Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinol-binding protein 2

Gene

Rbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Intracellular transport of retinol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41Retinoic acidBy similarity1
Binding sitei109Retinoic acidBy similarity1

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: MGI
  • retinol binding Source: MGI

GO - Biological processi

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 2
Alternative name(s):
Cellular retinol-binding protein II
Short name:
CRBP-II
Gene namesi
Name:Rbp2
Synonyms:Crbpii
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97877 Rbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000673961 – 134Retinol-binding protein 2Add BLAST134

Proteomic databases

MaxQBiQ08652
PaxDbiQ08652
PRIDEiQ08652

PTM databases

PhosphoSitePlusiQ08652

Expressioni

Tissue specificityi

Expressed in prenatal liver, intestine and lung, and in adult intestine.

Gene expression databases

BgeeiENSMUSG00000032454 Expressed in 59 organ(s), highest expression level in colon
CleanExiMM_RBP2
ExpressionAtlasiQ08652 baseline and differential
GenevisibleiQ08652 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035029

Structurei

3D structure databases

ProteinModelPortaliQ08652
SMRiQ08652
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiQ08652
KOiK14622
OMAiWKQWVEG
OrthoDBiEOG091G0QSV
PhylomeDBiQ08652
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Q08652-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKDQNGTWE MESNENFEGY MKALDIDFAT RKIAVRLTQT KIITQDGDNF
60 70 80 90 100
KTKTNSTFRN YDLDFTVGVE FDEHTKGLDG RHVKTLVTWE GNTLVCVQKG
110 120 130
EKENRGWKQW VEGDKLYLEL TCGDQVCRQV FKKK
Length:134
Mass (Da):15,610
Last modified:January 23, 2007 - v2
Checksum:i6B29171BA6A7AB63
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98Q → H in BAB22708 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74154 mRNA Translation: CAA52268.1
AK003312 mRNA Translation: BAB22708.1
CCDSiCCDS23425.1
PIRiI48311 S34717
RefSeqiNP_033060.3, NM_009034.4
UniGeneiMm.12825

Genome annotation databases

EnsembliENSMUST00000035029; ENSMUSP00000035029; ENSMUSG00000032454
ENSMUST00000187905; ENSMUSP00000140630; ENSMUSG00000032454
ENSMUST00000189446; ENSMUSP00000140676; ENSMUSG00000032454
GeneIDi19660
KEGGimmu:19660
UCSCiuc009rdk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74154 mRNA Translation: CAA52268.1
AK003312 mRNA Translation: BAB22708.1
CCDSiCCDS23425.1
PIRiI48311 S34717
RefSeqiNP_033060.3, NM_009034.4
UniGeneiMm.12825

3D structure databases

ProteinModelPortaliQ08652
SMRiQ08652
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035029

PTM databases

PhosphoSitePlusiQ08652

Proteomic databases

MaxQBiQ08652
PaxDbiQ08652
PRIDEiQ08652

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035029; ENSMUSP00000035029; ENSMUSG00000032454
ENSMUST00000187905; ENSMUSP00000140630; ENSMUSG00000032454
ENSMUST00000189446; ENSMUSP00000140676; ENSMUSG00000032454
GeneIDi19660
KEGGimmu:19660
UCSCiuc009rdk.2 mouse

Organism-specific databases

CTDi5948
MGIiMGI:97877 Rbp2

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiQ08652
KOiK14622
OMAiWKQWVEG
OrthoDBiEOG091G0QSV
PhylomeDBiQ08652
TreeFamiTF316894

Enzyme and pathway databases

ReactomeiR-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

PROiPR:Q08652
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032454 Expressed in 59 organ(s), highest expression level in colon
CleanExiMM_RBP2
ExpressionAtlasiQ08652 baseline and differential
GenevisibleiQ08652 MM

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRET2_MOUSE
AccessioniPrimary (citable) accession number: Q08652
Secondary accession number(s): Q9D1N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again