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Protein

Anaphase-promoting complex subunit 5

Gene

APC5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • anaphase-promoting complex-dependent catabolic process Source: SGD
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • chromatin assembly Source: SGD
  • protein ubiquitination Source: SGD

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-33741-MONOMER
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 5
Gene namesi
Name:APC5
Synonyms:RMC1
Ordered Locus Names:YOR249C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR249C
SGDiS000005775 APC5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646251 – 685Anaphase-promoting complex subunit 5Add BLAST685

Proteomic databases

MaxQBiQ08683
PaxDbiQ08683
PRIDEiQ08683

Interactioni

Subunit structurei

The APC/C is composed of at least 13 subunits that stay tightly associated throughout the cell cycle: APC1, APC2, APC4, APC5, APC9, APC11, CDC16, CDC23, CDC26, CDC27, DOC1, MND2 and SWM1. APC5 directly interacts with MND2 and SWM1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi34639, 640 interactors
ComplexPortaliCPX-756 Anaphase-Promoting Complex variant 1
CPX-760 Anaphase-Promoting Complex variant 2
CPX-761 Anaphase-Promoting Complex variant 3
CPX-762 Anaphase-Promoting Complex variant 4
DIPiDIP-1127N
IntActiQ08683, 25 interactors
MINTiQ08683
STRINGi4932.YOR249C

Structurei

3D structure databases

ProteinModelPortaliQ08683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi497 – 500Poly-Ser4

Sequence similaritiesi

Belongs to the APC5 family.Curated

Phylogenomic databases

HOGENOMiHOG000033989
InParanoidiQ08683
KOiK03352
OMAiLNLIMIW
OrthoDBiEOG092C3YT6

Family and domain databases

InterProiView protein in InterPro
IPR037679 Apc5
IPR026000 Apc5_dom
PANTHERiPTHR12830 PTHR12830, 1 hit
PfamiView protein in Pfam
PF12862 ANAPC5, 1 hit

Sequencei

Sequence statusi: Complete.

Q08683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKYGPLGIT NFITPYDLCI LILIHAHCSQ DNGISVPTAV FLRLISPTRP
60 70 80 90 100
SLEWNPLLKD NSNLRSSSIV PPPVLPILDN IIRILLDDKD GNKIALTLMG
110 120 130 140 150
YLEAINGLDS INRLMMDLEK NCLVNNYRSM KMRTTSTRRQ MTRASFLGTF
160 170 180 190 200
LSTCIRKYQI GDFEMRETIW INLQNFKTVF KHTPLWLRFK DNVHIQKVKN
210 220 230 240 250
CLLANDEISV EDQQMVEFFQ HFNNGNDADS KTMNEENYGT LISIQHLQSI
260 270 280 290 300
VNRQIVNWLD NTEFNLMGQE ETSSTYEEQS GLVFDLLDTL SLNDATKFPL
310 320 330 340 350
IFILKYLEAI KENSYQTALD SLHNYFDYKS TGNSQNYFHI SLLSLATFHS
360 370 380 390 400
SFNECDAAIN SFEEATRIAR ENKDMETLNL IMIWIINFIE VHPEYANRFY
410 420 430 440 450
ITVEQIIKYL KNSSDVEDAN IFSNAYKFET LLSMVKESKT AEVSSSLLKF
460 470 480 490 500
MAITLQNVPS QNFDLFQSLV SYEVKFWKEL GYESISDVYE KFLSKTSSSS
510 520 530 540 550
LRNYDSSIIN QDIKVAFKAL EEDDFLKVKQ YLLKSESLEL DYDQKINLKY
560 570 580 590 600
LRVKYLVKIG DYDLSMRLIN QYVKECCEEV ADSNWRFKFE IESINVLLLS
610 620 630 640 650
DVGIRSLPKI IKLIDEYKEI GNPLRCVILL LKLCEVLIQV GKSMEAECLI
660 670 680
SCNLSTILEF PFVRKKTDEL LESLSVEEDR DVQMT
Length:685
Mass (Da):79,275
Last modified:November 1, 1996 - v1
Checksum:i59310B47D5A1865F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75157 Genomic DNA Translation: CAA99471.1
BK006948 Genomic DNA Translation: DAA11016.1
PIRiS67146
RefSeqiNP_014892.3, NM_001183668.3

Genome annotation databases

EnsemblFungiiYOR249C; YOR249C; YOR249C
GeneIDi854423
KEGGisce:YOR249C

Similar proteinsi

Entry informationi

Entry nameiAPC5_YEAST
AccessioniPrimary (citable) accession number: Q08683
Secondary accession number(s): D6W2V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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