Prolactin receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ciliary neurotrophic factor receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cytokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cytokine receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• leukemia inhibitory factor receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• peptide hormone binding Source: MGI
• prolactin receptor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf "little" mouse."
    Herington A.C., Harrison D., Graystone J.
    Endocrinology 112:2032-2038(1983) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: MGI

GO - Biological processⁱ

• activation of Janus kinase activity Source: MGI
• activation of transmembrane receptor protein tyrosine kinase activity Source: MGI
• cytokine-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• lactation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium."
    Miyoshi K., Shillingford J.M., Smith G.H., Grimm S.L., Wagner K.U., Oka T., Rosen J.M., Robinson G.W., Hennighausen L.
    J Cell Biol 155:531-542(2001) [PubMed] [Europe PMC] [Abstract]
  • "Socs2 and elf5 mediate prolactin-induced mammary gland development."
    Harris J., Stanford P.M., Sutherland K., Oakes S.R., Naylor M.J., Robertson F.G., Blazek K.D., Kazlauskas M., Hilton H.N., Wittlin S., Alexander W.S., Lindeman G.J., Visvader J.E., Ormandy C.J.
    Mol Endocrinol 20:1177-1187(2006) [PubMed] [Europe PMC] [Abstract]
• mammary gland alveolus development Source: MGIInferred from mutant phenotypeⁱ
  • "Socs2 and elf5 mediate prolactin-induced mammary gland development."
    Harris J., Stanford P.M., Sutherland K., Oakes S.R., Naylor M.J., Robertson F.G., Blazek K.D., Kazlauskas M., Hilton H.N., Wittlin S., Alexander W.S., Lindeman G.J., Visvader J.E., Ormandy C.J.
    Mol Endocrinol 20:1177-1187(2006) [PubMed] [Europe PMC] [Abstract]
• mammary gland epithelial cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Socs2 and elf5 mediate prolactin-induced mammary gland development."
    Harris J., Stanford P.M., Sutherland K., Oakes S.R., Naylor M.J., Robertson F.G., Blazek K.D., Kazlauskas M., Hilton H.N., Wittlin S., Alexander W.S., Lindeman G.J., Visvader J.E., Ormandy C.J.
    Mol Endocrinol 20:1177-1187(2006) [PubMed] [Europe PMC] [Abstract]
• mammary gland epithelium development Source: MGIInferred from mutant phenotypeⁱ
  • "Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis."
    Shillingford J.M., Miyoshi K., Flagella M., Shull G.E., Hennighausen L.
    Mol Endocrinol 16:1309-1321(2002) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: MGI
• oncostatin-M-mediated signaling pathway Source: GOC
• positive regulation of cell population proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cold-induced thermogenesis Source: YuBioLabInferred from mutant phenotypeⁱ
  • "Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2."
    Viengchareun S., Servel N., Feve B., Freemark M., Lombes M., Binart N.
    PLoS One 3:e1535-e1535(2008) [PubMed] [Europe PMC] [Abstract]
• prostate gland growth Source: MGIInferred from mutant phenotypeⁱ
  • "Prostate development and carcinogenesis in prolactin receptor knockout mice."
    Robertson F.G., Harris J., Naylor M.J., Oakes S.R., Kindblom J., Dillner K., Wennbo H., Tornell J., Kelly P.A., Green J., Ormandy C.J.
    Endocrinology 144:3196-3205(2003) [PubMed] [Europe PMC] [Abstract]
• receptor signaling pathway via JAK-STAT Source: MGIInferred from mutant phenotypeⁱ
  • "Socs2 and elf5 mediate prolactin-induced mammary gland development."
    Harris J., Stanford P.M., Sutherland K., Oakes S.R., Naylor M.J., Robertson F.G., Blazek K.D., Kazlauskas M., Hilton H.N., Wittlin S., Alexander W.S., Lindeman G.J., Visvader J.E., Ormandy C.J.
    Mol Endocrinol 20:1177-1187(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of cell adhesion Source: MGIInferred from mutant phenotypeⁱ
  • "Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium."
    Miyoshi K., Shillingford J.M., Smith G.H., Grimm S.L., Wagner K.U., Oka T., Rosen J.M., Robinson G.W., Hennighausen L.
    J Cell Biol 155:531-542(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of epithelial cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium."
    Miyoshi K., Shillingford J.M., Smith G.H., Grimm S.L., Wagner K.U., Oka T., Rosen J.M., Robinson G.W., Hennighausen L.
    J Cell Biol 155:531-542(2001) [PubMed] [Europe PMC] [Abstract]
• response to bacterium Source: MGI <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Impact of lactobacilli on orally acquired listeriosis."
    Archambaud C., Nahori M.A., Soubigou G., Becavin C., Laval L., Lechat P., Smokvina T., Langella P., Lecuit M., Cossart P.
    Proc Natl Acad Sci U S A 109:16684-16689(2012) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• ciliary neurotrophic factor receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cytokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSSALAYMLL VLSISLLNGQ SPPGKPEIHK CRSPDKETFT CWWNPGSDGG 
        60         70         80         90        100
LPTNYSLTYS KEGEKNTYEC PDYKTSGPNS CFFSKQYTSI WKIYIITVNA 
       110        120        130        140        150
TNEMGSSTSD PLYVDVTYIV EPEPPRNLTL EVKQLKDKKT YLWVKWLPPT 
       160        170        180        190        200
ITDVKTGWFT MEYEIRLKSE EADEWEIHFT GHQTQFKVFD LYPGQKYLVQ 
       210        220        230        240        250
TRCKPDHGYW SRWGQEKSIE IPNDFTLKDT TVWIIVAVLS AVICLIMVWA 
       260        270        280        290        300
VALKGYSMMT CIFPPVPGPK IKGFDTHLLE KGKSEELLSA LGCQDFPPTS 
       310        320        330        340        350
DCEDLLVEFL EVDDNEDERL MPSHSKEYPG QGVKPTHLDP DSDSGHGSYD 
       360        370        380        390        400
SHSLLSEKCE EPQAYPPAFH IPEITEKPEN PEANIPPTPN PQNNTPNCHT 
       410        420        430        440        450
DTSKSTTWPL PPGQHTRRSP YHSIADVCKL AGSPGDTLDS FLDKAEENVL 
       460        470        480        490        500
KLSEDAGEEE VAVQEGAKSF PSDKQNTSWP PLQEKGPIVY AKPPDYVEIH 
       510        520        530        540        550
KVNKDGVLSL LPKQRENHQT ENPGVPETSK EYAKVSGVTD NNILVLVPDS 
       560        570        580        590        600
RAQNTALLEE SAKKVPPSLE QNQSEKDLAS FTATSSNCRL QLGRLDYLDP 

TCFMHSFH                                               

        10         20         30         40         50
MSSALAYMLL VLSISLLNGQ SPPGKPEIHK CRSPDKETFT CWWNPGSDGG 
        60         70         80         90        100
LPTNYSLTYS KEGEKNTYEC PDYKTSGPNS CFFSKQYTSI WKIYIITVNA 
       110        120        130        140        150
TNEMGSSTSD PLYVDVTYIV EPEPPRNLTL EVKQLKDKKT YLWVKWLPPT 
       160        170        180        190        200
ITDVKTGWFT MEYEIRLKSE EADEWEIHFT GHQTQFKVFD LYPGQKYLVQ 
       210        220        230        240        250
TRCKPDHGYW SRWGQEKSIE IPNDFTLKDT TVWIIVAVLS AVICLIMVWA 
       260        270        280        290        300
VALKGYSMMT CIFPPVPGPK IKGFDTHLLE LWCSILQLTS LVKIPTTEFL 

CDL                                                    

        10         20         30         40         50
MSSALAYMLL VLSISLLNGQ SPPGKPEIHK CRSPDKETFT CWWNPGSDGG 
        60         70         80         90        100
LPTNYSLTYS KEGEKNTYEC PDYKTSGPNS CFFSKQYTSI WKIYIITVNA 
       110        120        130        140        150
TNEMGSSTSD PLYVDVTYIV EPEPPRNLTL EVKQLKDKKT YLWVKWLPPT 
       160        170        180        190        200
ITDVKTGWFT MEYEIRLKSE EADEWEIHFT GHQTQFKVFD LYPGQKYLVQ 
       210        220        230        240        250
TRCKPDHGYW SRWGQEKSIE IPNDFTLKDT TVWIIVAVLS AVICLIMVWA 
       260        270        280        290 
VALKGYSMMT CIFPPVPGPK IKGFDTHLLE VHNKEQLENY VY         

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families