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UniProtKB - Q08562 (ULS1_YEAST)
Protein
ATP-dependent helicase ULS1
Gene
ULS1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
ATP-dependent helicase involved mating type switching and in silencing interference through its interaction with the silencing regulator SIR4. Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 969 – 976 | ATPPROSITE-ProRule annotation | 8 | |
Zinc fingeri | 1330 – 1386 | RING-typePROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP-dependent activity, acting on DNA Source: SGD
- ATP-dependent chromatin remodeler activity Source: InterPro
- helicase activity Source: UniProtKB-KW
- hydrolase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- SUMO binding Source: SGD
GO - Biological processi
- chromatin assembly or disassembly Source: SGD
- mating type switching Source: SGD
- negative regulation of double-strand break repair via nonhomologous end joining Source: SGD
Keywordsi
Molecular function | Activator, Helicase, Hydrolase |
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-dependent helicase ULS1 (EC:3.6.4.-)Alternative name(s): Role in silencing protein 1 Ubiquitin ligase for SUMO conjugates protein 1 |
Gene namesi | Name:ULS1 Synonyms:DIS1, RIS1, TID4 Ordered Locus Names:YOR191W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005717, ULS1 |
VEuPathDBi | FungiDB:YOR191W |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Mitochondrion
- mitochondrion Source: SGD
Nucleus
Other locations
- cytoplasm Source: SGD
- kinetochore Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000268702 | 1 – 1619 | ATP-dependent helicase ULS1Add BLAST | 1619 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 121 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q08562 |
PaxDbi | Q08562 |
PRIDEi | Q08562 |
PTM databases
iPTMneti | Q08562 |
Interactioni
Subunit structurei
Interacts with CDC3, CDC11, EBP2, SIR4, UBC4 and SUMO/SMT3.
3 PublicationsGO - Molecular functioni
- SUMO binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 34586, 201 interactors |
DIPi | DIP-996N |
IntActi | Q08562, 8 interactors |
MINTi | Q08562 |
STRINGi | 4932.YOR191W |
Miscellaneous databases
RNActi | Q08562, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 956 – 1157 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 202 | |
Domaini | 1447 – 1606 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 160 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 86 – 123 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 200 – 279 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 347 – 371 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 429 – 450 | DisorderedSequence analysisAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 7 – 10 | SUMO interacting motif; type a 1 | 4 | |
Motifi | 371 – 378 | SUMO interacting motif; type b 1 | 8 | |
Motifi | 470 – 473 | SUMO interacting motif; type a 2 | 4 | |
Motifi | 543 – 550 | SUMO interacting motif; type b 2 | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 86 – 107 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 223 – 279 | Polar residuesSequence analysisAdd BLAST | 57 |
Sequence similaritiesi
Belongs to the SNF2/RAD54 helicase family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1330 – 1386 | RING-typePROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1001, Eukaryota |
HOGENOMi | CLU_000315_34_1_1 |
InParanoidi | Q08562 |
OMAi | VHRLFIK |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit 3.40.50.10810, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00176, SNF2-rel_dom, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08562-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVPTIDLT LADSDNEDIF HSFSSSTSVD KIDIRKENGK LRMAGLEVAQ
60 70 80 90 100
SNDDAARQAF HVFKTNISNN ETFDTILSKS KTITDSTFNN EKSSNEVKQQ
110 120 130 140 150
QVLKEETMGS SNDEKKTQES SPSAEMIKLF YENDDVPLSD SFKQKEEGKR
160 170 180 190 200
INQDEQVKEN ICGISSSYVS KDYDGVEDDF EPNTCQDSNL DFQEEKLNLN
210 220 230 240 250
NKPSQQQFSD PETKDNSLKS ENKDQIKGVT TTSYRDLPIE SSAFQDSETQ
260 270 280 290 300
NNSKNTIPNI VNEKRTPALP SNLSSVESSL KNETAKVEGK TTVRLPGLQN
310 320 330 340 350
NVALLEQEQS ELFKHFSEQP VDISDFGRKI KRKHSGDFAD NKILKRPILP
360 370 380 390 400
SKNMDHTTHN SHDSEQKNSS IIILSDEDES GAGINDIESP LKVSEPNTAD
410 420 430 440 450
ALRSSVPEVI SLLDLPNIDL NNSVIKEASG SNSIPTSETD AQSSSSSVLQ
460 470 480 490 500
GTIMTEQATQ SSQHECNSSL DTLKKNHQKL LKDLNSRESE LRNALSCCKT
510 520 530 540 550
NSEILRRKLS RREKEVSDAE KHWQLLLTSM ARGGRTISST QQILVDEAEN
560 570 580 590 600
QLNKLKEKRQ LTKSKLDSIN LKMYNYNEQW KSFVHSKNIN LQKSLAALER
610 620 630 640 650
SARDSKASAT VNKRNECLAE KEKLDQMLKE GTLSFSTYKQ LTGEIQQKLN
660 670 680 690 700
DLKLGDQRTT DINSVLPIVR QPLAKRDLFI KSIDTAKDLL AKNTSRTEMT
710 720 730 740 750
KRILYRHLDN LVSYKNFFED GRSLIDINRR HVAHESAQIL FTNGVKMPIV
760 770 780 790 800
FETLQDYGIK FSNPAIVNPD RRAQYFKSIE VARDLISKST RSEDAKRKIT
810 820 830 840 850
RFLNIIEEFR KDIDTGFPPT PLKREGVGKA VVGLRQQGLK MDRLYENLRR
860 870 880 890 900
YKIPITSEEL LQQSYLFPVN ADQRPPSNWN IVENTEDTSS TANDLSMQDE
910 920 930 940 950
FHISNMHAAE DQEQIRALLE NVKQSESIID GEALTPEDMT VNLLKHQRLG
960 970 980 990 1000
LHWLLQVENS AKKGGLLADD MGLGKTIQAI ALMLANRSEE SKCKTNLIVA
1010 1020 1030 1040 1050
PVSVLRVWKG ELETKVKKRA KFTTFIFGGS GNGKVKHWRD LARYDAVLVS
1060 1070 1080 1090 1100
YQTLANEFKK HWPKKLDGEQ NQLPAVPHIQ ALNRLKTSNE YYSPFFCNDS
1110 1120 1130 1140 1150
TFYRILLDEG QNIKNKNTRA SKACCTINGM YRWVLSGTPI QNSMDELYSL
1160 1170 1180 1190 1200
IRFLRIPPYH KEQRFKLDIG RFFQRNKQYQ YDNEDRKNAL RKVRVLLNAI
1210 1220 1230 1240 1250
MLRRSKADKI DGKPLLELPP KIVEVDESRL KGEELKFYTA LESKNQALAK
1260 1270 1280 1290 1300
KLLNNSTRGS YSSVLTLLLR LRQACCHSEL VVMGEKKAEG TKVANGKSFE
1310 1320 1330 1340 1350
DDWLRLYYKI THMSGEAQAQ VITSMNSMTC FWCMEQLEPE AMSVLTGCGH
1360 1370 1380 1390 1400
LICDTCIEPF IEESSMLPQA KKTKGGAFAI PCKDCQRLTN EKDIVSHKLY
1410 1420 1430 1440 1450
DQVINQGFTE EDLHAEYLSE MEKQKIQQKN VYVPNFESLE PSTKIEQCIQ
1460 1470 1480 1490 1500
VIQRVFDESA TEKIIIFSQF TTFFEILEHF LKNKLNFPYL KYIGSMNAQR
1510 1520 1530 1540 1550
RSDVINEFYR DPEKRILLIS MKAGNSGLTL TCANHVVIVD PFWNPYVEEQ
1560 1570 1580 1590 1600
AQDRCYRISQ TKKVQVHKLF IKDSVEDRIS ELQKRKKEMV DSAMDPGKIK
1610
EVNSLGRREL GFLFGLNAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z75099 Genomic DNA Translation: CAA99400.1 BK006948 Genomic DNA Translation: DAA10963.1 |
PIRi | S67083 |
RefSeqi | NP_014834.1, NM_001183610.1 |
Genome annotation databases
EnsemblFungii | YOR191W_mRNA; YOR191W; YOR191W |
GeneIDi | 854363 |
KEGGi | sce:YOR191W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z75099 Genomic DNA Translation: CAA99400.1 BK006948 Genomic DNA Translation: DAA10963.1 |
PIRi | S67083 |
RefSeqi | NP_014834.1, NM_001183610.1 |
3D structure databases
AlphaFoldDBi | Q08562 |
SMRi | Q08562 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34586, 201 interactors |
DIPi | DIP-996N |
IntActi | Q08562, 8 interactors |
MINTi | Q08562 |
STRINGi | 4932.YOR191W |
PTM databases
iPTMneti | Q08562 |
Proteomic databases
MaxQBi | Q08562 |
PaxDbi | Q08562 |
PRIDEi | Q08562 |
Genome annotation databases
EnsemblFungii | YOR191W_mRNA; YOR191W; YOR191W |
GeneIDi | 854363 |
KEGGi | sce:YOR191W |
Organism-specific databases
SGDi | S000005717, ULS1 |
VEuPathDBi | FungiDB:YOR191W |
Phylogenomic databases
eggNOGi | KOG1001, Eukaryota |
HOGENOMi | CLU_000315_34_1_1 |
InParanoidi | Q08562 |
OMAi | VHRLFIK |
Miscellaneous databases
PROi | PR:Q08562 |
RNActi | Q08562, protein |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit 3.40.50.10810, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00176, SNF2-rel_dom, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ULS1_YEAST | |
Accessioni | Q08562Primary (citable) accession number: Q08562 Secondary accession number(s): D6W2P7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - SIMILARITY comments
Index of protein domains and families