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Entry version 162 (22 Apr 2020)
Sequence version 3 (15 May 2007)
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Protein

Fibrinogen-like protein 1

Gene

FGL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibrinogen-like protein 11 Publication
Alternative name(s):
HP-0411 Publication
Hepassocin1 Publication
Short name:
HPS1 Publication
Hepatocyte-derived fibrinogen-related protein 11 Publication
Short name:
HFREP-11 Publication
Liver fibrinogen-related protein 11 Publication
Short name:
LFIRE-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGL11 PublicationImported
Synonyms:HFREP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3695 FGL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605776 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08830

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2267

Open Targets

More...
OpenTargetsi
ENSG00000104760

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28133

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q08830 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FGL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147744562

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000910523 – 312Fibrinogen-like protein 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi26InterchainPROSITE-ProRule annotation
Disulfide bondi83 ↔ 112PROSITE-ProRule annotation
Disulfide bondi248 ↔ 261PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q08830

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q08830

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08830

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08830

PeptideAtlas

More...
PeptideAtlasi
Q08830

PRoteomics IDEntifications database

More...
PRIDEi
Q08830

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58649

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08830

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08830

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Under normal conditions, liver-specific.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced by interleukin-6 (IL6) (PubMed:18039467). Up-regulated in a number of cancers, such as lung cancer, prostate cancer, melanoma and colorectal cancer (PubMed:30580966).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104760 Expressed in liver and 110 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08830 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000104760 Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:11470158).

Interacts (via the Fibrinogen C-terminal domain) with LAG3 (via Ig-like domains 1 and 2) (PubMed:30580966).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108558, 72 interactors

Protein interaction database and analysis system

More...
IntActi
Q08830, 62 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381133

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q08830 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q08830

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 306Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST233

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili23 – 61Sequence analysisAdd BLAST39

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2579 Eukaryota
ENOG410ZYS4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160647

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_038628_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08830

Identification of Orthologs from Complete Genome Data

More...
OMAi
NFHPEVQ

Database of Orthologous Groups

More...
OrthoDBi
523014at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08830

TreeFam database of animal gene trees

More...
TreeFami
TF336658

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00087 FReD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00147 Fibrinogen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00186 FBG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q08830-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK
60 70 80 90 100
IKQLLQENEV QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK
110 120 130 140 150
PLQSPAEFSV YCDMSDGGGW TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK
160 170 180 190 200
HGEYWLGNKN LHFLTTQEDY TLKIDLADFE KNSRYAQYKN FKVGDEKNFY
210 220 230 240 250
ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD HDNYEGNCAE
260 270 280 290 300
EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
310
KIRPNDFIPN VI
Length:312
Mass (Da):36,379
Last modified:May 15, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9297153AEA746C31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69N → D in BAA03336 (PubMed:8390249).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02400215T → I5 PublicationsCorresponds to variant dbSNP:rs484373Ensembl.1
Natural variantiVAR_02400372I → V4 PublicationsCorresponds to variant dbSNP:rs3739406Ensembl.1
Natural variantiVAR_024004105P → L2 PublicationsCorresponds to variant dbSNP:rs2653406Ensembl.1
Natural variantiVAR_024005111Y → H1 PublicationCorresponds to variant dbSNP:rs34019703Ensembl.1
Natural variantiVAR_049067114M → V. Corresponds to variant dbSNP:rs35311020Ensembl.1
Natural variantiVAR_024006121T → S1 PublicationCorresponds to variant dbSNP:rs34239530Ensembl.1
Natural variantiVAR_024007140Y → F1 PublicationCorresponds to variant dbSNP:rs35431851Ensembl.1
Natural variantiVAR_049068256W → L. Corresponds to variant dbSNP:rs2653414Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D14446 mRNA Translation: BAA03336.1
D87342 mRNA Translation: BAB70690.1
AF168954 mRNA Translation: AAM88911.1
BT006635 mRNA Translation: AAP35281.1
DQ086826 Genomic DNA Translation: AAY68216.1
AK289448 mRNA Translation: BAF82137.1
AC087273 Genomic DNA No translation available.
BC007047 mRNA Translation: AAH07047.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6004.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JN0596

NCBI Reference Sequences

More...
RefSeqi
NP_004458.3, NM_004467.3
NP_671736.2, NM_147203.2
NP_963846.1, NM_201552.1
NP_963847.1, NM_201553.1
XP_016868721.1, XM_017013232.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381840; ENSP00000371262; ENSG00000104760
ENST00000381841; ENSP00000371263; ENSG00000104760
ENST00000398054; ENSP00000381131; ENSG00000104760
ENST00000398056; ENSP00000381133; ENSG00000104760
ENST00000427924; ENSP00000401952; ENSG00000104760
ENST00000518650; ENSP00000428430; ENSG00000104760
ENST00000522444; ENSP00000429757; ENSG00000104760

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2267

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2267

UCSC genome browser

More...
UCSCi
uc003wxx.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14446 mRNA Translation: BAA03336.1
D87342 mRNA Translation: BAB70690.1
AF168954 mRNA Translation: AAM88911.1
BT006635 mRNA Translation: AAP35281.1
DQ086826 Genomic DNA Translation: AAY68216.1
AK289448 mRNA Translation: BAF82137.1
AC087273 Genomic DNA No translation available.
BC007047 mRNA Translation: AAH07047.1
CCDSiCCDS6004.1
PIRiJN0596
RefSeqiNP_004458.3, NM_004467.3
NP_671736.2, NM_147203.2
NP_963846.1, NM_201552.1
NP_963847.1, NM_201553.1
XP_016868721.1, XM_017013232.1

3D structure databases

SMRiQ08830
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108558, 72 interactors
IntActiQ08830, 62 interactors
STRINGi9606.ENSP00000381133

PTM databases

iPTMnetiQ08830
PhosphoSitePlusiQ08830

Polymorphism and mutation databases

BioMutaiFGL1
DMDMi147744562

Proteomic databases

EPDiQ08830
MassIVEiQ08830
MaxQBiQ08830
PaxDbiQ08830
PeptideAtlasiQ08830
PRIDEiQ08830
ProteomicsDBi58649

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22306 367 antibodies

The DNASU plasmid repository

More...
DNASUi
2267

Genome annotation databases

EnsembliENST00000381840; ENSP00000371262; ENSG00000104760
ENST00000381841; ENSP00000371263; ENSG00000104760
ENST00000398054; ENSP00000381131; ENSG00000104760
ENST00000398056; ENSP00000381133; ENSG00000104760
ENST00000427924; ENSP00000401952; ENSG00000104760
ENST00000518650; ENSP00000428430; ENSG00000104760
ENST00000522444; ENSP00000429757; ENSG00000104760
GeneIDi2267
KEGGihsa:2267
UCSCiuc003wxx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2267
DisGeNETi2267

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FGL1
HGNCiHGNC:3695 FGL1
HPAiENSG00000104760 Tissue enriched (liver)
MIMi605776 gene
neXtProtiNX_Q08830
OpenTargetsiENSG00000104760
PharmGKBiPA28133

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00940000160647
HOGENOMiCLU_038628_1_3_1
InParanoidiQ08830
OMAiNFHPEVQ
OrthoDBi523014at2759
PhylomeDBiQ08830
TreeFamiTF336658

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FGL1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FGL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2267
PharosiQ08830 Tbio

Protein Ontology

More...
PROi
PR:Q08830
RNActiQ08830 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104760 Expressed in liver and 110 other tissues
GenevisibleiQ08830 HS

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08830
Secondary accession number(s): A6NKU4
, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 15, 2007
Last modified: April 22, 2020
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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