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Protein

Leukocyte surface antigen CD47

Gene

CD47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q08722

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.N.1.1.1 the osteoclast fusion complex (ofc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte surface antigen CD47
Alternative name(s):
Antigenic surface determinant protein OA3
Integrin-associated protein
Short name:
IAP
Protein MER6
CD_antigen: CD47
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD47
Synonyms:MER6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196776.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1682 CD47

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601028 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08722

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 141ExtracellularSequence analysisAdd BLAST123
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 176CytoplasmicSequence analysisAdd BLAST14
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 207ExtracellularSequence analysis10
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 235CytoplasmicSequence analysis7
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 268ExtracellularSequence analysisAdd BLAST12
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 323CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
961

Open Targets

More...
OpenTargetsi
ENSG00000196776

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26222

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3714583

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD47

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1171879

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001488019 – 323Leukocyte surface antigen CD47Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi23N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 2631 Publication
Glycosylationi34N-linked (GlcNAc...) asparagine1
Disulfide bondi41 ↔ 1141 Publication
Glycosylationi50N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi73N-linked (GlcNAc...) asparagine3 Publications1
Modified residuei89PhosphoserineBy similarity1
Glycosylationi111N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q08722

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q08722

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q08722

PeptideAtlas

More...
PeptideAtlasi
Q08722

PRoteomics IDEntifications database

More...
PRIDEi
Q08722

ProteomicsDB human proteome resource

More...
ProteomicsDBi
58643
58644 [Q08722-2]
58645 [Q08722-3]
58646 [Q08722-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1456

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q08722

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q08722

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q08722

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196776 Expressed in 230 organ(s), highest expression level in visceral pleura

CleanEx database of gene expression profiles

More...
CleanExi
HS_CD47

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q08722 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q08722 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016055
HPA044659

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107399, 26 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q08722

Database of interacting proteins

More...
DIPi
DIP-39948N

Protein interaction database and analysis system

More...
IntActi
Q08722, 12 interactors

Molecular INTeraction database

More...
MINTi
Q08722

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355361

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q08722

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q08722

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q08722

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 127Ig-like V-typeAdd BLAST109

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJTS Eukaryota
ENOG41113GI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007697

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013020

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG003808

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q08722

KEGG Orthology (KO)

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KOi
K06266

Identification of Orthologs from Complete Genome Data

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OMAi
WGQFGIV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0HUR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q08722

TreeFam database of animal gene trees

More...
TreeFami
TF336026

Family and domain databases

Conserved Domains Database

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CDDi
cd16090 IgV_CD47, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006704 CD47
IPR013147 CD47_TM
IPR013270 CD47_Vset
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR037805 IgV_CD47

The PANTHER Classification System

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PANTHERi
PTHR10613 PTHR10613, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04549 CD47, 1 hit
PF08204 V-set_CD47, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform OA3-323 (identifier: Q08722-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN
60 70 80 90 100
TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM
110 120 130 140 150
DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI
160 170 180 190 200
FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG
210 220 230 240 250
EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI
260 270 280 290 300
LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ
310 320
PPRKAVEEPL NAFKESKGMM NDE
Length:323
Mass (Da):35,214
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D20730A2632D550
GO
Isoform OA3-293 (identifier: Q08722-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-323: Missing.

Show »
Length:292
Mass (Da):31,743
Checksum:i81A2F6696D11F4E1
GO
Isoform OA3-305 (identifier: Q08722-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-305: KA → NN
     306-323: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:305
Mass (Da):33,192
Checksum:i145DD178068F8DBD
GO
Isoform OA3-312 (identifier: Q08722-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-323: Missing.

Show »
Length:311
Mass (Da):33,845
Checksum:i8BBBB21A590D4DCA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC40H0YC40_HUMAN
Leukocyte surface antigen CD47
CD47
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y484A0A2R8Y484_HUMAN
Leukocyte surface antigen CD47
CD47
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYS8H7BYS8_HUMAN
Leukocyte surface antigen CD47
CD47
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002535293 – 323Missing in isoform OA3-293. CuratedAdd BLAST31
Alternative sequenceiVSP_002536304 – 305KA → NN in isoform OA3-305. 3 Publications2
Alternative sequenceiVSP_002537306 – 323Missing in isoform OA3-305. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_002538312 – 323Missing in isoform OA3-312. CuratedAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X69398 mRNA Translation: CAA49196.1
Z25521 mRNA Translation: CAA80977.1
BT006907 mRNA Translation: AAP35553.1
AK289813 mRNA Translation: BAF82502.1
CH471052 Genomic DNA Translation: EAW79733.1
CH471052 Genomic DNA Translation: EAW79734.1
BC010016 mRNA Translation: AAH10016.1
BC012884 mRNA Translation: AAH12884.1
BC037306 mRNA Translation: AAH37306.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43125.1 [Q08722-3]
CCDS43126.1 [Q08722-1]

Protein sequence database of the Protein Information Resource

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PIRi
A48997

NCBI Reference Sequences

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RefSeqi
NP_001768.1, NM_001777.3 [Q08722-1]
NP_942088.1, NM_198793.2 [Q08722-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.446414

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000355354; ENSP00000347512; ENSG00000196776 [Q08722-3]
ENST00000361309; ENSP00000355361; ENSG00000196776 [Q08722-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
961

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:961

UCSC genome browser

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UCSCi
uc003dwt.2 human [Q08722-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69398 mRNA Translation: CAA49196.1
Z25521 mRNA Translation: CAA80977.1
BT006907 mRNA Translation: AAP35553.1
AK289813 mRNA Translation: BAF82502.1
CH471052 Genomic DNA Translation: EAW79733.1
CH471052 Genomic DNA Translation: EAW79734.1
BC010016 mRNA Translation: AAH10016.1
BC012884 mRNA Translation: AAH12884.1
BC037306 mRNA Translation: AAH37306.1
CCDSiCCDS43125.1 [Q08722-3]
CCDS43126.1 [Q08722-1]
PIRiA48997
RefSeqiNP_001768.1, NM_001777.3 [Q08722-1]
NP_942088.1, NM_198793.2 [Q08722-3]
UniGeneiHs.446414

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJSX-ray1.85C/D20-136[»]
2JJTX-ray2.30C/D20-136[»]
2VSCX-ray1.90A/B/C/D20-136[»]
4CMMX-ray1.92B20-136[»]
4KJYX-ray1.93A/C19-135[»]
5IWLX-ray2.80C/D20-132[»]
5TZ2X-ray2.30C19-141[»]
5TZTX-ray2.89C/D20-141[»]
5TZUX-ray2.10C19-141[»]
ProteinModelPortaliQ08722
SMRiQ08722
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107399, 26 interactors
CORUMiQ08722
DIPiDIP-39948N
IntActiQ08722, 12 interactors
MINTiQ08722
STRINGi9606.ENSP00000355361

Chemistry databases

ChEMBLiCHEMBL3714583

Protein family/group databases

TCDBi1.N.1.1.1 the osteoclast fusion complex (ofc) family

PTM databases

GlyConnecti1456
iPTMnetiQ08722
PhosphoSitePlusiQ08722
SwissPalmiQ08722

Polymorphism and mutation databases

BioMutaiCD47
DMDMi1171879

Proteomic databases

EPDiQ08722
MaxQBiQ08722
PaxDbiQ08722
PeptideAtlasiQ08722
PRIDEiQ08722
ProteomicsDBi58643
58644 [Q08722-2]
58645 [Q08722-3]
58646 [Q08722-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
961
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355354; ENSP00000347512; ENSG00000196776 [Q08722-3]
ENST00000361309; ENSP00000355361; ENSG00000196776 [Q08722-1]
GeneIDi961
KEGGihsa:961
UCSCiuc003dwt.2 human [Q08722-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
961
DisGeNETi961
EuPathDBiHostDB:ENSG00000196776.14

GeneCards: human genes, protein and diseases

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GeneCardsi
CD47
HGNCiHGNC:1682 CD47
HPAiCAB016055
HPA044659
MIMi601028 gene
neXtProtiNX_Q08722
OpenTargetsiENSG00000196776
PharmGKBiPA26222

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJTS Eukaryota
ENOG41113GI LUCA
GeneTreeiENSGT00390000007697
HOGENOMiHOG000013020
HOVERGENiHBG003808
InParanoidiQ08722
KOiK06266
OMAiWGQFGIV
OrthoDBiEOG091G0HUR
PhylomeDBiQ08722
TreeFamiTF336026

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-6798695 Neutrophil degranulation
SIGNORiQ08722

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CD47 human
EvolutionaryTraceiQ08722

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD47

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
961

Protein Ontology

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PROi
PR:Q08722

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196776 Expressed in 230 organ(s), highest expression level in visceral pleura
CleanExiHS_CD47
ExpressionAtlasiQ08722 baseline and differential
GenevisibleiQ08722 HS

Family and domain databases

CDDicd16090 IgV_CD47, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR006704 CD47
IPR013147 CD47_TM
IPR013270 CD47_Vset
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR037805 IgV_CD47
PANTHERiPTHR10613 PTHR10613, 1 hit
PfamiView protein in Pfam
PF04549 CD47, 1 hit
PF08204 V-set_CD47, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD47_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08722
Secondary accession number(s): A8K198
, D3DN59, Q53Y71, Q96A60
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 5, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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