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Protein

Syntaxin-3

Gene

Stx3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones.

GO - Molecular functioni

  • arachidonic acid binding Source: HGNC
  • SNAP receptor activity Source: FlyBase
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-449836 Other interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-3
Gene namesi
Name:Stx3
Synonyms:Stx3a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621005 Stx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 263CytoplasmicSequence analysisAdd BLAST263
Transmembranei264 – 284Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini285 – 289ExtracellularSequence analysis5

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102011 – 289Syntaxin-3Add BLAST289

Proteomic databases

PaxDbiQ08849
PRIDEiQ08849

PTM databases

iPTMnetiQ08849
PhosphoSitePlusiQ08849

Expressioni

Tissue specificityi

Heart, spleen, lung and kidney.

Gene expression databases

BgeeiENSRNOG00000021013 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiQ08849 baseline and differential
GenevisibleiQ08849 RN

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Snap25P608814EBI-8311156,EBI-1027214

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249660, 3 interactors
CORUMiQ08849
IntActiQ08849, 3 interactors
MINTiQ08849
STRINGi10116.ENSRNOP00000028535

Structurei

3D structure databases

ProteinModelPortaliQ08849
SMRiQ08849
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 253t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 111Sequence analysisAdd BLAST80

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiQ08849
KOiK08486
OMAiKMANSVR
OrthoDBiEOG091G0EUK
PhylomeDBiQ08849
TreeFamiTF313763

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR031186 Stx3
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF34 PTHR19957:SF34, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Q08849-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDRLEQLKA KQLTQDDDTD EVEIAIDNTA FMDEFFSEIE ETRLNIDKIS
60 70 80 90 100
EHVEEAKKLY SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK
110 120 130 140 150
HIEEDEVRSS ADLRIRKSQH SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ
160 170 180 190 200
RQLEITGKKT TDEELEEMLE SGNPAIFTSG IIDSQISKQA LSEIEGRHKD
210 220 230 240 250
IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV DHVEKARDET
260 270 280
KRAMKYQGQA RKKLIIIIVI VVVLLGILAL IIGLSVGLK
Length:289
Mass (Da):33,257
Last modified:November 1, 1996 - v1
Checksum:i4A8EAFD4684EEE6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20820 mRNA Translation: AAA03045.1
PIRiD48213
RefSeqiNP_112386.1, NM_031124.1
XP_017445263.1, XM_017589774.1
UniGeneiRn.10951

Genome annotation databases

EnsembliENSRNOT00000028535; ENSRNOP00000028535; ENSRNOG00000021013
GeneIDi81802
KEGGirno:81802
UCSCiRGD:621005 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20820 mRNA Translation: AAA03045.1
PIRiD48213
RefSeqiNP_112386.1, NM_031124.1
XP_017445263.1, XM_017589774.1
UniGeneiRn.10951

3D structure databases

ProteinModelPortaliQ08849
SMRiQ08849
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249660, 3 interactors
CORUMiQ08849
IntActiQ08849, 3 interactors
MINTiQ08849
STRINGi10116.ENSRNOP00000028535

PTM databases

iPTMnetiQ08849
PhosphoSitePlusiQ08849

Proteomic databases

PaxDbiQ08849
PRIDEiQ08849

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028535; ENSRNOP00000028535; ENSRNOG00000021013
GeneIDi81802
KEGGirno:81802
UCSCiRGD:621005 rat

Organism-specific databases

CTDi6809
RGDi621005 Stx3

Phylogenomic databases

eggNOGiKOG0810 Eukaryota
COG5074 LUCA
GeneTreeiENSGT00760000119200
HOGENOMiHOG000286023
HOVERGENiHBG000497
InParanoidiQ08849
KOiK08486
OMAiKMANSVR
OrthoDBiEOG091G0EUK
PhylomeDBiQ08849
TreeFamiTF313763

Enzyme and pathway databases

ReactomeiR-RNO-449836 Other interleukin signaling

Miscellaneous databases

PROiPR:Q08849

Gene expression databases

BgeeiENSRNOG00000021013 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiQ08849 baseline and differential
GenevisibleiQ08849 RN

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR031186 Stx3
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF34 PTHR19957:SF34, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTX3_RAT
AccessioniPrimary (citable) accession number: Q08849
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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