UniProtKB - Q08499 (PDE4D_HUMAN)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
PDE4D
Functioni
Catalytic activityi
- EC:3.1.4.53
Cofactori
Activity regulationi
: 3',5'-cyclic AMP degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.Proteins known to be involved in this subpathway in this organism are:
- Phosphodiesterase, Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4C), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4D), Phosphodiesterase (PDE8A), Phosphodiesterase, Phosphodiesterase (PDE4B), Phosphodiesterase (PDE4C), Phosphodiesterase, Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase (PDE4B), 3',5'-cyclic-AMP phosphodiesterase (PDE4D), Phosphodiesterase (PDE8B), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4D), 3',5'-cyclic-AMP phosphodiesterase (PDE4DN2), Phosphodiesterase, cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), 3',5'-cyclic-AMP phosphodiesterase (HSPDE4D), Phosphodiesterase, Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4D), Phosphodiesterase (PDE4C), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4D), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), 3',5'-cyclic-AMP phosphodiesterase (PDE4A), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4B), 3',5'-cyclic-AMP phosphodiesterase (PDE4C), 3',5'-cyclic-AMP phosphodiesterase (PDE4A), Phosphodiesterase (PDE4C), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase (PDE4C)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 462 | Proton donorBy similarity | 1 | |
Metal bindingi | 466 | Divalent metal cation 1 | 1 | |
Metal bindingi | 502 | Divalent metal cation 1 | 1 | |
Metal bindingi | 503 | Divalent metal cation 1 | 1 | |
Metal bindingi | 503 | Divalent metal cation 2 | 1 | |
Binding sitei | 503 | cAMP2 Publications | 1 | |
Metal bindingi | 620 | Divalent metal cation 1 | 1 | |
Binding sitei | 620 | cAMP2 Publications | 1 | |
Sitei | 623 | Binds AMP, but not cAMP | 1 | |
Binding sitei | 671 | cAMP2 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 462 – 466 | cAMP2 Publications | 5 |
GO - Molecular functioni
- 3',5'-cyclic-AMP phosphodiesterase activity Source: BHF-UCL
- 3',5'-cyclic-nucleotide phosphodiesterase activity Source: GO_Central
- ATPase binding Source: BHF-UCL
- beta-2 adrenergic receptor binding Source: BHF-UCL
- cAMP binding Source: BHF-UCL
- drug binding Source: BHF-UCL
- enzyme binding Source: BHF-UCL
- ion channel binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- scaffold protein binding Source: BHF-UCL
- ubiquitin protein ligase binding Source: BHF-UCL
GO - Biological processi
- adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate Source: BHF-UCL
- adrenergic receptor signaling pathway Source: BHF-UCL
- aging Source: Ensembl
- cAMP catabolic process Source: BHF-UCL
- cAMP-mediated signaling Source: BHF-UCL
- cellular response to cAMP Source: BHF-UCL
- cellular response to epinephrine stimulus Source: BHF-UCL
- cellular response to lipopolysaccharide Source: Ensembl
- establishment of endothelial barrier Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
- multicellular organism growth Source: Ensembl
- negative regulation of cAMP-mediated signaling Source: UniProtKB
- negative regulation of heart contraction Source: BHF-UCL
- negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
- negative regulation of relaxation of cardiac muscle Source: BHF-UCL
- neutrophil chemotaxis Source: Ensembl
- positive regulation of interferon-gamma production Source: BHF-UCL
- positive regulation of interleukin-2 production Source: BHF-UCL
- positive regulation of interleukin-5 production Source: BHF-UCL
- regulation of cardiac muscle cell contraction Source: BHF-UCL
- regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
- regulation of heart rate Source: BHF-UCL
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
- regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
- regulation of signaling receptor activity Source: BHF-UCL
- signal transduction Source: GO_Central
- smooth muscle contraction Source: Ensembl
- T cell receptor signaling pathway Source: BHF-UCL
Keywordsi
Molecular function | Hydrolase |
Ligand | cAMP, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.4.53, 2681 |
PathwayCommonsi | Q08499 |
Reactomei | R-HSA-180024, DARPP-32 events R-HSA-418555, G alpha (s) signalling events |
SignaLinki | Q08499 |
SIGNORi | Q08499 |
UniPathwayi | UPA00762;UER00747 |
Names & Taxonomyi
Protein namesi | Recommended name: cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC:3.1.4.53)Alternative name(s): DPDE3 PDE43 |
Gene namesi | Name:PDE4D Synonyms:DPDE3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000113448.16 |
HGNCi | HGNC:8783, PDE4D |
MIMi | 600129, gene |
neXtProti | NX_Q08499 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
- centrosome By similarity
Plasma membrane
- Apical cell membrane 1 Publication
Other locations
Note: Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells.By similarity
Cytoskeleton
- centrosome Source: Ensembl
Cytosol
- cytosol Source: BHF-UCL
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: HPA
- voltage-gated calcium channel complex Source: BHF-UCL
Other locations
- calcium channel complex Source: BHF-UCL
- membrane Source: BHF-UCL
- perinuclear region of cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Involvement in diseasei
Acrodysostosis 2, with or without hormone resistance (ACRDYS2)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068242 | 190 | S → A in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514466EnsemblClinVar. | 1 | |
Natural variantiVAR_068243 | 225 | P → T in ACRDYS2. 2 PublicationsCorresponds to variant dbSNP:rs397514464EnsemblClinVar. | 1 | |
Natural variantiVAR_068244 | 226 | F → S in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514465EnsemblClinVar. | 1 | |
Natural variantiVAR_069448 | 227 | A → S in ACRDYS2. 1 Publication | 1 | |
Natural variantiVAR_069449 | 228 | Q → E in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514468EnsemblClinVar. | 1 | |
Natural variantiVAR_069450 | 301 | S → T in ACRDYS2. 1 Publication | 1 | |
Natural variantiVAR_069451 | 304 | A → V in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397515433EnsemblClinVar. | 1 | |
Natural variantiVAR_069452 | 329 | V → A in ACRDYS2. 1 Publication | 1 | |
Natural variantiVAR_068245 | 587 | T → P in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514467EnsemblClinVar. | 1 | |
Natural variantiVAR_069453 | 590 | E → A in ACRDYS2. 2 Publications | 1 | |
Natural variantiVAR_069454 | 673 | G → D in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514469EnsemblClinVar. | 1 | |
Natural variantiVAR_069455 | 678 | I → T in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs587777188EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 503 | D → N: Abolishes catalytic activity. | 1 | |
Mutagenesisi | 527 | D → R: Abolishes homodimerization. 1 Publication | 1 | |
Mutagenesisi | 563 | R → D: Abolishes homodimerization. 1 Publication | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 5144 |
MalaCardsi | PDE4D |
MIMi | 614613, phenotype |
OpenTargetsi | ENSG00000113448 |
Orphaneti | 950, Acrodysostosis 280651, Acrodysostosis with multiple hormone resistance 439822, PDE4D haploinsufficiency syndrome |
PharmGKBi | PA33130 |
Miscellaneous databases
Pharosi | Q08499, Tclin |
Chemistry databases
ChEMBLi | CHEMBL288 |
DrugBanki | DB06842, (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one DB04149, (R)-Rolipram DB03606, (S)-Rolipram DB03183, 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB04469, 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB02676, 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol DB01959, 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB07051, 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER DB04271, 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB07954, 3-isobutyl-1-methyl-7H-xanthine DB08299, 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid DB00131, Adenosine phosphate DB01427, Amrinone DB00201, Caffeine DB03849, Cilomilast DB05219, Crisaborole DB00651, Dyphylline DB06246, Exisulind DB05266, Ibudilast DB01088, Iloprost DB01791, Piclamilast DB01656, Roflumilast DB01954, Rolipram DB05298, Tetomilast DB09283, Trapidil DB02918, Zardaverine |
DrugCentrali | Q08499 |
GuidetoPHARMACOLOGYi | 1303 |
Polymorphism and mutation databases
BioMutai | PDE4D |
DMDMi | 12644392 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000198814 | 1 – 809 | cAMP-specific 3',5'-cyclic phosphodiesterase 4DAdd BLAST | 809 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 142 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 299 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 301 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 348 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 375 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 387 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) | |||
Isoform 3 (identifier: Q08499-2) | |||||
Modified residuei | 54 | Phosphoserine1 Publication | 1 | ||
Isoform 5 (identifier: Q08499-6) | |||||
Modified residuei | 59 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 63 | PhosphoserineCombined sources | 1 | ||
Isoform N3 (identifier: Q08499-7) | |||||
Modified residuei | 59 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 63 | PhosphoserineCombined sources | 1 | ||
Isoform 12 (identifier: Q08499-12) | |||||
Modified residuei | 59 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 63 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q08499 |
MassIVEi | Q08499 |
MaxQBi | Q08499 |
PaxDbi | Q08499 |
PeptideAtlasi | Q08499 |
PRIDEi | Q08499 |
ProteomicsDBi | 58620 [Q08499-1] 58621 [Q08499-10] 58622 [Q08499-11] 58623 [Q08499-12] 58624 [Q08499-2] 58625 [Q08499-3] 58626 [Q08499-4] 58627 [Q08499-5] 58628 [Q08499-6] 58629 [Q08499-7] 58630 [Q08499-8] 58631 [Q08499-9] |
PTM databases
iPTMneti | Q08499 |
PhosphoSitePlusi | Q08499 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000113448, Expressed in stomach and 228 other tissues |
ExpressionAtlasi | Q08499, baseline and differential |
Genevisiblei | Q08499, HS |
Organism-specific databases
HPAi | ENSG00000113448, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9.
Interacts with PDE4DIP.
Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity). Isoform 5, isoform N3 and isoform 12 bind RACK1 via their unique N-terminus. Binds ARRB2.
Interacts (via N-terminal region) with SHANK2 (via proline-rich region); the interaction is increased in a PKA-dependent manner.
By similarity15 PublicationsBinary interactionsi
Hide detailsQ08499
Isoform 3 [Q08499-2]
With | #Exp. | IntAct |
---|---|---|
ARRB2 [P32121] | 2 | EBI-8095525,EBI-714559 |
Adcy2 [P26769] from Rattus norvegicus. | 3 | EBI-8095525,EBI-1027877 |
Isoform 6 [Q08499-8]
With | #Exp. | IntAct |
---|---|---|
COIL [P38432] | 3 | EBI-9090666,EBI-945751 |
ZDHHC17 [Q8IUH5] | 2 | EBI-9090666,EBI-524753 |
GO - Molecular functioni
- ATPase binding Source: BHF-UCL
- beta-2 adrenergic receptor binding Source: BHF-UCL
- enzyme binding Source: BHF-UCL
- ion channel binding Source: BHF-UCL
- scaffold protein binding Source: BHF-UCL
- ubiquitin protein ligase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111170, 55 interactors |
CORUMi | Q08499 |
DIPi | DIP-41115N |
IntActi | Q08499, 27 interactors |
MINTi | Q08499 |
STRINGi | 9606.ENSP00000345502 |
Chemistry databases
BindingDBi | Q08499 |
Miscellaneous databases
RNActi | Q08499, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q08499 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q08499 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 386 – 715 | PDEasePROSITE-ProRule annotationAdd BLAST | 330 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 42 – 88 | Pro-richAdd BLAST | 47 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3689, Eukaryota |
GeneTreei | ENSGT00940000155674 |
HOGENOMi | CLU_005940_5_2_1 |
OMAi | VNKWGLQ |
OrthoDBi | 67372at2759 |
PhylomeDBi | Q08499 |
TreeFami | TF314638 |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.1300.10, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR040844, PDE4_UCR IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS |
Pfami | View protein in Pfam PF18100, PDE4_UCR, 1 hit PF00233, PDEase_I, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
s (12+)i Sequence
Sequence statusi: Complete.
This entry describes 12 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 12 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAEGSSAPA RAGSGEGSDS AGGATLKAPK HLWRHEQHHQ YPLRQPQFRL
60 70 80 90 100
LHPHHHLPPP PPPSPQPQPQ CPLQPPPPPP LPPPPPPPGA ARGRYASSGA
110 120 130 140 150
TGRVRHRGYS DTERYLYCRA MDRTSYAVET GHRPGLKKSR MSWPSSFQGL
160 170 180 190 200
RRFDVDNGTS AGRSPLDPMT SPGSGLILQA NFVHSQRRES FLYRSDSDYD
210 220 230 240 250
LSPKSMSRNS SIASDIHGDD LIVTPFAQVL ASLRTVRNNF AALTNLQDRA
260 270 280 290 300
PSKRSPMCNQ PSINKATITE EAYQKLASET LEELDWCLDQ LETLQTRHSV
310 320 330 340 350
SEMASNKFKR MLNRELTHLS EMSRSGNQVS EFISNTFLDK QHEVEIPSPT
360 370 380 390 400
QKEKEKKKRP MSQISGVKKL MHSSSLTNSS IPRFGVKTEQ EDVLAKELED
410 420 430 440 450
VNKWGLHVFR IAELSGNRPL TVIMHTIFQE RDLLKTFKIP VDTLITYLMT
460 470 480 490 500
LEDHYHADVA YHNNIHAADV VQSTHVLLST PALEAVFTDL EILAAIFASA
510 520 530 540 550
IHDVDHPGVS NQFLINTNSE LALMYNDSSV LENHHLAVGF KLLQEENCDI
560 570 580 590 600
FQNLTKKQRQ SLRKMVIDIV LATDMSKHMN LLADLKTMVE TKKVTSSGVL
610 620 630 640 650
LLDNYSDRIQ VLQNMVHCAD LSNPTKPLQL YRQWTDRIME EFFRQGDRER
660 670 680 690 700
ERGMEISPMC DKHNASVEKS QVGFIDYIVH PLWETWADLV HPDAQDILDT
710 720 730 740 750
LEDNREWYQS TIPQSPSPAP DDPEEGRQGQ TEKFQFELTL EEDGESDTEK
760 770 780 790 800
DSGSQVEEDT SCSDSKTLCT QDSESTEIPL DEQVEEEAVG EEEESQPEAC
VIDDRSPDT
The sequence of this isoform differs from the canonical sequence as follows:
1-152: MEAEGSSAPA...WPSSFQGLRR → MMHVNNFPFRRHSWIC
The sequence of this isoform differs from the canonical sequence as follows:
1-205: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-152: MEAEGSSAPA...WPSSFQGLRR → MAQQTSPDTL...QRRFTVAHTC
270-279: EEAYQKLASE → GLYNGIIAFL
280-809: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-152: MEAEGSSAPA...WPSSFQGLRR → MAQQTSPDTL...QRRFTVAHTC
270-283: EEAYQKLASETLEE → GSWMELNPYTLLDM
284-809: Missing.
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WSZ7 | A0A087WSZ7_HUMAN | Phosphodiesterase | PDE4D | 678 | Annotation score: | ||
A0A1B0GW84 | A0A1B0GW84_HUMAN | Phosphodiesterase | PDE4D | 699 | Annotation score: | ||
D6RHE0 | D6RHE0_HUMAN | Phosphodiesterase | PDE4D | 422 | Annotation score: | ||
A0A1W2PQN6 | A0A1W2PQN6_HUMAN | 3',5'-cyclic-AMP phosphodiesterase | PDE4D | 125 | Annotation score: | ||
D6RAQ0 | D6RAQ0_HUMAN | cAMP-specific 3',5'-cyclic phosphod... | PDE4D | 74 | Annotation score: | ||
D6RIG1 | D6RIG1_HUMAN | cAMP-specific 3',5'-cyclic phosphod... | PDE4D | 81 | Annotation score: | ||
D6R9L4 | D6R9L4_HUMAN | cAMP-specific 3',5'-cyclic phosphod... | PDE4D | 17 | Annotation score: | ||
D6RBB2 | D6RBB2_HUMAN | cAMP-specific 3',5'-cyclic phosphod... | PDE4D | 29 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 510 | S → F in AAH36319 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 549 | D → G in AAN10119 (PubMed:12834813).Curated | 1 | |
Sequence conflicti | 644 | R → P (PubMed:8797812).Curated | 1 | |
Sequence conflicti | 769 | C → R in AAA97890 (PubMed:8125310).Curated | 1 | |
Sequence conflicti | 769 | C → R in AAA97891 (PubMed:8125310).Curated | 1 | |
Sequence conflicti | 769 | C → R in AAA97892 (PubMed:8125310).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068242 | 190 | S → A in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514466EnsemblClinVar. | 1 | |
Natural variantiVAR_068243 | 225 | P → T in ACRDYS2. 2 PublicationsCorresponds to variant dbSNP:rs397514464EnsemblClinVar. | 1 | |
Natural variantiVAR_068244 | 226 | F → S in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514465EnsemblClinVar. | 1 | |
Natural variantiVAR_069448 | 227 | A → S in ACRDYS2. 1 Publication | 1 | |
Natural variantiVAR_069449 | 228 | Q → E in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514468EnsemblClinVar. | 1 | |
Natural variantiVAR_069450 | 301 | S → T in ACRDYS2. 1 Publication | 1 | |
Natural variantiVAR_069451 | 304 | A → V in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397515433EnsemblClinVar. | 1 | |
Natural variantiVAR_069452 | 329 | V → A in ACRDYS2. 1 Publication | 1 | |
Natural variantiVAR_068245 | 587 | T → P in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514467EnsemblClinVar. | 1 | |
Natural variantiVAR_069453 | 590 | E → A in ACRDYS2. 2 Publications | 1 | |
Natural variantiVAR_069454 | 673 | G → D in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs397514469EnsemblClinVar. | 1 | |
Natural variantiVAR_069455 | 678 | I → T in ACRDYS2. 1 PublicationCorresponds to variant dbSNP:rs587777188EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004580 | 1 – 302 | Missing in isoform 2. 2 PublicationsAdd BLAST | 302 | |
Alternative sequenceiVSP_012383 | 1 – 291 | Missing in isoform 6. 2 PublicationsAdd BLAST | 291 | |
Alternative sequenceiVSP_004579 | 1 – 269 | MEAEG…KATIT → MKEQPSCAGTGHPMAGYGRM APFELASGPVKRLRTESPFP CLFA in isoform 1. 2 PublicationsAdd BLAST | 269 | |
Alternative sequenceiVSP_004578 | 1 – 205 | Missing in isoform 10. 2 PublicationsAdd BLAST | 205 | |
Alternative sequenceiVSP_004577 | 1 – 152 | MEAEG…QGLRR → MMHVNNFPFRRHSWIC in isoform 3. 2 PublicationsAdd BLAST | 152 | |
Alternative sequenceiVSP_012384 | 1 – 152 | MEAEG…QGLRR → MAQQTSPDTLTVPEVDNPHC PNPWLNEDLVKSLRENLLQH EKSKTARKSVSPKLSPVISP RNSPRLLRRMLLSSNIPKQR RFTVAHTC in isoform 5, isoform N3 and isoform 12. 4 PublicationsAdd BLAST | 152 | |
Alternative sequenceiVSP_012385 | 1 – 130 | Missing in isoform 9. 2 PublicationsAdd BLAST | 130 | |
Alternative sequenceiVSP_012386 | 1 – 122 | Missing in isoform 8. 1 PublicationAdd BLAST | 122 | |
Alternative sequenceiVSP_012387 | 1 – 61 | Missing in isoform 7. 2 PublicationsAdd BLAST | 61 | |
Alternative sequenceiVSP_012388 | 62 – 152 | PPSPQ…QGLRR → MKRNTCDLLSRSKSASEETL HSSNEEEDPFRGMEPYLVRR LSCRNIQLPPLAFRQLEQAD LKSESENIQRPTSLPLKILP LIAITSAESSG in isoform 7. 2 PublicationsAdd BLAST | 91 | |
Alternative sequenceiVSP_012389 | 123 – 152 | RTSYA…QGLRR → MAFVWDPLGATVPGPSTRAK SRLRFSKSYS in isoform 8. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_012390 | 131 – 152 | GHRPG…QGLRR → MSIIMKPRSRSTSSLRTAEA VC in isoform 9. 2 PublicationsAdd BLAST | 22 | |
Alternative sequenceiVSP_023326 | 270 – 283 | EEAYQ…ETLEE → GSWMELNPYTLLDM in isoform 12. 2 PublicationsAdd BLAST | 14 | |
Alternative sequenceiVSP_012391 | 270 – 279 | EEAYQKLASE → GLYNGIIAFL in isoform N3. 1 Publication | 10 | |
Alternative sequenceiVSP_012392 | 280 – 809 | Missing in isoform N3. 1 PublicationAdd BLAST | 530 | |
Alternative sequenceiVSP_023327 | 284 – 809 | Missing in isoform 12. 2 PublicationsAdd BLAST | 526 | |
Alternative sequenceiVSP_012393 | 292 – 306 | ETLQT…EMASN → MPEANYLLSVSWGYI in isoform 6. 2 PublicationsAdd BLAST | 15 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) (PDE4D) Leiden Open Variation Database (LOVD) |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1E9K | NMR | - | A | - | [»] | |
1MKD | X-ray | 2.90 | A/B/C/D/E/F/G/H/I/J/K/L | 388-715 | [»] | |
1OYN | X-ray | 2.00 | A/B/C/D | 381-740 | [»] | |
1PTW | X-ray | 2.30 | A/B/C/D | 381-740 | [»] | |
1Q9M | X-ray | 2.30 | A/B/C/D | 381-740 | [»] | |
1TB7 | X-ray | 1.63 | A/B | 388-715 | [»] | |
1TBB | X-ray | 1.60 | A/B | 388-715 | [»] | |
1XOM | X-ray | 1.55 | A/B | 388-715 | [»] | |
1XON | X-ray | 1.72 | A/B | 388-715 | [»] | |
1XOQ | X-ray | 1.83 | A/B | 388-715 | [»] | |
1XOR | X-ray | 1.54 | A/B | 388-715 | [»] | |
1Y2B | X-ray | 1.40 | A/B | 388-715 | [»] | |
1Y2C | X-ray | 1.67 | A/B | 388-715 | [»] | |
1Y2D | X-ray | 1.70 | A/B | 388-715 | [»] | |
1Y2E | X-ray | 2.10 | A/B | 388-715 | [»] | |
1Y2K | X-ray | 1.36 | A/B | 388-715 | [»] | |
1ZKN | X-ray | 2.10 | A/B/C/D | 381-714 | [»] | |
2FM0 | X-ray | 2.00 | A/B/C/D | 381-741 | [»] | |
2FM5 | X-ray | 2.03 | A/B/C/D | 381-741 | [»] | |
2PW3 | X-ray | 1.56 | A/B | 388-714 | [»] | |
2QYN | X-ray | 1.57 | A/B | 388-715 | [»] | |
3G4G | X-ray | 2.30 | A/B/C/D | 299-347 | [»] | |
A/B/C/D | 360-714 | [»] | ||||
3G4I | X-ray | 1.90 | A/B/C/D | 380-753 | [»] | |
3G4K | X-ray | 1.95 | A/B/C/D | 380-753 | [»] | |
3G4L | X-ray | 2.50 | A/B/C/D | 380-753 | [»] | |
3G58 | X-ray | 2.05 | A/B/C/D | 380-753 | [»] | |
3IAD | X-ray | 2.65 | A/B/C/D | 326-339 | [»] | |
A/B/C/D | 380-714 | [»] | ||||
3IAK | X-ray | 2.80 | A | 388-715 | [»] | |
3K4S | X-ray | 2.05 | A | 388-715 | [»] | |
3SL3 | X-ray | 2.10 | A/B/C/D | 381-741 | [»] | |
3SL4 | X-ray | 1.90 | A/B/C/D | 381-741 | [»] | |
3SL5 | X-ray | 2.65 | A/B/C/D | 381-714 | [»] | |
3SL6 | X-ray | 2.44 | A/B/C/D | 381-741 | [»] | |
3SL8 | X-ray | 2.60 | A/B/C/D | 381-741 | [»] | |
3V9B | X-ray | 2.10 | A/B/C/D | 381-740 | [»] | |
4OGB | X-ray | 2.03 | A/B/C/D | 381-741 | [»] | |
4W1O | X-ray | 2.20 | A/B/C/D | 381-739 | [»] | |
4WCU | X-ray | 2.35 | A/B/C/D | 381-739 | [»] | |
5K1I | X-ray | 2.61 | A/B/C/D/E/F/G/H | 388-713 | [»] | |
5K32 | X-ray | 1.99 | A/B | 390-713 | [»] | |
5LBO | X-ray | 2.25 | A/B/C/D | 381-740 | [»] | |
5TKB | X-ray | 2.16 | A/B/C/D | 380-753 | [»] | |
5WH5 | X-ray | 1.80 | A/B | 388-714 | [»] | |
5WH6 | X-ray | 1.60 | A/B | 303-809 | [»] | |
5WQA | X-ray | 2.30 | A/B | 381-714 | [»] | |
6AKR | X-ray | 2.33 | A/B/C/D | 381-740 | [»] | |
6BOJ | X-ray | 1.70 | A/B/C/D | 380-718 | [»] | |
A/B/C/D | 730-734 | [»] | ||||
6F6U | X-ray | 1.83 | A/B | 380-714 | [»] | |
6F8R | X-ray | 1.83 | A/B | 380-714 | [»] | |
6F8T | X-ray | 1.80 | A/B | 380-714 | [»] | |
6F8U | X-ray | 2.10 | A/B | 380-714 | [»] | |
6F8V | X-ray | 1.85 | A/B | 380-714 | [»] | |
6F8W | X-ray | 1.60 | A/B | 380-714 | [»] | |
6F8X | X-ray | 1.95 | A/B | 380-715 | [»] | |
6FDC | X-ray | 1.45 | A/B | 380-714 | [»] | |
6FDI | X-ray | 1.90 | A/B/C/D | 381-740 | [»] | |
6FE7 | X-ray | 2.00 | A/B/C/D | 381-740 | [»] | |
6FEB | X-ray | 1.93 | A/B | 381-740 | [»] | |
6FET | X-ray | 1.88 | A/B/C/D | 381-740 | [»] | |
6FT0 | X-ray | 2.10 | A/B/C/D | 381-740 | [»] | |
6FTA | X-ray | 2.34 | A/B/C/D | 381-740 | [»] | |
6FTW | X-ray | 2.16 | A/B/C/D | 381-740 | [»] | |
6FW3 | X-ray | 1.78 | A/B/C/D | 381-740 | [»] | |
6HWO | X-ray | 1.99 | A/B/C/D | 381-740 | [»] | |
6IAG | X-ray | 2.00 | A/B/C/D | 381-740 | [»] | |
6IBF | X-ray | 2.31 | A/B/C/D | 381-740 | [»] | |
6IM6 | X-ray | 1.70 | A/B | 388-715 | [»] | |
6IMB | X-ray | 1.55 | A/B | 388-715 | [»] | |
6IMD | X-ray | 1.50 | A/B | 388-715 | [»] | |
6IMI | X-ray | 1.46 | A/B | 388-715 | [»] | |
6IMO | X-ray | 1.55 | A/B | 388-715 | [»] | |
6IMR | X-ray | 1.50 | A/B | 388-715 | [»] | |
6IMT | X-ray | 1.48 | A/B | 388-715 | [»] | |
6IND | X-ray | 1.87 | A/B | 388-715 | [»] | |
6INK | X-ray | 1.70 | A/B | 388-715 | [»] | |
6INM | X-ray | 2.00 | A/B | 388-715 | [»] | |
6KJZ | X-ray | 2.20 | A/B | 387-714 | [»] | |
6KK0 | X-ray | 2.20 | A/B | 388-713 | [»] | |
6NJH | X-ray | 2.15 | A/B/C/D | 326-339 | [»] | |
A/B/C/D | 380-718 | [»] | ||||
6NJI | X-ray | 2.45 | A/B | 326-339 | [»] | |
A/B | 380-718 | [»] | ||||
6NJJ | X-ray | 2.30 | A/B/C/D | 326-339 | [»] | |
A/B/C/D | 380-718 | [»] | ||||
6RCW | X-ray | 2.08 | A/B/C/D | 381-740 | [»] | |
SMRi | Q08499 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111170, 55 interactors |
CORUMi | Q08499 |
DIPi | DIP-41115N |
IntActi | Q08499, 27 interactors |
MINTi | Q08499 |
STRINGi | 9606.ENSP00000345502 |
Chemistry databases
BindingDBi | Q08499 |
ChEMBLi | CHEMBL288 |
DrugBanki | DB06842, (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one DB04149, (R)-Rolipram DB03606, (S)-Rolipram DB03183, 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB04469, 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB02676, 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol DB01959, 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB07051, 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER DB04271, 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester DB07954, 3-isobutyl-1-methyl-7H-xanthine DB08299, 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid DB00131, Adenosine phosphate DB01427, Amrinone DB00201, Caffeine DB03849, Cilomilast DB05219, Crisaborole DB00651, Dyphylline DB06246, Exisulind DB05266, Ibudilast DB01088, Iloprost DB01791, Piclamilast DB01656, Roflumilast DB01954, Rolipram DB05298, Tetomilast DB09283, Trapidil DB02918, Zardaverine |
DrugCentrali | Q08499 |
GuidetoPHARMACOLOGYi | 1303 |
PTM databases
iPTMneti | Q08499 |
PhosphoSitePlusi | Q08499 |
Polymorphism and mutation databases
BioMutai | PDE4D |
DMDMi | 12644392 |
Proteomic databases
jPOSTi | Q08499 |
MassIVEi | Q08499 |
MaxQBi | Q08499 |
PaxDbi | Q08499 |
PeptideAtlasi | Q08499 |
PRIDEi | Q08499 |
ProteomicsDBi | 58620 [Q08499-1] 58621 [Q08499-10] 58622 [Q08499-11] 58623 [Q08499-12] 58624 [Q08499-2] 58625 [Q08499-3] 58626 [Q08499-4] 58627 [Q08499-5] 58628 [Q08499-6] 58629 [Q08499-7] 58630 [Q08499-8] 58631 [Q08499-9] |
Protocols and materials databases
Antibodypediai | 23607, 445 antibodies |
DNASUi | 5144 |
Genome annotation databases
Organism-specific databases
CTDi | 5144 |
DisGeNETi | 5144 |
EuPathDBi | HostDB:ENSG00000113448.16 |
GeneCardsi | PDE4D |
HGNCi | HGNC:8783, PDE4D |
HPAi | ENSG00000113448, Tissue enhanced (skeletal) |
MalaCardsi | PDE4D |
MIMi | 600129, gene 614613, phenotype |
neXtProti | NX_Q08499 |
OpenTargetsi | ENSG00000113448 |
Orphaneti | 950, Acrodysostosis 280651, Acrodysostosis with multiple hormone resistance 439822, PDE4D haploinsufficiency syndrome |
PharmGKBi | PA33130 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3689, Eukaryota |
GeneTreei | ENSGT00940000155674 |
HOGENOMi | CLU_005940_5_2_1 |
OMAi | VNKWGLQ |
OrthoDBi | 67372at2759 |
PhylomeDBi | Q08499 |
TreeFami | TF314638 |
Enzyme and pathway databases
UniPathwayi | UPA00762;UER00747 |
BRENDAi | 3.1.4.53, 2681 |
PathwayCommonsi | Q08499 |
Reactomei | R-HSA-180024, DARPP-32 events R-HSA-418555, G alpha (s) signalling events |
SignaLinki | Q08499 |
SIGNORi | Q08499 |
Miscellaneous databases
BioGRID-ORCSi | 5144, 8 hits in 845 CRISPR screens |
ChiTaRSi | PDE4D, human |
EvolutionaryTracei | Q08499 |
GeneWikii | PDE4D |
GenomeRNAii | 5144 |
Pharosi | Q08499, Tclin |
PROi | PR:Q08499 |
RNActi | Q08499, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113448, Expressed in stomach and 228 other tissues |
ExpressionAtlasi | Q08499, baseline and differential |
Genevisiblei | Q08499, HS |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.1300.10, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR040844, PDE4_UCR IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS |
Pfami | View protein in Pfam PF18100, PDE4_UCR, 1 hit PF00233, PDEase_I, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDE4D_HUMAN | |
Accessioni | Q08499Primary (citable) accession number: Q08499 Secondary accession number(s): O43433 Q9HCX7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 219 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations