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UniProtKB - Q08545 (P21_BYVU)
Protein
RNA silencing suppressor
Gene
ORF8
Organism
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus)
Status
Functioni
Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to ssRNAs and dsRNAs in vitro. Also functions as replication enhancer.
1 PublicationGO - Molecular functioni
- identical protein binding Source: IntAct
- RNA binding Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding, Suppressor of RNA silencing |
Names & Taxonomyi
Protein namesi | Recommended name: RNA silencing suppressorAlternative name(s): 21 kDa protein p21 |
Gene namesi | ORF Names:ORF8 |
Organismi | Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus) |
Taxonomic identifieri | 478555 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Kitrinoviricota › Alsuviricetes › Martellivirales › Closteroviridae › Closterovirus › |
Virus hosti | Beta vulgaris (Sugar beet) [TaxID: 161934] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312570 | 1 – 177 | RNA silencing suppressorAdd BLAST | 177 |
Interactioni
Subunit structurei
Homooctamer. The eight monomers assemble into a closed ring that binds RNA.
Binary interactionsi
Q08545
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-15556683,EBI-15556683 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q08545 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q08545 |
Family & Domainsi
Family and domain databases
InterProi | View protein in InterPro IPR021742, RSS_P20_N IPR021575, Suppressor_P21_C |
Pfami | View protein in Pfam PF11757, RSS_P20, 1 hit PF11479, Suppressor_P21, 1 hit |
i Sequence
Sequence statusi: Complete.
Q08545-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFFLKDGET SRALSRSESL LRRVKELGTN SQQSEISECV DEFNELASFN
60 70 80 90 100
HLLVTVEHRE WMEQHPNQSS KLRVPSRIGE MLKEIRAFLK VRVVTPMHKE
110 120 130 140 150
TASDTLNAFL EEYCRITGLA REDALREKMR KVKSVVLFHH SELLKFEVTE
160 170
NMFSYTELLK LNLSLRVISS QILGMAI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53462 Genomic RNA Translation: CAA37556.1 X73476 Genomic RNA Translation: CAA51870.1 |
PIRi | S28717 |
RefSeqi | NP_041877.1, NC_001598.1 |
Genome annotation databases
GeneIDi | 1724788 |
KEGGi | vg:1724788 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53462 Genomic RNA Translation: CAA37556.1 X73476 Genomic RNA Translation: CAA51870.1 |
PIRi | S28717 |
RefSeqi | NP_041877.1, NC_001598.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CWO | X-ray | 3.30 | A/B/C/D | 1-177 | [»] | |
SMRi | Q08545 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
GeneIDi | 1724788 |
KEGGi | vg:1724788 |
Miscellaneous databases
EvolutionaryTracei | Q08545 |
Family and domain databases
InterProi | View protein in InterPro IPR021742, RSS_P20_N IPR021575, Suppressor_P21_C |
Pfami | View protein in Pfam PF11757, RSS_P20, 1 hit PF11479, Suppressor_P21, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P21_BYVU | |
Accessioni | Q08545Primary (citable) accession number: Q08545 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | November 1, 1996 | |
Last modified: | June 2, 2021 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references