UniProtKB - Q08722 (CD47_HUMAN)
Leukocyte surface antigen CD47
CD47
Functioni
GO - Molecular functioni
- cell-cell adhesion mediator activity Source: ARUK-UCL
- protein binding involved in heterotypic cell-cell adhesion Source: ARUK-UCL
- thrombospondin receptor activity Source: BHF-UCL
GO - Biological processi
- ATP export Source: ARUK-UCL
- cell migration Source: ARUK-UCL
- cellular response to interferon-gamma Source: ARUK-UCL
- cellular response to interleukin-1 Source: ARUK-UCL
- cellular response to interleukin-12 Source: ARUK-UCL
- extracellular matrix organization Source: Reactome
- integrin-mediated signaling pathway Source: ProtInc
- leukocyte migration Source: Reactome
- monocyte extravasation Source: ARUK-UCL
- negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Source: ARUK-UCL
- neutrophil degranulation Source: Reactome
- positive regulation of cell-cell adhesion Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of inflammatory response Source: GO_Central
- positive regulation of phagocytosis Source: GO_Central
- positive regulation of stress fiber assembly Source: ARUK-UCL
- positive regulation of T cell activation Source: UniProtKB
- regulation of interferon-gamma production Source: ARUK-UCL
- regulation of interleukin-10 production Source: ARUK-UCL
- regulation of interleukin-12 production Source: ARUK-UCL
- regulation of interleukin-6 production Source: ARUK-UCL
- regulation of nitric oxide biosynthetic process Source: ARUK-UCL
- regulation of tumor necrosis factor production Source: ARUK-UCL
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q08722 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-216083, Integrin cell surface interactions R-HSA-391160, Signal regulatory protein family interactions R-HSA-6798695, Neutrophil degranulation |
SIGNORi | Q08722 |
Protein family/group databases
TCDBi | 1.N.1.1.1, the osteoclast fusion complex (ofc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte surface antigen CD47Alternative name(s): Antigenic surface determinant protein OA3 Integrin-associated protein Short name: IAP Protein MER6 CD_antigen: CD47 |
Gene namesi | Name:CD47 Synonyms:MER6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1682, CD47 |
MIMi | 601028, gene |
neXtProti | NX_Q08722 |
VEuPathDBi | HostDB:ENSG00000196776.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Extracellular region or secreted
- extracellular exosome Source: GO_Central
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- cell surface Source: ARUK-UCL
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 141 | ExtracellularSequence analysisAdd BLAST | 123 | |
Transmembranei | 142 – 162 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 176 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 177 – 197 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 198 – 207 | ExtracellularSequence analysis | 10 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 229 – 235 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 236 – 256 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 268 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 290 – 323 | CytoplasmicSequence analysisAdd BLAST | 34 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 961 |
OpenTargetsi | ENSG00000196776 |
PharmGKBi | PA26222 |
Miscellaneous databases
Pharosi | Q08722, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3714583 |
Genetic variation databases
BioMutai | CD47 |
DMDMi | 1171879 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000014880 | 19 – 323 | Leukocyte surface antigen CD47Add BLAST | 305 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Glycosylationi | 23 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 33 ↔ 263 | 1 Publication | ||
Glycosylationi | 34 | N-linked (GlcNAc...) asparagine | 1 | |
Disulfide bondi | 41 ↔ 114 | 1 Publication | ||
Glycosylationi | 50 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 73 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Modified residuei | 89 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 111 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 206 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acidProteomic databases
EPDi | Q08722 |
jPOSTi | Q08722 |
MassIVEi | Q08722 |
MaxQBi | Q08722 |
PaxDbi | Q08722 |
PeptideAtlasi | Q08722 |
PRIDEi | Q08722 |
ProteomicsDBi | 58643 [Q08722-1] 58644 [Q08722-2] 58645 [Q08722-3] 58646 [Q08722-4] |
PTM databases
GlyConnecti | 1456, 18 N-Linked glycans (1 site) |
GlyGeni | Q08722, 6 sites, 2 N-linked glycans (1 site) |
iPTMneti | Q08722 |
PhosphoSitePlusi | Q08722 |
SwissPalmi | Q08722 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000196776, Expressed in visceral pleura and 242 other tissues |
ExpressionAtlasi | Q08722, baseline and differential |
Genevisiblei | Q08722, HS |
Organism-specific databases
HPAi | ENSG00000196776, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with THBS1 and fibrinogen (By similarity). Monomer.
Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.
By similarity4 PublicationsBinary interactionsi
Hide detailsQ08722
With | #Exp. | IntAct |
---|---|---|
SIRPG [Q9P1W8] | 2 | EBI-1268321,EBI-1268284 |
SYNE4 [Q8N205] | 3 | EBI-1268321,EBI-7131783 |
Isoform OA3-305 [Q08722-3]
GO - Molecular functioni
- cell-cell adhesion mediator activity Source: ARUK-UCL
- protein binding involved in heterotypic cell-cell adhesion Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 107399, 36 interactors |
CORUMi | Q08722 |
DIPi | DIP-39948N |
IntActi | Q08722, 31 interactors |
MINTi | Q08722 |
STRINGi | 9606.ENSP00000355361 |
Chemistry databases
BindingDBi | Q08722 |
Miscellaneous databases
RNActi | Q08722, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q08722 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q08722 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 127 | Ig-like V-typeAdd BLAST | 109 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYTQ, Eukaryota |
GeneTreei | ENSGT00390000007697 |
HOGENOMi | CLU_860392_0_0_1 |
InParanoidi | Q08722 |
OMAi | AEMWPLV |
OrthoDBi | 1287706at2759 |
PhylomeDBi | Q08722 |
TreeFami | TF336026 |
Family and domain databases
CDDi | cd16090, IgV_CD47, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR006704, CD47 IPR013147, CD47_TM IPR013270, CD47_Vset IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR037805, IgV_CD47 |
PANTHERi | PTHR10613, PTHR10613, 1 hit |
Pfami | View protein in Pfam PF04549, CD47, 1 hit PF08204, V-set_CD47, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN
60 70 80 90 100
TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM
110 120 130 140 150
DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI
160 170 180 190 200
FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG
210 220 230 240 250
EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI
260 270 280 290 300
LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ
310 320
PPRKAVEEPL NAFKESKGMM NDE
The sequence of this isoform differs from the canonical sequence as follows:
293-323: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
304-305: KA → NN
306-323: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
312-323: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y484 | A0A2R8Y484_HUMAN | Integrin-associated protein | CD47 | 183 | Annotation score: | ||
H0YC40 | H0YC40_HUMAN | Leukocyte surface antigen CD47 | CD47 | 109 | Annotation score: | ||
H7BYS8 | H7BYS8_HUMAN | Leukocyte surface antigen CD47 | CD47 | 86 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002535 | 293 – 323 | Missing in isoform OA3-293. CuratedAdd BLAST | 31 | |
Alternative sequenceiVSP_002536 | 304 – 305 | KA → NN in isoform OA3-305. 3 Publications | 2 | |
Alternative sequenceiVSP_002537 | 306 – 323 | Missing in isoform OA3-305. 3 PublicationsAdd BLAST | 18 | |
Alternative sequenceiVSP_002538 | 312 – 323 | Missing in isoform OA3-312. CuratedAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69398 mRNA Translation: CAA49196.1 Z25521 mRNA Translation: CAA80977.1 BT006907 mRNA Translation: AAP35553.1 AK289813 mRNA Translation: BAF82502.1 CH471052 Genomic DNA Translation: EAW79733.1 CH471052 Genomic DNA Translation: EAW79734.1 BC010016 mRNA Translation: AAH10016.1 BC012884 mRNA Translation: AAH12884.1 BC037306 mRNA Translation: AAH37306.1 |
CCDSi | CCDS43125.1 [Q08722-3] CCDS43126.1 [Q08722-1] |
PIRi | A48997 |
RefSeqi | NP_001768.1, NM_001777.3 [Q08722-1] NP_942088.1, NM_198793.2 [Q08722-3] |
Genome annotation databases
Ensembli | ENST00000355354; ENSP00000347512; ENSG00000196776 [Q08722-3] ENST00000361309; ENSP00000355361; ENSG00000196776 [Q08722-1] |
GeneIDi | 961 |
KEGGi | hsa:961 |
UCSCi | uc003dwt.2, human [Q08722-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69398 mRNA Translation: CAA49196.1 Z25521 mRNA Translation: CAA80977.1 BT006907 mRNA Translation: AAP35553.1 AK289813 mRNA Translation: BAF82502.1 CH471052 Genomic DNA Translation: EAW79733.1 CH471052 Genomic DNA Translation: EAW79734.1 BC010016 mRNA Translation: AAH10016.1 BC012884 mRNA Translation: AAH12884.1 BC037306 mRNA Translation: AAH37306.1 |
CCDSi | CCDS43125.1 [Q08722-3] CCDS43126.1 [Q08722-1] |
PIRi | A48997 |
RefSeqi | NP_001768.1, NM_001777.3 [Q08722-1] NP_942088.1, NM_198793.2 [Q08722-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JJS | X-ray | 1.85 | C/D | 20-136 | [»] | |
2JJT | X-ray | 2.30 | C/D | 20-136 | [»] | |
2VSC | X-ray | 1.90 | A/B/C/D | 20-136 | [»] | |
4CMM | X-ray | 1.92 | B | 20-136 | [»] | |
4KJY | X-ray | 1.93 | A/C | 19-135 | [»] | |
5IWL | X-ray | 2.80 | C/D | 20-132 | [»] | |
5TZ2 | X-ray | 2.30 | C | 19-141 | [»] | |
5TZT | X-ray | 2.89 | C/D | 20-141 | [»] | |
5TZU | X-ray | 2.10 | C | 19-141 | [»] | |
SMRi | Q08722 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107399, 36 interactors |
CORUMi | Q08722 |
DIPi | DIP-39948N |
IntActi | Q08722, 31 interactors |
MINTi | Q08722 |
STRINGi | 9606.ENSP00000355361 |
Chemistry databases
BindingDBi | Q08722 |
ChEMBLi | CHEMBL3714583 |
Protein family/group databases
TCDBi | 1.N.1.1.1, the osteoclast fusion complex (ofc) family |
PTM databases
GlyConnecti | 1456, 18 N-Linked glycans (1 site) |
GlyGeni | Q08722, 6 sites, 2 N-linked glycans (1 site) |
iPTMneti | Q08722 |
PhosphoSitePlusi | Q08722 |
SwissPalmi | Q08722 |
Genetic variation databases
BioMutai | CD47 |
DMDMi | 1171879 |
Proteomic databases
EPDi | Q08722 |
jPOSTi | Q08722 |
MassIVEi | Q08722 |
MaxQBi | Q08722 |
PaxDbi | Q08722 |
PeptideAtlasi | Q08722 |
PRIDEi | Q08722 |
ProteomicsDBi | 58643 [Q08722-1] 58644 [Q08722-2] 58645 [Q08722-3] 58646 [Q08722-4] |
Protocols and materials databases
ABCDi | Q08722, 50 sequenced antibodies |
Antibodypediai | 4228, 1485 antibodies |
CPTCi | Q08722, 4 antibodies |
DNASUi | 961 |
Genome annotation databases
Ensembli | ENST00000355354; ENSP00000347512; ENSG00000196776 [Q08722-3] ENST00000361309; ENSP00000355361; ENSG00000196776 [Q08722-1] |
GeneIDi | 961 |
KEGGi | hsa:961 |
UCSCi | uc003dwt.2, human [Q08722-1] |
Organism-specific databases
CTDi | 961 |
DisGeNETi | 961 |
GeneCardsi | CD47 |
HGNCi | HGNC:1682, CD47 |
HPAi | ENSG00000196776, Low tissue specificity |
MIMi | 601028, gene |
neXtProti | NX_Q08722 |
OpenTargetsi | ENSG00000196776 |
PharmGKBi | PA26222 |
VEuPathDBi | HostDB:ENSG00000196776.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYTQ, Eukaryota |
GeneTreei | ENSGT00390000007697 |
HOGENOMi | CLU_860392_0_0_1 |
InParanoidi | Q08722 |
OMAi | AEMWPLV |
OrthoDBi | 1287706at2759 |
PhylomeDBi | Q08722 |
TreeFami | TF336026 |
Enzyme and pathway databases
PathwayCommonsi | Q08722 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-216083, Integrin cell surface interactions R-HSA-391160, Signal regulatory protein family interactions R-HSA-6798695, Neutrophil degranulation |
SIGNORi | Q08722 |
Miscellaneous databases
BioGRID-ORCSi | 961, 5 hits in 1004 CRISPR screens |
ChiTaRSi | CD47, human |
EvolutionaryTracei | Q08722 |
GeneWikii | CD47 |
GenomeRNAii | 961 |
Pharosi | Q08722, Tbio |
PROi | PR:Q08722 |
RNActi | Q08722, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196776, Expressed in visceral pleura and 242 other tissues |
ExpressionAtlasi | Q08722, baseline and differential |
Genevisiblei | Q08722, HS |
Family and domain databases
CDDi | cd16090, IgV_CD47, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR006704, CD47 IPR013147, CD47_TM IPR013270, CD47_Vset IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR037805, IgV_CD47 |
PANTHERi | PTHR10613, PTHR10613, 1 hit |
Pfami | View protein in Pfam PF04549, CD47, 1 hit PF08204, V-set_CD47, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD47_HUMAN | |
Accessioni | Q08722Primary (citable) accession number: Q08722 Secondary accession number(s): A8K198 Q96A60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references