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Protein

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

Gene

PDE4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cation2 PublicationsNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.2 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by rolipram. Activated by phosphatidic acid.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 3',5'-cyclic AMP degradation

This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.
Proteins known to be involved in this subpathway in this organism are:
  1. High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B)
This subpathway is part of the pathway 3',5'-cyclic AMP degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei462Proton donorBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi466Divalent metal cation 11
Metal bindingi502Divalent metal cation 11
Metal bindingi503Divalent metal cation 11
Metal bindingi503Divalent metal cation 21
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei503cAMP2 Publications1
Metal bindingi620Divalent metal cation 11
Binding sitei620cAMP2 Publications1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei623Binds AMP, but not cAMP1
Binding sitei671cAMP2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi462 – 466cAMP2 Publications5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: BHF-UCL
  • 3',5'-cyclic-nucleotide phosphodiesterase activity Source: UniProtKB
  • ATPase binding Source: BHF-UCL
  • beta-2 adrenergic receptor binding Source: BHF-UCL
  • cAMP binding Source: BHF-UCL
  • drug binding Source: UniProtKB
  • enzyme binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • scaffold protein binding Source: BHF-UCL
  • ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.4.53 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-180024 DARPP-32 events
R-HSA-418555 G alpha (s) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q08499

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q08499

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00762;UER00747

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC:3.1.4.53)
Alternative name(s):
DPDE3
PDE43
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDE4D
Synonyms:DPDE3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000113448.16

Human Gene Nomenclature Database

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HGNCi
HGNC:8783 PDE4D

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600129 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q08499

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.1 Publication
Acrodysostosis 2, with or without hormone resistance (ACRDYS2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.
See also OMIM:614613
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068242190S → A in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514466Ensembl.1
Natural variantiVAR_068243225P → T in ACRDYS2. 2 PublicationsCorresponds to variant dbSNP:rs397514464Ensembl.1
Natural variantiVAR_068244226F → S in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514465Ensembl.1
Natural variantiVAR_069448227A → S in ACRDYS2. 1 Publication1
Natural variantiVAR_069449228Q → E in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514468Ensembl.1
Natural variantiVAR_069450301S → T in ACRDYS2. 1 Publication1
Natural variantiVAR_069451304A → V in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397515433Ensembl.1
Natural variantiVAR_069452329V → A in ACRDYS2. 1 Publication1
Natural variantiVAR_068245587T → P in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514467Ensembl.1
Natural variantiVAR_069453590E → A in ACRDYS2. 2 Publications1
Natural variantiVAR_069454673G → D in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514469Ensembl.1
Natural variantiVAR_069455678I → T in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs587777188Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi503D → N: Abolishes catalytic activity. 1
Mutagenesisi527D → R: Abolishes homodimerization. 1 Publication1
Mutagenesisi563R → D: Abolishes homodimerization. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
5144

MalaCards human disease database

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MalaCardsi
PDE4D
MIMi614613 phenotype

Open Targets

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OpenTargetsi
ENSG00000113448

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
950 Acrodysostosis
280651 Acrodysostosis with multiple hormone resistance
439822 PDE4D haploinsufficiency syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33130

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL288

Drug and drug target database

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DrugBanki
DB06842 (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one
DB04149 (R)-Rolipram
DB03606 (S)-Rolipram
DB07954 3-isobutyl-1-methyl-7H-xanthine
DB02918 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One
DB00131 Adenosine monophosphate
DB05676 Apremilast
DB00201 Caffeine
DB03849 Cilomilast
DB05219 Crisaborole
DB00651 Dyphylline
DB05266 Ibudilast
DB01088 Iloprost
DB05298 OPC-6535
DB01791 Piclamilast
DB01656 Roflumilast
DB01954 Rolipram

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1303

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PDE4D

Domain mapping of disease mutations (DMDM)

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DMDMi
12644392

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001988141 – 809cAMP-specific 3',5'-cyclic phosphodiesterase 4DAdd BLAST809

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei142PhosphoserineBy similarity1
Modified residuei299PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki387Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Isoform 3 (identifier: Q08499-2)
Modified residuei53Phosphoserine1 Publication1
Isoform 5 (identifier: Q08499-6)
Modified residuei59PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Isoform N3 (identifier: Q08499-7)
Modified residuei59PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Isoform 12 (identifier: Q08499-12)
Modified residuei59PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation (By similarity). Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59.By similarity
Sumoylation of long isoforms by PIAS4 augments their activation by PKA phosphorylation and represses their inhibition by ERK phosphorylation.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q08499

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q08499

PeptideAtlas

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PeptideAtlasi
Q08499

PRoteomics IDEntifications database

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PRIDEi
Q08499

ProteomicsDB human proteome resource

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ProteomicsDBi
58620
58621 [Q08499-10]
58622 [Q08499-11]
58623 [Q08499-12]
58624 [Q08499-2]
58625 [Q08499-3]
58626 [Q08499-4]
58627 [Q08499-5]
58628 [Q08499-6]
58629 [Q08499-7]
58630 [Q08499-8]
58631 [Q08499-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q08499

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q08499

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000113448 Expressed in 215 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q08499 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q08499 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA045895

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity). Isoform 5, isoform N3 and isoform 12 bind RACK1 via their unique N-terminus. Binds ARRB2. Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner.By similarity15 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111170, 52 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q08499

Database of interacting proteins

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DIPi
DIP-41115N

Protein interaction database and analysis system

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IntActi
Q08499, 25 interactors

Molecular INTeraction database

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MINTi
Q08499

STRING: functional protein association networks

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STRINGi
9606.ENSP00000345502

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q08499

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1809
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q08499

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q08499

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q08499

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini386 – 715PDEasePROSITE-ProRule annotationAdd BLAST330

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 88Pro-richAdd BLAST47

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3689 Eukaryota
ENOG410XRI7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155674

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108239

KEGG Orthology (KO)

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KOi
K13293

Identification of Orthologs from Complete Genome Data

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OMAi
EDHSPDT

Database of Orthologous Groups

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OrthoDBi
EOG091G06CD

Database for complete collections of gene phylogenies

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PhylomeDBi
Q08499

TreeFam database of animal gene trees

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TreeFami
TF314638

Family and domain databases

Conserved Domains Database

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CDDi
cd00077 HDc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1300.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS

Pfam protein domain database

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Pfami
View protein in Pfam
PF00233 PDEase_I, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00387 PDIESTERASE1

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 12 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q08499-1) [UniParc]FASTAAdd to basket
Also known as: hPDE4D4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAEGSSAPA RAGSGEGSDS AGGATLKAPK HLWRHEQHHQ YPLRQPQFRL
60 70 80 90 100
LHPHHHLPPP PPPSPQPQPQ CPLQPPPPPP LPPPPPPPGA ARGRYASSGA
110 120 130 140 150
TGRVRHRGYS DTERYLYCRA MDRTSYAVET GHRPGLKKSR MSWPSSFQGL
160 170 180 190 200
RRFDVDNGTS AGRSPLDPMT SPGSGLILQA NFVHSQRRES FLYRSDSDYD
210 220 230 240 250
LSPKSMSRNS SIASDIHGDD LIVTPFAQVL ASLRTVRNNF AALTNLQDRA
260 270 280 290 300
PSKRSPMCNQ PSINKATITE EAYQKLASET LEELDWCLDQ LETLQTRHSV
310 320 330 340 350
SEMASNKFKR MLNRELTHLS EMSRSGNQVS EFISNTFLDK QHEVEIPSPT
360 370 380 390 400
QKEKEKKKRP MSQISGVKKL MHSSSLTNSS IPRFGVKTEQ EDVLAKELED
410 420 430 440 450
VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP VDTLITYLMT
460 470 480 490 500
LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA
510 520 530 540 550
IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI
560 570 580 590 600
FQNLTKKQRQ SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL
610 620 630 640 650
LLDNYSDRIQ VLQNMVHCAD LSNPTKPLQL YRQWTDRIME EFFRQGDRER
660 670 680 690 700
ERGMEISPMC DKHNASVEKS QVGFIDYIVH PLWETWADLV HPDAQDILDT
710 720 730 740 750
LEDNREWYQS TIPQSPSPAP DDPEEGRQGQ TEKFQFELTL EEDGESDTEK
760 770 780 790 800
DSGSQVEEDT SCSDSKTLCT QDSESTEIPL DEQVEEEAVG EEEESQPEAC

VIDDRSPDT
Length:809
Mass (Da):91,115
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A4773DD3A044F57
GO
Isoform 3 (identifier: Q08499-2) [UniParc]FASTAAdd to basket
Also known as: hPDE4D3

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: MEAEGSSAPA...WPSSFQGLRR → MMHVNNFPFRRHSWIC

Note: Activated by phosphorylation at Ser-53. Mutagenesis of Ser-53 abolishes activation.1 Publication
Show »
Length:673
Mass (Da):76,467
Checksum:iBDC04171BA91A297
GO
Isoform 10 (identifier: Q08499-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-205: Missing.

Show »
Length:604
Mass (Da):68,607
Checksum:i446D0C31C86399AB
GO
Isoform 1 (identifier: Q08499-4) [UniParc]FASTAAdd to basket
Also known as: hPDE4D1

The sequence of this isoform differs from the canonical sequence as follows:
     1-269: MEAEGSSAPA...QPSINKATIT → MKEQPSCAGT...TESPFPCLFA

Show »
Length:584
Mass (Da):66,376
Checksum:iC1761886FF962102
GO
Isoform 2 (identifier: Q08499-5) [UniParc]FASTAAdd to basket
Also known as: hPDE4D2

The sequence of this isoform differs from the canonical sequence as follows:
     1-302: Missing.

Show »
Length:507
Mass (Da):57,792
Checksum:i6C07C949952EE5DF
GO
Isoform 5 (identifier: Q08499-6) [UniParc]FASTAAdd to basket
Also known as: hPDE4D5

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: MEAEGSSAPA...WPSSFQGLRR → MAQQTSPDTL...QRRFTVAHTC

Show »
Length:745
Mass (Da):84,428
Checksum:iD136AE2B7132DAAC
GO
Isoform N3 (identifier: Q08499-7) [UniParc]FASTAAdd to basket
Also known as: PDE4DN3

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: MEAEGSSAPA...WPSSFQGLRR → MAQQTSPDTL...QRRFTVAHTC
     270-279: EEAYQKLASE → GLYNGIIAFL
     280-809: Missing.

Show »
Length:215
Mass (Da):23,839
Checksum:i255EF7985DB75353
GO
Isoform 6 (identifier: Q08499-8) [UniParc]FASTAAdd to basket
Also known as: PDE4D6

The sequence of this isoform differs from the canonical sequence as follows:
     1-291: Missing.
     292-306: ETLQTRHSVSEMASN → MPEANYLLSVSWGYI

Show »
Length:518
Mass (Da):59,113
Checksum:i069F18EB90BAAF4B
GO
Isoform 8 (identifier: Q08499-9) [UniParc]FASTAAdd to basket
Also known as: PDE4D8

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     123-152: RTSYAVETGHRPGLKKSRMSWPSSFQGLRR → MAFVWDPLGATVPGPSTRAKSRLRFSKSYS

Show »
Length:687
Mass (Da):77,705
Checksum:i90B1ED110D7ED77C
GO
Isoform 9 (identifier: Q08499-10) [UniParc]FASTAAdd to basket
Also known as: PDE4D9

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.
     131-152: GHRPGLKKSRMSWPSSFQGLRR → MSIIMKPRSRSTSSLRTAEAVC

Show »
Length:679
Mass (Da):76,816
Checksum:iD35B0A2D975C5705
GO
Isoform 7 (identifier: Q08499-11) [UniParc]FASTAAdd to basket
Also known as: PDE4D7

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     62-152: PPSPQPQPQC...WPSSFQGLRR → MKRNTCDLLS...IAITSAESSG

Show »
Length:748
Mass (Da):84,662
Checksum:iD10CF5036B1EA7C8
GO
Isoform 12 (identifier: Q08499-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: MEAEGSSAPA...WPSSFQGLRR → MAQQTSPDTL...QRRFTVAHTC
     270-283: EEAYQKLASETLEE → GSWMELNPYTLLDM
     284-809: Missing.

Show »
Length:219
Mass (Da):24,429
Checksum:i04C84B400D6F7D2C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSZ7A0A087WSZ7_HUMAN
Phosphodiesterase
PDE4D
678Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GW84A0A1B0GW84_HUMAN
Phosphodiesterase
PDE4D
699Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHE0D6RHE0_HUMAN
Phosphodiesterase
PDE4D
422Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIG1D6RIG1_HUMAN
cAMP-specific 3',5'-cyclic phosphod...
PDE4D
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAQ0D6RAQ0_HUMAN
cAMP-specific 3',5'-cyclic phosphod...
PDE4D
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBB2D6RBB2_HUMAN
cAMP-specific 3',5'-cyclic phosphod...
PDE4D
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9L4D6R9L4_HUMAN
cAMP-specific 3',5'-cyclic phosphod...
PDE4D
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQN6A0A1W2PQN6_HUMAN
cAMP-specific 3',5'-cyclic phosphod...
PDE4D
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti510S → F in AAH36319 (PubMed:15489334).Curated1
Sequence conflicti549D → G in AAN10119 (PubMed:12834813).Curated1
Sequence conflicti644R → P (PubMed:8797812).Curated1
Sequence conflicti769C → R in AAA97890 (PubMed:8125310).Curated1
Sequence conflicti769C → R in AAA97891 (PubMed:8125310).Curated1
Sequence conflicti769C → R in AAA97892 (PubMed:8125310).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068242190S → A in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514466Ensembl.1
Natural variantiVAR_068243225P → T in ACRDYS2. 2 PublicationsCorresponds to variant dbSNP:rs397514464Ensembl.1
Natural variantiVAR_068244226F → S in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514465Ensembl.1
Natural variantiVAR_069448227A → S in ACRDYS2. 1 Publication1
Natural variantiVAR_069449228Q → E in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514468Ensembl.1
Natural variantiVAR_069450301S → T in ACRDYS2. 1 Publication1
Natural variantiVAR_069451304A → V in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397515433Ensembl.1
Natural variantiVAR_069452329V → A in ACRDYS2. 1 Publication1
Natural variantiVAR_068245587T → P in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514467Ensembl.1
Natural variantiVAR_069453590E → A in ACRDYS2. 2 Publications1
Natural variantiVAR_069454673G → D in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514469Ensembl.1
Natural variantiVAR_069455678I → T in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs587777188Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0045801 – 302Missing in isoform 2. 2 PublicationsAdd BLAST302
Alternative sequenceiVSP_0123831 – 291Missing in isoform 6. 2 PublicationsAdd BLAST291
Alternative sequenceiVSP_0045791 – 269MEAEG…KATIT → MKEQPSCAGTGHPMAGYGRM APFELASGPVKRLRTESPFP CLFA in isoform 1. 2 PublicationsAdd BLAST269
Alternative sequenceiVSP_0045781 – 205Missing in isoform 10. 2 PublicationsAdd BLAST205
Alternative sequenceiVSP_0045771 – 152MEAEG…QGLRR → MMHVNNFPFRRHSWIC in isoform 3. 2 PublicationsAdd BLAST152
Alternative sequenceiVSP_0123841 – 152MEAEG…QGLRR → MAQQTSPDTLTVPEVDNPHC PNPWLNEDLVKSLRENLLQH EKSKTARKSVSPKLSPVISP RNSPRLLRRMLLSSNIPKQR RFTVAHTC in isoform 5, isoform N3 and isoform 12. 4 PublicationsAdd BLAST152
Alternative sequenceiVSP_0123851 – 130Missing in isoform 9. 2 PublicationsAdd BLAST130
Alternative sequenceiVSP_0123861 – 122Missing in isoform 8. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_0123871 – 61Missing in isoform 7. 2 PublicationsAdd BLAST61
Alternative sequenceiVSP_01238862 – 152PPSPQ…QGLRR → MKRNTCDLLSRSKSASEETL HSSNEEEDPFRGMEPYLVRR LSCRNIQLPPLAFRQLEQAD LKSESENIQRPTSLPLKILP LIAITSAESSG in isoform 7. 2 PublicationsAdd BLAST91
Alternative sequenceiVSP_012389123 – 152RTSYA…QGLRR → MAFVWDPLGATVPGPSTRAK SRLRFSKSYS in isoform 8. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_012390131 – 152GHRPG…QGLRR → MSIIMKPRSRSTSSLRTAEA VC in isoform 9. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_023326270 – 283EEAYQ…ETLEE → GSWMELNPYTLLDM in isoform 12. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_012391270 – 279EEAYQKLASE → GLYNGIIAFL in isoform N3. 1 Publication10
Alternative sequenceiVSP_012392280 – 809Missing in isoform N3. 1 PublicationAdd BLAST530
Alternative sequenceiVSP_023327284 – 809Missing in isoform 12. 2 PublicationsAdd BLAST526
Alternative sequenceiVSP_012393292 – 306ETLQT…EMASN → MPEANYLLSVSWGYI in isoform 6. 2 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L20970 mRNA Translation: AAA03592.1
L20969 mRNA Translation: AAC00042.1
U02882 mRNA Translation: AAC13745.1
U50157 mRNA Translation: AAA97890.1
U50158 mRNA Translation: AAA97891.1
U50159 mRNA Translation: AAA97892.1
AF012074 mRNA Translation: AAC00070.1
AF012073 mRNA Translation: AAC00069.1
AJ250854 mRNA Translation: CAC03757.1
AF536975 mRNA Translation: AAN10117.1
AF536976 mRNA Translation: AAN10118.1
AF536977 mRNA Translation: AAN10119.1
AY388960 mRNA Translation: AAQ90404.1
AY245866 mRNA Translation: AAP75760.1
AY245867 mRNA Translation: AAP75761.1
BT007398 mRNA Translation: AAP36062.1
BC008390 mRNA Translation: AAH08390.1
BC036319 mRNA Translation: AAH36319.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47213.1 [Q08499-1]
CCDS54858.1 [Q08499-2]
CCDS54859.1 [Q08499-11]
CCDS56369.1 [Q08499-8]
CCDS56370.1 [Q08499-5]
CCDS56371.1 [Q08499-10]
CCDS56372.1 [Q08499-9]
CCDS56373.1 [Q08499-6]

Protein sequence database of the Protein Information Resource

More...
PIRi
I61358

NCBI Reference Sequences

More...
RefSeqi
NP_001098101.1, NM_001104631.1 [Q08499-1]
NP_001159371.1, NM_001165899.1 [Q08499-11]
NP_001184147.1, NM_001197218.1 [Q08499-6]
NP_001184148.1, NM_001197219.1 [Q08499-9]
NP_001184149.1, NM_001197220.1 [Q08499-10]
NP_001184150.1, NM_001197221.1 [Q08499-5]
NP_001184151.1, NM_001197222.1
NP_001184152.1, NM_001197223.1 [Q08499-8]
NP_006194.2, NM_006203.4 [Q08499-2]
XP_005248595.1, XM_005248538.4
XP_011541773.1, XM_011543471.1 [Q08499-11]
XP_011541775.1, XM_011543473.1 [Q08499-11]
XP_016865055.1, XM_017009566.1 [Q08499-11]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.117545

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309641; ENSP00000308485; ENSG00000113448 [Q08499-7]
ENST00000317118; ENSP00000321739; ENSG00000113448 [Q08499-8]
ENST00000340635; ENSP00000345502; ENSG00000113448 [Q08499-1]
ENST00000358923; ENSP00000351800; ENSG00000113448 [Q08499-5]
ENST00000360047; ENSP00000353152; ENSG00000113448 [Q08499-2]
ENST00000405755; ENSP00000384806; ENSG00000113448 [Q08499-9]
ENST00000502484; ENSP00000423094; ENSG00000113448 [Q08499-11]
ENST00000502575; ENSP00000425917; ENSG00000113448 [Q08499-12]
ENST00000503258; ENSP00000425605; ENSG00000113448 [Q08499-10]
ENST00000507116; ENSP00000424852; ENSG00000113448 [Q08499-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5144

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5144

UCSC genome browser

More...
UCSCi
uc003jrs.4 human [Q08499-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) (PDE4D)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20970 mRNA Translation: AAA03592.1
L20969 mRNA Translation: AAC00042.1
U02882 mRNA Translation: AAC13745.1
U50157 mRNA Translation: AAA97890.1
U50158 mRNA Translation: AAA97891.1
U50159 mRNA Translation: AAA97892.1
AF012074 mRNA Translation: AAC00070.1
AF012073 mRNA Translation: AAC00069.1
AJ250854 mRNA Translation: CAC03757.1
AF536975 mRNA Translation: AAN10117.1
AF536976 mRNA Translation: AAN10118.1
AF536977 mRNA Translation: AAN10119.1
AY388960 mRNA Translation: AAQ90404.1
AY245866 mRNA Translation: AAP75760.1
AY245867 mRNA Translation: AAP75761.1
BT007398 mRNA Translation: AAP36062.1
BC008390 mRNA Translation: AAH08390.1
BC036319 mRNA Translation: AAH36319.1
CCDSiCCDS47213.1 [Q08499-1]
CCDS54858.1 [Q08499-2]
CCDS54859.1 [Q08499-11]
CCDS56369.1 [Q08499-8]
CCDS56370.1 [Q08499-5]
CCDS56371.1 [Q08499-10]
CCDS56372.1 [Q08499-9]
CCDS56373.1 [Q08499-6]
PIRiI61358
RefSeqiNP_001098101.1, NM_001104631.1 [Q08499-1]
NP_001159371.1, NM_001165899.1 [Q08499-11]
NP_001184147.1, NM_001197218.1 [Q08499-6]
NP_001184148.1, NM_001197219.1 [Q08499-9]
NP_001184149.1, NM_001197220.1 [Q08499-10]
NP_001184150.1, NM_001197221.1 [Q08499-5]
NP_001184151.1, NM_001197222.1
NP_001184152.1, NM_001197223.1 [Q08499-8]
NP_006194.2, NM_006203.4 [Q08499-2]
XP_005248595.1, XM_005248538.4
XP_011541773.1, XM_011543471.1 [Q08499-11]
XP_011541775.1, XM_011543473.1 [Q08499-11]
XP_016865055.1, XM_017009566.1 [Q08499-11]
UniGeneiHs.117545

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E9KNMR-A-[»]
1MKDX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L388-715[»]
1OYNX-ray2.00A/B/C/D381-740[»]
1PTWX-ray2.30A/B/C/D381-740[»]
1Q9MX-ray2.30A/B/C/D381-740[»]
1TB7X-ray1.63A/B388-715[»]
1TBBX-ray1.60A/B388-715[»]
1XOMX-ray1.55A/B388-715[»]
1XONX-ray1.72A/B388-715[»]
1XOQX-ray1.83A/B388-715[»]
1XORX-ray1.54A/B388-715[»]
1Y2BX-ray1.40A/B388-715[»]
1Y2CX-ray1.67A/B388-715[»]
1Y2DX-ray1.70A/B388-715[»]
1Y2EX-ray2.10A/B388-715[»]
1Y2KX-ray1.36A/B388-715[»]
1ZKNX-ray2.10A/B/C/D381-714[»]
2FM0X-ray2.00A/B/C/D381-741[»]
2FM5X-ray2.03A/B/C/D381-741[»]
2PW3X-ray1.56A/B388-714[»]
2QYNX-ray1.57A/B388-715[»]
3G4GX-ray2.30A/B/C/D299-347[»]
A/B/C/D360-714[»]
3G4IX-ray1.90A/B/C/D380-753[»]
3G4KX-ray1.95A/B/C/D380-753[»]
3G4LX-ray2.50A/B/C/D380-753[»]
3G58X-ray2.05A/B/C/D380-753[»]
3IADX-ray2.65A/B/C/D326-339[»]
A/B/C/D380-714[»]
3IAKX-ray2.80A388-715[»]
3K4SX-ray2.05A388-715[»]
3SL3X-ray2.10A/B/C/D381-741[»]
3SL4X-ray1.90A/B/C/D381-741[»]
3SL5X-ray2.65A/B/C/D381-714[»]
3SL6X-ray2.44A/B/C/D381-741[»]
3SL8X-ray2.60A/B/C/D381-741[»]
3V9BX-ray2.10A/B/C/D381-740[»]
4OGBX-ray2.03A/B/C/D381-741[»]
4W1OX-ray2.20A/B/C/D381-739[»]
4WCUX-ray2.35A/B/C/D381-739[»]
5K1IX-ray2.61A/B/C/D/E/F/G/H388-713[»]
5K32X-ray1.99A/B390-713[»]
5LBOX-ray2.25A/B/C/D381-740[»]
5TKBX-ray2.16A/B/C/D380-753[»]
5WH5X-ray1.80A/B388-714[»]
5WH6X-ray1.60A/B303-809[»]
5WQAX-ray2.30A/B381-714[»]
6BOJX-ray1.70A/B/C/D380-718[»]
A/B/C/D730-734[»]
6F6UX-ray1.83A/B380-714[»]
6F8RX-ray1.83A/B380-714[»]
6F8TX-ray1.80A/B380-714[»]
6F8UX-ray2.10A/B380-714[»]
6F8VX-ray1.85A/B380-714[»]
6F8WX-ray1.60A/B380-714[»]
6F8XX-ray1.95A/B380-715[»]
6FDCX-ray1.45A/B380-714[»]
ProteinModelPortaliQ08499
SMRiQ08499
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111170, 52 interactors
CORUMiQ08499
DIPiDIP-41115N
IntActiQ08499, 25 interactors
MINTiQ08499
STRINGi9606.ENSP00000345502

Chemistry databases

BindingDBiQ08499
ChEMBLiCHEMBL288
DrugBankiDB06842 (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one
DB04149 (R)-Rolipram
DB03606 (S)-Rolipram
DB07954 3-isobutyl-1-methyl-7H-xanthine
DB02918 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One
DB00131 Adenosine monophosphate
DB05676 Apremilast
DB00201 Caffeine
DB03849 Cilomilast
DB05219 Crisaborole
DB00651 Dyphylline
DB05266 Ibudilast
DB01088 Iloprost
DB05298 OPC-6535
DB01791 Piclamilast
DB01656 Roflumilast
DB01954 Rolipram
GuidetoPHARMACOLOGYi1303

PTM databases

iPTMnetiQ08499
PhosphoSitePlusiQ08499

Polymorphism and mutation databases

BioMutaiPDE4D
DMDMi12644392

Proteomic databases

MaxQBiQ08499
PaxDbiQ08499
PeptideAtlasiQ08499
PRIDEiQ08499
ProteomicsDBi58620
58621 [Q08499-10]
58622 [Q08499-11]
58623 [Q08499-12]
58624 [Q08499-2]
58625 [Q08499-3]
58626 [Q08499-4]
58627 [Q08499-5]
58628 [Q08499-6]
58629 [Q08499-7]
58630 [Q08499-8]
58631 [Q08499-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5144
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309641; ENSP00000308485; ENSG00000113448 [Q08499-7]
ENST00000317118; ENSP00000321739; ENSG00000113448 [Q08499-8]
ENST00000340635; ENSP00000345502; ENSG00000113448 [Q08499-1]
ENST00000358923; ENSP00000351800; ENSG00000113448 [Q08499-5]
ENST00000360047; ENSP00000353152; ENSG00000113448 [Q08499-2]
ENST00000405755; ENSP00000384806; ENSG00000113448 [Q08499-9]
ENST00000502484; ENSP00000423094; ENSG00000113448 [Q08499-11]
ENST00000502575; ENSP00000425917; ENSG00000113448 [Q08499-12]
ENST00000503258; ENSP00000425605; ENSG00000113448 [Q08499-10]
ENST00000507116; ENSP00000424852; ENSG00000113448 [Q08499-6]
GeneIDi5144
KEGGihsa:5144
UCSCiuc003jrs.4 human [Q08499-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5144
DisGeNETi5144
EuPathDBiHostDB:ENSG00000113448.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PDE4D
HGNCiHGNC:8783 PDE4D
HPAiHPA045895
MalaCardsiPDE4D
MIMi600129 gene
614613 phenotype
neXtProtiNX_Q08499
OpenTargetsiENSG00000113448
Orphaneti950 Acrodysostosis
280651 Acrodysostosis with multiple hormone resistance
439822 PDE4D haploinsufficiency syndrome
PharmGKBiPA33130

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00940000155674
HOVERGENiHBG108239
KOiK13293
OMAiEDHSPDT
OrthoDBiEOG091G06CD
PhylomeDBiQ08499
TreeFamiTF314638

Enzyme and pathway databases

UniPathwayi
UPA00762;UER00747

BRENDAi3.1.4.53 2681
ReactomeiR-HSA-180024 DARPP-32 events
R-HSA-418555 G alpha (s) signalling events
SignaLinkiQ08499
SIGNORiQ08499

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PDE4D human
EvolutionaryTraceiQ08499

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PDE4D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5144

Protein Ontology

More...
PROi
PR:Q08499

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113448 Expressed in 215 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ08499 baseline and differential
GenevisibleiQ08499 HS

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDE4D_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q08499
Secondary accession number(s): O43433
, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q96HL4, Q9HCX7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: December 5, 2018
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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