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Protein

Leukocyte surface antigen CD47

Gene

CD47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-6798695 Neutrophil degranulation
SIGNORiQ08722

Protein family/group databases

TCDBi1.N.1.1.1 the osteoclast fusion complex (ofc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte surface antigen CD47
Alternative name(s):
Antigenic surface determinant protein OA3
Integrin-associated protein
Short name:
IAP
Protein MER6
CD_antigen: CD47
Gene namesi
Name:CD47
Synonyms:MER6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000196776.14
HGNCiHGNC:1682 CD47
MIMi601028 gene
neXtProtiNX_Q08722

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 141ExtracellularSequence analysisAdd BLAST123
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 176CytoplasmicSequence analysisAdd BLAST14
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 207ExtracellularSequence analysis10
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 235CytoplasmicSequence analysis7
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 268ExtracellularSequence analysisAdd BLAST12
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 323CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi961
OpenTargetsiENSG00000196776
PharmGKBiPA26222

Chemistry databases

ChEMBLiCHEMBL3714583

Polymorphism and mutation databases

BioMutaiCD47
DMDMi1171879

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001488019 – 323Leukocyte surface antigen CD47Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Glycosylationi23N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi33 ↔ 2631 Publication
Glycosylationi34N-linked (GlcNAc...) asparagine1
Disulfide bondi41 ↔ 1141 Publication
Glycosylationi50N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi73N-linked (GlcNAc...) asparagine3 Publications1
Modified residuei89PhosphoserineBy similarity1
Glycosylationi111N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiQ08722
MaxQBiQ08722
PaxDbiQ08722
PeptideAtlasiQ08722
PRIDEiQ08722
ProteomicsDBi58643
58644 [Q08722-2]
58645 [Q08722-3]
58646 [Q08722-4]

PTM databases

GlyConnecti1456
iPTMnetiQ08722
PhosphoSitePlusiQ08722
SwissPalmiQ08722

Expressioni

Tissue specificityi

Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Gene expression databases

BgeeiENSG00000196776 Expressed in 230 organ(s), highest expression level in visceral pleura
CleanExiHS_CD47
ExpressionAtlasiQ08722 baseline and differential
GenevisibleiQ08722 HS

Organism-specific databases

HPAiCAB016055
HPA044659

Interactioni

Subunit structurei

Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107399, 26 interactors
CORUMiQ08722
DIPiDIP-39948N
IntActiQ08722, 10 interactors
MINTiQ08722
STRINGi9606.ENSP00000355361

Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ08722
SMRiQ08722
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08722

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 127Ig-like V-typeAdd BLAST109

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJTS Eukaryota
ENOG41113GI LUCA
GeneTreeiENSGT00390000007697
HOGENOMiHOG000013020
HOVERGENiHBG003808
InParanoidiQ08722
KOiK06266
OMAiWGQFGIV
OrthoDBiEOG091G0HUR
PhylomeDBiQ08722
TreeFamiTF336026

Family and domain databases

CDDicd16090 IgV_CD47, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR006704 CD47
IPR013147 CD47_TM
IPR013270 CD47_Vset
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR037805 IgV_CD47
PANTHERiPTHR10613 PTHR10613, 1 hit
PfamiView protein in Pfam
PF04549 CD47, 1 hit
PF08204 V-set_CD47, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform OA3-323 (identifier: Q08722-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN
60 70 80 90 100
TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM
110 120 130 140 150
DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI
160 170 180 190 200
FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG
210 220 230 240 250
EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI
260 270 280 290 300
LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ
310 320
PPRKAVEEPL NAFKESKGMM NDE
Length:323
Mass (Da):35,214
Last modified:November 1, 1995 - v1
Checksum:i5D20730A2632D550
GO
Isoform OA3-293 (identifier: Q08722-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-323: Missing.

Show »
Length:292
Mass (Da):31,743
Checksum:i81A2F6696D11F4E1
GO
Isoform OA3-305 (identifier: Q08722-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-305: KA → NN
     306-323: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:305
Mass (Da):33,192
Checksum:i145DD178068F8DBD
GO
Isoform OA3-312 (identifier: Q08722-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-323: Missing.

Show »
Length:311
Mass (Da):33,845
Checksum:i8BBBB21A590D4DCA
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC40H0YC40_HUMAN
Leukocyte surface antigen CD47
CD47
109Annotation score:
A0A2R8Y484A0A2R8Y484_HUMAN
Leukocyte surface antigen CD47
CD47
183Annotation score:
H7BYS8H7BYS8_HUMAN
Leukocyte surface antigen CD47
CD47
86Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002535293 – 323Missing in isoform OA3-293. CuratedAdd BLAST31
Alternative sequenceiVSP_002536304 – 305KA → NN in isoform OA3-305. 3 Publications2
Alternative sequenceiVSP_002537306 – 323Missing in isoform OA3-305. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_002538312 – 323Missing in isoform OA3-312. CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69398 mRNA Translation: CAA49196.1
Z25521 mRNA Translation: CAA80977.1
BT006907 mRNA Translation: AAP35553.1
AK289813 mRNA Translation: BAF82502.1
CH471052 Genomic DNA Translation: EAW79733.1
CH471052 Genomic DNA Translation: EAW79734.1
BC010016 mRNA Translation: AAH10016.1
BC012884 mRNA Translation: AAH12884.1
BC037306 mRNA Translation: AAH37306.1
CCDSiCCDS43125.1 [Q08722-3]
CCDS43126.1 [Q08722-1]
PIRiA48997
RefSeqiNP_001768.1, NM_001777.3 [Q08722-1]
NP_942088.1, NM_198793.2 [Q08722-3]
UniGeneiHs.446414

Genome annotation databases

EnsembliENST00000355354; ENSP00000347512; ENSG00000196776 [Q08722-3]
ENST00000361309; ENSP00000355361; ENSG00000196776 [Q08722-1]
GeneIDi961
KEGGihsa:961
UCSCiuc003dwt.2 human [Q08722-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69398 mRNA Translation: CAA49196.1
Z25521 mRNA Translation: CAA80977.1
BT006907 mRNA Translation: AAP35553.1
AK289813 mRNA Translation: BAF82502.1
CH471052 Genomic DNA Translation: EAW79733.1
CH471052 Genomic DNA Translation: EAW79734.1
BC010016 mRNA Translation: AAH10016.1
BC012884 mRNA Translation: AAH12884.1
BC037306 mRNA Translation: AAH37306.1
CCDSiCCDS43125.1 [Q08722-3]
CCDS43126.1 [Q08722-1]
PIRiA48997
RefSeqiNP_001768.1, NM_001777.3 [Q08722-1]
NP_942088.1, NM_198793.2 [Q08722-3]
UniGeneiHs.446414

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJSX-ray1.85C/D20-136[»]
2JJTX-ray2.30C/D20-136[»]
2VSCX-ray1.90A/B/C/D20-136[»]
4CMMX-ray1.92B20-136[»]
4KJYX-ray1.93A/C19-135[»]
5IWLX-ray2.80C/D20-132[»]
5TZ2X-ray2.30C19-141[»]
5TZTX-ray2.89C/D20-141[»]
5TZUX-ray2.10C19-141[»]
ProteinModelPortaliQ08722
SMRiQ08722
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107399, 26 interactors
CORUMiQ08722
DIPiDIP-39948N
IntActiQ08722, 10 interactors
MINTiQ08722
STRINGi9606.ENSP00000355361

Chemistry databases

ChEMBLiCHEMBL3714583

Protein family/group databases

TCDBi1.N.1.1.1 the osteoclast fusion complex (ofc) family

PTM databases

GlyConnecti1456
iPTMnetiQ08722
PhosphoSitePlusiQ08722
SwissPalmiQ08722

Polymorphism and mutation databases

BioMutaiCD47
DMDMi1171879

Proteomic databases

EPDiQ08722
MaxQBiQ08722
PaxDbiQ08722
PeptideAtlasiQ08722
PRIDEiQ08722
ProteomicsDBi58643
58644 [Q08722-2]
58645 [Q08722-3]
58646 [Q08722-4]

Protocols and materials databases

DNASUi961
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355354; ENSP00000347512; ENSG00000196776 [Q08722-3]
ENST00000361309; ENSP00000355361; ENSG00000196776 [Q08722-1]
GeneIDi961
KEGGihsa:961
UCSCiuc003dwt.2 human [Q08722-1]

Organism-specific databases

CTDi961
DisGeNETi961
EuPathDBiHostDB:ENSG00000196776.14
GeneCardsiCD47
HGNCiHGNC:1682 CD47
HPAiCAB016055
HPA044659
MIMi601028 gene
neXtProtiNX_Q08722
OpenTargetsiENSG00000196776
PharmGKBiPA26222
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJTS Eukaryota
ENOG41113GI LUCA
GeneTreeiENSGT00390000007697
HOGENOMiHOG000013020
HOVERGENiHBG003808
InParanoidiQ08722
KOiK06266
OMAiWGQFGIV
OrthoDBiEOG091G0HUR
PhylomeDBiQ08722
TreeFamiTF336026

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-6798695 Neutrophil degranulation
SIGNORiQ08722

Miscellaneous databases

ChiTaRSiCD47 human
EvolutionaryTraceiQ08722
GeneWikiiCD47
GenomeRNAii961
PROiPR:Q08722
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196776 Expressed in 230 organ(s), highest expression level in visceral pleura
CleanExiHS_CD47
ExpressionAtlasiQ08722 baseline and differential
GenevisibleiQ08722 HS

Family and domain databases

CDDicd16090 IgV_CD47, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR006704 CD47
IPR013147 CD47_TM
IPR013270 CD47_Vset
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR037805 IgV_CD47
PANTHERiPTHR10613 PTHR10613, 1 hit
PfamiView protein in Pfam
PF04549 CD47, 1 hit
PF08204 V-set_CD47, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD47_HUMAN
AccessioniPrimary (citable) accession number: Q08722
Secondary accession number(s): A8K198
, D3DN59, Q53Y71, Q96A60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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