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Protein

Fibrinogen-like protein 1

Gene

FGL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has hepatocyte mitogenic activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen-like protein 1
Alternative name(s):
HP-041
Hepassocin
Hepatocyte-derived fibrinogen-related protein 1
Short name:
HFREP-1
Liver fibrinogen-related protein 1
Short name:
LFIRE-1
Gene namesi
Name:FGL1
Synonyms:HFREP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104760.16
HGNCiHGNC:3695 FGL1
MIMi605776 gene
neXtProtiNX_Q08830

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2267
OpenTargetsiENSG00000104760
PharmGKBiPA28133

Polymorphism and mutation databases

BioMutaiFGL1
DMDMi147744562

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000000910523 – 312Fibrinogen-like protein 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26InterchainPROSITE-ProRule annotation
Disulfide bondi83 ↔ 112PROSITE-ProRule annotation
Disulfide bondi248 ↔ 261PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ08830
MaxQBiQ08830
PaxDbiQ08830
PeptideAtlasiQ08830
PRIDEiQ08830
ProteomicsDBi58649

PTM databases

iPTMnetiQ08830
PhosphoSitePlusiQ08830

Expressioni

Tissue specificityi

Liver specific.

Gene expression databases

BgeeiENSG00000104760 Expressed in 111 organ(s), highest expression level in liver
CleanExiHS_FGL1
GenevisibleiQ08830 HS

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

BioGridi108558, 71 interactors
IntActiQ08830, 2 interactors
STRINGi9606.ENSP00000221204

Structurei

3D structure databases

ProteinModelPortaliQ08830
SMRiQ08830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 306Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST233

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili23 – 61Sequence analysisAdd BLAST39

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150824
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiQ08830
OMAiNFHPEVQ
OrthoDBiEOG091G03M1
PhylomeDBiQ08830
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08830-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVFSFILV TTALTMGREI SALEDCAQEQ MRLRAQVRLL ETRVKQQQVK
60 70 80 90 100
IKQLLQENEV QFLDKGDENT VIDLGSKRQY ADCSEIFNDG YKLSGFYKIK
110 120 130 140 150
PLQSPAEFSV YCDMSDGGGW TVIQRRSDGS ENFNRGWKDY ENGFGNFVQK
160 170 180 190 200
HGEYWLGNKN LHFLTTQEDY TLKIDLADFE KNSRYAQYKN FKVGDEKNFY
210 220 230 240 250
ELNIGEYSGT AGDSLAGNFH PEVQWWASHQ RMKFSTWDRD HDNYEGNCAE
260 270 280 290 300
EDQSGWWFNR CHSANLNGVY YSGPYTAKTD NGIVWYTWHG WWYSLKSVVM
310
KIRPNDFIPN VI
Length:312
Mass (Da):36,379
Last modified:May 15, 2007 - v3
Checksum:i9297153AEA746C31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69N → D in BAA03336 (PubMed:8390249).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02400215T → I5 PublicationsCorresponds to variant dbSNP:rs484373Ensembl.1
Natural variantiVAR_02400372I → V4 PublicationsCorresponds to variant dbSNP:rs3739406Ensembl.1
Natural variantiVAR_024004105P → L2 PublicationsCorresponds to variant dbSNP:rs2653406Ensembl.1
Natural variantiVAR_024005111Y → H1 PublicationCorresponds to variant dbSNP:rs34019703Ensembl.1
Natural variantiVAR_049067114M → V. Corresponds to variant dbSNP:rs35311020Ensembl.1
Natural variantiVAR_024006121T → S1 PublicationCorresponds to variant dbSNP:rs34239530Ensembl.1
Natural variantiVAR_024007140Y → F1 PublicationCorresponds to variant dbSNP:rs35431851Ensembl.1
Natural variantiVAR_049068256W → L. Corresponds to variant dbSNP:rs2653414Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14446 mRNA Translation: BAA03336.1
D87342 mRNA Translation: BAB70690.1
AF168954 mRNA Translation: AAM88911.1
BT006635 mRNA Translation: AAP35281.1
DQ086826 Genomic DNA Translation: AAY68216.1
AK289448 mRNA Translation: BAF82137.1
AC087273 Genomic DNA No translation available.
BC007047 mRNA Translation: AAH07047.1
CCDSiCCDS6004.1
PIRiJN0596
RefSeqiNP_004458.3, NM_004467.3
NP_671736.2, NM_147203.2
NP_963846.1, NM_201552.1
NP_963847.1, NM_201553.1
XP_016868721.1, XM_017013232.1
UniGeneiHs.491143

Genome annotation databases

EnsembliENST00000381840; ENSP00000371262; ENSG00000104760
ENST00000381841; ENSP00000371263; ENSG00000104760
ENST00000398054; ENSP00000381131; ENSG00000104760
ENST00000398056; ENSP00000381133; ENSG00000104760
ENST00000427924; ENSP00000401952; ENSG00000104760
ENST00000518650; ENSP00000428430; ENSG00000104760
ENST00000522444; ENSP00000429757; ENSG00000104760
GeneIDi2267
KEGGihsa:2267
UCSCiuc003wxx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14446 mRNA Translation: BAA03336.1
D87342 mRNA Translation: BAB70690.1
AF168954 mRNA Translation: AAM88911.1
BT006635 mRNA Translation: AAP35281.1
DQ086826 Genomic DNA Translation: AAY68216.1
AK289448 mRNA Translation: BAF82137.1
AC087273 Genomic DNA No translation available.
BC007047 mRNA Translation: AAH07047.1
CCDSiCCDS6004.1
PIRiJN0596
RefSeqiNP_004458.3, NM_004467.3
NP_671736.2, NM_147203.2
NP_963846.1, NM_201552.1
NP_963847.1, NM_201553.1
XP_016868721.1, XM_017013232.1
UniGeneiHs.491143

3D structure databases

ProteinModelPortaliQ08830
SMRiQ08830
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108558, 71 interactors
IntActiQ08830, 2 interactors
STRINGi9606.ENSP00000221204

PTM databases

iPTMnetiQ08830
PhosphoSitePlusiQ08830

Polymorphism and mutation databases

BioMutaiFGL1
DMDMi147744562

Proteomic databases

EPDiQ08830
MaxQBiQ08830
PaxDbiQ08830
PeptideAtlasiQ08830
PRIDEiQ08830
ProteomicsDBi58649

Protocols and materials databases

DNASUi2267
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381840; ENSP00000371262; ENSG00000104760
ENST00000381841; ENSP00000371263; ENSG00000104760
ENST00000398054; ENSP00000381131; ENSG00000104760
ENST00000398056; ENSP00000381133; ENSG00000104760
ENST00000427924; ENSP00000401952; ENSG00000104760
ENST00000518650; ENSP00000428430; ENSG00000104760
ENST00000522444; ENSP00000429757; ENSG00000104760
GeneIDi2267
KEGGihsa:2267
UCSCiuc003wxx.4 human

Organism-specific databases

CTDi2267
DisGeNETi2267
EuPathDBiHostDB:ENSG00000104760.16
GeneCardsiFGL1
HGNCiHGNC:3695 FGL1
MIMi605776 gene
neXtProtiNX_Q08830
OpenTargetsiENSG00000104760
PharmGKBiPA28133
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150824
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiQ08830
OMAiNFHPEVQ
OrthoDBiEOG091G03M1
PhylomeDBiQ08830
TreeFamiTF336658

Miscellaneous databases

ChiTaRSiFGL1 human
GeneWikiiFGL1
GenomeRNAii2267
PROiPR:Q08830
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104760 Expressed in 111 organ(s), highest expression level in liver
CleanExiHS_FGL1
GenevisibleiQ08830 HS

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGL1_HUMAN
AccessioniPrimary (citable) accession number: Q08830
Secondary accession number(s): A6NKU4
, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 15, 2007
Last modified: November 7, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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