The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q08760 (RAX1_YEAST)
Protein
Bud site selection protein RAX1
Gene
RAX1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for the establishment of the bipolar budding pattern. Involved in selecting bud sites at both the distal and proximal poles of daughter cells as well as near previously used division sites on mother cells. Has a role in the localization of BUD8, the distal bipolar budding landmark, and of BUD9, the proximal pole landmark.
1 PublicationGO - Biological processi
- axial cellular bud site selection Source: SGD
- bipolar cellular bud site selection Source: SGD
- cellular protein localization Source: SGD
- protein localization Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
Reactomei | R-SCE-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: Bud site selection protein RAX1Alternative name(s): Revert to axial protein 1 |
Gene namesi | Name:RAX1 Ordered Locus Names:YOR301W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005827, RAX1 |
VEuPathDBi | FungiDB:YOR301W |
Subcellular locationi
Plasma membrane
Other locations
Note: Before cytokinesis, RAX1 concentrates as a ring at the mother-bud neck and to the tip of the bud. The RAX1 ring splits at cytokinesis, endowing each progeny cell with a RAX1 ring and additional RAX1 localization at the distal bud pole of the newborn daughter cell. The rings persist at the cell cortex for several generations, giving rise to cells decorated by multiple rings.
Cell Wall
- cellular bud scar Source: SGD
Plasma Membrane
- plasma membrane Source: GO_Central
Vacuole
- fungal-type vacuole Source: SGD
Other locations
- cellular bud neck Source: SGD
- cellular bud tip Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 297 | CytoplasmicSequence analysisAdd BLAST | 297 | |
Transmembranei | 298 – 318 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 319 – 325 | ExtracellularSequence analysis | 7 | |
Transmembranei | 326 – 346 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 347 – 409 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 410 – 430 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 431 – 435 | ExtracellularSequence analysis | 5 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000262736 | 1 – 435 | Bud site selection protein RAX1Add BLAST | 435 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 167 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q08760 |
PaxDbi | Q08760 |
PRIDEi | Q08760 |
PTM databases
iPTMneti | Q08760 |
Interactioni
Subunit structurei
Interacts with BUD8, BUD9 and RAX2.
1 PublicationProtein-protein interaction databases
BioGRIDi | 34689, 82 interactors |
IntActi | Q08760, 4 interactors |
MINTi | Q08760 |
STRINGi | 4932.YOR301W |
Miscellaneous databases
RNActi | Q08760, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q08760 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 126 – 257 | RGSAdd BLAST | 132 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRI8, Eukaryota |
GeneTreei | ENSGT00390000015077 |
HOGENOMi | CLU_029881_1_1_1 |
InParanoidi | Q08760 |
OMAi | VYSWFGV |
Family and domain databases
Gene3Di | 1.10.167.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR036305, RGS_sf IPR044926, RGS_subdomain_2 |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08760-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKEELSKVSS MQNFEMIQRE RLPTLYEVLI QRTSQPVDLW TFYTFLSQFP
60 70 80 90 100
YAINYLDFWV DLMTHTRLCK NYIELVRKSL INFPQEQQQN GSTSTATFDL
110 120 130 140 150
LNALIEEGHL DPEAPDKLLE NSGPDVPFSP KLNELLGDWK HQSGIGQEAL
160 170 180 190 200
RNEDVALIVD EIMKRRSQQD GKPQITTKQL LHSAVGLCNT YLVSPEQSER
210 220 230 240 250
YLSNIPMETR NRIIESVQIE RKYDIEIFDD LKNLTYQFLE MDCFPKFLSR
260 270 280 290 300
VALHNIHDEI SDWRFHSVGV TNEKSNRSRG QTHISRSPFS NHTSISRIGF
310 320 330 340 350
GLLWLGIGFW IGYVLIFLAY SRAIRVVTVV PFTLGCYCIV CGMYQVDIVY
360 370 380 390 400
SWFGVTQRLL HRHKNAGNDE GDASSDTDHV PMILAVFGGR RRLTRIEHPF
410 420 430
TRQLLRKRGL WCLLLVVGAT AAFTVIFSCV PGRRV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z75209 Genomic DNA Translation: CAA99619.1 BK006948 Genomic DNA Translation: DAA11066.1 |
PIRi | S67205 |
RefSeqi | NP_014945.3, NM_001183720.3 |
Genome annotation databases
EnsemblFungii | YOR301W_mRNA; YOR301W; YOR301W |
GeneIDi | 854477 |
KEGGi | sce:YOR301W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z75209 Genomic DNA Translation: CAA99619.1 BK006948 Genomic DNA Translation: DAA11066.1 |
PIRi | S67205 |
RefSeqi | NP_014945.3, NM_001183720.3 |
3D structure databases
AlphaFoldDBi | Q08760 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 34689, 82 interactors |
IntActi | Q08760, 4 interactors |
MINTi | Q08760 |
STRINGi | 4932.YOR301W |
PTM databases
iPTMneti | Q08760 |
Proteomic databases
MaxQBi | Q08760 |
PaxDbi | Q08760 |
PRIDEi | Q08760 |
Genome annotation databases
EnsemblFungii | YOR301W_mRNA; YOR301W; YOR301W |
GeneIDi | 854477 |
KEGGi | sce:YOR301W |
Organism-specific databases
SGDi | S000005827, RAX1 |
VEuPathDBi | FungiDB:YOR301W |
Phylogenomic databases
eggNOGi | ENOG502QRI8, Eukaryota |
GeneTreei | ENSGT00390000015077 |
HOGENOMi | CLU_029881_1_1_1 |
InParanoidi | Q08760 |
OMAi | VYSWFGV |
Enzyme and pathway databases
Reactomei | R-SCE-983231, Factors involved in megakaryocyte development and platelet production |
Miscellaneous databases
PROi | PR:Q08760 |
RNActi | Q08760, protein |
Family and domain databases
Gene3Di | 1.10.167.10, 1 hit |
InterProi | View protein in InterPro IPR016137, RGS IPR036305, RGS_sf IPR044926, RGS_subdomain_2 |
SMARTi | View protein in SMART SM00315, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RAX1_YEAST | |
Accessioni | Q08760Primary (citable) accession number: Q08760 Secondary accession number(s): D6W300 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names