicSequence analysisAdd BLAST333
Transmembranei334 – 354Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini355VesicularSequence analysis1

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102071 – 355Syntaxin-5Add BLAST355

Proteomic databases

PaxDbiQ08851
PRIDEiQ08851

PTM databases

PhosphoSitePlusiQ08851

Miscellaneous databases

PMAP-CutDBiQ08851

Expressioni

Tissue specificityi

Expressed in the brain, heart, spleen, lung, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSRNOG00000018847 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiQ08851 RN

Interactioni

Subunit structurei

Part of a ternary complex containing STX5A, NSFL1C and VCP (PubMed:9506515). Part of a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2 and YKT6. This complex also includes VTI1A (By similarity). Interacts with COG4 (By similarity). Interacts with GM130/GOLGA2 (PubMed:18167358). Interacts (via IxM motif) with SEC24C and SEC24D; mediates STX5 packaging into COPII-coated vesicles (By similarity).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249255, 2 interactors
CORUMiQ08851
IntActiQ08851, 11 interactors
STRINGi10116.ENSRNOP00000025664

Structurei

3D structure databases

ProteinModelPortaliQ08851
SMRiQ08851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 325t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili287 – 318Sequence analysisAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi245 – 247IxM motif; signal for cargo packaging into COPII-coated vesiclesBy similarity3

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0812 Eukaryota
ENOG410Y2MB LUCA
GeneTreeiENSGT00390000000652
HOGENOMiHOG000194860
HOVERGENiHBG001973
InParanoidiQ08851
KOiK08490
OMAiQDRTNEF
OrthoDBiEOG091G0HR8
PhylomeDBiQ08851
TreeFamiTF315068

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR021538 Syntaxin-5_N
IPR006012 Syntaxin/epimorphin_CS
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF11416 Syntaxin-5_N, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket
Isoform 1 (identifier: Q08851-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AINSSSDIAP LPTPVALVPS
60 70 80 90 100
PPDTMSCRDR TQEFLSACKS LQSRQNGIQT NKPALHATRQ CSEFTLMARR
110 120 130 140 150
IGKDLSNTFA KLEKLTILAK RKSLFDDKAV EIEELTYIIK QDINSLNKQI
160 170 180 190 200
AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ SKLASMSNDF KSVLEVRTEN
210 220 230 240 250
LKQQRNRREQ FSRAPVSALP LAPNNLGGGP IVLGGESRAS RDVAIDMMDP
260 270 280 290 300
RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET
310 320 330 340 350
IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF

VVFLA
Length:355
Mass (Da):39,751
Last modified:September 5, 2006 - v2
Checksum:i0B0D0B2C261A39B4
GO
Isoform 2 (identifier: Q08851-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Note: Produced by alternative initiation at Met-55 of isoform 1.
Show »
Length:301
Mass (Da):34,117
Checksum:iF560A1A079C8A9F7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0201171 – 54Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20822 mRNA Translation: AAA03047.1
BC127489 mRNA Translation: AAI27490.1
U87971 mRNA Translation: AAB93844.1
PIRiF48213
RefSeqiNP_113892.2, NM_031704.2 [Q08851-1]
XP_006231059.1, XM_006230997.2 [Q08851-1]
UniGeneiRn.5782

Genome annotation databases

EnsembliENSRNOT00000025664; ENSRNOP00000025664; ENSRNOG00000018847 [Q08851-1]
GeneIDi65134
KEGGirno:65134
UCSCiRGD:68426 rat [Q08851-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20822 mRNA Translation: AAA03047.1
BC127489 mRNA Translation: AAI27490.1
U87971 mRNA Translation: AAB93844.1
PIRiF48213
RefSeqiNP_113892.2, NM_031704.2 [Q08851-1]
XP_006231059.1, XM_006230997.2 [Q08851-1]
UniGeneiRn.5782

3D structure databases

ProteinModelPortaliQ08851
SMRiQ08851
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249255, 2 interactors
CORUMiQ08851
IntActiQ08851, 11 interactors
STRINGi10116.ENSRNOP00000025664

PTM databases

PhosphoSitePlusiQ08851

Proteomic databases

PaxDbiQ08851
PRIDEiQ08851

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025664; ENSRNOP00000025664; ENSRNOG00000018847 [Q08851-1]
GeneIDi65134
KEGGirno:65134
UCSCiRGD:68426 rat [Q08851-1]

Organism-specific databases

CTDi6811
RGDi68426 Stx5

Phylogenomic databases

eggNOGiKOG0812 Eukaryota
ENOG410Y2MB LUCA
GeneTreeiENSGT00390000000652
HOGENOMiHOG000194860
HOVERGENiHBG001973
InParanoidiQ08851
KOiK08490
OMAiQDRTNEF
OrthoDBiEOG091G0HR8
PhylomeDBiQ08851
TreeFamiTF315068

Enzyme and pathway databases

ReactomeiR-RNO-204005 COPII-mediated vesicle transport
R-RNO-5694530 Cargo concentration in the ER
R-RNO-6807878 COPI-mediated anterograde transport
R-RNO-6811438 Intra-Golgi traffic

Miscellaneous databases

PMAP-CutDBiQ08851
PROiPR:Q08851

Gene expression databases

BgeeiENSRNOG00000018847 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiQ08851 RN

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR021538 Syntaxin-5_N
IPR006012 Syntaxin/epimorphin_CS
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF11416 Syntaxin-5_N, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTX5_RAT
AccessioniPrimary (citable) accession number: Q08851
Secondary accession number(s): A0JPL4, O55200
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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