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UniProtKB - Q08495 (DEMA_HUMAN)

Protein

Dematin

Gene

DMTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.6 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: GO_Central
  • protein self-association Source: UniProtKB
  • signaling receptor binding Source: UniProtKB
  • spectrin binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin capping, Actin-binding

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Dematin
Alternative name(s):
Dematin actin-binding protein
Erythrocyte membrane protein band 4.9
Gene namesi
Name:DMTN
Synonyms:DMT, EPB49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000158856.17
HGNCiHGNC:3382 DMTN
MIMi125305 gene
neXtProtiNX_Q08495

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi124S → A: Reduces interaction with plasmodium berghei 14-3-3 protein. Inhibits phosphorylation and interaction with plasmodium berghei 14-3-3 protein; when associated with A-333 and A-403. 1 Publication1
Mutagenesisi333S → A: Reduces interaction with plasmodium berghei 14-3-3 protein. Inhibits phosphorylation and interaction with plasmodium berghei 14-3-3 protein; when associated with A-124 and A-403. 1 Publication1
Mutagenesisi403S → A: Inhibits phosphorylation and interaction with plasmodium berghei 14-3-3 protein; when associated with A-124 and A-333. 2 Publications1
Mutagenesisi403S → E: Reduces F-actin bundling but not F-actin binding activity. 2 Publications1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi2039
OpenTargetsiENSG00000158856
PharmGKBiPA27815

Polymorphism and mutation databases

BioMutaiDMTN
DMDMi22654240

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187551 – 405DematinAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei18PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei110PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei156PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei315PhosphoserineBy similarity1
Modified residuei333PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei403Phosphoserine; by PKA3 Publications1

Post-translational modificationi

Phosphorylated. Phosphorylation at Ser-403 by PKA causes the C-terminal headpiece domain to associate with the N-terminal core domain, and leads to the inhibition of its actin bundling activity.4 Publications
The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ08495
MaxQBiQ08495
PaxDbiQ08495
PeptideAtlasiQ08495
PRIDEiQ08495
ProteomicsDBi58618
58619 [Q08495-2]

PTM databases

iPTMnetiQ08495
PhosphoSitePlusiQ08495

Expressioni

Tissue specificityi

Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney.1 Publication

Gene expression databases

BgeeiENSG00000158856 Expressed in 212 organ(s), highest expression level in right frontal lobe
CleanExiHS_EPB49
ExpressionAtlasiQ08495 baseline and differential
GenevisibleiQ08495 HS

Organism-specific databases

HPAiHPA024290

Interactioni

Subunit structurei

Monomeric (isoform 2); under reducing conditions. Self-associates. Exists under oxidizing condition as a trimer of two isoforms 2 and isoform 1 linked by disulfide bonds (Probable). Found in a complex with DMTN, F-actin and spectrin. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with F-actin, ITPKB, RASGRF2 and spectrin. Isoform 2 interacts with SLC2A1 (via C-terminus cytoplasmic region). Isoform 1 and isoform 2 interact (phosphorylated form) with plasmodium berghei 14-3-3 protein; the interaction occurs in a PKA-dependent manner.Curated8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-715275,EBI-618309

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi108353, 20 interactors
CORUMiQ08495
IntActiQ08495, 10 interactors
STRINGi9606.ENSP00000265800

Structurei

Secondary structure

1405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ08495
SMRiQ08495
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08495

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini337 – 405HPPROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 308Interaction with RASGRF21 PublicationAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi216 – 222Poly-Glu7

Domaini

Both the N-terminal core domain and the C-terminal headpiece domain are sufficient for binding to F-actin and necessary for actin bundling activity.

Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1044 Eukaryota
ENOG410XRPY LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000285997
HOVERGENiHBG031499
InParanoidiQ08495
OMAiMDNEVLG
OrthoDBiEOG091G06PE
PhylomeDBiQ08495
TreeFamiTF318042

Family and domain databases

Gene3Di1.10.950.10, 1 hit
InterProiView protein in InterPro
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
PfamiView protein in Pfam
PF16182 AbLIM_anchor, 2 hits
PF02209 VHP, 1 hit
SMARTiView protein in SMART
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q08495-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERLQKQPLT SPGSVSPSRD SSVPGSPSSI VAKMDNQVLG YKDLAAIPKD 
        60         70         80         90        100
KAILDIERPD LMIYEPHFTY SLLEHVELPR SRERSLSPKS TSPPPSPEVW 
       110        120        130        140        150
ADSRSPGIIS QASAPRTTGT PRTSLPHFHH PETSRPDSNI YKKPPIYKQR 
       160        170        180        190        200
ESVGGSPQTK HLIEDLIIES SKFPAAQPPD PNQPAKIETD YWPCPPSLAV 
       210        220        230        240        250
VETEWRKRKA SRRGAEEEEE EEDDDSGEEM KALRERQREE LSKVTSNLGK 
       260        270        280        290        300
MILKEEMEKS LPIRRKTRSL PDRTPFHTSL HQGTSKSSSL PAYGRTTLSR 
       310        320        330        340        350
LQSTEFSPSG SETGSPGLQN GEGQRGRMDR GNSLPCVLEQ KIYPYEMLVV 
       360        370        380        390        400
TNKGRTKLPP GVDRMRLERH LSAEDFSRVF AMSPEEFGKL ALWKRNELKK 

KASLF
Length:405
Mass (Da):45,514
Last modified:August 30, 2002 - v3
Checksum:i77D6372E5B16EFF4
GO
Isoform 2 (identifier: Q08495-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     320-341: Missing.

Show »
Length:383
Mass (Da):43,088
Checksum:i3C46AB7704507B6E
GO
Isoform 3 (identifier: Q08495-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-31: Missing.
     320-341: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):40,680
Checksum:i1F985F9D3643F995
GO
Isoform 4 (identifier: Q08495-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-31: Missing.
     83-97: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):41,558
Checksum:iBD11861605E9B618
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFK4E5RFK4_HUMAN
Dematin
DMTN
218Annotation score:
E5RJ61E5RJ61_HUMAN
Dematin
DMTN
110Annotation score:
E5RGQ7E5RGQ7_HUMAN
Dematin
DMTN
148Annotation score:
E5RJC0E5RJC0_HUMAN
Dematin
DMTN
162Annotation score:
E5RFK6E5RFK6_HUMAN
Dematin
DMTN
71Annotation score:
A0A087WUC0A0A087WUC0_HUMAN
Dematin
DMTN
73Annotation score:
A0A087WT94A0A087WT94_HUMAN
Dematin
DMTN
71Annotation score:
E5RGQ0E5RGQ0_HUMAN
Dematin
DMTN
201Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81S → Q in AAA58438 (PubMed:8341682).Curated1
Sequence conflicti81S → Q in AAC50223 (PubMed:7615546).Curated1
Sequence conflicti155G → A in BAG52385 (PubMed:14702039).Curated1
Sequence conflicti292A → R in AAA58438 (PubMed:8341682).Curated1
Sequence conflicti292A → R in AAC50223 (PubMed:7615546).Curated1
Sequence conflicti347M → V in AAA58438 (PubMed:8341682).Curated1
Sequence conflicti380F → S in AAA58438 (PubMed:8341682).Curated1
Sequence conflicti403S → P in BAG52385 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0448037 – 31Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_05742883 – 97Missing in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_004189320 – 341Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19713 mRNA Translation: AAA58438.1
U28389 mRNA Translation: AAC50223.1
AK055842 mRNA Translation: BAG51582.1
AK091581 mRNA Translation: BAG52385.1
AK289650 mRNA Translation: BAF82339.1
AK295452 mRNA Translation: BAG58387.1
BT007396 mRNA Translation: AAP36060.1
AC091171 Genomic DNA No translation available.
BC006318 mRNA Translation: AAH06318.1
BC017445 mRNA Translation: AAH17445.1
BC052805 mRNA Translation: AAH52805.1
CCDSiCCDS47820.1 [Q08495-2]
CCDS47821.1 [Q08495-3]
CCDS6020.1 [Q08495-1]
CCDS78311.1 [Q08495-4]
PIRiA48222
I39062
RefSeqiNP_001107607.1, NM_001114135.4 [Q08495-1]
NP_001107608.1, NM_001114136.2 [Q08495-1]
NP_001107609.1, NM_001114137.3 [Q08495-2]
NP_001107610.1, NM_001114138.2 [Q08495-2]
NP_001107611.1, NM_001114139.3 [Q08495-3]
NP_001289745.1, NM_001302816.2 [Q08495-2]
NP_001289746.1, NM_001302817.2 [Q08495-4]
NP_001310307.1, NM_001323378.1 [Q08495-1]
NP_001310308.1, NM_001323379.1 [Q08495-1]
NP_001310309.1, NM_001323380.1 [Q08495-1]
NP_001310310.1, NM_001323381.1 [Q08495-1]
NP_001310311.1, NM_001323382.1 [Q08495-1]
NP_001310312.1, NM_001323383.1 [Q08495-2]
NP_001310313.1, NM_001323384.1 [Q08495-2]
NP_001310314.1, NM_001323385.1 [Q08495-2]
NP_001310316.1, NM_001323387.1 [Q08495-3]
NP_001310317.1, NM_001323388.1 [Q08495-4]
NP_001310318.1, NM_001323389.1
NP_001310319.1, NM_001323390.1
NP_001310320.1, NM_001323391.1
NP_001310321.1, NM_001323392.1
NP_001310322.1, NM_001323393.1
NP_001310323.1, NM_001323394.1
NP_001310324.1, NM_001323395.1
NP_001310325.1, NM_001323396.1
NP_001310326.1, NM_001323397.1
NP_001310327.1, NM_001323398.1
NP_001310328.1, NM_001323399.1
NP_001310329.1, NM_001323400.1
NP_001310330.1, NM_001323401.1
NP_001969.2, NM_001978.4 [Q08495-1]
XP_005273489.1, XM_005273432.1
XP_016868678.1, XM_017013189.1 [Q08495-2]
XP_016868682.1, XM_017013193.1 [Q08495-4]
XP_016868683.1, XM_017013194.1 [Q08495-4]
XP_016868684.1, XM_017013195.1 [Q08495-3]
XP_016868685.1, XM_017013196.1 [Q08495-3]
XP_016868686.1, XM_017013197.1 [Q08495-3]
XP_016868687.1, XM_017013198.1 [Q08495-3]
UniGeneiHs.106124

Genome annotation databases

EnsembliENST00000265800; ENSP00000265800; ENSG00000158856 [Q08495-1]
ENST00000358242; ENSP00000350977; ENSG00000158856 [Q08495-1]
ENST00000381470; ENSP00000370879; ENSG00000158856 [Q08495-2]
ENST00000415253; ENSP00000401291; ENSG00000158856 [Q08495-2]
ENST00000432128; ENSP00000416111; ENSG00000158856 [Q08495-1]
ENST00000443491; ENSP00000397904; ENSG00000158856 [Q08495-3]
ENST00000517305; ENSP00000430609; ENSG00000158856 [Q08495-1]
ENST00000517600; ENSP00000430618; ENSG00000158856 [Q08495-4]
ENST00000519907; ENSP00000429377; ENSG00000158856 [Q08495-2]
ENST00000523266; ENSP00000427866; ENSG00000158856 [Q08495-1]
ENST00000523782; ENSP00000429234; ENSG00000158856 [Q08495-3]
GeneIDi2039
KEGGihsa:2039
UCSCiuc064kwf.1 human [Q08495-1]
uc064kwj.1 human

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19713 mRNA Translation: AAA58438.1
U28389 mRNA Translation: AAC50223.1
AK055842 mRNA Translation: BAG51582.1
AK091581 mRNA Translation: BAG52385.1
AK289650 mRNA Translation: BAF82339.1
AK295452 mRNA Translation: BAG58387.1
BT007396 mRNA Translation: AAP36060.1
AC091171 Genomic DNA No translation available.
BC006318 mRNA Translation: AAH06318.1
BC017445 mRNA Translation: AAH17445.1
BC052805 mRNA Translation: AAH52805.1
CCDSiCCDS47820.1 [Q08495-2]
CCDS47821.1 [Q08495-3]
CCDS6020.1 [Q08495-1]
CCDS78311.1 [Q08495-4]
PIRiA48222
I39062
RefSeqiNP_001107607.1, NM_001114135.4 [Q08495-1]
NP_001107608.1, NM_001114136.2 [Q08495-1]
NP_001107609.1, NM_001114137.3 [Q08495-2]
NP_001107610.1, NM_001114138.2 [Q08495-2]
NP_001107611.1, NM_001114139.3 [Q08495-3]
NP_001289745.1, NM_001302816.2 [Q08495-2]
NP_001289746.1, NM_001302817.2 [Q08495-4]
NP_001310307.1, NM_001323378.1 [Q08495-1]
NP_001310308.1, NM_001323379.1 [Q08495-1]
NP_001310309.1, NM_001323380.1 [Q08495-1]
NP_001310310.1, NM_001323381.1 [Q08495-1]
NP_001310311.1, NM_001323382.1 [Q08495-1]
NP_001310312.1, NM_001323383.1 [Q08495-2]
NP_001310313.1, NM_001323384.1 [Q08495-2]
NP_001310314.1, NM_001323385.1 [Q08495-2]
NP_001310316.1, NM_001323387.1 [Q08495-3]
NP_001310317.1, NM_001323388.1 [Q08495-4]
NP_001310318.1, NM_001323389.1
NP_001310319.1, NM_001323390.1
NP_001310320.1, NM_001323391.1
NP_001310321.1, NM_001323392.1
NP_001310322.1, NM_001323393.1
NP_001310323.1, NM_001323394.1
NP_001310324.1, NM_001323395.1
NP_001310325.1, NM_001323396.1
NP_001310326.1, NM_001323397.1
NP_001310327.1, NM_001323398.1
NP_001310328.1, NM_001323399.1
NP_001310329.1, NM_001323400.1
NP_001310330.1, NM_001323401.1
NP_001969.2, NM_001978.4 [Q08495-1]
XP_005273489.1, XM_005273432.1
XP_016868678.1, XM_017013189.1 [Q08495-2]
XP_016868682.1, XM_017013193.1 [Q08495-4]
XP_016868683.1, XM_017013194.1 [Q08495-4]
XP_016868684.1, XM_017013195.1 [Q08495-3]
XP_016868685.1, XM_017013196.1 [Q08495-3]
XP_016868686.1, XM_017013197.1 [Q08495-3]
XP_016868687.1, XM_017013198.1 [Q08495-3]
UniGeneiHs.106124

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QZPNMR-A342-405[»]
1ZV6NMR-A342-405[»]
ProteinModelPortaliQ08495
SMRiQ08495
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108353, 20 interactors
CORUMiQ08495
IntActiQ08495, 10 interactors
STRINGi9606.ENSP00000265800

PTM databases

iPTMnetiQ08495
PhosphoSitePlusiQ08495

Polymorphism and mutation databases

BioMutaiDMTN
DMDMi22654240

Proteomic databases

EPDiQ08495
MaxQBiQ08495
PaxDbiQ08495
PeptideAtlasiQ08495
PRIDEiQ08495
ProteomicsDBi58618
58619 [Q08495-2]

Protocols and materials databases

DNASUi2039
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265800; ENSP00000265800; ENSG00000158856 [Q08495-1]
ENST00000358242; ENSP00000350977; ENSG00000158856 [Q08495-1]
ENST00000381470; ENSP00000370879; ENSG00000158856 [Q08495-2]
ENST00000415253; ENSP00000401291; ENSG00000158856 [Q08495-2]
ENST00000432128; ENSP00000416111; ENSG00000158856 [Q08495-1]
ENST00000443491; ENSP00000397904; ENSG00000158856 [Q08495-3]
ENST00000517305; ENSP00000430609; ENSG00000158856 [Q08495-1]
ENST00000517600; ENSP00000430618; ENSG00000158856 [Q08495-4]
ENST00000519907; ENSP00000429377; ENSG00000158856 [Q08495-2]
ENST00000523266; ENSP00000427866; ENSG00000158856 [Q08495-1]
ENST00000523782; ENSP00000429234; ENSG00000158856 [Q08495-3]
GeneIDi2039
KEGGihsa:2039
UCSCiuc064kwf.1 human [Q08495-1]
uc064kwj.1 human

Organism-specific databases

CTDi2039
DisGeNETi2039
EuPathDBiHostDB:ENSG00000158856.17
GeneCardsiDMTN
HGNCiHGNC:3382 DMTN
HPAiHPA024290
MIMi125305 gene
neXtProtiNX_Q08495
OpenTargetsiENSG00000158856
PharmGKBiPA27815
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1044 Eukaryota
ENOG410XRPY LUCA
GeneTreeiENSGT00760000119039
HOGENOMiHOG000285997
HOVERGENiHBG031499
InParanoidiQ08495
OMAiMDNEVLG
OrthoDBiEOG091G06PE
PhylomeDBiQ08495
TreeFamiTF318042

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Miscellaneous databases

ChiTaRSiDMTN human
EvolutionaryTraceiQ08495
GeneWikiiEPB49
GenomeRNAii2039
PROiPR:Q08495
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158856 Expressed in 212 organ(s), highest expression level in right frontal lobe
CleanExiHS_EPB49
ExpressionAtlasiQ08495 baseline and differential
GenevisibleiQ08495 HS

Family and domain databases

Gene3Di1.10.950.10, 1 hit
InterProiView protein in InterPro
IPR032402 AbLIM_anchor
IPR003128 Villin_headpiece
IPR036886 Villin_headpiece_dom_sf
PfamiView protein in Pfam
PF16182 AbLIM_anchor, 2 hits
PF02209 VHP, 1 hit
SMARTiView protein in SMART
SM00153 VHP, 1 hit
SUPFAMiSSF47050 SSF47050, 1 hit
PROSITEiView protein in PROSITE
PS51089 HP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEMA_HUMAN
AccessioniPrimary (citable) accession number: Q08495
Secondary accession number(s): A8K0T5
, B3KP70, B3KRH3, B4DI75, E9PEJ0, Q13215, Q9BRE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 30, 2002
Last modified: November 7, 2018
This is version 187 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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