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UniProtKB - Q08501 (PRLR_MOUSE)

Entry version 184 (25 May 2022)
Sequence version 1 (01 Feb 1995)
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Protein

Prolactin receptor

Gene

Prlr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a receptor for the anterior pituitary hormone prolactin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi206ZincBy similarity1
Metal bindingi207ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1170546, Prolactin receptor signaling
R-MMU-982772, Growth hormone receptor signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prolactin receptor
Short name:
PRL-R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prlr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:97763, Prlr

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000005268

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 229ExtracellularBy similarityAdd BLAST210
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei230 – 253HelicalBy similarityAdd BLAST24
Topological domaini254 – 608CytoplasmicBy similarityAdd BLAST355

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001097820 – 608Prolactin receptorAdd BLAST589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 41By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi70 ↔ 81By similarity
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q08501

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q08501

PRoteomics IDEntifications database

More...PRIDEi		Q08501

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		291814 [Q08501-1]
291815 [Q08501-2]
291816 [Q08501-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q08501, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q08501

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q08501

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000005268, Expressed in islet of Langerhans and 195 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q08501, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q08501, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMARCA1.

Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		202385, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q08501, 3 interactors

Molecular INTeraction database

More...MINTi		Q08501

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000122219

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q08501, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q08501

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q08501

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 122Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST101
Domaini124 – 224Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni317 – 355DisorderedSequence analysisAdd BLAST39
Regioni377 – 419DisorderedSequence analysisAdd BLAST43
Regioni466 – 487DisorderedSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi210 – 214WSXWS motif5
Motifi262 – 270Box 1 motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi394 – 413Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 1 subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R22A, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154851

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017892_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q08501

Identification of Orthologs from Complete Genome Data

More...OMAi		YHYELRL

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q08501

TreeFam database of animal gene trees

More...TreeFami		TF330851

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR015152, Growth/epo_recpt_lig-bind
IPR013783, Ig-like_fold
IPR003528, Long_hematopoietin_rcpt_CS
IPR033230, PRLR

The PANTHER Classification System

More...PANTHERi		PTHR23036:SF86, PTHR23036:SF86, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09067, EpoR_lig-bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 2 hits
PS01352, HEMATOPO_REC_L_F1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform PRL-R3 (identifier: Q08501-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSALAYMLL VLSISLLNGQ SPPGKPEIHK CRSPDKETFT CWWNPGSDGG 
        60         70         80         90        100
LPTNYSLTYS KEGEKNTYEC PDYKTSGPNS CFFSKQYTSI WKIYIITVNA 
       110        120        130        140        150
TNEMGSSTSD PLYVDVTYIV EPEPPRNLTL EVKQLKDKKT YLWVKWLPPT 
       160        170        180        190        200
ITDVKTGWFT MEYEIRLKSE EADEWEIHFT GHQTQFKVFD LYPGQKYLVQ 
       210        220        230        240        250
TRCKPDHGYW SRWGQEKSIE IPNDFTLKDT TVWIIVAVLS AVICLIMVWA 
       260        270        280        290        300
VALKGYSMMT CIFPPVPGPK IKGFDTHLLE KGKSEELLSA LGCQDFPPTS 
       310        320        330        340        350
DCEDLLVEFL EVDDNEDERL MPSHSKEYPG QGVKPTHLDP DSDSGHGSYD 
       360        370        380        390        400
SHSLLSEKCE EPQAYPPAFH IPEITEKPEN PEANIPPTPN PQNNTPNCHT 
       410        420        430        440        450
DTSKSTTWPL PPGQHTRRSP YHSIADVCKL AGSPGDTLDS FLDKAEENVL 
       460        470        480        490        500
KLSEDAGEEE VAVQEGAKSF PSDKQNTSWP PLQEKGPIVY AKPPDYVEIH 
       510        520        530        540        550
KVNKDGVLSL LPKQRENHQT ENPGVPETSK EYAKVSGVTD NNILVLVPDS 
       560        570        580        590        600
RAQNTALLEE SAKKVPPSLE QNQSEKDLAS FTATSSNCRL QLGRLDYLDP 

TCFMHSFH
Length:608
Mass (Da):68,241
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8CE202B2EFC9FC6
GO
Isoform PRL-R1 (identifier: Q08501-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-303: KGKSEELLSALGCQDFPPTSDCE → LWCSILQLTSLVKIPTTEFLCDL
     304-608: Missing.

Show »
Length:303
Mass (Da):34,734
Checksum:iE22B50EFDB77B755
GO
Isoform PRL-R2 (identifier: Q08501-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-292: KGKSEELLSALG → VHNKEQLENYVY
     293-608: Missing.

Show »
Length:292
Mass (Da):33,633
Checksum:iF02BA23FE6AC74F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UVW6G3UVW6_MOUSE
Prolactin receptor
Prlr PRLR, prlr
310Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q2L5E9Q2L5_MOUSE
Prolactin receptor
Prlr PRLR
119Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q0U8E9Q0U8_MOUSE
Prolactin receptor
Prlr PRLR
155Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q631E9Q631_MOUSE
Prolactin receptor
Prlr PRLR
185Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti558L → F in CAA51789 (PubMed:8319571).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001723281 – 303KGKSE…TSDCE → LWCSILQLTSLVKIPTTEFL CDL in isoform PRL-R1. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_001721281 – 292KGKSE…LSALG → VHNKEQLENYVY in isoform PRL-R2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_001722293 – 608Missing in isoform PRL-R2. 1 PublicationAdd BLAST316
Alternative sequenceiVSP_001724304 – 608Missing in isoform PRL-R1. 1 PublicationAdd BLAST305

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L13593 mRNA Translation: AAC37641.1
L14811 mRNA Translation: AAA02686.1
D10214 mRNA Translation: BAA01066.1
X73372 mRNA Translation: CAA51789.1
M22959 mRNA Translation: AAA39977.1
M22958 mRNA Translation: AAA39976.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS27377.1 [Q08501-1]
CCDS56975.1 [Q08501-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I53269
I77524
I77525

NCBI Reference Sequences

More...RefSeqi		NP_001240711.1, NM_001253782.2 [Q08501-2]
NP_035299.4, NM_011169.5 [Q08501-1]
XP_006520097.1, XM_006520034.3 [Q08501-1]
XP_006520098.1, XM_006520035.1 [Q08501-1]
XP_006520099.1, XM_006520036.1 [Q08501-1]
XP_006520100.1, XM_006520037.2 [Q08501-1]
XP_006520101.1, XM_006520038.1 [Q08501-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000124470; ENSMUSP00000122219; ENSMUSG00000005268 [Q08501-1]
ENSMUST00000128450; ENSMUSP00000122209; ENSMUSG00000005268 [Q08501-3]
ENSMUST00000137867; ENSMUSP00000121935; ENSMUSG00000005268 [Q08501-3]
ENSMUST00000148257; ENSMUSP00000118355; ENSMUSG00000005268 [Q08501-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		19116

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:19116

UCSC genome browser

More...UCSCi		uc007vfw.2, mouse [Q08501-3]
uc007vfy.2, mouse [Q08501-1]
uc029snt.1, mouse [Q08501-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13593 mRNA Translation: AAC37641.1
L14811 mRNA Translation: AAA02686.1
D10214 mRNA Translation: BAA01066.1
X73372 mRNA Translation: CAA51789.1
M22959 mRNA Translation: AAA39977.1
M22958 mRNA Translation: AAA39976.1
CCDSiCCDS27377.1 [Q08501-1]
CCDS56975.1 [Q08501-2]
PIRiI53269
I77524
I77525
RefSeqiNP_001240711.1, NM_001253782.2 [Q08501-2]
NP_035299.4, NM_011169.5 [Q08501-1]
XP_006520097.1, XM_006520034.3 [Q08501-1]
XP_006520098.1, XM_006520035.1 [Q08501-1]
XP_006520099.1, XM_006520036.1 [Q08501-1]
XP_006520100.1, XM_006520037.2 [Q08501-1]
XP_006520101.1, XM_006520038.1 [Q08501-2]

3D structure databases

AlphaFoldDBiQ08501
SMRiQ08501
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi202385, 4 interactors
IntActiQ08501, 3 interactors
MINTiQ08501
STRINGi10090.ENSMUSP00000122219

Chemistry databases

GuidetoPHARMACOLOGYi1721

PTM databases

GlyGeniQ08501, 3 sites
iPTMnetiQ08501
PhosphoSitePlusiQ08501

Proteomic databases

MaxQBiQ08501
PaxDbiQ08501
PRIDEiQ08501
ProteomicsDBi291814 [Q08501-1]
291815 [Q08501-2]
291816 [Q08501-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		19116

Genome annotation databases

EnsembliENSMUST00000124470; ENSMUSP00000122219; ENSMUSG00000005268 [Q08501-1]
ENSMUST00000128450; ENSMUSP00000122209; ENSMUSG00000005268 [Q08501-3]
ENSMUST00000137867; ENSMUSP00000121935; ENSMUSG00000005268 [Q08501-3]
ENSMUST00000148257; ENSMUSP00000118355; ENSMUSG00000005268 [Q08501-2]
GeneIDi19116
KEGGimmu:19116
UCSCiuc007vfw.2, mouse [Q08501-3]
uc007vfy.2, mouse [Q08501-1]
uc029snt.1, mouse [Q08501-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5618
MGIiMGI:97763, Prlr
VEuPathDBiHostDB:ENSMUSG00000005268

Phylogenomic databases

eggNOGiENOG502R22A, Eukaryota
GeneTreeiENSGT00940000154851
HOGENOMiCLU_017892_2_0_1
InParanoidiQ08501
OMAiYHYELRL
PhylomeDBiQ08501
TreeFamiTF330851

Enzyme and pathway databases

ReactomeiR-MMU-1170546, Prolactin receptor signaling
R-MMU-982772, Growth hormone receptor signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		19116, 6 hits in 72 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Prlr, mouse

Protein Ontology

More...PROi		PR:Q08501
RNActiQ08501, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000005268, Expressed in islet of Langerhans and 195 other tissues
ExpressionAtlasiQ08501, baseline and differential
GenevisibleiQ08501, MM

Family and domain databases

CDDicd00063, FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR015152, Growth/epo_recpt_lig-bind
IPR013783, Ig-like_fold
IPR003528, Long_hematopoietin_rcpt_CS
IPR033230, PRLR
PANTHERiPTHR23036:SF86, PTHR23036:SF86, 2 hits
PfamiView protein in Pfam
PF09067, EpoR_lig-bind, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 2 hits
SUPFAMiSSF49265, SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 2 hits
PS01352, HEMATOPO_REC_L_F1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRLR_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08501
Secondary accession number(s): P15212, P15213, Q62099
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 25, 2022
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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