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UniProtKB - Q08722 (CD47_HUMAN)

Entry version 192 (29 Sep 2021)
Sequence version 1 (01 Nov 1995)
Previous versions | rss
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Protein

Leukocyte surface antigen CD47

Gene

CD47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity).

Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q08722

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-216083, Integrin cell surface interactions
R-HSA-391160, Signal regulatory protein family interactions
R-HSA-6798695, Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q08722

Protein family/group databases

Transport Classification Database

More...TCDBi		1.N.1.1.1, the osteoclast fusion complex (ofc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte surface antigen CD47
Alternative name(s):
Antigenic surface determinant protein OA3
Integrin-associated protein
Short name:
IAP
Protein MER6
CD_antigen: CD47
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD47
Synonyms:MER6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1682, CD47

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601028, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q08722

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196776

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 141ExtracellularSequence analysisAdd BLAST123
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 176CytoplasmicSequence analysisAdd BLAST14
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 207ExtracellularSequence analysis10
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 235CytoplasmicSequence analysis7
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 268ExtracellularSequence analysisAdd BLAST12
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 323CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		961

Open Targets

More...OpenTargetsi		ENSG00000196776

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26222

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q08722, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3714583

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD47

Domain mapping of disease mutations (DMDM)

More...DMDMi		1171879

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001488019 – 323Leukocyte surface antigen CD47Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi23N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 2631 Publication
Glycosylationi34N-linked (GlcNAc...) asparagine1
Disulfide bondi41 ↔ 1141 Publication
Glycosylationi50N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi73N-linked (GlcNAc...) asparagine3 Publications1
Modified residuei89PhosphoserineBy similarity1
Glycosylationi111N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q08722

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q08722

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q08722

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q08722

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q08722

PeptideAtlas

More...PeptideAtlasi		Q08722

PRoteomics IDEntifications database

More...PRIDEi		Q08722

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58643 [Q08722-1]
58644 [Q08722-2]
58645 [Q08722-3]
58646 [Q08722-4]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1456, 18 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q08722, 7 sites, 21 N-linked glycans (1 site), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q08722

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q08722

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q08722

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196776, Expressed in visceral pleura and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q08722, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q08722, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196776, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with THBS1 and fibrinogen (By similarity). Monomer.

Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107399, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q08722

Database of interacting proteins

More...DIPi		DIP-39948N

Protein interaction database and analysis system

More...IntActi		Q08722, 31 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355361

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q08722

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q08722, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q08722

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q08722

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 127Ig-like V-typeAdd BLAST109

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RYTQ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007697

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_860392_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q08722

Identification of Orthologs from Complete Genome Data

More...OMAi		AEMWPLV

Database of Orthologous Groups

More...OrthoDBi		1287706at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q08722

TreeFam database of animal gene trees

More...TreeFami		TF336026

Family and domain databases

Conserved Domains Database

More...CDDi		cd16090, IgV_CD47, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006704, CD47
IPR013147, CD47_TM
IPR013270, CD47_Vset
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR037805, IgV_CD47

The PANTHER Classification System

More...PANTHERi		PTHR10613, PTHR10613, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04549, CD47, 1 hit
PF08204, V-set_CD47, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform OA3-323 (identifier: Q08722-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPLVAALLL GSACCGSAQL LFNKTKSVEF TFCNDTVVIP CFVTNMEAQN 
        60         70         80         90        100
TTEVYVKWKF KGRDIYTFDG ALNKSTVPTD FSSAKIEVSQ LLKGDASLKM 
       110        120        130        140        150
DKSDAVSHTG NYTCEVTELT REGETIIELK YRVVSWFSPN ENILIVIFPI 
       160        170        180        190        200
FAILLFWGQF GIKTLKYRSG GMDEKTIALL VAGLVITVIV IVGAILFVPG 
       210        220        230        240        250
EYSLKNATGL GLIVTSTGIL ILLHYYVFST AIGLTSFVIA ILVIQVIAYI 
       260        270        280        290        300
LAVVGLSLCI AACIPMHGPL LISGLSILAL AQLLGLVYMK FVASNQKTIQ 
       310        320 
PPRKAVEEPL NAFKESKGMM NDE
Length:323
Mass (Da):35,214
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D20730A2632D550
GO
Isoform OA3-293 (identifier: Q08722-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-323: Missing.

Show »
Length:292
Mass (Da):31,743
Checksum:i81A2F6696D11F4E1
GO
Isoform OA3-305 (identifier: Q08722-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-305: KA → NN
     306-323: Missing.

Show »
Length:305
Mass (Da):33,192
Checksum:i145DD178068F8DBD
GO
Isoform OA3-312 (identifier: Q08722-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-323: Missing.

Show »
Length:311
Mass (Da):33,845
Checksum:i8BBBB21A590D4DCA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y484A0A2R8Y484_HUMAN
Integrin-associated protein
CD47
183Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC40H0YC40_HUMAN
Leukocyte surface antigen CD47
CD47
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYS8H7BYS8_HUMAN
Leukocyte surface antigen CD47
CD47
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002535293 – 323Missing in isoform OA3-293. CuratedAdd BLAST31
Alternative sequenceiVSP_002536304 – 305KA → NN in isoform OA3-305. 3 Publications2
Alternative sequenceiVSP_002537306 – 323Missing in isoform OA3-305. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_002538312 – 323Missing in isoform OA3-312. CuratedAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X69398 mRNA Translation: CAA49196.1
Z25521 mRNA Translation: CAA80977.1
BT006907 mRNA Translation: AAP35553.1
AK289813 mRNA Translation: BAF82502.1
CH471052 Genomic DNA Translation: EAW79733.1
CH471052 Genomic DNA Translation: EAW79734.1
BC010016 mRNA Translation: AAH10016.1
BC012884 mRNA Translation: AAH12884.1
BC037306 mRNA Translation: AAH37306.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43125.1 [Q08722-3]
CCDS43126.1 [Q08722-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A48997

NCBI Reference Sequences

More...RefSeqi		NP_001768.1, NM_001777.3 [Q08722-1]
NP_942088.1, NM_198793.2 [Q08722-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355354; ENSP00000347512; ENSG00000196776 [Q08722-3]
ENST00000361309; ENSP00000355361; ENSG00000196776 [Q08722-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		961

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:961

UCSC genome browser

More...UCSCi		uc003dwt.2, human [Q08722-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69398 mRNA Translation: CAA49196.1
Z25521 mRNA Translation: CAA80977.1
BT006907 mRNA Translation: AAP35553.1
AK289813 mRNA Translation: BAF82502.1
CH471052 Genomic DNA Translation: EAW79733.1
CH471052 Genomic DNA Translation: EAW79734.1
BC010016 mRNA Translation: AAH10016.1
BC012884 mRNA Translation: AAH12884.1
BC037306 mRNA Translation: AAH37306.1
CCDSiCCDS43125.1 [Q08722-3]
CCDS43126.1 [Q08722-1]
PIRiA48997
RefSeqiNP_001768.1, NM_001777.3 [Q08722-1]
NP_942088.1, NM_198793.2 [Q08722-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJSX-ray1.85C/D20-136[»]
2JJTX-ray2.30C/D20-136[»]
2VSCX-ray1.90A/B/C/D20-136[»]
4CMMX-ray1.92B20-136[»]
4KJYX-ray1.93A/C19-135[»]
5IWLX-ray2.80C/D20-132[»]
5TZ2X-ray2.30C19-141[»]
5TZTX-ray2.89C/D20-141[»]
5TZUX-ray2.10C19-141[»]
SMRiQ08722
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107399, 40 interactors
CORUMiQ08722
DIPiDIP-39948N
IntActiQ08722, 31 interactors
STRINGi9606.ENSP00000355361

Chemistry databases

BindingDBiQ08722
ChEMBLiCHEMBL3714583

Protein family/group databases

TCDBi1.N.1.1.1, the osteoclast fusion complex (ofc) family

PTM databases

GlyConnecti1456, 18 N-Linked glycans (1 site)
GlyGeniQ08722, 7 sites, 21 N-linked glycans (1 site), 1 O-linked glycan (1 site)
iPTMnetiQ08722
PhosphoSitePlusiQ08722
SwissPalmiQ08722

Genetic variation databases

BioMutaiCD47
DMDMi1171879

Proteomic databases

EPDiQ08722
jPOSTiQ08722
MassIVEiQ08722
MaxQBiQ08722
PaxDbiQ08722
PeptideAtlasiQ08722
PRIDEiQ08722
ProteomicsDBi58643 [Q08722-1]
58644 [Q08722-2]
58645 [Q08722-3]
58646 [Q08722-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q08722, 50 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4228, 1596 antibodies

The CPTC Antibody Portal

More...CPTCi		Q08722, 4 antibodies

The DNASU plasmid repository

More...DNASUi		961

Genome annotation databases

EnsembliENST00000355354; ENSP00000347512; ENSG00000196776 [Q08722-3]
ENST00000361309; ENSP00000355361; ENSG00000196776 [Q08722-1]
GeneIDi961
KEGGihsa:961
UCSCiuc003dwt.2, human [Q08722-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		961
DisGeNETi961

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD47
HGNCiHGNC:1682, CD47
HPAiENSG00000196776, Low tissue specificity
MIMi601028, gene
neXtProtiNX_Q08722
OpenTargetsiENSG00000196776
PharmGKBiPA26222
VEuPathDBiHostDB:ENSG00000196776

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RYTQ, Eukaryota
GeneTreeiENSGT00390000007697
HOGENOMiCLU_860392_0_0_1
InParanoidiQ08722
OMAiAEMWPLV
OrthoDBi1287706at2759
PhylomeDBiQ08722
TreeFamiTF336026

Enzyme and pathway databases

PathwayCommonsiQ08722
ReactomeiR-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-216083, Integrin cell surface interactions
R-HSA-391160, Signal regulatory protein family interactions
R-HSA-6798695, Neutrophil degranulation
SIGNORiQ08722

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		961, 6 hits in 1027 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD47, human
EvolutionaryTraceiQ08722

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD47

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		961
PharosiQ08722, Tchem

Protein Ontology

More...PROi		PR:Q08722
RNActiQ08722, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196776, Expressed in visceral pleura and 243 other tissues
ExpressionAtlasiQ08722, baseline and differential
GenevisibleiQ08722, HS

Family and domain databases

CDDicd16090, IgV_CD47, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR006704, CD47
IPR013147, CD47_TM
IPR013270, CD47_Vset
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR037805, IgV_CD47
PANTHERiPTHR10613, PTHR10613, 1 hit
PfamiView protein in Pfam
PF04549, CD47, 1 hit
PF08204, V-set_CD47, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD47_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08722
Secondary accession number(s): A8K198
, D3DN59, Q53Y71, Q96A60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 29, 2021
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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