UniProtKB - Q08849 (STX3_RAT)
Protein
Syntaxin-3
Gene
Stx3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Potentially involved in docking of synaptic vesicles at presynaptic active zones.
GO - Molecular functioni
- arachidonic acid binding Source: HGNC-UCL
- SNAP receptor activity Source: FlyBase
- SNARE binding Source: GO_Central
GO - Biological processi
- exocytic insertion of neurotransmitter receptor to postsynaptic membrane Source: RGD
- exocytosis Source: RGD
- intracellular protein transport Source: GO_Central
- intracellular transport Source: RGD
- long-term synaptic potentiation Source: RGD
- membrane fusion Source: RGD
- neuron projection development Source: HGNC-UCL
- positive regulation of cell adhesion Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of chemotaxis Source: RGD
- positive regulation of protein localization to cell surface Source: RGD
- positive regulation of protein localization to plasma membrane Source: RGD
- synaptic vesicle docking Source: RGD
- synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
- vesicle docking Source: GO_Central
- vesicle fusion Source: RGD
- vesicle-mediated transport Source: RGD
- vesicle-mediated transport in synapse Source: RGD
Keywordsi
Biological process | Neurotransmitter transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-449836, Other interleukin signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-3 |
Gene namesi | Name:Stx3 Synonyms:Stx3a |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621005, Stx3 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type IV membrane protein Curated
Note: Localized to the inner and outer plexiform layers, the cell body and the inner segments of photoreceptors.By similarity
Lysosome
- azurophil granule Source: RGD
Plasma Membrane
- apical plasma membrane Source: RGD
- plasma membrane Source: BHF-UCL
- presynaptic active zone membrane Source: GO_Central
- presynaptic membrane Source: RGD
Other locations
- cell-cell junction Source: RGD
- dendrite Source: RGD
- endomembrane system Source: GO_Central
- glutamatergic synapse Source: RGD
- growth cone Source: HGNC-UCL
- integral component of membrane Source: GO_Central
- lamellipodium Source: RGD
- melanosome Source: RGD
- membrane Source: RGD
- neuron projection Source: HGNC-UCL
- photoreceptor cell terminal bouton Source: RGD
- postsynapse Source: RGD
- ribbon synapse Source: RGD
- Schaffer collateral - CA1 synapse Source: RGD
- secretory granule Source: RGD
- SNARE complex Source: HGNC-UCL
- specific granule Source: RGD
- synaptic vesicle Source: RGD
- zymogen granule membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 263 | CytoplasmicSequence analysisAdd BLAST | 263 | |
Transmembranei | 264 – 284 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 285 – 289 | ExtracellularSequence analysis | 5 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210201 | 1 – 289 | Syntaxin-3Add BLAST | 289 |
Proteomic databases
PaxDbi | Q08849 |
PRIDEi | Q08849 |
PTM databases
iPTMneti | Q08849 |
PhosphoSitePlusi | Q08849 |
Expressioni
Tissue specificityi
Heart, spleen, lung and kidney.
Gene expression databases
Bgeei | ENSRNOG00000021013, Expressed in duodenum and 20 other tissues |
ExpressionAtlasi | Q08849, baseline and differential |
Genevisiblei | Q08849, RN |
Interactioni
Subunit structurei
Interacts with REEP6 (By similarity).
Interacts with PRPH2 in rod and cone photoreceptors (By similarity).
Interacts with ROM1 (By similarity).
Interacts with SNAP25 (By similarity).
Interacts with VAMP2 (By similarity).
By similarityBinary interactionsi
Q08849
With | #Exp. | IntAct |
---|---|---|
Snap25 [P60881] | 4 | EBI-8311156,EBI-1027214 |
GO - Molecular functioni
- SNARE binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 249660, 3 interactors |
CORUMi | Q08849 |
IntActi | Q08849, 3 interactors |
MINTi | Q08849 |
STRINGi | 10116.ENSRNOP00000028535 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 191 – 253 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 32 – 111 | Sequence analysisAdd BLAST | 80 |
Sequence similaritiesi
Belongs to the syntaxin family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0810, Eukaryota |
GeneTreei | ENSGT01010000222341 |
HOGENOMi | CLU_042423_2_2_1 |
InParanoidi | Q08849 |
OMAi | VENEAFM |
OrthoDBi | 1033833at2759 |
PhylomeDBi | Q08849 |
TreeFami | TF313763 |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR031186, Stx3 IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957:SF34, PTHR19957:SF34, 1 hit |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08849-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KRAMKYQGQA RKKLIIIIVI VVVLLGILAL IIGLSVGLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20820 mRNA Translation: AAA03045.1 |
PIRi | D48213 |
RefSeqi | NP_112386.1, NM_031124.1 XP_017445263.1, XM_017589774.1 |
Genome annotation databases
Ensembli | ENSRNOT00000028535; ENSRNOP00000028535; ENSRNOG00000021013 |
GeneIDi | 81802 |
KEGGi | rno:81802 |
UCSCi | RGD:621005, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20820 mRNA Translation: AAA03045.1 |
PIRi | D48213 |
RefSeqi | NP_112386.1, NM_031124.1 XP_017445263.1, XM_017589774.1 |
3D structure databases
SMRi | Q08849 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 249660, 3 interactors |
CORUMi | Q08849 |
IntActi | Q08849, 3 interactors |
MINTi | Q08849 |
STRINGi | 10116.ENSRNOP00000028535 |
PTM databases
iPTMneti | Q08849 |
PhosphoSitePlusi | Q08849 |
Proteomic databases
PaxDbi | Q08849 |
PRIDEi | Q08849 |
Genome annotation databases
Ensembli | ENSRNOT00000028535; ENSRNOP00000028535; ENSRNOG00000021013 |
GeneIDi | 81802 |
KEGGi | rno:81802 |
UCSCi | RGD:621005, rat |
Organism-specific databases
CTDi | 6809 |
RGDi | 621005, Stx3 |
Phylogenomic databases
eggNOGi | KOG0810, Eukaryota |
GeneTreei | ENSGT01010000222341 |
HOGENOMi | CLU_042423_2_2_1 |
InParanoidi | Q08849 |
OMAi | VENEAFM |
OrthoDBi | 1033833at2759 |
PhylomeDBi | Q08849 |
TreeFami | TF313763 |
Enzyme and pathway databases
Reactomei | R-RNO-449836, Other interleukin signaling |
Miscellaneous databases
PROi | PR:Q08849 |
Gene expression databases
Bgeei | ENSRNOG00000021013, Expressed in duodenum and 20 other tissues |
ExpressionAtlasi | Q08849, baseline and differential |
Genevisiblei | Q08849, RN |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR031186, Stx3 IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
PANTHERi | PTHR19957:SF34, PTHR19957:SF34, 1 hit |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STX3_RAT | |
Accessioni | Q08849Primary (citable) accession number: Q08849 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families