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UniProtKB - Q08629 (TICN1_HUMAN)
Protein
Testican-1
Gene
SPOCK1
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- cysteine-type endopeptidase inhibitor activity Source: UniProtKB
- metalloendopeptidase inhibitor activity Source: UniProtKB
- serine-type endopeptidase inhibitor activity Source: UniProtKB
GO - Biological processi
- cell adhesion Source: UniProtKB
- central nervous system neuron differentiation Source: UniProtKB
- negative regulation of cell-substrate adhesion Source: UniProtKB
- negative regulation of endopeptidase activity Source: UniProtKB
- negative regulation of neuron projection development Source: UniProtKB
- nervous system development Source: UniProtKB
- neurogenesis Source: UniProtKB
- neuron migration Source: UniProtKB
- regulation of cell growth Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q08629 |
SignaLinki | Q08629 |
Protein family/group databases
MEROPSi | I31.006 |
Names & Taxonomyi
Protein namesi | Recommended name: Testican-1Alternative name(s): Protein SPOCK |
Gene namesi | Name:SPOCK1 Synonyms:SPOCK, TIC1, TICN1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11251, SPOCK1 |
MIMi | 602264, gene |
neXtProti | NX_Q08629 |
VEuPathDBi | HostDB:ENSG00000152377 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- neuromuscular junction Source: UniProtKB
- node of Ranvier Source: UniProtKB
- postsynaptic density Source: UniProtKB
- sarcoplasm Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 6695 |
OpenTargetsi | ENSG00000152377 |
PharmGKBi | PA36081 |
Miscellaneous databases
Pharosi | Q08629, Tbio |
Genetic variation databases
BioMutai | SPOCK1 |
DMDMi | 24212472 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000026699 | 22 – 439 | Testican-1Add BLAST | 418 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 86 ↔ 97 | By similarity | ||
Disulfide bondi | 91 ↔ 107 | By similarity | ||
Disulfide bondi | 136 ↔ 166 | By similarity | ||
Disulfide bondi | 139 ↔ 159 | By similarity | ||
Disulfide bondi | 148 ↔ 180 | By similarity | ||
Glycosylationi | 228 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 313 ↔ 337 | By similarity | ||
Disulfide bondi | 348 ↔ 355 | By similarity | ||
Disulfide bondi | 357 ↔ 376 | By similarity | ||
Glycosylationi | 383 | O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis | 1 | |
Glycosylationi | 388 | O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis | 1 |
Post-translational modificationi
O-glycosylated. Glycosaminoglycan that contains chondroitin sulfate and heparan sulfate.2 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, Heparan sulfate, ProteoglycanProteomic databases
jPOSTi | Q08629 |
MassIVEi | Q08629 |
MaxQBi | Q08629 |
PaxDbi | Q08629 |
PeptideAtlasi | Q08629 |
PRIDEi | Q08629 |
ProteomicsDBi | 58637 |
TopDownProteomicsi | Q08629 |
PTM databases
GlyConnecti | 719, 1 O-Linked glycan (1 site) |
GlyGeni | Q08629, 5 sites, 2 O-linked glycans (1 site) |
iPTMneti | Q08629 |
PhosphoSitePlusi | Q08629 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152377, Expressed in cerebellum and 237 other tissues |
ExpressionAtlasi | Q08629, baseline and differential |
Genevisiblei | Q08629, HS |
Organism-specific databases
HPAi | ENSG00000152377, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Q08629
With | #Exp. | IntAct |
---|---|---|
BCL2L13 [Q9BXK5] | 3 | EBI-2682560,EBI-747430 |
CREB3L1 [Q96BA8] | 3 | EBI-2682560,EBI-6942903 |
Protein-protein interaction databases
BioGRIDi | 112573, 6 interactors |
IntActi | Q08629, 5 interactors |
STRINGi | 9606.ENSP00000378401 |
Miscellaneous databases
RNActi | Q08629, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 130 – 182 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 310 – 376 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 415 – 439 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 422 – 439 | Acidic residuesSequence analysisAdd BLAST | 18 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3555, Eukaryota |
GeneTreei | ENSGT00940000158371 |
InParanoidi | Q08629 |
OMAi | PNCDEDP |
OrthoDBi | 1235834at2759 |
PhylomeDBi | Q08629 |
TreeFami | TF317779 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR019577, SPARC/Testican_Ca-bd-dom IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF07648, Kazal_2, 1 hit PF10591, SPARC_Ca_bdg, 1 hit PF00086, Thyroglobulin_1, 1 hit |
SMARTi | View protein in SMART SM00280, KAZAL, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q08629-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPAIAVLAAA AAAWCFLQVE SRHLDALAGG AGPNHGNFLD NDQWLSTVSQ
60 70 80 90 100
YDRDKYWNRF RDDDYFRNWN PNKPFDQALD PSKDPCLKVK CSPHKVCVTQ
110 120 130 140 150
DYQTALCVSR KHLLPRQKKG NVAQKHWVGP SNLVKCKPCP VAQSAMVCGS
160 170 180 190 200
DGHSYTSKCK LEFHACSTGK SLATLCDGPC PCLPEPEPPK HKAERSACTD
210 220 230 240 250
KELRNLASRL KDWFGALHED ANRVIKPTSS NTAQGRFDTS ILPICKDSLG
260 270 280 290 300
WMFNKLDMNY DLLLDPSEIN AIYLDKYEPC IKPLFNSCDS FKDGKLSNNE
310 320 330 340 350
WCYCFQKPGG LPCQNEMNRI QKLSKGKSLL GAFIPRCNEE GYYKATQCHG
360 370 380 390 400
STGQCWCVDK YGNELAGSRK QGAVSCEEEQ ETSGDFGSGG SVVLLDDLEY
410 420 430
ERELGPKDKE GKLRVHTRAV TEDDEDEDDD KEDEVGYIW
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MQX7 | A0A0A0MQX7_HUMAN | Testican-1 | SPOCK1 | 377 | Annotation score: | ||
D6RB21 | D6RB21_HUMAN | Testican-1 | SPOCK1 | 139 | Annotation score: | ||
D6RAM7 | D6RAM7_HUMAN | Testican-1 | SPOCK1 | 67 | Annotation score: |
Sequence cautioni
The sequence BAD92938 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | D → DEVE in BAD92938 (Ref. 4) Curated | 1 | |
Sequence conflicti | 77 | Q → K in AAH30691 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73608 mRNA Translation: CAA51999.1 AF231124 mRNA Translation: AAF43687.1 AK094489 mRNA Translation: BAG52875.1 AB209701 mRNA Translation: BAD92938.1 Different initiation. AC005213 Genomic DNA Translation: AAC24945.1 AC091818 Genomic DNA No translation available. AC106746 Genomic DNA No translation available. AC106809 Genomic DNA No translation available. BC030691 mRNA Translation: AAH30691.1 |
CCDSi | CCDS4191.1 |
PIRi | S33293 |
RefSeqi | NP_004589.1, NM_004598.3 |
Genome annotation databases
Ensembli | ENST00000394945.6; ENSP00000378401.1; ENSG00000152377.14 |
GeneIDi | 6695 |
KEGGi | hsa:6695 |
MANE-Selecti | ENST00000394945.6; ENSP00000378401.1; NM_004598.4; NP_004589.1 |
UCSCi | uc003lbp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73608 mRNA Translation: CAA51999.1 AF231124 mRNA Translation: AAF43687.1 AK094489 mRNA Translation: BAG52875.1 AB209701 mRNA Translation: BAD92938.1 Different initiation. AC005213 Genomic DNA Translation: AAC24945.1 AC091818 Genomic DNA No translation available. AC106746 Genomic DNA No translation available. AC106809 Genomic DNA No translation available. BC030691 mRNA Translation: AAH30691.1 |
CCDSi | CCDS4191.1 |
PIRi | S33293 |
RefSeqi | NP_004589.1, NM_004598.3 |
3D structure databases
AlphaFoldDBi | Q08629 |
SMRi | Q08629 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112573, 6 interactors |
IntActi | Q08629, 5 interactors |
STRINGi | 9606.ENSP00000378401 |
Protein family/group databases
MEROPSi | I31.006 |
PTM databases
GlyConnecti | 719, 1 O-Linked glycan (1 site) |
GlyGeni | Q08629, 5 sites, 2 O-linked glycans (1 site) |
iPTMneti | Q08629 |
PhosphoSitePlusi | Q08629 |
Genetic variation databases
BioMutai | SPOCK1 |
DMDMi | 24212472 |
Proteomic databases
jPOSTi | Q08629 |
MassIVEi | Q08629 |
MaxQBi | Q08629 |
PaxDbi | Q08629 |
PeptideAtlasi | Q08629 |
PRIDEi | Q08629 |
ProteomicsDBi | 58637 |
TopDownProteomicsi | Q08629 |
Protocols and materials databases
Antibodypediai | 26517, 130 antibodies from 23 providers |
DNASUi | 6695 |
Genome annotation databases
Ensembli | ENST00000394945.6; ENSP00000378401.1; ENSG00000152377.14 |
GeneIDi | 6695 |
KEGGi | hsa:6695 |
MANE-Selecti | ENST00000394945.6; ENSP00000378401.1; NM_004598.4; NP_004589.1 |
UCSCi | uc003lbp.4, human |
Organism-specific databases
CTDi | 6695 |
DisGeNETi | 6695 |
GeneCardsi | SPOCK1 |
HGNCi | HGNC:11251, SPOCK1 |
HPAi | ENSG00000152377, Tissue enhanced (brain) |
MIMi | 602264, gene |
neXtProti | NX_Q08629 |
OpenTargetsi | ENSG00000152377 |
PharmGKBi | PA36081 |
VEuPathDBi | HostDB:ENSG00000152377 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3555, Eukaryota |
GeneTreei | ENSGT00940000158371 |
InParanoidi | Q08629 |
OMAi | PNCDEDP |
OrthoDBi | 1235834at2759 |
PhylomeDBi | Q08629 |
TreeFami | TF317779 |
Enzyme and pathway databases
PathwayCommonsi | Q08629 |
SignaLinki | Q08629 |
Miscellaneous databases
BioGRID-ORCSi | 6695, 8 hits in 1068 CRISPR screens |
ChiTaRSi | SPOCK1, human |
GeneWikii | SPOCK1 |
GenomeRNAii | 6695 |
Pharosi | Q08629, Tbio |
PROi | PR:Q08629 |
RNActi | Q08629, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152377, Expressed in cerebellum and 237 other tissues |
ExpressionAtlasi | Q08629, baseline and differential |
Genevisiblei | Q08629, HS |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR019577, SPARC/Testican_Ca-bd-dom IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF07648, Kazal_2, 1 hit PF10591, SPARC_Ca_bdg, 1 hit PF00086, Thyroglobulin_1, 1 hit |
SMARTi | View protein in SMART SM00280, KAZAL, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TICN1_HUMAN | |
Accessioni | Q08629Primary (citable) accession number: Q08629 Secondary accession number(s): B3KSW3 Q9UCL8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot