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UniProtKB - Q08534 (R1AB_BYVU)

Entry version 99 (02 Dec 2020)
Sequence version 2 (04 Dec 2007)
Previous versions | rss
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Protein

Replicase polyprotein 1ab

Gene

1a-1b

Organism
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

L-pro is involved in systemic transport and in RNA amplification.1 Publication
RNA-dependent RNA polymerase replicates the viral genome.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei509For leader protease activity1 Publication1
Active sitei569For leader protease activity1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Methyltransferase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...MEROPSi		C42.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1ab
Cleaved into the following 2 chains:
Leader protease (EC:3.4.22.-)
Short name:
L-Pro
Alternative name(s):
Papain-like cysteine proteinase
Short name:
PCP
Methyltransferase/helicase/RNA-directed RNA polymerase (EC:2.1.1.-, EC:2.7.7.48, EC:3.6.4.13)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:1a-1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBeet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri478555 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Kitrinoviricota › Alsuviricetes › Martellivirales › Closteroviridae › Closterovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBeta vulgaris (Sugar beet) [TaxID: 161934]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000359 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasmic vesicle, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003125621 – 3094Replicase polyprotein 1abAdd BLAST3094
ChainiPRO_00003125631 – 588Leader proteaseAdd BLAST588
ChainiPRO_0000312564589 – 3094Methyltransferase/helicase/RNA-directed RNA polymeraseAdd BLAST2506

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The leader protease is released by autoproteolysis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei588 – 589Cleavage; by the leader protease2

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q08534

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini670 – 857Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST188
Domaini2215 – 2387(+)RNA virus helicase ATP-bindingAdd BLAST173
Domaini2388 – 2548(+)RNA virus helicase C-terminalAdd BLAST161
Domaini2817 – 2930RdRp catalyticPROSITE-ProRule annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili622 – 647Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1959 – 1962Poly-Ser4
Compositional biasi2015 – 2018Poly-Glu4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain is required for autoproteolysis.

Keywords - Domaini

Coiled coil

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR027417, P-loop_NTPase
IPR008749, Peptidase_C42
IPR007094, RNA-dir_pol_PSvirus
IPR001788, Tymovirus_RNA-dep_RNA_pol
IPR040910, Zemlya

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05533, Peptidase_C42, 1 hit
PF00978, RdRP_2, 1 hit
PF01443, Viral_helicase1, 1 hit
PF01660, Vmethyltransf, 1 hit
PF17646, Zemlya, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Note: The replicase 1a is produced from conventional translation of the 1a ORF. The replicase 1ab is generated probably by a +1 ribosomal frameshifting mechanism occurring at the 1a-1b genes boundary.1 Publication
Isoform Replicase 1ab (identifier: Q08534-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFLNVSAVP SCAFAPAFAP HAGASPIVPD SFPCVPRYSD DISHFRLTLS 
        60         70         80         90        100
LDFSVPRPLS LNARVHLSAS TDNPLPSLPL GFHAETFVLE LNGSSAPFSI 
       110        120        130        140        150
PSRHIDFVVN RPFSVFPTEV LSVSSLRTPS RLFALLCDFF LYCSKPGPCV 
       160        170        180        190        200
EIASFSTPPP CLVSNCVAQI PTHAEMESIR FPTKTLPAGR FLQFHKRKYT 
       210        220        230        240        250
KRPETLIIHE SGLALKTSAL GVTSKPNSRP ITVKSASGEK YEAYEISRKD 
       260        270        280        290        300
FERSRRRQQT PRVRSHKPRK INKAVEPFFF PEEPKKDKRK RASLPTEDEG 
       310        320        330        340        350
FITFGTLRFP LSETPKEEPR LPKFREVEIP VVKKHAVPAV VSKPVRTFRP 
       360        370        380        390        400
VATTGAEYVN ARNQCSRRPR NHPILRSASY TFGFKKMPLQ RFMKEKKEYY 
       410        420        430        440        450
VKRSKVVSSC SVTKSPLEAL ASILKNLPQY SYNSERLKFY DHFIGDDFEI 
       460        470        480        490        500
EVHPLRGGKL SVLLILPKGE AYCVVTAATP QYHAALTIAR GDRPRVGELL 
       510        520        530        540        550
QYRPGEGLCY LAHAALCCAL QKRTFREEDF FVGMYPTKFV FAKRLTEKLG 
       560        570        580        590        600
PSALKHPVRG RQVSRSLFHC DVASAFSSPF YSLPRFIGGV EEEAPEITSS 
       610        620        630        640        650
LKHKAIESVY ERVSIHKDNL LARSVEKDLI DFKDEIKSLS KEKRSVTVPF 
       660        670        680        690        700
YMGEAVQSGL TRAYPQFNLS FTHSVYSDHP AAAGSRLLEN ETLASMAKSS 
       710        720        730        740        750
FSDIGGCPLF HIKRGSTDYH VCRPIYDMKD AQRRVSRELQ ARGLVENLSR 
       760        770        780        790        800
EQLVEAQARV SVCPHTLGNC NVKSDVLIMV QVYDASLNEI ASAMVLKESK 
       810        820        830        840        850
VAYLTMVTPG ELLDEREAFA IDALGCDVVV DTRRDMVQYK FGSSCYCHKL 
       860        870        880        890        900
SNIKSIMLTP AFTFSGNLFS VEMYENRMGV NYYKITRSAY SPEIRGVKTL 
       910        920        930        940        950
RYRRACTEVV QVKLPRFDKT LKTFLSGYDY IYLDAKFVSR VFDYVVSNCS 
       960        970        980        990       1000
VVNSKTFEWV WSYIKSSKSR VVISGKVIHR DVHIDLKHSE CFAAVMLAVG 
      1010       1020       1030       1040       1050
VRSRTTTEFL AKNLNYYTGD ASCFETIRFL FREWSRRAYA EINRSFRKLM 
      1060       1070       1080       1090       1100
KSILSAGLDY EFLDLDNSLQ HLLEYSEVEV RVSIAQNGEV DCNEENRVLT 
      1110       1120       1130       1140       1150
EIIAEAADRK SIAQGLSGAL SSVPTQPRGG LRGGSRRSGV SFLYNLVEEV 
      1160       1170       1180       1190       1200
GNLFFSVGDA VRFLVKVFKT FSDSPIFRVV RMFLDLAEAA SPFVSVVSLC 
      1210       1220       1230       1240       1250
AWLREAVSAF SSWVADRTVS ESVKTFVNRT VKRFLNFMSA KTLTKKFFRF 
      1260       1270       1280       1290       1300
FLSASALAKT VVRKAKVILE AYWEVWFESI LSDSGEYSAV EFCSSVVITL 
      1310       1320       1330       1340       1350
LTNSGRLLPG FSPSAIITEV LLDLATKISI EVLLKQISPA DSTASSALYR 
      1360       1370       1380       1390       1400
RVLSEILSNF RTMGEHGIFT KVFLLCGFLP VFVRKCVALC VPGDMATYAR 
      1410       1420       1430       1440       1450
FLEYGVDDLF FLGRSVNSIK NYLCVVAAGL VDSIVDSVVL KLSGVAKERV 
      1460       1470       1480       1490       1500
LGFKSKIIKN FLNVFRKAKV VTRTSSSTDL SEDEYFSCDE SKPGLRGGSS 
      1510       1520       1530       1540       1550
RFTLSRLLDI FFNFLKSSKL VIENACFSAY ERIERNMKLY FFPLNSSEEE 
      1560       1570       1580       1590       1600
ARRLIRCAGD FDYLSDSAFD EDEMLRQAFE QYYSSDDESV TYDGKPTVLR 
      1610       1620       1630       1640       1650
SYLNVSRRFL ETFCNGPKFF VKVSNYFKAL YSRLLRVLPW VDRNLSDSPG 
      1660       1670       1680       1690       1700
LKGGNEKALL AKFFKTCVIT ACECVSQICC LRLIRLCWGT PACGLVRLFY 
      1710       1720       1730       1740       1750
ITYSSTRVLS RVVVAVAVCP LLVRNELDGL SDGLTNMGVS VFRRLFVALR 
      1760       1770       1780       1790       1800
RALSAYSNSA LRRKIIEFIF GNIHHPFDVA VIETNEVAPE PLSPEVDIDV 
      1810       1820       1830       1840       1850
DCDFGSDSES VSSDEVASNP RPGLHGGSRR SSNFLTSLVK VVFKLARRIP 
      1860       1870       1880       1890       1900
RLLFRLRNFV AYFVERRLAS KRLKTFIGLA RLFDNFSLTS VVYLLQEYDS 
      1910       1920       1930       1940       1950
VLNAFIDVEL ILLNSGSVNV LPLVSWVRGS LTKLAEAIVG SGFASFLGRM 
      1960       1970       1980       1990       2000
CCRVSDWCSS SSNAGCNFMS PVRTKGKFVP PSSSGSTASM YERLEALESD 
      2010       2020       2030       2040       2050
IREHVLSTCR VGSDEEEERP KEVTEPGIEH TSEDVVPIRS HSQPLSGGEC 
      2060       2070       2080       2090       2100
SYSEDREENE RANLLPHVSK IVSERRGLET ARRNKRTLHG VSEFLNAINT 
      2110       2120       2130       2140       2150
SNEQPRPIIV DHSPESRALT NSVREFYYLQ ELALFELSCK LREYYDQLKV 
      2160       2170       2180       2190       2200
ANFNRQECLC DKDEDMFVLR AGQGVVSGRN SRLPLKHFKG HEFCFRSGGL 
      2210       2220       2230       2240       2250
VPYDGTSRVD TIFHTQTNFV SANALLSGYL SYRTFTFTNL SANVLLYEAP 
      2260       2270       2280       2290       2300
PGGGKTTTLI KVFCETFSKV NSLILTANKS SREEILAKVN RIVLDEGDTP 
      2310       2320       2330       2340       2350
LQTRDRILTI DSYLMNNRGL TCKVLYLDEC FMVHAGAAVA CIEFTKCDSA 
      2360       2370       2380       2390       2400
ILFGDSRQIR YGRCSELDTA VLSDLNRFVD DESRVYGEVS YRCPWDVCAW 
      2410       2420       2430       2440       2450
LSTFYPKTVA TTNLVSAGQS SMQVREIESV DDVEYSSEFV YLTMLQSEKK 
      2460       2470       2480       2490       2500
DLLKSFGKRS RSSVEKPTVL TVHEAQGETY RKVNLVRTKF QEDDPFRSEN 
      2510       2520       2530       2540       2550
HITVALSRHV ESLTYSVLSS KRDDAIAQAI VKAKQLVDAY RVYPTSFGGS 
      2560       2570       2580       2590       2600
TLDVSVNPST SDRSKCKASS APYEVINSFL ESVVPGTTSV DFGDVSEEMG 
      2610       2620       2630       2640       2650
TQVFESGADN VVIRDSAPVN KSTDHDPQRV SSIRSQAIPK RKPSLQENLY 
      2660       2670       2680       2690       2700
SYESRNYNFT VCERFSGPQE FGQAMAMVML ERSFDLEKVA KVRSDVIAIT 
      2710       2720       2730       2740       2750
EKGVRTWMSK REPSQLRALS SDLQKPLNLE EEITTFKLMV KRDAKVKLDS 
      2760       2770       2780       2790       2800
SCLVKHPPAQ NIMFHRKAVN AIFSPCFDEF KNRVITCTNS NIVFFTEMTN 
      2810       2820       2830       2840       2850
STLASIAKEM LGSEHVYNVG EIDFSKFDKS QDAFIKSFER TLYSAFGFDE 
      2860       2870       2880       2890       2900
DLLDVWMQGE YTSNATTLDG QLSFSVDNQR KSGASNTWIG NSIETLGILS 
      2910       2920       2930       2940       2950
MFYYTNRFKA LFVSGDDSLI FSESPIRNSA DAMCTELGFE TKFLTPSVPY 
      2960       2970       2980       2990       3000
FCSKFFVMTG HDVFFVPDPY KLLVKLGASK DEVDDEFLFE VFTSFRDLTK 
      3010       3020       3030       3040       3050
DLVDERVIEL LTHLVHSKYG YESGDTYAAL CAIHCIRSNF SSFKKLYPKV 
      3060       3070       3080       3090 
KGWVVHYGKL KFVLRKFANC FREKFDTAFG ERTFLLTTKL ETVL
Length:3,094
Mass (Da):348,277
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83078999DA9D64C7
GO
Isoform Replicase 1a (identifier: Q08534-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2631-3094: Missing.

Show »
Length:2,630
Mass (Da):295,166
Checksum:iB31E30EF40426D46
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0298602631 – 3094Missing in isoform Replicase 1a. CuratedAdd BLAST464

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X73476 Genomic RNA Translation: CAA51871.1
X53462 Genomic RNA Translation: CAA37549.1

NCBI Reference Sequences

More...RefSeqi		NP_041870.2, NC_001598.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1493976

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:1493976

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73476 Genomic RNA Translation: CAA51871.1
X53462 Genomic RNA Translation: CAA37549.1
RefSeqiNP_041870.2, NC_001598.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

MEROPSiC42.001

Proteomic databases

PRIDEiQ08534

Genome annotation databases

GeneIDi1493976
KEGGivg:1493976

Family and domain databases

InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR027417, P-loop_NTPase
IPR008749, Peptidase_C42
IPR007094, RNA-dir_pol_PSvirus
IPR001788, Tymovirus_RNA-dep_RNA_pol
IPR040910, Zemlya
PfamiView protein in Pfam
PF05533, Peptidase_C42, 1 hit
PF00978, RdRP_2, 1 hit
PF01443, Viral_helicase1, 1 hit
PF01660, Vmethyltransf, 1 hit
PF17646, Zemlya, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1AB_BYVU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08534
Secondary accession number(s): Q66109
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 2, 2020
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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