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Protein

Testican-1

Gene

SPOCK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • collagen binding Source: GO_Central
  • cysteine-type endopeptidase inhibitor activity Source: UniProtKB
  • extracellular matrix binding Source: GO_Central
  • metalloendopeptidase inhibitor activity Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

Protein family/group databases

MEROPSiI31.006

Names & Taxonomyi

Protein namesi
Recommended name:
Testican-1
Alternative name(s):
Protein SPOCK
Gene namesi
Name:SPOCK1
Synonyms:SPOCK, TIC1, TICN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000152377.13
HGNCiHGNC:11251 SPOCK1
MIMi602264 gene
neXtProtiNX_Q08629

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6695
OpenTargetsiENSG00000152377
PharmGKBiPA36081

Polymorphism and mutation databases

BioMutaiSPOCK1
DMDMi24212472

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002669922 – 439Testican-1Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi86 ↔ 97By similarity
Disulfide bondi91 ↔ 107By similarity
Disulfide bondi136 ↔ 166By similarity
Disulfide bondi139 ↔ 159By similarity
Disulfide bondi148 ↔ 180By similarity
Glycosylationi228O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi313 ↔ 337By similarity
Disulfide bondi348 ↔ 355By similarity
Disulfide bondi357 ↔ 376By similarity
Glycosylationi383O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi388O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1

Post-translational modificationi

O-glycosylated. Glycosaminoglycan that contains chondroitin sulfate and heparan sulfate.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

MaxQBiQ08629
PaxDbiQ08629
PeptideAtlasiQ08629
PRIDEiQ08629
ProteomicsDBi58637
TopDownProteomicsiQ08629

PTM databases

GlyConnecti719
iPTMnetiQ08629
PhosphoSitePlusiQ08629
UniCarbKBiQ08629

Expressioni

Gene expression databases

BgeeiENSG00000152377 Expressed in 223 organ(s), highest expression level in cerebellum
CleanExiHS_SPOCK1
ExpressionAtlasiQ08629 baseline and differential
GenevisibleiQ08629 HS

Organism-specific databases

HPAiHPA007450
HPA026770

Interactioni

Protein-protein interaction databases

BioGridi112573, 2 interactors
IntActiQ08629, 4 interactors
STRINGi9606.ENSP00000282223

Structurei

3D structure databases

ProteinModelPortaliQ08629
SMRiQ08629
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 182Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini310 – 376Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST67

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3555 Eukaryota
ENOG410Y6A8 LUCA
GeneTreeiENSGT00510000046429
HOGENOMiHOG000293295
HOVERGENiHBG026595
InParanoidiQ08629
KOiK08136
OMAiCKLEFQS
OrthoDBiEOG091G086I
PhylomeDBiQ08629
TreeFamiTF317779

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q08629-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAIAVLAAA AAAWCFLQVE SRHLDALAGG AGPNHGNFLD NDQWLSTVSQ
60 70 80 90 100
YDRDKYWNRF RDDDYFRNWN PNKPFDQALD PSKDPCLKVK CSPHKVCVTQ
110 120 130 140 150
DYQTALCVSR KHLLPRQKKG NVAQKHWVGP SNLVKCKPCP VAQSAMVCGS
160 170 180 190 200
DGHSYTSKCK LEFHACSTGK SLATLCDGPC PCLPEPEPPK HKAERSACTD
210 220 230 240 250
KELRNLASRL KDWFGALHED ANRVIKPTSS NTAQGRFDTS ILPICKDSLG
260 270 280 290 300
WMFNKLDMNY DLLLDPSEIN AIYLDKYEPC IKPLFNSCDS FKDGKLSNNE
310 320 330 340 350
WCYCFQKPGG LPCQNEMNRI QKLSKGKSLL GAFIPRCNEE GYYKATQCHG
360 370 380 390 400
STGQCWCVDK YGNELAGSRK QGAVSCEEEQ ETSGDFGSGG SVVLLDDLEY
410 420 430
ERELGPKDKE GKLRVHTRAV TEDDEDEDDD KEDEVGYIW
Length:439
Mass (Da):49,124
Last modified:November 1, 1996 - v1
Checksum:i1971601D90F1D0AD
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQX7A0A0A0MQX7_HUMAN
Testican-1
SPOCK1
377Annotation score:
D6RB21D6RB21_HUMAN
Testican-1
SPOCK1
139Annotation score:
D6RAM7D6RAM7_HUMAN
Testican-1
SPOCK1
67Annotation score:

Sequence cautioni

The sequence BAD92938 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62D → DEVE in BAD92938 (Ref. 4) Curated1
Sequence conflicti77Q → K in AAH30691 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73608 mRNA Translation: CAA51999.1
AF231124 mRNA Translation: AAF43687.1
AK094489 mRNA Translation: BAG52875.1
AB209701 mRNA Translation: BAD92938.1 Different initiation.
AC005213 Genomic DNA Translation: AAC24945.1
AC091818 Genomic DNA No translation available.
AC106746 Genomic DNA No translation available.
AC106809 Genomic DNA No translation available.
BC030691 mRNA Translation: AAH30691.1
CCDSiCCDS4191.1
PIRiS33293
RefSeqiNP_004589.1, NM_004598.3
UniGeneiHs.596136

Genome annotation databases

EnsembliENST00000394945; ENSP00000378401; ENSG00000152377
GeneIDi6695
KEGGihsa:6695
UCSCiuc003lbp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73608 mRNA Translation: CAA51999.1
AF231124 mRNA Translation: AAF43687.1
AK094489 mRNA Translation: BAG52875.1
AB209701 mRNA Translation: BAD92938.1 Different initiation.
AC005213 Genomic DNA Translation: AAC24945.1
AC091818 Genomic DNA No translation available.
AC106746 Genomic DNA No translation available.
AC106809 Genomic DNA No translation available.
BC030691 mRNA Translation: AAH30691.1
CCDSiCCDS4191.1
PIRiS33293
RefSeqiNP_004589.1, NM_004598.3
UniGeneiHs.596136

3D structure databases

ProteinModelPortaliQ08629
SMRiQ08629
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112573, 2 interactors
IntActiQ08629, 4 interactors
STRINGi9606.ENSP00000282223

Protein family/group databases

MEROPSiI31.006

PTM databases

GlyConnecti719
iPTMnetiQ08629
PhosphoSitePlusiQ08629
UniCarbKBiQ08629

Polymorphism and mutation databases

BioMutaiSPOCK1
DMDMi24212472

Proteomic databases

MaxQBiQ08629
PaxDbiQ08629
PeptideAtlasiQ08629
PRIDEiQ08629
ProteomicsDBi58637
TopDownProteomicsiQ08629

Protocols and materials databases

DNASUi6695
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394945; ENSP00000378401; ENSG00000152377
GeneIDi6695
KEGGihsa:6695
UCSCiuc003lbp.4 human

Organism-specific databases

CTDi6695
DisGeNETi6695
EuPathDBiHostDB:ENSG00000152377.13
GeneCardsiSPOCK1
HGNCiHGNC:11251 SPOCK1
HPAiHPA007450
HPA026770
MIMi602264 gene
neXtProtiNX_Q08629
OpenTargetsiENSG00000152377
PharmGKBiPA36081
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3555 Eukaryota
ENOG410Y6A8 LUCA
GeneTreeiENSGT00510000046429
HOGENOMiHOG000293295
HOVERGENiHBG026595
InParanoidiQ08629
KOiK08136
OMAiCKLEFQS
OrthoDBiEOG091G086I
PhylomeDBiQ08629
TreeFamiTF317779

Miscellaneous databases

ChiTaRSiSPOCK1 human
GeneWikiiSPOCK1
GenomeRNAii6695
PROiPR:Q08629
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152377 Expressed in 223 organ(s), highest expression level in cerebellum
CleanExiHS_SPOCK1
ExpressionAtlasiQ08629 baseline and differential
GenevisibleiQ08629 HS

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTICN1_HUMAN
AccessioniPrimary (citable) accession number: Q08629
Secondary accession number(s): B3KSW3
, Q59EW0, Q8N630, Q9UCL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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