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Protein

Secretin

Gene

Sct

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates formation of NaHCO3-rich pancreatic juice and secretion of NaHCO3-rich bile and inhibits HCl production by the stomach.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin
Gene namesi
Name:Sct
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99466 Sct

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
PropeptideiPRO_000001142623 – 30By similarity8
PeptideiPRO_000001142732 – 58SecretinBy similarityAdd BLAST27
PropeptideiPRO_000001142862 – 133By similarityAdd BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Valine amideBy similarity1
Modified residuei62PhosphoserineBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiQ08535
PRIDEiQ08535

PTM databases

PhosphoSitePlusiQ08535

Expressioni

Gene expression databases

BgeeiENSMUSG00000038580 Expressed in 111 organ(s), highest expression level in placenta
CleanExiMM_SCT
ExpressionAtlasiQ08535 baseline and differential
GenevisibleiQ08535 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128729

Structurei

3D structure databases

ProteinModelPortaliQ08535
SMRiQ08535
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JG0Y Eukaryota
ENOG4111AMM LUCA
GeneTreeiENSGT00390000002624
HOVERGENiHBG017786
InParanoidiQ08535
KOiK05263
OMAiMPLGGAW
PhylomeDBiQ08535

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
IPR015675 Prosecretin
PANTHERiPTHR17378 PTHR17378, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q08535-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPPLPTPML LLLLLLLSSS AALPAPPRTP RHSDGMFTSE LSRLQDSARL
60 70 80 90 100
QRLLQGLVGK RSEQDTENIP ENSLARSKPL EDQLCLLWSN TQTLQDWLLP
110 120 130
RLSLDGSLSL WLPPGPRSAV DRSEWTETTR PPR
Length:133
Mass (Da):14,914
Last modified:October 1, 1994 - v1
Checksum:i9B69CBCF74CA9709
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80ZS9Q80ZS9_MOUSE
Sct protein
Sct
139Annotation score:
A0A1B0GS37A0A1B0GS37_MOUSE
Secretin
Sct
77Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07568 Unassigned DNA Translation: AAA18453.1
X73580 mRNA Translation: CAA51982.1
CCDSiCCDS40184.1
PIRiJC2202
RefSeqiNP_035458.1, NM_011328.3
UniGeneiMm.4723

Genome annotation databases

EnsembliENSMUST00000167790; ENSMUSP00000128729; ENSMUSG00000038580
GeneIDi20287
KEGGimmu:20287
UCSCiuc009kkl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07568 Unassigned DNA Translation: AAA18453.1
X73580 mRNA Translation: CAA51982.1
CCDSiCCDS40184.1
PIRiJC2202
RefSeqiNP_035458.1, NM_011328.3
UniGeneiMm.4723

3D structure databases

ProteinModelPortaliQ08535
SMRiQ08535
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128729

PTM databases

PhosphoSitePlusiQ08535

Proteomic databases

PaxDbiQ08535
PRIDEiQ08535

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167790; ENSMUSP00000128729; ENSMUSG00000038580
GeneIDi20287
KEGGimmu:20287
UCSCiuc009kkl.2 mouse

Organism-specific databases

CTDi6343
MGIiMGI:99466 Sct

Phylogenomic databases

eggNOGiENOG410JG0Y Eukaryota
ENOG4111AMM LUCA
GeneTreeiENSGT00390000002624
HOVERGENiHBG017786
InParanoidiQ08535
KOiK05263
OMAiMPLGGAW
PhylomeDBiQ08535

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Miscellaneous databases

PROiPR:Q08535
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038580 Expressed in 111 organ(s), highest expression level in placenta
CleanExiMM_SCT
ExpressionAtlasiQ08535 baseline and differential
GenevisibleiQ08535 MM

Family and domain databases

InterProiView protein in InterPro
IPR000532 Glucagon_GIP_secretin_VIP
IPR015675 Prosecretin
PANTHERiPTHR17378 PTHR17378, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSECR_MOUSE
AccessioniPrimary (citable) accession number: Q08535
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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