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Protein

Protein-arginine deiminase type-2

Gene

Padi2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium

Enzyme and pathway databases

BRENDAi3.5.3.15 3474
ReactomeiR-MMU-3247509 Chromatin modifying enzymes
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-2 (EC:3.5.3.15)
Alternative name(s):
Peptidylarginine deiminase II
Protein-arginine deiminase type II
Gene namesi
Name:Padi2
Synonyms:Pad2, Pdi, Pdi2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1338892 Padi2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2321611

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002200271 – 673Protein-arginine deiminase type-2Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei352Citrulline1 Publication1

Keywords - PTMi

Acetylation, Citrullination

Proteomic databases

EPDiQ08642
MaxQBiQ08642
PaxDbiQ08642
PeptideAtlasiQ08642
PRIDEiQ08642

PTM databases

iPTMnetiQ08642
PhosphoSitePlusiQ08642

Expressioni

Tissue specificityi

Expressed in various tissues including muscle, uterus, spinal cord, salivary gland and pancreas.1 Publication

Developmental stagei

Expressed during the estrus cycle. Expressed during diestrus and proestrus with an eight fold decline when estrus cycle is reached.

Gene expression databases

BgeeiENSMUSG00000028927 Expressed in 161 organ(s), highest expression level in cochlea
CleanExiMM_PADI2
GenevisibleiQ08642 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202093, 2 interactors
IntActiQ08642, 1 interactor
MINTiQ08642
STRINGi10090.ENSMUSP00000030765

Structurei

3D structure databases

ProteinModelPortaliQ08642
SMRiQ08642
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
GeneTreeiENSGT00390000008680
HOGENOMiHOG000220908
HOVERGENiHBG053016
InParanoidiQ08642
KOiK01481
OMAiCTFVDDI
OrthoDBiEOG091G02QG
TreeFamiTF331952

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

Sequencei

Sequence statusi: Complete.

Q08642-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPPIRENML RERTVRLQYG SRVEAVYVLG TQLWTDVYSA APAGAKTFSL
60 70 80 90 100
KHSEGVKVEV VRDGEAEEVV TNGKQRWALS PSSTLRLSMA QASTEASSDK
110 120 130 140 150
VTVNYYEEEG SAPIDQAGLF LTAIEISLDV DADRDGEVEK NNPKKASWTW
160 170 180 190 200
GPEGQGAILL VNCDRDTPWL PKEDCSDEKV YSKQDLQDMS QMILRTKGPD
210 220 230 240 250
RLPAGYEIVL YISMSDSDKV GVFYVENPFF GQRYIHILGR QKLYHVVKYT
260 270 280 290 300
GGSAELLFFV EGLCFPDESF SGLVSIHVSL LEYMAEGIPL TPIFTDTVMF
310 320 330 340 350
RIAPWIMTPN ILPPVSVFVC CMKDNYLFLK EVKNLVEKTN CELKVCFQYM
360 370 380 390 400
NRGDRWIQDE IEFGYIEAPH KGFPVVLDSP RDGNLKDFPI KQLLGPDFGY
410 420 430 440 450
VTREPLFETV TSLDSFGNLE VSPPVTVNGK EYPLGRILIG SSFPLSGGRR
460 470 480 490 500
MTKVVRDFLQ AQQVQAPVEL YSDWLTVGHV DEFMTFIPIP GKKEFRLLMA
510 520 530 540 550
STSACYQLFR EKQKAGHGEA VMFKGLGGMS SKRITINKIL SNESLTQENQ
560 570 580 590 600
YFQRCLDWNR DILKRELALT EKDIIDLPAL FKMDENHQAR AFFPNMVNMI
610 620 630 640 650
VLDKDLGIPK PFGPQVEEEC CLETHVRGLL EPLGLACTFI DDISAYHKFL
660 670
GEVHCGTNVR RKPFTFKWWH MVP
Length:673
Mass (Da):76,250
Last modified:July 27, 2011 - v2
Checksum:iF72A36079DA914E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti665T → A in BAA04012 (PubMed:8354274).Curated1
Sequence conflicti665T → A in AAH40350 (PubMed:15489334).Curated1
Sequence conflicti665T → A in AAH49947 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16580 mRNA Translation: BAA04012.1
AB121692 Genomic DNA Translation: BAD16624.1
AL645625, AL807805 Genomic DNA Translation: CAM16760.1
AL807805, AL645625 Genomic DNA Translation: CAM25735.1
BC040350 mRNA Translation: AAH40350.1
BC049947 mRNA Translation: AAH49947.1
CCDSiCCDS18857.1
PIRiS35038 DIMSR1
RefSeqiNP_032838.2, NM_008812.2
UniGeneiMm.2296

Genome annotation databases

EnsembliENSMUST00000030765; ENSMUSP00000030765; ENSMUSG00000028927
GeneIDi18600
KEGGimmu:18600
UCSCiuc008vni.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPADI2_MOUSE
AccessioniPrimary (citable) accession number: Q08642
Secondary accession number(s): Q75WD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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