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Protein

Homeobox protein Hox-C4

Gene

Hoxc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi156 – 215HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C4
Alternative name(s):
Homeobox protein Hox-3.5
Gene namesi
Name:Hoxc4
Synonyms:Hox-3.5, Hoxc-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96195 Hoxc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001651 – 264Homeobox protein Hox-C4Add BLAST264

Proteomic databases

PaxDbiQ08624
PRIDEiQ08624

PTM databases

iPTMnetiQ08624
PhosphoSitePlusiQ08624

Expressioni

Gene expression databases

BgeeiENSMUSG00000075394 Expressed in 139 organ(s), highest expression level in skin of back
CleanExiMM_HOXC4
ExpressionAtlasiQ08624 baseline and differential
GenevisibleiQ08624 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200386, 6 interactors
STRINGi10090.ENSMUSP00000097740

Structurei

3D structure databases

ProteinModelPortaliQ08624
SMRiQ08624
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi135 – 140Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 60Poly-Pro7
Compositional biasi183 – 186Poly-Arg4

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiQ08624
KOiK09304
OMAiPPRASYQ
OrthoDBiEOG091G09XD
PhylomeDBiQ08624
TreeFamiTF352857

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q08624-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ
60 70 80 90 100
ELYPPPPPRP SYPERQYSCT SLQGPGNSRA HGPAQAGHHH PEKSQPLCEP
110 120 130 140 150
APLSGTSASP SPAPPACSQP APDHPSSAAS KQPIVYPWMK KIHVSTVNPN
160 170 180 190 200
YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY LTRRRRIEIA HSLCLSERQI
210 220 230 240 250
KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP GTSEDHSQSA
260
TPPEQQRAED ITRL
Length:264
Mass (Da):29,865
Last modified:October 1, 1994 - v1
Checksum:i35B0FA34B45BF30C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UX59G3UX59_MOUSE
Homeobox protein Hox-C4
Hoxc4
151Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80A → G in CAA48784 (PubMed:1363091).Curated1
Sequence conflicti96P → S in CAA48784 (PubMed:1363091).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11328 Genomic DNA Translation: BAA01947.1
S62287 Genomic DNA Translation: AAB27153.1
X69019 mRNA Translation: CAA48784.1
M81660 Genomic DNA Translation: AAA63313.1
CCDSiCCDS27897.1
PIRiS35219
RefSeqiNP_038581.2, NM_013553.2
XP_006520524.1, XM_006520461.2
XP_006520525.1, XM_006520462.3
XP_006520526.1, XM_006520463.2
XP_011243762.1, XM_011245460.2
UniGeneiMm.1351

Genome annotation databases

EnsembliENSMUST00000100164; ENSMUSP00000097740; ENSMUSG00000075394
GeneIDi15423
KEGGimmu:15423
UCSCiuc007xxg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11328 Genomic DNA Translation: BAA01947.1
S62287 Genomic DNA Translation: AAB27153.1
X69019 mRNA Translation: CAA48784.1
M81660 Genomic DNA Translation: AAA63313.1
CCDSiCCDS27897.1
PIRiS35219
RefSeqiNP_038581.2, NM_013553.2
XP_006520524.1, XM_006520461.2
XP_006520525.1, XM_006520462.3
XP_006520526.1, XM_006520463.2
XP_011243762.1, XM_011245460.2
UniGeneiMm.1351

3D structure databases

ProteinModelPortaliQ08624
SMRiQ08624
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200386, 6 interactors
STRINGi10090.ENSMUSP00000097740

PTM databases

iPTMnetiQ08624
PhosphoSitePlusiQ08624

Proteomic databases

PaxDbiQ08624
PRIDEiQ08624

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100164; ENSMUSP00000097740; ENSMUSG00000075394
GeneIDi15423
KEGGimmu:15423
UCSCiuc007xxg.1 mouse

Organism-specific databases

CTDi3221
MGIiMGI:96195 Hoxc4

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiQ08624
KOiK09304
OMAiPPRASYQ
OrthoDBiEOG091G09XD
PhylomeDBiQ08624
TreeFamiTF352857

Miscellaneous databases

PROiPR:Q08624
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075394 Expressed in 139 organ(s), highest expression level in skin of back
CleanExiMM_HOXC4
ExpressionAtlasiQ08624 baseline and differential
GenevisibleiQ08624 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXC4_MOUSE
AccessioniPrimary (citable) accession number: Q08624
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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