We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q08642 (PADI2_MOUSE)
Protein
Protein-arginine deiminase type-2
Gene
Padi2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the deimination of arginine residues of proteins.
By similarityCatalytic activityi
- EC:3.5.3.15By similarity
Cofactori
Ca2+By similarityNote: Binding of Ca2+ triggers a conformation change that is essential for catalytic activity.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 131 | Calcium 1By similarity | 1 | |
Metal bindingi | 133 | Calcium 1By similarity | 1 | |
Metal bindingi | 135 | Calcium 1By similarity | 1 | |
Metal bindingi | 139 | Calcium 1By similarity | 1 | |
Metal bindingi | 162 | Calcium 2By similarity | 1 | |
Metal bindingi | 164 | Calcium 2By similarity | 1 | |
Metal bindingi | 164 | Calcium 3By similarity | 1 | |
Metal bindingi | 166 | Calcium 2By similarity | 1 | |
Metal bindingi | 166 | Calcium 3By similarity | 1 | |
Metal bindingi | 174 | Calcium 2By similarity | 1 | |
Metal bindingi | 174 | Calcium 4; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 177 | Calcium 4By similarity | 1 | |
Metal bindingi | 179 | Calcium 4; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 185 | Calcium 2By similarity | 1 | |
Metal bindingi | 188 | Calcium 2By similarity | 1 | |
Metal bindingi | 188 | Calcium 3By similarity | 1 | |
Metal bindingi | 362 | Calcium 5By similarity | 1 | |
Metal bindingi | 397 | Calcium 3By similarity | 1 | |
Metal bindingi | 416 | Calcium 5; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 419 | Calcium 5; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 420 | Calcium 5By similarity | 1 | |
Active sitei | 655 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- estrogen receptor binding Source: MGI
- protein-arginine deiminase activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: MGI
- epigenetic maintenance of chromatin in transcription-competent conformation Source: MGI
- histone citrullination Source: GO_Central
- histone H3-R26 citrullination Source: MGI
- intracellular estrogen receptor signaling pathway Source: MGI
- negative regulation of chemokine-mediated signaling pathway Source: MGI
- negative regulation of lymphocyte chemotaxis Source: MGI
- protein citrullination Source: UniProtKB
- regulation of chromatin disassembly Source: MGI
Keywordsi
Molecular function | Hydrolase |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.5.3.15, 3474 |
Reactomei | R-MMU-3247509, Chromatin modifying enzymes R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein-arginine deiminase type-2 (EC:3.5.3.15By similarity)Alternative name(s): Peptidylarginine deiminase II Protein-arginine deiminase type II |
Gene namesi | Name:Padi2 Synonyms:Pad2, Pdi, Pdi2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338892, Padi2 |
VEuPathDBi | HostDB:ENSMUSG00000028927 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: MGI
- transcriptionally active chromatin Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220027 | 1 – 673 | Protein-arginine deiminase type-2Add BLAST | 673 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Modified residuei | 352 | Citrulline1 Publication | 1 |
Keywords - PTMi
Acetylation, CitrullinationProteomic databases
EPDi | Q08642 |
MaxQBi | Q08642 |
PaxDbi | Q08642 |
PeptideAtlasi | Q08642 |
PRIDEi | Q08642 |
ProteomicsDBi | 294148 |
PTM databases
iPTMneti | Q08642 |
PhosphoSitePlusi | Q08642 |
SwissPalmi | Q08642 |
Expressioni
Tissue specificityi
Expressed in various tissues including muscle, uterus, spinal cord, salivary gland and pancreas.1 Publication
Developmental stagei
Expressed during the estrus cycle. Expressed during diestrus and proestrus with an eight fold decline when estrus cycle is reached.
Gene expression databases
Bgeei | ENSMUSG00000028927, Expressed in cochlea and 197 other tissues |
Genevisiblei | Q08642, MM |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- estrogen receptor binding Source: MGI
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 202093, 2 interactors |
STRINGi | 10090.ENSMUSP00000030765 |
Chemistry databases
BindingDBi | Q08642 |
Miscellaneous databases
RNActi | Q08642, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the protein arginine deiminase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QVJA, Eukaryota |
GeneTreei | ENSGT00940000153217 |
HOGENOMi | CLU_021911_0_0_1 |
InParanoidi | Q08642 |
OMAi | DFPIKQL |
OrthoDBi | 787070at2759 |
PhylomeDBi | Q08642 |
TreeFami | TF331952 |
Family and domain databases
Gene3Di | 2.60.40.1700, 1 hit 2.60.40.1860, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR004303, PAD IPR013530, PAD_C IPR036556, PAD_central_sf IPR013732, PAD_N IPR038685, PAD_N_sf IPR013733, Prot_Arg_deaminase_cen_dom |
PANTHERi | PTHR10837, PTHR10837, 1 hit |
Pfami | View protein in Pfam PF03068, PAD, 1 hit PF08527, PAD_M, 1 hit PF08526, PAD_N, 1 hit |
PIRSFi | PIRSF001247, Protein-arginine_deiminase, 1 hit |
SUPFAMi | SSF110083, SSF110083, 1 hit SSF49503, SSF49503, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08642-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPPIRENML RERTVRLQYG SRVEAVYVLG TQLWTDVYSA APAGAKTFSL
60 70 80 90 100
KHSEGVKVEV VRDGEAEEVV TNGKQRWALS PSSTLRLSMA QASTEASSDK
110 120 130 140 150
VTVNYYEEEG SAPIDQAGLF LTAIEISLDV DADRDGEVEK NNPKKASWTW
160 170 180 190 200
GPEGQGAILL VNCDRDTPWL PKEDCSDEKV YSKQDLQDMS QMILRTKGPD
210 220 230 240 250
RLPAGYEIVL YISMSDSDKV GVFYVENPFF GQRYIHILGR QKLYHVVKYT
260 270 280 290 300
GGSAELLFFV EGLCFPDESF SGLVSIHVSL LEYMAEGIPL TPIFTDTVMF
310 320 330 340 350
RIAPWIMTPN ILPPVSVFVC CMKDNYLFLK EVKNLVEKTN CELKVCFQYM
360 370 380 390 400
NRGDRWIQDE IEFGYIEAPH KGFPVVLDSP RDGNLKDFPI KQLLGPDFGY
410 420 430 440 450
VTREPLFETV TSLDSFGNLE VSPPVTVNGK EYPLGRILIG SSFPLSGGRR
460 470 480 490 500
MTKVVRDFLQ AQQVQAPVEL YSDWLTVGHV DEFMTFIPIP GKKEFRLLMA
510 520 530 540 550
STSACYQLFR EKQKAGHGEA VMFKGLGGMS SKRITINKIL SNESLTQENQ
560 570 580 590 600
YFQRCLDWNR DILKRELALT EKDIIDLPAL FKMDENHQAR AFFPNMVNMI
610 620 630 640 650
VLDKDLGIPK PFGPQVEEEC CLETHVRGLL EPLGLACTFI DDISAYHKFL
660 670
GEVHCGTNVR RKPFTFKWWH MVP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 665 | T → A in BAA04012 (PubMed:8354274).Curated | 1 | |
Sequence conflicti | 665 | T → A in AAH40350 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 665 | T → A in AAH49947 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16580 mRNA Translation: BAA04012.1 AB121692 Genomic DNA Translation: BAD16624.1 AL645625 Genomic DNA No translation available. AL807805 Genomic DNA No translation available. BC040350 mRNA Translation: AAH40350.1 BC049947 mRNA Translation: AAH49947.1 |
CCDSi | CCDS18857.1 |
PIRi | S35038, DIMSR1 |
RefSeqi | NP_032838.2, NM_008812.2 |
Genome annotation databases
Ensembli | ENSMUST00000030765; ENSMUSP00000030765; ENSMUSG00000028927 |
GeneIDi | 18600 |
KEGGi | mmu:18600 |
UCSCi | uc008vni.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16580 mRNA Translation: BAA04012.1 AB121692 Genomic DNA Translation: BAD16624.1 AL645625 Genomic DNA No translation available. AL807805 Genomic DNA No translation available. BC040350 mRNA Translation: AAH40350.1 BC049947 mRNA Translation: AAH49947.1 |
CCDSi | CCDS18857.1 |
PIRi | S35038, DIMSR1 |
RefSeqi | NP_032838.2, NM_008812.2 |
3D structure databases
SMRi | Q08642 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202093, 2 interactors |
STRINGi | 10090.ENSMUSP00000030765 |
Chemistry databases
BindingDBi | Q08642 |
ChEMBLi | CHEMBL2321611 |
PTM databases
iPTMneti | Q08642 |
PhosphoSitePlusi | Q08642 |
SwissPalmi | Q08642 |
Proteomic databases
EPDi | Q08642 |
MaxQBi | Q08642 |
PaxDbi | Q08642 |
PeptideAtlasi | Q08642 |
PRIDEi | Q08642 |
ProteomicsDBi | 294148 |
Protocols and materials databases
Antibodypediai | 29317, 274 antibodies from 28 providers |
DNASUi | 18600 |
Genome annotation databases
Ensembli | ENSMUST00000030765; ENSMUSP00000030765; ENSMUSG00000028927 |
GeneIDi | 18600 |
KEGGi | mmu:18600 |
UCSCi | uc008vni.2, mouse |
Organism-specific databases
CTDi | 11240 |
MGIi | MGI:1338892, Padi2 |
VEuPathDBi | HostDB:ENSMUSG00000028927 |
Phylogenomic databases
eggNOGi | ENOG502QVJA, Eukaryota |
GeneTreei | ENSGT00940000153217 |
HOGENOMi | CLU_021911_0_0_1 |
InParanoidi | Q08642 |
OMAi | DFPIKQL |
OrthoDBi | 787070at2759 |
PhylomeDBi | Q08642 |
TreeFami | TF331952 |
Enzyme and pathway databases
BRENDAi | 3.5.3.15, 3474 |
Reactomei | R-MMU-3247509, Chromatin modifying enzymes R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 18600, 3 hits in 64 CRISPR screens |
ChiTaRSi | Padi2, mouse |
PROi | PR:Q08642 |
RNActi | Q08642, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028927, Expressed in cochlea and 197 other tissues |
Genevisiblei | Q08642, MM |
Family and domain databases
Gene3Di | 2.60.40.1700, 1 hit 2.60.40.1860, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR004303, PAD IPR013530, PAD_C IPR036556, PAD_central_sf IPR013732, PAD_N IPR038685, PAD_N_sf IPR013733, Prot_Arg_deaminase_cen_dom |
PANTHERi | PTHR10837, PTHR10837, 1 hit |
Pfami | View protein in Pfam PF03068, PAD, 1 hit PF08527, PAD_M, 1 hit PF08526, PAD_N, 1 hit |
PIRSFi | PIRSF001247, Protein-arginine_deiminase, 1 hit |
SUPFAMi | SSF110083, SSF110083, 1 hit SSF49503, SSF49503, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PADI2_MOUSE | |
Accessioni | Q08642Primary (citable) accession number: Q08642 Secondary accession number(s): Q75WD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families