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Entry version 99 (02 Dec 2020)
Sequence version 2 (04 Dec 2007)
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Protein

Replicase polyprotein 1ab

Gene

1a-1b

Organism
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

L-pro is involved in systemic transport and in RNA amplification.1 Publication
RNA-dependent RNA polymerase replicates the viral genome.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei509For leader protease activity1 Publication1
Active sitei569For leader protease activity1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Methyltransferase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C42.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1ab
Cleaved into the following 2 chains:
Leader protease (EC:3.4.22.-)
Short name:
L-Pro
Alternative name(s):
Papain-like cysteine proteinase
Short name:
PCP
Methyltransferase/helicase/RNA-directed RNA polymerase (EC:2.1.1.-, EC:2.7.7.48, EC:3.6.4.13)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:1a-1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBeet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri478555 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeKitrinoviricotaAlsuviricetesMartelliviralesClosteroviridaeClosterovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBeta vulgaris (Sugar beet) [TaxID: 161934]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000359 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasmic vesicle, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003125621 – 3094Replicase polyprotein 1abAdd BLAST3094
ChainiPRO_00003125631 – 588Leader proteaseAdd BLAST588
ChainiPRO_0000312564589 – 3094Methyltransferase/helicase/RNA-directed RNA polymeraseAdd BLAST2506

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The leader protease is released by autoproteolysis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei588 – 589Cleavage; by the leader protease2

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q08534

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini670 – 857Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST188
Domaini2215 – 2387(+)RNA virus helicase ATP-bindingAdd BLAST173
Domaini2388 – 2548(+)RNA virus helicase C-terminalAdd BLAST161
Domaini2817 – 2930RdRp catalyticPROSITE-ProRule annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili622 – 647Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1959 – 1962Poly-Ser4
Compositional biasi2015 – 2018Poly-Glu4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain is required for autoproteolysis.

Keywords - Domaini

Coiled coil

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR027417, P-loop_NTPase
IPR008749, Peptidase_C42
IPR007094, RNA-dir_pol_PSvirus
IPR001788, Tymovirus_RNA-dep_RNA_pol
IPR040910, Zemlya

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05533, Peptidase_C42, 1 hit
PF00978, RdRP_2, 1 hit
PF01443, Viral_helicase1, 1 hit
PF01660, Vmethyltransf, 1 hit
PF17646, Zemlya, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Note: The replicase 1a is produced from conventional translation of the 1a ORF. The replicase 1ab is generated probably by a +1 ribosomal frameshifting mechanism occurring at the 1a-1b genes boundary.1 Publication
Isoform Replicase 1ab (identifier: Q08534-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFLNVSAVP SCAFAPAFAP HAGASPIVPD SFPCVPRYSD DISHFRLTLS
60 70 80 90 100
LDFSVPRPLS LNARVHLSAS TDNPLPSLPL GFHAETFVLE LNGSSAPFSI
110 120 130 140 150
PSRHIDFVVN RPFSVFPTEV LSVSSLRTPS RLFALLCDFF LYCSKPGPCV
160 170 180 190 200
EIASFSTPPP CLVSNCVAQI PTHAEMESIR FPTKTLPAGR FLQFHKRKYT
210 220 230 240 250
KRPETLIIHE SGLALKTSAL GVTSKPNSRP ITVKSASGEK YEAYEISRKD
260 270 280 290 300
FERSRRRQQT PRVRSHKPRK INKAVEPFFF PEEPKKDKRK RASLPTEDEG
310 320 330 340 350
FITFGTLRFP LSETPKEEPR LPKFREVEIP VVKKHAVPAV VSKPVRTFRP
360 370 380 390 400
VATTGAEYVN ARNQCSRRPR NHPILRSASY TFGFKKMPLQ RFMKEKKEYY
410 420 430 440 450
VKRSKVVSSC SVTKSPLEAL ASILKNLPQY SYNSERLKFY DHFIGDDFEI
460 470 480 490 500
EVHPLRGGKL SVLLILPKGE AYCVVTAATP QYHAALTIAR GDRPRVGELL
510 520 530 540 550
QYRPGEGLCY LAHAALCCAL QKRTFREEDF FVGMYPTKFV FAKRLTEKLG
560 570 580 590 600
PSALKHPVRG RQVSRSLFHC DVASAFSSPF YSLPRFIGGV EEEAPEITSS
610 620 630 640 650
LKHKAIESVY ERVSIHKDNL LARSVEKDLI DFKDEIKSLS KEKRSVTVPF
660 670 680 690 700
YMGEAVQSGL TRAYPQFNLS FTHSVYSDHP AAAGSRLLEN ETLASMAKSS
710 720 730 740 750
FSDIGGCPLF HIKRGSTDYH VCRPIYDMKD AQRRVSRELQ ARGLVENLSR
760 770 780 790 800
EQLVEAQARV SVCPHTLGNC NVKSDVLIMV QVYDASLNEI ASAMVLKESK
810 820 830 840 850
VAYLTMVTPG ELLDEREAFA IDALGCDVVV DTRRDMVQYK FGSSCYCHKL
860 870 880 890 900
SNIKSIMLTP AFTFSGNLFS VEMYENRMGV NYYKITRSAY SPEIRGVKTL
910 920 930 940 950
RYRRACTEVV QVKLPRFDKT LKTFLSGYDY IYLDAKFVSR VFDYVVSNCS
960 970 980 990 1000
VVNSKTFEWV WSYIKSSKSR VVISGKVIHR DVHIDLKHSE CFAAVMLAVG
1010 1020 1030 1040 1050
VRSRTTTEFL AKNLNYYTGD ASCFETIRFL FREWSRRAYA EINRSFRKLM
1060 1070 1080 1090 1100
KSILSAGLDY EFLDLDNSLQ HLLEYSEVEV RVSIAQNGEV DCNEENRVLT
1110 1120 1130 1140 1150
EIIAEAADRK SIAQGLSGAL SSVPTQPRGG LRGGSRRSGV SFLYNLVEEV
1160 1170 1180 1190 1200
GNLFFSVGDA VRFLVKVFKT FSDSPIFRVV RMFLDLAEAA SPFVSVVSLC
1210 1220 1230 1240 1250
AWLREAVSAF SSWVADRTVS ESVKTFVNRT VKRFLNFMSA KTLTKKFFRF
1260 1270 1280 1290 1300
FLSASALAKT VVRKAKVILE AYWEVWFESI LSDSGEYSAV EFCSSVVITL
1310 1320 1330 1340 1350
LTNSGRLLPG FSPSAIITEV LLDLATKISI EVLLKQISPA DSTASSALYR
1360 1370 1380 1390 1400
RVLSEILSNF RTMGEHGIFT KVFLLCGFLP VFVRKCVALC VPGDMATYAR
1410 1420 1430 1440 1450
FLEYGVDDLF FLGRSVNSIK NYLCVVAAGL VDSIVDSVVL KLSGVAKERV
1460 1470 1480 1490 1500
LGFKSKIIKN FLNVFRKAKV VTRTSSSTDL SEDEYFSCDE SKPGLRGGSS
1510 1520 1530 1540 1550
RFTLSRLLDI FFNFLKSSKL VIENACFSAY ERIERNMKLY FFPLNSSEEE
1560 1570 1580 1590 1600
ARRLIRCAGD FDYLSDSAFD EDEMLRQAFE QYYSSDDESV TYDGKPTVLR
1610 1620 1630 1640 1650
SYLNVSRRFL ETFCNGPKFF VKVSNYFKAL YSRLLRVLPW VDRNLSDSPG
1660 1670 1680 1690 1700
LKGGNEKALL AKFFKTCVIT ACECVSQICC LRLIRLCWGT PACGLVRLFY
1710 1720 1730 1740 1750
ITYSSTRVLS RVVVAVAVCP LLVRNELDGL SDGLTNMGVS VFRRLFVALR
1760 1770 1780 1790 1800
RALSAYSNSA LRRKIIEFIF GNIHHPFDVA VIETNEVAPE PLSPEVDIDV
1810 1820 1830 1840 1850
DCDFGSDSES VSSDEVASNP RPGLHGGSRR SSNFLTSLVK VVFKLARRIP
1860 1870 1880 1890 1900
RLLFRLRNFV AYFVERRLAS KRLKTFIGLA RLFDNFSLTS VVYLLQEYDS
1910 1920 1930 1940 1950
VLNAFIDVEL ILLNSGSVNV LPLVSWVRGS LTKLAEAIVG SGFASFLGRM
1960 1970 1980 1990 2000
CCRVSDWCSS SSNAGCNFMS PVRTKGKFVP PSSSGSTASM YERLEALESD
2010 2020 2030 2040 2050
IREHVLSTCR VGSDEEEERP KEVTEPGIEH TSEDVVPIRS HSQPLSGGEC
2060 2070 2080 2090 2100
SYSEDREENE RANLLPHVSK IVSERRGLET ARRNKRTLHG VSEFLNAINT
2110 2120 2130 2140 2150
SNEQPRPIIV DHSPESRALT NSVREFYYLQ ELALFELSCK LREYYDQLKV
2160 2170 2180 2190 2200
ANFNRQECLC DKDEDMFVLR AGQGVVSGRN SRLPLKHFKG HEFCFRSGGL
2210 2220 2230 2240 2250
VPYDGTSRVD TIFHTQTNFV SANALLSGYL SYRTFTFTNL SANVLLYEAP
2260 2270 2280 2290 2300
PGGGKTTTLI KVFCETFSKV NSLILTANKS SREEILAKVN RIVLDEGDTP
2310 2320 2330 2340 2350
LQTRDRILTI DSYLMNNRGL TCKVLYLDEC FMVHAGAAVA CIEFTKCDSA
2360 2370 2380 2390 2400
ILFGDSRQIR YGRCSELDTA VLSDLNRFVD DESRVYGEVS YRCPWDVCAW
2410 2420 2430 2440 2450
LSTFYPKTVA TTNLVSAGQS SMQVREIESV DDVEYSSEFV YLTMLQSEKK
2460 2470 2480 2490 2500
DLLKSFGKRS RSSVEKPTVL TVHEAQGETY RKVNLVRTKF QEDDPFRSEN
2510 2520 2530 2540 2550
HITVALSRHV ESLTYSVLSS KRDDAIAQAI VKAKQLVDAY RVYPTSFGGS
2560 2570 2580 2590 2600
TLDVSVNPST SDRSKCKASS APYEVINSFL ESVVPGTTSV DFGDVSEEMG
2610 2620 2630 2640 2650
TQVFESGADN VVIRDSAPVN KSTDHDPQRV SSIRSQAIPK RKPSLQENLY
2660 2670 2680 2690 2700
SYESRNYNFT VCERFSGPQE FGQAMAMVML ERSFDLEKVA KVRSDVIAIT
2710 2720 2730 2740 2750
EKGVRTWMSK REPSQLRALS SDLQKPLNLE EEITTFKLMV KRDAKVKLDS
2760 2770 2780 2790 2800
SCLVKHPPAQ NIMFHRKAVN AIFSPCFDEF KNRVITCTNS NIVFFTEMTN
2810 2820 2830 2840 2850
STLASIAKEM LGSEHVYNVG EIDFSKFDKS QDAFIKSFER TLYSAFGFDE
2860 2870 2880 2890 2900
DLLDVWMQGE YTSNATTLDG QLSFSVDNQR KSGASNTWIG NSIETLGILS
2910 2920 2930 2940 2950
MFYYTNRFKA LFVSGDDSLI FSESPIRNSA DAMCTELGFE TKFLTPSVPY
2960 2970 2980 2990 3000
FCSKFFVMTG HDVFFVPDPY KLLVKLGASK DEVDDEFLFE VFTSFRDLTK
3010 3020 3030 3040 3050
DLVDERVIEL LTHLVHSKYG YESGDTYAAL CAIHCIRSNF SSFKKLYPKV
3060 3070 3080 3090
KGWVVHYGKL KFVLRKFANC FREKFDTAFG ERTFLLTTKL ETVL
Length:3,094
Mass (Da):348,277
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83078999DA9D64C7
GO
Isoform Replicase 1a (identifier: Q08534-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2631-3094: Missing.

Show »
Length:2,630
Mass (Da):295,166
Checksum:iB31E30EF40426D46
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0298602631 – 3094Missing in isoform Replicase 1a. CuratedAdd BLAST464

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X73476 Genomic RNA Translation: CAA51871.1
X53462 Genomic RNA Translation: CAA37549.1

NCBI Reference Sequences

More...
RefSeqi
NP_041870.2, NC_001598.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1493976

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1493976

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73476 Genomic RNA Translation: CAA51871.1
X53462 Genomic RNA Translation: CAA37549.1
RefSeqiNP_041870.2, NC_001598.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC42.001

Proteomic databases

PRIDEiQ08534

Genome annotation databases

GeneIDi1493976
KEGGivg:1493976

Family and domain databases

InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR027417, P-loop_NTPase
IPR008749, Peptidase_C42
IPR007094, RNA-dir_pol_PSvirus
IPR001788, Tymovirus_RNA-dep_RNA_pol
IPR040910, Zemlya
PfamiView protein in Pfam
PF05533, Peptidase_C42, 1 hit
PF00978, RdRP_2, 1 hit
PF01443, Viral_helicase1, 1 hit
PF01660, Vmethyltransf, 1 hit
PF17646, Zemlya, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1AB_BYVU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08534
Secondary accession number(s): Q66109
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: December 2, 2020
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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