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Protein

Sorting nexin-3

Gene

SNX3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Phosphatidylinositol 3-phosphate1 Publication1
Binding sitei83Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen1 Publication1
Binding sitei112Phosphatidylinositol 3-phosphate1 Publication1
Binding sitei127Phosphatidylinositol 3-phosphate1 Publication1

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33828-MONOMER
ReactomeiR-SCE-3238698 WNT ligand biogenesis and trafficking
R-SCE-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-3
Alternative name(s):
Golgi retention deficient protein 19
Gene namesi
Name:SNX3
Synonyms:GRD19
Ordered Locus Names:YOR357C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR357C
SGDiS000005884 SNX3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138051 – 162Sorting nexin-3Add BLAST162

Proteomic databases

MaxQBiQ08826
PaxDbiQ08826
PRIDEiQ08826

PTM databases

iPTMnetiQ08826

Interactioni

Subunit structurei

Monomer. Interacts with RBD2, YIF1, YIP1 and YIP5.2 Publications

Protein-protein interaction databases

BioGridi34742, 99 interactors
IntActiQ08826, 15 interactors
MINTiQ08826
STRINGi4932.YOR357C

Structurei

Secondary structure

1162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00482
ProteinModelPortaliQ08826
SMRiQ08826
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08826

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 161PXPROSITE-ProRule annotationAdd BLAST124

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

GeneTreeiENSGT00650000093174
HOGENOMiHOG000234882
InParanoidiQ08826
KOiK17918
OMAiRQLPFRS
OrthoDBiEOG092C4ZGK

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR039358 Sorting_nexin-like
PANTHERiPTHR10555 PTHR10555, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

Q08826-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPREFKSFGS TEKSLLSKGH GEPSYSEIYA EPENFLEIEV HNPKTHIPNG
60 70 80 90 100
MDSKGMFTDY EIICRTNLPS FHKRVSKVRR RYSDFEFFRK CLIKEISMLN
110 120 130 140 150
HPKVMVPHLP GKILLSNRFS NEVIEERRQG LNTWMQSVAG HPLLQSGSKV
160
LVRFIEAEKF VG
Length:162
Mass (Da):18,770
Last modified:November 1, 1996 - v1
Checksum:i0633831F6CF165FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016101 Genomic DNA Translation: AAC15913.1
Z75265 Genomic DNA Translation: CAA99686.1
BK006948 Genomic DNA Translation: DAA11118.1
PIRiS67269
RefSeqiNP_015002.3, NM_001183777.3

Genome annotation databases

EnsemblFungiiYOR357C; YOR357C; YOR357C
GeneIDi854539
KEGGisce:YOR357C

Similar proteinsi

Entry informationi

Entry nameiSNX3_YEAST
AccessioniPrimary (citable) accession number: Q08826
Secondary accession number(s): D6W352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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