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Entry version 194 (08 May 2019)
Sequence version 2 (02 Nov 2001)
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Protein

Runt-related transcription factor 2

Gene

Runx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8878166 Transcriptional regulation by RUNX2
R-MMU-8939902 Regulation of RUNX2 expression and activity
R-MMU-8940973 RUNX2 regulates osteoblast differentiation
R-MMU-8941326 RUNX2 regulates bone development

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Runt-related transcription factor 2
Alternative name(s):
Acute myeloid leukemia 3 protein
Core-binding factor subunit alpha-1
Short name:
CBF-alpha-1
Oncogene AML-3
Osteoblast-specific transcription factor 2
Short name:
OSF-2
Polyomavirus enhancer-binding protein 2 alpha A subunit
Short name:
PEA2-alpha A
Short name:
PEBP2-alpha A
SL3-3 enhancer factor 1 alpha A subunit
SL3/AKV core-binding factor alpha A subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Runx2
Synonyms:Aml3, Cbfa1, Osf2, Pebp2a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99829 Runx2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1681609

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001746601 – 607Runt-related transcription factor 2Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei353Asymmetric dimethylarginineCombined sources1
Modified residuei537Phosphoserine; by CDK1By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation. Phosphorylation at Ser-537 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08775

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08775

PeptideAtlas

More...
PeptideAtlasi
Q08775

PRoteomics IDEntifications database

More...
PRIDEi
Q08775

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08775

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08775

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in thymus and testis, T-cell lines but not in B-cell lines. Isoform 2 is exclusively found in bone, particularly in osteoblasts; isoforms 3 and 4 are expressed in T-cell lines; isoforms 5, 6, 7, 8 and 9 can be found in osteoblasts and osteosarcoma cell lines.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression occurs early during skeletal development and is restricted to cells of the mesenchymal condensations and of the osteoblast lineage. Expression of isoform 2 in the embryo reaches a peak at 12.5 dpc.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039153 Expressed in 286 organ(s), highest expression level in hindlimb long bone

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q08775 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q08775 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with CCNB1, KAT6A and KAT6B (By similarity). Interacts with HIVEP3. Interacts with IFI204. Interaction with SATB2; the interaction results in enhanced DNA binding and transactivation by these transcription factors. Binds to HIPK3. Interacts (isoform 3) with DDX5. Interacts with FOXO1 (via a C-terminal region); the interaction inhibits RUNX2 transcriptional activity towards BGLAP. Interacts with FOXP3 (By similarity). Interacts with TMEM119 (PubMed:21239498). Interacts with OLFM2 (By similarity).By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198518, 21 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q08775

Database of interacting proteins

More...
DIPi
DIP-36316N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q08775

Protein interaction database and analysis system

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IntActi
Q08775, 13 interactors

Molecular INTeraction database

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MINTi
Q08775

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109202

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q08775

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini187 – 315RuntPROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 88Interaction with IFI2041 PublicationAdd BLAST88
Regioni242 – 258Required for interaction with FOXO11 PublicationAdd BLAST17
Regioni422 – 525Interaction with KAT6ABy similarityAdd BLAST104
Regioni460 – 554Interaction with KAT6BBy similarityAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi128 – 156Poly-GlnAdd BLAST29
Compositional biasi158 – 175Poly-AlaAdd BLAST18
Compositional biasi323 – 607Pro/Ser/Thr-richAdd BLAST285

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and contains the phosphorylation sites.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3982 Eukaryota
ENOG4111J4Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160171

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q08775

KEGG Orthology (KO)

More...
KOi
K09278

Database of Orthologous Groups

More...
OrthoDBi
562214at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08775

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.720, 1 hit
4.10.770.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000040 AML1_Runt
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR013524 Runt_dom
IPR027384 Runx_central_dom_sf
IPR013711 RunxI_C_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11950 PTHR11950, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00853 Runt, 1 hit
PF08504 RunxI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00967 ONCOGENEAML1

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417 SSF49417, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51062 RUNT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 9 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08775-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLHSPHKQPQ NHKCGANFLQ EDCKKALAFK WLISAGHYQP PRPTESVSAL
60 70 80 90 100
TTVHAGIFKA ASSIYNRGHK FYLEKKGGTM ASNSLFSAVT PCQQSFFWDP
110 120 130 140 150
STSRRFSPPS SSLQPGKMSD VSPVVAAQQQ QQQQQQQQQQ QQQQQQQQQQ
160 170 180 190 200
QQQQQQEAAA AAAAAAAAAA AAAAAVPRLR PPHDNRTMVE IIADHPAELV
210 220 230 240 250
RTDSPNFLCS VLPSHWRCNK TLPVAFKVVA LGEVPDGTVV TVMAGNDENY
260 270 280 290 300
SAELRNASAV MKNQVARFND LRFVGRSGRG KSFTLTITVF TNPPQVATYH
310 320 330 340 350
RAIKVTVDGP REPRRHRQKL DDSKPSLFSD RLSDLGRIPH PSMRVGVPPQ
360 370 380 390 400
NPRPSLNSAP SPFNPQGQSQ ITDPRQAQSS PPWSYDQSYP SYLSQMTSPS
410 420 430 440 450
IHSTTPLSST RGTGLPAITD VPRRISDDDT ATSDFCLWPS SLSKKSQAGA
460 470 480 490 500
SELGPFSDPR QFPSISSLTE SRFSNPRMHY PATFTYTPPV TSGMSLGMSA
510 520 530 540 550
TTHYHTYLPP PYPGSSQSQS GPFQTSSTPY LYYGTSSASY QFPMVPGGDR
560 570 580 590 600
SPSRMVPPCT TTSNGSTLLN PNLPNQNDGV DADGSHSSSP TVLNSSGRMD

ESVWRPY
Length:607
Mass (Da):66,205
Last modified:November 2, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE87A4497ED19EE0E
GO
Isoform 2 (identifier: Q08775-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-57: Missing.

Show »
Length:596
Mass (Da):65,154
Checksum:i3365DB4F7F199BA0
GO
Isoform 3 (identifier: Q08775-3) [UniParc]FASTAAdd to basket
Also known as: PEBP2-alpha A1

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: MLHSPHKQPQ...VTPCQQSFFW → MRIPV
     156-156: Missing.

Show »
Length:513
Mass (Da):55,752
Checksum:iEAF92506819B2D28
GO
Isoform 4 (identifier: Q08775-4) [UniParc]FASTAAdd to basket
Also known as: PEBP2-alpha A2

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: MLHSPHKQPQ...VTPCQQSFFW → MRIPV
     156-156: Missing.
     399-400: PS → LS
     401-607: Missing.

Show »
Length:306
Mass (Da):33,599
Checksum:i0CF6BFF4B8CD4DBB
GO
Isoform 5 (identifier: Q08775-5) [UniParc]FASTAAdd to basket
Also known as: G1

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:528
Mass (Da):57,417
Checksum:i1675D3EA1CB5D4EE
GO
Isoform 6 (identifier: Q08775-6) [UniParc]FASTAAdd to basket
Also known as: G2

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     316-373: Missing.

Show »
Length:470
Mass (Da):51,032
Checksum:iE77D395B48886713
GO
Isoform 7 (identifier: Q08775-7) [UniParc]FASTAAdd to basket
Also known as: U1

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     427-439: DDDTATSDFCLWP → GFCGTTTTTTTKL
     440-607: Missing.

Show »
Length:360
Mass (Da):39,277
Checksum:i38F2DE7E6AC8747C
GO
Isoform 8 (identifier: Q08775-8) [UniParc]FASTAAdd to basket
Also known as: Y1

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     428-607: DDTATSDFCL...RMDESVWRPY → SEPSTLDSQS...QPVPEAPDAN

Show »
Length:548
Mass (Da):58,669
Checksum:iC05C800013B5A912
GO
Isoform 9 (identifier: Q08775-9) [UniParc]FASTAAdd to basket
Also known as: Y2

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     316-373: Missing.
     428-607: DDTATSDFCL...RMDESVWRPY → SEPSTLDSQS...QPVPEAPDAN

Show »
Length:490
Mass (Da):52,285
Checksum:i86043D899DFA524F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHN7F8WHN7_MOUSE
Runt-related transcription factor
Runx2
514Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CY45E0CY45_MOUSE
Runt-related transcription factor
Runx2
492Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PUK7E9PUK7_MOUSE
Runt-related transcription factor
Runx2
506Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CZ12E0CZ12_MOUSE
Runt-related transcription factor
Runx2
421Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CZC6E0CZC6_MOUSE
Runt-related transcription factor 2
Runx2
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CZB5F7CZB5_MOUSE
Runt-related transcription factor 2
Runx2
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TRA6F6TRA6_MOUSE
Runt-related transcription factor 2
Runx2
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CN98F7CN98_MOUSE
Runt-related transcription factor 2
Runx2
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q1PAG7Q1PAG7_MOUSE
Runt-related transcription factor 2
Runx2
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti266A → S in AAC78626 (PubMed:9651525).Curated1
Sequence conflicti280G → S in AAC78626 (PubMed:9651525).Curated1
Sequence conflicti373D → N in AAC78626 (PubMed:9651525).Curated1
Sequence conflicti375R → T in AAC78626 (PubMed:9651525).Curated1
Sequence conflicti396M → L in AAC78626 (PubMed:9651525).Curated1
Sequence conflicti459P → L in AAC78626 (PubMed:9651525).Curated1
Sequence conflicti472R → P in AAC78626 (PubMed:9651525).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0059401 – 98MLHSP…QSFFW → MRIPV in isoform 3 and isoform 4. 2 PublicationsAdd BLAST98
Alternative sequenceiVSP_0059391 – 79Missing in isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_00594147 – 57Missing in isoform 2. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_005942156Missing in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_005943316 – 373Missing in isoform 6 and isoform 9. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_005944399 – 400PS → LS in isoform 4. 2 Publications2
Alternative sequenceiVSP_005945401 – 607Missing in isoform 4. 2 PublicationsAdd BLAST207
Alternative sequenceiVSP_005946427 – 439DDDTA…FCLWP → GFCGTTTTTTTKL in isoform 7. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_005947428 – 607DDTAT…VWRPY → SEPSTLDSQSSTTLFLSSEE PGPSTAALPSPSSSCEPQPF SPSPMLPPLLQPLSTASTVP APCVPRRTGLYTIVTSSPEA APHLVDWMPSCPTATSPGVR GKDHERPQTMMAPAPALASE RGHSQHAGPARDDHAEHPGT SPKPCAPPAAAATLEASVGD ILVELRTMNGHLDIIAKALT KLASSLVPQSQPVPEAPDAN in isoform 8 and isoform 9. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_005948440 – 607Missing in isoform 7. 1 PublicationAdd BLAST168

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D14636 mRNA Translation: BAA03485.1
D14637 mRNA Translation: BAA03486.1
AF010284 mRNA Translation: AAB65409.1
AF005936 mRNA Translation: AAB82419.1
AF053948 Genomic DNA Translation: AAC77440.1
AF053951 mRNA Translation: AAC78623.1
AF053956 mRNA Translation: AAC78626.1
AF134836 Genomic DNA Translation: AAF22568.1
AF134836 Genomic DNA Translation: AAF22569.1
AB013129 Genomic DNA Translation: BAA85345.1
AB013129 Genomic DNA Translation: BAA85346.1
AH009404 Genomic DNA Translation: AAF73290.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37624.2 [Q08775-5]

Protein sequence database of the Protein Information Resource

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PIRi
A48233

NCBI Reference Sequences

More...
RefSeqi
NP_001139510.1, NM_001146038.2 [Q08775-5]
NP_001258556.1, NM_001271627.1 [Q08775-5]
NP_033950.2, NM_009820.5 [Q08775-5]
XP_006523607.1, XM_006523544.2 [Q08775-1]
XP_006523608.1, XM_006523545.2 [Q08775-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000113571; ENSMUSP00000109201; ENSMUSG00000039153 [Q08775-5]
ENSMUST00000159943; ENSMUSP00000124918; ENSMUSG00000039153 [Q08775-5]
ENSMUST00000160673; ENSMUSP00000123743; ENSMUSG00000039153 [Q08775-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
12393

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12393

UCSC genome browser

More...
UCSCi
uc008cpy.3 mouse [Q08775-6]
uc008cqa.3 mouse [Q08775-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14636 mRNA Translation: BAA03485.1
D14637 mRNA Translation: BAA03486.1
AF010284 mRNA Translation: AAB65409.1
AF005936 mRNA Translation: AAB82419.1
AF053948 Genomic DNA Translation: AAC77440.1
AF053951 mRNA Translation: AAC78623.1
AF053956 mRNA Translation: AAC78626.1
AF134836 Genomic DNA Translation: AAF22568.1
AF134836 Genomic DNA Translation: AAF22569.1
AB013129 Genomic DNA Translation: BAA85345.1
AB013129 Genomic DNA Translation: BAA85346.1
AH009404 Genomic DNA Translation: AAF73290.1
CCDSiCCDS37624.2 [Q08775-5]
PIRiA48233
RefSeqiNP_001139510.1, NM_001146038.2 [Q08775-5]
NP_001258556.1, NM_001271627.1 [Q08775-5]
NP_033950.2, NM_009820.5 [Q08775-5]
XP_006523607.1, XM_006523544.2 [Q08775-1]
XP_006523608.1, XM_006523545.2 [Q08775-2]

3D structure databases

SMRiQ08775
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198518, 21 interactors
CORUMiQ08775
DIPiDIP-36316N
ELMiQ08775
IntActiQ08775, 13 interactors
MINTiQ08775
STRINGi10090.ENSMUSP00000109202

Chemistry databases

ChEMBLiCHEMBL1681609

PTM databases

iPTMnetiQ08775
PhosphoSitePlusiQ08775

Proteomic databases

MaxQBiQ08775
PaxDbiQ08775
PeptideAtlasiQ08775
PRIDEiQ08775

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113571; ENSMUSP00000109201; ENSMUSG00000039153 [Q08775-5]
ENSMUST00000159943; ENSMUSP00000124918; ENSMUSG00000039153 [Q08775-5]
ENSMUST00000160673; ENSMUSP00000123743; ENSMUSG00000039153 [Q08775-2]
GeneIDi12393
KEGGimmu:12393
UCSCiuc008cpy.3 mouse [Q08775-6]
uc008cqa.3 mouse [Q08775-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
860
MGIiMGI:99829 Runx2

Phylogenomic databases

eggNOGiKOG3982 Eukaryota
ENOG4111J4Y LUCA
GeneTreeiENSGT00940000160171
InParanoidiQ08775
KOiK09278
OrthoDBi562214at2759
PhylomeDBiQ08775

Enzyme and pathway databases

ReactomeiR-MMU-8878166 Transcriptional regulation by RUNX2
R-MMU-8939902 Regulation of RUNX2 expression and activity
R-MMU-8940973 RUNX2 regulates osteoblast differentiation
R-MMU-8941326 RUNX2 regulates bone development

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Runx2 mouse

Protein Ontology

More...
PROi
PR:Q08775

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039153 Expressed in 286 organ(s), highest expression level in hindlimb long bone
ExpressionAtlasiQ08775 baseline and differential
GenevisibleiQ08775 MM

Family and domain databases

Gene3Di2.60.40.720, 1 hit
4.10.770.10, 1 hit
InterProiView protein in InterPro
IPR000040 AML1_Runt
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR013524 Runt_dom
IPR027384 Runx_central_dom_sf
IPR013711 RunxI_C_dom
PANTHERiPTHR11950 PTHR11950, 1 hit
PfamiView protein in Pfam
PF00853 Runt, 1 hit
PF08504 RunxI, 1 hit
PRINTSiPR00967 ONCOGENEAML1
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS51062 RUNT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRUNX2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08775
Secondary accession number(s): O35183
, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: May 8, 2019
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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