CD47

Functionⁱ

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.By similarity3 Publications

GO - Molecular functionⁱ

cell-cell adhesion mediator activity
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 11509594
protein binding involved in heterotypic cell-cell adhesion Source: ARUK-UCL
thrombospondin receptor activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15700281

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell migration Source: ARUK-UCL
cellular response to interferon-gamma Source: ARUK-UCL
cellular response to interleukin-1 Source: ARUK-UCL
cellular response to interleukin-12
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 11509594
extracellular matrix organization Source: Reactome
integrin-mediated signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8294396
leukocyte migration Source: Reactome
monocyte extravasation Source: ARUK-UCL
negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Source: ARUK-UCL
neutrophil degranulation Source: Reactome
opsonization Source: Ensembl
positive regulation of cell-cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 15383453
positive regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 15383453
positive regulation of inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of phagocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of stress fiber assembly Source: ARUK-UCL
positive regulation of T cell activation
Source: UniProtKB
Inferred from direct assayⁱ
- 15383453
regulation of interferon-gamma production
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 11509594
regulation of interleukin-10 production
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 11509594
regulation of interleukin-12 production
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 11509594
regulation of interleukin-6 production
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 11509594
regulation of nitric oxide biosynthetic process Source: ARUK-UCL
regulation of tumor necrosis factor production
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 11509594
response to bacterium Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-216083 Integrin cell surface interactions R-HSA-391160 Signal regulatory protein family interactions R-HSA-6798695 Neutrophil degranulation
SIGNORⁱ	Q08722

Protein family/group databases

TCDBⁱ	1.N.1.1.1 the osteoclast fusion complex (ofc) family

TCDBⁱ

1.N.1.1.1 the osteoclast fusion complex (ofc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leukocyte surface antigen CD47 Alternative name(s): Antigenic surface determinant protein OA3 Integrin-associated protein Short name: IAP Protein MER6 CD_antigen: CD47
Gene namesⁱ	Name:CD47 Synonyms:MER6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196776.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1682 CD47
MIMⁱ	601028 gene
neXtProtⁱ	NX_Q08722

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 141	ExtracellularSequence analysisAdd BLAST	123
Transmembraneⁱ	142 – 162	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	163 – 176	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	177 – 197	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	198 – 207	ExtracellularSequence analysis	10
Transmembraneⁱ	208 – 228	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	229 – 235	CytoplasmicSequence analysis	7
Transmembraneⁱ	236 – 256	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	257 – 268	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	269 – 289	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	290 – 323	CytoplasmicSequence analysisAdd BLAST	34

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	961
Open Targets More...OpenTargetsⁱ	ENSG00000196776
PharmGKBⁱ	PA26222

Chemistry databases

ChEMBLⁱ	CHEMBL3714583

ChEMBLⁱ

CHEMBL3714583

Polymorphism and mutation databases

BioMutaⁱ	CD47
DMDMⁱ	1171879

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000014880	19 – 323	Leukocyte surface antigen CD47Add BLAST		305

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	19	Pyrrolidone carboxylic acid1 Publication	1
Glycosylationⁱ	23	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	33 ↔ 263	1 Publication
Glycosylationⁱ	34	N-linked (GlcNAc...) asparagine	1
Disulfide bondⁱ	41 ↔ 114	1 Publication
Glycosylationⁱ	50	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	73	N-linked (GlcNAc...) asparagine3 Publications	1
Modified residueⁱ	89	PhosphoserineBy similarity	1
Glycosylationⁱ	111	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	206	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDⁱ	Q08722
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q08722
PaxDbⁱ	Q08722
PeptideAtlas More...PeptideAtlasⁱ	Q08722
PRIDEⁱ	Q08722
ProteomicsDBⁱ	58643 58644 [Q08722-2] 58645 [Q08722-3] 58646 [Q08722-4]

PTM databases

GlyConnectⁱ	1456
iPTMnetⁱ	Q08722
PhosphoSitePlusⁱ	Q08722
SwissPalmⁱ	Q08722

Expressionⁱ

Tissue specificityⁱ

Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Gene expression databases

Bgeeⁱ	ENSG00000196776 Expressed in 230 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_CD47
ExpressionAtlasⁱ	Q08722 baseline and differential
Genevisibleⁱ	Q08722 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016055 HPA044659

HPAⁱ

CAB016055
HPA044659

Interactionⁱ

Subunit structureⁱ

Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SIRPG	Q9P1W8	2	EBI-1268321,EBI-1268284
SYNE4	Q8N205	3	EBI-1268321,EBI-7131783

GO - Molecular functionⁱ

cell-cell adhesion mediator activity
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 11509594
protein binding involved in heterotypic cell-cell adhesion Source: ARUK-UCL

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107399, 26 interactors
CORUMⁱ	Q08722
Database of interacting proteins More...DIPⁱ	DIP-39948N
IntActⁱ	Q08722, 10 interactors
Molecular INTeraction database More...MINTⁱ	Q08722
STRINGⁱ	9606.ENSP00000355361

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	26 – 30	Combined sources	5
Beta strandⁱ	35 – 39	Combined sources	5
Beta strandⁱ	42 – 45	Combined sources	4
Helixⁱ	51 – 53	Combined sources	3
Beta strandⁱ	54 – 60	Combined sources	7
Beta strandⁱ	63 – 69	Combined sources	7
Helixⁱ	70 – 72	Combined sources	3
Beta strandⁱ	74 – 76	Combined sources	3
Helixⁱ	79 – 81	Combined sources	3
Helixⁱ	88 – 93	Combined sources	6
Beta strandⁱ	98 – 101	Combined sources	4
Helixⁱ	102 – 106	Combined sources	5
Beta strandⁱ	110 – 118	Combined sources	9
Beta strandⁱ	121 – 131	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q08722
SMRⁱ	Q08722
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q08722

EvolutionaryTraceⁱ

Q08722

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	19 – 127	Ig-like V-typeAdd BLAST		109

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IJTS Eukaryota ENOG41113GI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007697
HOGENOMⁱ	HOG000013020
HOVERGENⁱ	HBG003808
InParanoidⁱ	Q08722
KEGG Orthology (KO) More...KOⁱ	K06266
OMAⁱ	WGQFGIV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HUR
PhylomeDBⁱ	Q08722
TreeFamⁱ	TF336026

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd16090 IgV_CD47, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR006704 CD47 IPR013147 CD47_TM IPR013270 CD47_Vset IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR037805 IgV_CD47
PANTHERⁱ	PTHR10613 PTHR10613, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04549 CD47, 1 hit PF08204 V-set_CD47, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform OA3-323 (identifier: Q08722-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN 
        60         70         80         90        100
TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM 
       110        120        130        140        150
DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI 
       160        170        180        190        200
FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG 
       210        220        230        240        250
EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI 
       260        270        280        290        300
LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 
       310        320 
PPRKAVEEPL NAFKESKGMM NDE

Length:323

Mass (Da):35,214

Last modified:November 1, 1995 - v1

Checksum:ⁱ5D20730A2632D550

GO

Isoform OA3-293 (identifier: Q08722-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
293-323: Missing.

« Hide

        10         20         30         40         50
MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN 
        60         70         80         90        100
TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM 
       110        120        130        140        150
DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI 
       160        170        180        190        200
FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG 
       210        220        230        240        250
EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI 
       260        270        280        290 
LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FV

Show »

Length:292

Mass (Da):31,743

Checksum:ⁱ81A2F6696D11F4E1

GO

Isoform OA3-305 (identifier: Q08722-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
304-305: KA → NN
306-323: Missing.

« Hide

        10         20         30         40         50
MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN 
        60         70         80         90        100
TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM 
       110        120        130        140        150
DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI 
       160        170        180        190        200
FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG 
       210        220        230        240        250
EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI 
       260        270        280        290        300
LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 

PPRNN

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:305

Mass (Da):33,192

Checksum:ⁱ145DD178068F8DBD

GO

Isoform OA3-312 (identifier: Q08722-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
312-323: Missing.

« Hide

        10         20         30         40         50
MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN 
        60         70         80         90        100
TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM 
       110        120        130        140        150
DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI 
       160        170        180        190        200
FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG 
       210        220        230        240        250
EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI 
       260        270        280        290        300
LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 
       310 
PPRKAVEEPL N

Show »

Length:311

Mass (Da):33,845

Checksum:ⁱ8BBBB21A590D4DCA

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YC40	H0YC40_HUMAN	Leukocyte surface antigen CD47 Leukocyte surface antigen CD47	CD47	109	Annotation score:
A0A2R8Y484	A0A2R8Y484_HUMAN	Leukocyte surface antigen CD47 Leukocyte surface antigen CD47	CD47	183	Annotation score:
H7BYS8	H7BYS8_HUMAN	Leukocyte surface antigen CD47 Leukocyte surface antigen CD47	CD47	86	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002535	293 – 323	Missing in isoform OA3-293. CuratedAdd BLAST	31
Alternative sequenceⁱVSP_002536	304 – 305	KA → NN in isoform OA3-305. 3 Publications	2
Alternative sequenceⁱVSP_002537	306 – 323	Missing in isoform OA3-305. 3 PublicationsAdd BLAST	18
Alternative sequenceⁱVSP_002538	312 – 323	Missing in isoform OA3-312. CuratedAdd BLAST	12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X69398 mRNA Translation: CAA49196.1 Z25521 mRNA Translation: CAA80977.1 BT006907 mRNA Translation: AAP35553.1 AK289813 mRNA Translation: BAF82502.1 CH471052 Genomic DNA Translation: EAW79733.1 CH471052 Genomic DNA Translation: EAW79734.1 BC010016 mRNA Translation: AAH10016.1 BC012884 mRNA Translation: AAH12884.1 BC037306 mRNA Translation: AAH37306.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43125.1 [Q08722-3] CCDS43126.1 [Q08722-1]
PIRⁱ	A48997
NCBI Reference Sequences More...RefSeqⁱ	NP_001768.1, NM_001777.3 [Q08722-1] NP_942088.1, NM_198793.2 [Q08722-3]
UniGeneⁱ	Hs.446414

Genome annotation databases

Ensemblⁱ	ENST00000355354; ENSP00000347512; ENSG00000196776 [Q08722-3] ENST00000361309; ENSP00000355361; ENSG00000196776 [Q08722-1]
GeneIDⁱ	961
KEGGⁱ	hsa:961
UCSC genome browser More...UCSCⁱ	uc003dwt.2 human [Q08722-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q08722	Isoform OA3-293 of Leukocyte surface antigen CD47		HUMAN		292	UniRef100_Q08722
Isoform OA3-312 of Leukocyte surface antigen CD47		HUMAN		311
Leukocyte surface antigen CD47 (Fragment)		HUMAN		183

Protein	Similar proteins		Species	Score	Length	Source
Q08722	Leukocyte surface antigen CD47		PONAB		323	UniRef90_Q08722
Isoform OA3-293 of Leukocyte surface antigen CD47		HUMAN		292
CD47 isoform 2		PANTR		323
Uncharacterized protein		AOTNA		323
Uncharacterized protein		PAPAN		323
+31
Q08722-3	Uncharacterized protein		RHIBE		333	UniRef90_Q08722-3
CD47 molecule		PANTR		330
Leukocyte surface antigen CD47		PONAB		324
Uncharacterized protein		MACMU		318
Uncharacterized protein		CERAT		312
+51

Protein	Similar proteins		Species	Score	Length	Source
Q08722	Leukocyte surface antigen CD47		PONAB		323	UniRef50_Q08722
Leukocyte surface antigen CD47		PIG		303
Leukocyte surface antigen CD47		MOUSE		303
Leukocyte surface antigen CD47		RAT		303
Isoform OA3-293 of Leukocyte surface antigen CD47		HUMAN		292
+314

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X69398 mRNA Translation: CAA49196.1 Z25521 mRNA Translation: CAA80977.1 BT006907 mRNA Translation: AAP35553.1 AK289813 mRNA Translation: BAF82502.1 CH471052 Genomic DNA Translation: EAW79733.1 CH471052 Genomic DNA Translation: EAW79734.1 BC010016 mRNA Translation: AAH10016.1 BC012884 mRNA Translation: AAH12884.1 BC037306 mRNA Translation: AAH37306.1
CCDSⁱ	CCDS43125.1 [Q08722-3] CCDS43126.1 [Q08722-1]
PIRⁱ	A48997
RefSeqⁱ	NP_001768.1, NM_001777.3 [Q08722-1] NP_942088.1, NM_198793.2 [Q08722-3]
UniGeneⁱ	Hs.446414

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2JJS	X-ray	1.85	C/D	20-136	[»]
	2JJT	X-ray	2.30	C/D	20-136	[»]
	2VSC	X-ray	1.90	A/B/C/D	20-136	[»]
	4CMM	X-ray	1.92	B	20-136	[»]
	4KJY	X-ray	1.93	A/C	19-135	[»]
	5IWL	X-ray	2.80	C/D	20-132	[»]
	5TZ2	X-ray	2.30	C	19-141	[»]
	5TZT	X-ray	2.89	C/D	20-141	[»]
	5TZU	X-ray	2.10	C	19-141	[»]
ProteinModelPortalⁱ	Q08722
SMRⁱ	Q08722
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107399, 26 interactors
CORUMⁱ	Q08722
DIPⁱ	DIP-39948N
IntActⁱ	Q08722, 10 interactors
MINTⁱ	Q08722
STRINGⁱ	9606.ENSP00000355361

Chemistry databases

ChEMBLⁱ	CHEMBL3714583

ChEMBLⁱ

CHEMBL3714583

Protein family/group databases

TCDBⁱ	1.N.1.1.1 the osteoclast fusion complex (ofc) family

TCDBⁱ

1.N.1.1.1 the osteoclast fusion complex (ofc) family

PTM databases

GlyConnectⁱ	1456
iPTMnetⁱ	Q08722
PhosphoSitePlusⁱ	Q08722
SwissPalmⁱ	Q08722

Polymorphism and mutation databases

BioMutaⁱ	CD47
DMDMⁱ	1171879

Proteomic databases

EPDⁱ	Q08722
MaxQBⁱ	Q08722
PaxDbⁱ	Q08722
PeptideAtlasⁱ	Q08722
PRIDEⁱ	Q08722
ProteomicsDBⁱ	58643 58644 [Q08722-2] 58645 [Q08722-3] 58646 [Q08722-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	961
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000355354; ENSP00000347512; ENSG00000196776 [Q08722-3] ENST00000361309; ENSP00000355361; ENSG00000196776 [Q08722-1]
GeneIDⁱ	961
KEGGⁱ	hsa:961
UCSCⁱ	uc003dwt.2 human [Q08722-1]

Organism-specific databases

CTDⁱ	961
DisGeNETⁱ	961
EuPathDBⁱ	HostDB:ENSG00000196776.14
GeneCardsⁱ	CD47
HGNCⁱ	HGNC:1682 CD47
HPAⁱ	CAB016055 HPA044659
MIMⁱ	601028 gene
neXtProtⁱ	NX_Q08722
OpenTargetsⁱ	ENSG00000196776
PharmGKBⁱ	PA26222
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJTS Eukaryota ENOG41113GI LUCA
GeneTreeⁱ	ENSGT00390000007697
HOGENOMⁱ	HOG000013020
HOVERGENⁱ	HBG003808
InParanoidⁱ	Q08722
KOⁱ	K06266
OMAⁱ	WGQFGIV
OrthoDBⁱ	EOG091G0HUR
PhylomeDBⁱ	Q08722
TreeFamⁱ	TF336026

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-216083 Integrin cell surface interactions R-HSA-391160 Signal regulatory protein family interactions R-HSA-6798695 Neutrophil degranulation
SIGNORⁱ	Q08722

Miscellaneous databases

ChiTaRSⁱ	CD47 human
EvolutionaryTraceⁱ	Q08722
GeneWikiⁱ	CD47
GenomeRNAiⁱ	961
Protein Ontology More...PROⁱ	PR:Q08722
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196776 Expressed in 230 organ(s), highest expression level in visceral pleura
CleanExⁱ	HS_CD47
ExpressionAtlasⁱ	Q08722 baseline and differential
Genevisibleⁱ	Q08722 HS

Family and domain databases

CDDⁱ	cd16090 IgV_CD47, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR006704 CD47 IPR013147 CD47_TM IPR013270 CD47_Vset IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR037805 IgV_CD47
PANTHERⁱ	PTHR10613 PTHR10613, 1 hit
Pfamⁱ	View protein in Pfam PF04549 CD47, 1 hit PF08204 V-set_CD47, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD47_HUMAN
Accessionⁱ	Q08722Primary (citable) accession number: Q08722 Secondary accession number(s): A8K198 , D3DN59, Q53Y71, Q96A60
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q08722 (CD47_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Leukocyte surface antigen CD47

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ