UniProtKB - Q08501 (PRLR_MOUSE)
Prolactin receptor
Prlr
Functioni
This is a receptor for the anterior pituitary hormone prolactin.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 206 | ZincBy similarity | 1 | |
Metal bindingi | 207 | ZincBy similarity | 1 |
GO - Molecular functioni
- ciliary neurotrophic factor receptor binding Source: GO_Central
- cytokine binding Source: GO_Central
- cytokine receptor activity Source: GO_Central
- leukemia inhibitory factor receptor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- peptide hormone binding Source: MGI
- prolactin receptor activity Source: MGI
- protein kinase binding Source: MGI
GO - Biological processi
- activation of Janus kinase activity Source: MGI
- activation of transmembrane receptor protein tyrosine kinase activity Source: MGI
- cytokine-mediated signaling pathway Source: GO_Central
- lactation Source: MGI
- mammary gland alveolus development Source: MGI
- mammary gland epithelial cell differentiation Source: MGI
- mammary gland epithelium development Source: MGI
- negative regulation of apoptotic process Source: MGI
- oncostatin-M-mediated signaling pathway Source: GOC
- positive regulation of cell population proliferation Source: GO_Central
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- prostate gland growth Source: MGI
- receptor signaling pathway via JAK-STAT Source: MGI
- regulation of cell adhesion Source: MGI
- regulation of epithelial cell differentiation Source: MGI
- response to bacterium Source: MGI
Keywordsi
Molecular function | Receptor |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-1170546, Prolactin receptor signaling R-MMU-982772, Growth hormone receptor signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Prolactin receptorShort name: PRL-R |
Gene namesi | Name:Prlr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97763, Prlr |
VEuPathDBi | HostDB:ENSMUSG00000005268 |
Subcellular locationi
Other locations
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 229 | ExtracellularBy similarityAdd BLAST | 210 | |
Transmembranei | 230 – 253 | HelicalBy similarityAdd BLAST | 24 | |
Topological domaini | 254 – 608 | CytoplasmicBy similarityAdd BLAST | 355 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000010978 | 20 – 608 | Prolactin receptorAdd BLAST | 589 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 41 | By similarity | ||
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 70 ↔ 81 | By similarity | ||
Glycosylationi | 99 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q08501 |
PaxDbi | Q08501 |
PRIDEi | Q08501 |
ProteomicsDBi | 291814 [Q08501-1] 291815 [Q08501-2] 291816 [Q08501-3] |
PTM databases
GlyGeni | Q08501, 3 sites |
iPTMneti | Q08501 |
PhosphoSitePlusi | Q08501 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000005268, Expressed in islet of Langerhans and 195 other tissues |
ExpressionAtlasi | Q08501, baseline and differential |
Genevisiblei | Q08501, MM |
Interactioni
Subunit structurei
Interacts with SMARCA1.
Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
By similarityBinary interactionsi
Q08501
With | #Exp. | IntAct |
---|---|---|
AGAP2 - isoform 2 [Q99490-2] from Homo sapiens. | 2 | EBI-7737664,EBI-7737644 |
GO - Molecular functioni
- ciliary neurotrophic factor receptor binding Source: GO_Central
- cytokine binding Source: GO_Central
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202385, 4 interactors |
IntActi | Q08501, 3 interactors |
MINTi | Q08501 |
STRINGi | 10090.ENSMUSP00000122219 |
Miscellaneous databases
RNActi | Q08501, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 122 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 124 – 224 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 101 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 317 – 355 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 377 – 419 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 466 – 487 | DisorderedSequence analysisAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 210 – 214 | WSXWS motif | 5 | |
Motifi | 262 – 270 | Box 1 motif | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 394 – 413 | Polar residuesSequence analysisAdd BLAST | 20 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R22A, Eukaryota |
GeneTreei | ENSGT00940000154851 |
HOGENOMi | CLU_017892_2_0_1 |
InParanoidi | Q08501 |
OMAi | YHYELRL |
PhylomeDBi | Q08501 |
TreeFami | TF330851 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR015152, Growth/epo_recpt_lig-bind IPR013783, Ig-like_fold IPR003528, Long_hematopoietin_rcpt_CS IPR033230, PRLR |
PANTHERi | PTHR23036:SF86, PTHR23036:SF86, 2 hits |
Pfami | View protein in Pfam PF09067, EpoR_lig-bind, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 2 hits |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01352, HEMATOPO_REC_L_F1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSALAYMLL VLSISLLNGQ SPPGKPEIHK CRSPDKETFT CWWNPGSDGG
60 70 80 90 100
LPTNYSLTYS KEGEKNTYEC PDYKTSGPNS CFFSKQYTSI WKIYIITVNA
110 120 130 140 150
TNEMGSSTSD PLYVDVTYIV EPEPPRNLTL EVKQLKDKKT YLWVKWLPPT
160 170 180 190 200
ITDVKTGWFT MEYEIRLKSE EADEWEIHFT GHQTQFKVFD LYPGQKYLVQ
210 220 230 240 250
TRCKPDHGYW SRWGQEKSIE IPNDFTLKDT TVWIIVAVLS AVICLIMVWA
260 270 280 290 300
VALKGYSMMT CIFPPVPGPK IKGFDTHLLE KGKSEELLSA LGCQDFPPTS
310 320 330 340 350
DCEDLLVEFL EVDDNEDERL MPSHSKEYPG QGVKPTHLDP DSDSGHGSYD
360 370 380 390 400
SHSLLSEKCE EPQAYPPAFH IPEITEKPEN PEANIPPTPN PQNNTPNCHT
410 420 430 440 450
DTSKSTTWPL PPGQHTRRSP YHSIADVCKL AGSPGDTLDS FLDKAEENVL
460 470 480 490 500
KLSEDAGEEE VAVQEGAKSF PSDKQNTSWP PLQEKGPIVY AKPPDYVEIH
510 520 530 540 550
KVNKDGVLSL LPKQRENHQT ENPGVPETSK EYAKVSGVTD NNILVLVPDS
560 570 580 590 600
RAQNTALLEE SAKKVPPSLE QNQSEKDLAS FTATSSNCRL QLGRLDYLDP
TCFMHSFH
The sequence of this isoform differs from the canonical sequence as follows:
281-303: KGKSEELLSALGCQDFPPTSDCE → LWCSILQLTSLVKIPTTEFLCDL
304-608: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
281-292: KGKSEELLSALG → VHNKEQLENYVY
293-608: Missing.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3UVW6 | G3UVW6_MOUSE | Prolactin receptor | Prlr PRLR, prlr | 310 | Annotation score: | ||
E9Q2L5 | E9Q2L5_MOUSE | Prolactin receptor | Prlr PRLR | 119 | Annotation score: | ||
E9Q0U8 | E9Q0U8_MOUSE | Prolactin receptor | Prlr PRLR | 155 | Annotation score: | ||
E9Q631 | E9Q631_MOUSE | Prolactin receptor | Prlr PRLR | 185 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 558 | L → F in CAA51789 (PubMed:8319571).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001723 | 281 – 303 | KGKSE…TSDCE → LWCSILQLTSLVKIPTTEFL CDL in isoform PRL-R1. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_001721 | 281 – 292 | KGKSE…LSALG → VHNKEQLENYVY in isoform PRL-R2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_001722 | 293 – 608 | Missing in isoform PRL-R2. 1 PublicationAdd BLAST | 316 | |
Alternative sequenceiVSP_001724 | 304 – 608 | Missing in isoform PRL-R1. 1 PublicationAdd BLAST | 305 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13593 mRNA Translation: AAC37641.1 L14811 mRNA Translation: AAA02686.1 D10214 mRNA Translation: BAA01066.1 X73372 mRNA Translation: CAA51789.1 M22959 mRNA Translation: AAA39977.1 M22958 mRNA Translation: AAA39976.1 |
CCDSi | CCDS27377.1 [Q08501-1] CCDS56975.1 [Q08501-2] |
PIRi | I53269 I77524 I77525 |
RefSeqi | NP_001240711.1, NM_001253782.2 [Q08501-2] NP_035299.4, NM_011169.5 [Q08501-1] XP_006520097.1, XM_006520034.3 [Q08501-1] XP_006520098.1, XM_006520035.1 [Q08501-1] XP_006520099.1, XM_006520036.1 [Q08501-1] XP_006520100.1, XM_006520037.2 [Q08501-1] XP_006520101.1, XM_006520038.1 [Q08501-2] |
Genome annotation databases
Ensembli | ENSMUST00000124470; ENSMUSP00000122219; ENSMUSG00000005268 [Q08501-1] ENSMUST00000128450; ENSMUSP00000122209; ENSMUSG00000005268 [Q08501-3] ENSMUST00000137867; ENSMUSP00000121935; ENSMUSG00000005268 [Q08501-3] ENSMUST00000148257; ENSMUSP00000118355; ENSMUSG00000005268 [Q08501-2] |
GeneIDi | 19116 |
KEGGi | mmu:19116 |
UCSCi | uc007vfw.2, mouse [Q08501-3] uc007vfy.2, mouse [Q08501-1] uc029snt.1, mouse [Q08501-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L13593 mRNA Translation: AAC37641.1 L14811 mRNA Translation: AAA02686.1 D10214 mRNA Translation: BAA01066.1 X73372 mRNA Translation: CAA51789.1 M22959 mRNA Translation: AAA39977.1 M22958 mRNA Translation: AAA39976.1 |
CCDSi | CCDS27377.1 [Q08501-1] CCDS56975.1 [Q08501-2] |
PIRi | I53269 I77524 I77525 |
RefSeqi | NP_001240711.1, NM_001253782.2 [Q08501-2] NP_035299.4, NM_011169.5 [Q08501-1] XP_006520097.1, XM_006520034.3 [Q08501-1] XP_006520098.1, XM_006520035.1 [Q08501-1] XP_006520099.1, XM_006520036.1 [Q08501-1] XP_006520100.1, XM_006520037.2 [Q08501-1] XP_006520101.1, XM_006520038.1 [Q08501-2] |
3D structure databases
AlphaFoldDBi | Q08501 |
SMRi | Q08501 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202385, 4 interactors |
IntActi | Q08501, 3 interactors |
MINTi | Q08501 |
STRINGi | 10090.ENSMUSP00000122219 |
Chemistry databases
GuidetoPHARMACOLOGYi | 1721 |
PTM databases
GlyGeni | Q08501, 3 sites |
iPTMneti | Q08501 |
PhosphoSitePlusi | Q08501 |
Proteomic databases
MaxQBi | Q08501 |
PaxDbi | Q08501 |
PRIDEi | Q08501 |
ProteomicsDBi | 291814 [Q08501-1] 291815 [Q08501-2] 291816 [Q08501-3] |
Protocols and materials databases
DNASUi | 19116 |
Genome annotation databases
Ensembli | ENSMUST00000124470; ENSMUSP00000122219; ENSMUSG00000005268 [Q08501-1] ENSMUST00000128450; ENSMUSP00000122209; ENSMUSG00000005268 [Q08501-3] ENSMUST00000137867; ENSMUSP00000121935; ENSMUSG00000005268 [Q08501-3] ENSMUST00000148257; ENSMUSP00000118355; ENSMUSG00000005268 [Q08501-2] |
GeneIDi | 19116 |
KEGGi | mmu:19116 |
UCSCi | uc007vfw.2, mouse [Q08501-3] uc007vfy.2, mouse [Q08501-1] uc029snt.1, mouse [Q08501-2] |
Organism-specific databases
CTDi | 5618 |
MGIi | MGI:97763, Prlr |
VEuPathDBi | HostDB:ENSMUSG00000005268 |
Phylogenomic databases
eggNOGi | ENOG502R22A, Eukaryota |
GeneTreei | ENSGT00940000154851 |
HOGENOMi | CLU_017892_2_0_1 |
InParanoidi | Q08501 |
OMAi | YHYELRL |
PhylomeDBi | Q08501 |
TreeFami | TF330851 |
Enzyme and pathway databases
Reactomei | R-MMU-1170546, Prolactin receptor signaling R-MMU-982772, Growth hormone receptor signaling |
Miscellaneous databases
BioGRID-ORCSi | 19116, 6 hits in 72 CRISPR screens |
ChiTaRSi | Prlr, mouse |
PROi | PR:Q08501 |
RNActi | Q08501, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000005268, Expressed in islet of Langerhans and 195 other tissues |
ExpressionAtlasi | Q08501, baseline and differential |
Genevisiblei | Q08501, MM |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR015152, Growth/epo_recpt_lig-bind IPR013783, Ig-like_fold IPR003528, Long_hematopoietin_rcpt_CS IPR033230, PRLR |
PANTHERi | PTHR23036:SF86, PTHR23036:SF86, 2 hits |
Pfami | View protein in Pfam PF09067, EpoR_lig-bind, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 2 hits |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01352, HEMATOPO_REC_L_F1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRLR_MOUSE | |
Accessioni | Q08501Primary (citable) accession number: Q08501 Secondary accession number(s): P15212, P15213, Q62099 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families