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Protein

Lithostathine-2

Gene

Reg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might act as an inhibitor of spontaneous calcium carbonate precipitation.

GO - Molecular functioni

  • oligosaccharide binding Source: GO_Central
  • peptidoglycan binding Source: GO_Central
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

LigandLectin

Protein family/group databases

MEROPSiI63.002

Names & Taxonomyi

Protein namesi
Recommended name:
Lithostathine-2
Alternative name(s):
Islet of Langerhans regenerating protein 2
Short name:
REG-2
Pancreatic stone protein 2
Short name:
PSP
Pancreatic thread protein 2
Short name:
PTP
Gene namesi
Name:Reg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:97896 Reg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001742723 – 173Lithostathine-2Add BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 54PROSITE-ProRule annotation
Disulfide bondi71 ↔ 169PROSITE-ProRule annotation
Disulfide bondi144 ↔ 161PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ08731
PeptideAtlasiQ08731
PRIDEiQ08731

PTM databases

iPTMnetiQ08731
PhosphoSitePlusiQ08731

Expressioni

Tissue specificityi

Expressed only in regenerating islets and normal exocrine pancreas, but not in normal pancreatic islets. Expressed strongly in pancreas, weakly in liver, but not at all in gall bladder.

Gene expression databases

BgeeiENSMUSG00000023140 Expressed in 30 organ(s), highest expression level in stomach
CleanExiMM_REG2
ExpressionAtlasiQ08731 baseline and differential
GenevisibleiQ08731 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023906

Structurei

3D structure databases

ProteinModelPortaliQ08731
SMRiQ08731
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 171C-type lectinPROSITE-ProRule annotationAdd BLAST131

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ08731
OMAiYCYYFME
OrthoDBiEOG091G0OLC
PhylomeDBiQ08731

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q08731-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQNNVYLIL FLCLMFLSYS QGQVAEEDFP LAEKDLPSAK INCPEGANAY
60 70 80 90 100
GSYCYYLIED RLTWGEADLF CQNMNAGHLV SILSQAESNF VASLVKESGT
110 120 130 140 150
TASNVWTGLH DPKSNRRWHW SSGSLFLFKS WATGAPSTAN RGYCVSLTSN
160 170
TAYKKWKDEN CEAQYSFVCK FRA
Length:173
Mass (Da):19,407
Last modified:November 1, 1995 - v1
Checksum:i7D34C4DAB232F25C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SVN9A0A0N4SVN9_MOUSE
Lithostathine-2
Reg2
131Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14011 Genomic DNA Translation: BAA03112.1
CCDSiCCDS20256.1
PIRiB47148
RefSeqiNP_033069.1, NM_009043.1
UniGeneiMm.46360

Genome annotation databases

EnsembliENSMUST00000023906; ENSMUSP00000023906; ENSMUSG00000023140
GeneIDi19693
KEGGimmu:19693
UCSCiuc009cjz.1 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Litho/Reg 1beta

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14011 Genomic DNA Translation: BAA03112.1
CCDSiCCDS20256.1
PIRiB47148
RefSeqiNP_033069.1, NM_009043.1
UniGeneiMm.46360

3D structure databases

ProteinModelPortaliQ08731
SMRiQ08731
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023906

Protein family/group databases

MEROPSiI63.002

PTM databases

iPTMnetiQ08731
PhosphoSitePlusiQ08731

Proteomic databases

PaxDbiQ08731
PeptideAtlasiQ08731
PRIDEiQ08731

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023906; ENSMUSP00000023906; ENSMUSG00000023140
GeneIDi19693
KEGGimmu:19693
UCSCiuc009cjz.1 mouse

Organism-specific databases

CTDi19693
MGIiMGI:97896 Reg2

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ08731
OMAiYCYYFME
OrthoDBiEOG091G0OLC
PhylomeDBiQ08731

Miscellaneous databases

PROiPR:Q08731
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023140 Expressed in 30 organ(s), highest expression level in stomach
CleanExiMM_REG2
ExpressionAtlasiQ08731 baseline and differential
GenevisibleiQ08731 MM

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIT2_MOUSE
AccessioniPrimary (citable) accession number: Q08731
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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