UniProtKB - Q08828 (ADCY1_HUMAN)
Adenylate cyclase type 1
ADCY1
Functioni
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels (By similarity).
May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).
By similarityCatalytic activityi
- EC:4.6.1.1By similarity
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 308 | Magnesium 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 308 | Magnesium 2; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 309 | Magnesium 2; via carbonyl oxygen; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 352 | Magnesium 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 352 | Magnesium 2; catalyticPROSITE-ProRule annotation | 1 | |
Binding sitei | 396 | ATPBy similarity | 1 | |
Binding sitei | 920 | ATPBy similarity | 1 | |
Binding sitei | 1044 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 308 – 313 | ATPBy similarity | 6 | |
Nucleotide bindingi | 350 – 352 | ATPBy similarity | 3 | |
Nucleotide bindingi | 997 – 999 | ATPBy similarity | 3 | |
Nucleotide bindingi | 1004 – 1008 | ATPBy similarity | 5 |
GO - Molecular functioni
- adenylate cyclase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- calcium- and calmodulin-responsive adenylate cyclase activity Source: UniProtKB
- calmodulin binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- axonogenesis Source: Ensembl
- brain development Source: Ensembl
- cAMP biosynthetic process Source: UniProtKB
- cAMP-mediated signaling Source: UniProtKB
- cellular response to calcium ion Source: UniProtKB
- cellular response to forskolin Source: UniProtKB
- circadian rhythm Source: Ensembl
- long-term memory Source: Ensembl
- neuroinflammatory response Source: UniProtKB
- positive regulation of CREB transcription factor activity Source: UniProtKB
- positive regulation of long-term synaptic potentiation Source: UniProtKB
- regulation of circadian rhythm Source: UniProtKB
- regulation of synaptic vesicle exocytosis Source: Ensembl
- response to lithium ion Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
Keywordsi
Molecular function | Calmodulin-binding, Lyase |
Biological process | Biological rhythms, cAMP biosynthesis |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 4.6.1.1, 2681 |
PathwayCommonsi | Q08828 |
Reactomei | R-HSA-163359, Glucagon signaling in metabolic regulation R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-170660, Adenylate cyclase activating pathway R-HSA-170670, Adenylate cyclase inhibitory pathway R-HSA-418555, G alpha (s) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-5610787, Hedgehog 'off' state R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis |
SignaLinki | Q08828 |
SIGNORi | Q08828 |
Names & Taxonomyi
Protein namesi | Recommended name: Adenylate cyclase type 1 (EC:4.6.1.1By similarity)Alternative name(s): ATP pyrophosphate-lyase 1 Adenylate cyclase type I Adenylyl cyclase 1 Ca(2+)/calmodulin-activated adenylyl cyclase |
Gene namesi | Name:ADCY1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:232, ADCY1 |
MIMi | 103072, gene |
neXtProti | NX_Q08828 |
VEuPathDBi | HostDB:ENSG00000164742 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
- Membrane raft By similarity
Note: Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia.By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic density membrane Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- hippocampal mossy fiber to CA3 synapse Source: Ensembl
- membrane raft Source: UniProtKB-SubCell
- Schaffer collateral - CA1 synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 63 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 125 – 145 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 183 – 203 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 214 – 234 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 235 – 610 | CytoplasmicSequence analysisAdd BLAST | 376 | |
Transmembranei | 611 – 631 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 635 – 655 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 674 – 694 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 725 – 745 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 753 – 773 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 775 – 794 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 795 – 1119 | CytoplasmicSequence analysisAdd BLAST | 325 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Deafness, autosomal recessive, 44 (DFNB44)1 Publication
Keywords - Diseasei
Deafness, Non-syndromic deafnessOrganism-specific databases
DisGeNETi | 107 |
MalaCardsi | ADCY1 |
MIMi | 610154, phenotype |
OpenTargetsi | ENSG00000164742 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA24560 |
Miscellaneous databases
Pharosi | Q08828, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2899 |
DrugBanki | DB00131, Adenosine phosphate DB00171, ATP DB09121, Aurothioglucose DB13749, Magnesium gluconate |
DrugCentrali | Q08828 |
GuidetoPHARMACOLOGYi | 1278 |
Genetic variation databases
BioMutai | ADCY1 |
DMDMi | 62512172 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195682 | 1 – 1119 | Adenylate cyclase type 1Add BLAST | 1119 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 551 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 704 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q08828 |
PaxDbi | Q08828 |
PeptideAtlasi | Q08828 |
PRIDEi | Q08828 |
ProteomicsDBi | 58648 |
PTM databases
GlyGeni | Q08828, 1 site |
iPTMneti | Q08828 |
PhosphoSitePlusi | Q08828 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000164742, Expressed in neocortex and 191 other tissues |
ExpressionAtlasi | Q08828, baseline and differential |
Genevisiblei | Q08828, HS |
Organism-specific databases
HPAi | ENSG00000164742, Group enriched (brain, liver, retina) |
Interactioni
Subunit structurei
Interacts with CALM.
By similarityGO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 106621, 4 interactors |
IntActi | Q08828, 2 interactors |
MINTi | Q08828 |
STRINGi | 9606.ENSP00000297323 |
Chemistry databases
BindingDBi | Q08828 |
Miscellaneous databases
RNActi | Q08828, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 493 – 520 | Interaction with calmodulinBy similarityAdd BLAST | 28 | |
Regioni | 1024 – 1047 | Interaction with calmodulinBy similarityAdd BLAST | 24 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3619, Eukaryota |
GeneTreei | ENSGT00940000154872 |
HOGENOMi | CLU_001072_2_1_1 |
InParanoidi | Q08828 |
OMAi | PALPCES |
OrthoDBi | 594476at2759 |
PhylomeDBi | Q08828 |
TreeFami | TF313845 |
Family and domain databases
CDDi | cd07302, CHD, 2 hits |
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR032628, AC_N IPR030672, Adcy IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF039050, Ade_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 2 hits |
SUPFAMi | SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 2 hits PS50125, GUANYLATE_CYCLASE_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAGAPRGGGG GGGGAGEPGG AERAAGTSRR RGLRACDEEF ACPELEALFR
60 70 80 90 100
GYTLRLEQAA TLKALAVLSL LAGALALAEL LGAPGPAPGL AKGSHPVHCV
110 120 130 140 150
LFLALLVVTN VRSLQVPQLQ QVGQLALLFS LTFALLCCPF ALGGPARGSA
160 170 180 190 200
GAAGGPATAE QGVWQLLLVT FVSYALLPVR SLLAIGFGLV VAASHLLVTA
210 220 230 240 250
TLVPAKRPRL WRTLGANALL FVGVNMYGVF VRILTERSQR KAFLQARSCI
260 270 280 290 300
EDRLRLEDEN EKQERLLMSL LPRNVAMEMK EDFLKPPERI FHKIYIQRHD
310 320 330 340 350
NVSILFADIV GFTGLASQCT AQELVKLLNE LFGKFDELAT ENHCRRIKIL
360 370 380 390 400
GDCYYCVSGL TQPKTDHAHC CVEMGLDMID TITSVAEATE VDLNMRVGLH
410 420 430 440 450
TGRVLCGVLG LRKWQYDVWS NDVTLANVME AAGLPGKVHI TKTTLACLNG
460 470 480 490 500
DYEVEPGYGH ERNSFLKTHN IETFFIVPSH RRKIFPGLIL SDIKPAKRMK
510 520 530 540 550
FKTVCYLLVQ LMHCRKMFKA EIPFSNVMTC EDDDKRRALR TASEKLRNRS
560 570 580 590 600
SFSTNVVYTT PGTRVNRYIS RLLEARQTEL EMADLNFFTL KYKHVEREQK
610 620 630 640 650
YHQLQDEYFT SAVVLTLILA ALFGLVYLLI FPQSVVVLLL LVFCICFLVA
660 670 680 690 700
CVLYLHITRV QCFPGCLTIQ IRTVLCIFIV VLIYSVAQGC VVGCLPWAWS
710 720 730 740 750
SKPNSSLVVL SSGGQRTALP TLPCESTHHA LLCCLVGTLP LAIFFRVSSL
760 770 780 790 800
PKMILLSGLT TSYILVLELS GYTRTGGGAV SGRSYEPIVA ILLFSCALAL
810 820 830 840 850
HARQVDIRLR LDYLWAAQAE EEREDMEKVK LDNRRILFNL LPAHVAQHFL
860 870 880 890 900
MSNPRNMDLY YQSYSQVGVM FASIPNFNDF YIELDGNNMG VECLRLLNEI
910 920 930 940 950
IADFDELMEK DFYKDIEKIK TIGSTYMAAV GLAPTSGTKA KKSISSHLST
960 970 980 990 1000
LADFAIEMFD VLDEINYQSY NDFVLRVGIN VGPVVAGVIG ARRPQYDIWG
1010 1020 1030 1040 1050
NTVNVASRMD STGVQGRIQV TEEVHRLLRR CPYHFVCRGK VSVKGKGEML
1060 1070 1080 1090 1100
TYFLEGRTDG NGSQIRSLGL DRKMCPFGRA GLQGRRPPVC PMPGVSVRAG
1110
LPPHSPGQYL PSAAAGKEA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J1J0 | C9J1J0_HUMAN | Adenylate cyclase | ADCY1 hCG_19245 | 338 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029186 | 456 | P → L. Corresponds to variant dbSNP:rs12721473Ensembl. | 1 | |
Natural variantiVAR_029187 | 940 | A → T. Corresponds to variant dbSNP:rs45444695EnsemblClinVar. | 1 | |
Natural variantiVAR_048246 | 984 | V → M. Corresponds to variant dbSNP:rs2293106Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC069008 Genomic DNA Translation: AAS07467.1 AC091439 Genomic DNA No translation available. CH236960 Genomic DNA Translation: EAL23741.1 L05500 mRNA Translation: AAA02907.1 |
CCDSi | CCDS34631.1 |
PIRi | A47007 |
RefSeqi | NP_066939.1, NM_021116.2 |
Genome annotation databases
Ensembli | ENST00000297323; ENSP00000297323; ENSG00000164742 |
GeneIDi | 107 |
KEGGi | hsa:107 |
MANE-Selecti | ENST00000297323.12; ENSP00000297323.7; NM_021116.4; NP_066939.1 |
UCSCi | uc003tne.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC069008 Genomic DNA Translation: AAS07467.1 AC091439 Genomic DNA No translation available. CH236960 Genomic DNA Translation: EAL23741.1 L05500 mRNA Translation: AAA02907.1 |
CCDSi | CCDS34631.1 |
PIRi | A47007 |
RefSeqi | NP_066939.1, NM_021116.2 |
3D structure databases
SMRi | Q08828 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106621, 4 interactors |
IntActi | Q08828, 2 interactors |
MINTi | Q08828 |
STRINGi | 9606.ENSP00000297323 |
Chemistry databases
BindingDBi | Q08828 |
ChEMBLi | CHEMBL2899 |
DrugBanki | DB00131, Adenosine phosphate DB00171, ATP DB09121, Aurothioglucose DB13749, Magnesium gluconate |
DrugCentrali | Q08828 |
GuidetoPHARMACOLOGYi | 1278 |
PTM databases
GlyGeni | Q08828, 1 site |
iPTMneti | Q08828 |
PhosphoSitePlusi | Q08828 |
Genetic variation databases
BioMutai | ADCY1 |
DMDMi | 62512172 |
Proteomic databases
MassIVEi | Q08828 |
PaxDbi | Q08828 |
PeptideAtlasi | Q08828 |
PRIDEi | Q08828 |
ProteomicsDBi | 58648 |
Protocols and materials databases
Antibodypediai | 4335, 242 antibodies from 29 providers |
DNASUi | 107 |
Genome annotation databases
Ensembli | ENST00000297323; ENSP00000297323; ENSG00000164742 |
GeneIDi | 107 |
KEGGi | hsa:107 |
MANE-Selecti | ENST00000297323.12; ENSP00000297323.7; NM_021116.4; NP_066939.1 |
UCSCi | uc003tne.5, human |
Organism-specific databases
CTDi | 107 |
DisGeNETi | 107 |
GeneCardsi | ADCY1 |
HGNCi | HGNC:232, ADCY1 |
HPAi | ENSG00000164742, Group enriched (brain, liver, retina) |
MalaCardsi | ADCY1 |
MIMi | 103072, gene 610154, phenotype |
neXtProti | NX_Q08828 |
OpenTargetsi | ENSG00000164742 |
Orphaneti | 90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB |
PharmGKBi | PA24560 |
VEuPathDBi | HostDB:ENSG00000164742 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3619, Eukaryota |
GeneTreei | ENSGT00940000154872 |
HOGENOMi | CLU_001072_2_1_1 |
InParanoidi | Q08828 |
OMAi | PALPCES |
OrthoDBi | 594476at2759 |
PhylomeDBi | Q08828 |
TreeFami | TF313845 |
Enzyme and pathway databases
BRENDAi | 4.6.1.1, 2681 |
PathwayCommonsi | Q08828 |
Reactomei | R-HSA-163359, Glucagon signaling in metabolic regulation R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-170660, Adenylate cyclase activating pathway R-HSA-170670, Adenylate cyclase inhibitory pathway R-HSA-418555, G alpha (s) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-442720, CREB1 phosphorylation through the activation of Adenylate Cyclase R-HSA-5610787, Hedgehog 'off' state R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis |
SignaLinki | Q08828 |
SIGNORi | Q08828 |
Miscellaneous databases
BioGRID-ORCSi | 107, 5 hits in 1044 CRISPR screens |
ChiTaRSi | ADCY1, human |
GeneWikii | ADCY1 |
GenomeRNAii | 107 |
Pharosi | Q08828, Tchem |
PROi | PR:Q08828 |
RNActi | Q08828, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164742, Expressed in neocortex and 191 other tissues |
ExpressionAtlasi | Q08828, baseline and differential |
Genevisiblei | Q08828, HS |
Family and domain databases
CDDi | cd07302, CHD, 2 hits |
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR032628, AC_N IPR030672, Adcy IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF039050, Ade_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 2 hits |
SUPFAMi | SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 2 hits PS50125, GUANYLATE_CYCLASE_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ADCY1_HUMAN | |
Accessioni | Q08828Primary (citable) accession number: Q08828 Secondary accession number(s): A4D2L8, Q75MI1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | April 12, 2005 | |
Last modified: | February 23, 2022 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families