UniProtKB - Q08493 (PDE4C_HUMAN)
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
PDE4C
Functioni
Catalytic activityi
- EC:3.1.4.53
Cofactori
Activity regulationi
: 3',5'-cyclic AMP degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.Proteins known to be involved in this subpathway in this organism are:
- Phosphodiesterase, Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4C), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4D), Phosphodiesterase (PDE8A), Phosphodiesterase, Phosphodiesterase (PDE4B), Phosphodiesterase (PDE4C), Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase (PDE4D), Phosphodiesterase (PDE8B), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4D), 3',5'-cyclic-AMP phosphodiesterase (PDE4DN2), Phosphodiesterase, cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), 3',5'-cyclic-AMP phosphodiesterase (HSPDE4D), Phosphodiesterase, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), Phosphodiesterase (PDE4D), Phosphodiesterase (PDE4C), Phosphodiesterase (PDE4C), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), Phosphodiesterase (PDE4C), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), Phosphodiesterase (PDE4D), 3',5'-cyclic-AMP phosphodiesterase (PDE4A), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), Phosphodiesterase (PDE4B), 3',5'-cyclic-AMP phosphodiesterase (PDE4C), 3',5'-cyclic-AMP phosphodiesterase (PDE4A), Phosphodiesterase (PDE4C), 3',5'-cyclic-AMP phosphodiesterase (PDE4B), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A), Phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase (PDE4C)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 388 | Proton donorBy similarity | 1 | |
Metal bindingi | 392 | Divalent metal cation 1 | 1 | |
Metal bindingi | 428 | Divalent metal cation 1 | 1 | |
Metal bindingi | 429 | Divalent metal cation 1 | 1 | |
Metal bindingi | 429 | Divalent metal cation 2 | 1 | |
Binding sitei | 429 | cAMPBy similarity | 1 | |
Metal bindingi | 546 | Divalent metal cation 1 | 1 | |
Binding sitei | 546 | cAMPBy similarity | 1 | |
Sitei | 549 | Binds AMP, but not cAMPBy similarity | 1 | |
Binding sitei | 597 | cAMPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 388 – 392 | cAMPBy similarity | 5 |
GO - Molecular functioni
- 3',5'-cyclic-AMP phosphodiesterase activity Source: GO_Central
- 3',5'-cyclic-nucleotide phosphodiesterase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cAMP catabolic process Source: UniProtKB-UniPathway
- G protein-coupled receptor signaling pathway Source: Reactome
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Ligand | cAMP, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.4.53, 2681 |
PathwayCommonsi | Q08493 |
Reactomei | R-HSA-180024, DARPP-32 events R-HSA-418555, G alpha (s) signalling events |
SIGNORi | Q08493 |
UniPathwayi | UPA00762;UER00747 |
Names & Taxonomyi
Protein namesi | Recommended name: cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC:3.1.4.53)Alternative name(s): DPDE1 PDE21 |
Gene namesi | Name:PDE4C Synonyms:DPDE1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8782, PDE4C |
MIMi | 600128, gene |
neXtProti | NX_Q08493 |
VEuPathDBi | HostDB:ENSG00000105650.21 |
Subcellular locationi
Other locations
- cilium By similarity
Cytosol
- cytosol Source: GO_Central
Extracellular region or secreted
- extracellular space Source: UniProtKB
Nucleus
- nucleus Source: GO_Central
Other locations
- cilium Source: UniProtKB
- perinuclear region of cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cell projection, CiliumPathology & Biotechi
Organism-specific databases
DisGeNETi | 5143 |
OpenTargetsi | ENSG00000105650 |
PharmGKBi | PA264 |
Miscellaneous databases
Pharosi | Q08493, Tclin |
Chemistry databases
ChEMBLi | CHEMBL291 |
DrugBanki | DB01427, Amrinone DB00201, Caffeine DB05219, Crisaborole DB00651, Dyphylline DB06246, Exisulind DB05266, Ibudilast DB01088, Iloprost DB01791, Piclamilast DB01656, Roflumilast DB09283, Trapidil |
DrugCentrali | Q08493 |
GuidetoPHARMACOLOGYi | 1302 |
Genetic variation databases
BioMutai | PDE4C |
DMDMi | 20141263 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000198811 | 1 – 712 | cAMP-specific 3',5'-cyclic phosphodiesterase 4CAdd BLAST | 712 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 73 | PhosphoserineBy similarity | 1 | |
Modified residuei | 641 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q08493 |
jPOSTi | Q08493 |
MassIVEi | Q08493 |
PaxDbi | Q08493 |
PeptideAtlasi | Q08493 |
PRIDEi | Q08493 |
ProteomicsDBi | 58615 [Q08493-1] 58616 [Q08493-2] 58617 [Q08493-3] |
PTM databases
iPTMneti | Q08493 |
PhosphoSitePlusi | Q08493 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000105650, Expressed in cerebellum and 247 other tissues |
ExpressionAtlasi | Q08493, baseline and differential |
Genevisiblei | Q08493, HS |
Organism-specific databases
HPAi | ENSG00000105650, Tissue enhanced (tongue) ENSG00000285188, Tissue enhanced (gallbladder, intestine, pancreas) |
Interactioni
Subunit structurei
Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.
By similarityBinary interactionsi
Hide detailsIsoform PDE4C2 [Q08493-2]
Isoform PDE4C3 [Q08493-3]
With | #Exp. | IntAct |
---|---|---|
SRI [P30626] | 3 | EBI-10225541,EBI-750459 |
Protein-protein interaction databases
BioGRIDi | 111169, 9 interactors |
IntActi | Q08493, 9 interactors |
STRINGi | 9606.ENSP00000347689 |
Chemistry databases
BindingDBi | Q08493 |
Miscellaneous databases
RNActi | Q08493, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q08493 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q08493 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 312 – 641 | PDEasePROSITE-ProRule annotationAdd BLAST | 330 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3689, Eukaryota |
GeneTreei | ENSGT00940000162285 |
HOGENOMi | CLU_005940_5_3_1 |
OMAi | LQAENCN |
OrthoDBi | 904682at2759 |
PhylomeDBi | Q08493 |
TreeFami | TF314638 |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.1300.10, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR040844, PDE4_UCR IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS |
Pfami | View protein in Pfam PF18100, PDE4_UCR, 1 hit PF00233, PDEase_I, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
SMARTi | View protein in SMART SM00471, HDc, 1 hit |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENLGVGEGA EACSRLSRSR GRHSMTRAPK HLWRQPRRPI RIQQRFYSDP
60 70 80 90 100
DKSAGCRERD LSPRPELRKS RLSWPVSSCR RFDLENGLSC GRRALDPQSS
110 120 130 140 150
PGLGRIMQAP VPHSQRRESF LYRSDSDYEL SPKAMSRNSS VASDLHGEDM
160 170 180 190 200
IVTPFAQVLA SLRTVRSNVA ALARQQCLGA AKQGPVGNPS SSNQLPPAED
210 220 230 240 250
TGQKLALETL DELDWCLDQL ETLQTRHSVG EMASNKFKRI LNRELTHLSE
260 270 280 290 300
TSRSGNQVSE YISRTFLDQQ TEVELPKVTA EEAPQPMSRI SGLHGLCHSA
310 320 330 340 350
SLSSATVPRF GVQTDQEEQL AKELEDTNKW GLDVFKVAEL SGNRPLTAII
360 370 380 390 400
FSIFQERDLL KTFQIPADTL ATYLLMLEGH YHANVAYHNS LHAADVAQST
410 420 430 440 450
HVLLATPALE AVFTDLEILA ALFASAIHDV DHPGVSNQFL INTNSELALM
460 470 480 490 500
YNDASVLENH HLAVGFKLLQ AENCDIFQNL SAKQRLSLRR MVIDMVLATD
510 520 530 540 550
MSKHMNLLAD LKTMVETKKV TSLGVLLLDN YSDRIQVLQN LVHCADLSNP
560 570 580 590 600
TKPLPLYRQW TDRIMAEFFQ QGDRERESGL DISPMCDKHT ASVEKSQVGF
610 620 630 640 650
IDYIAHPLWE TWADLVHPDA QDLLDTLEDN REWYQSKIPR SPSDLTNPER
660 670 680 690 700
DGPDRFQFEL TLEEAEEEDE EEEEEGEETA LAKEALELPD TELLSPEAGP
710
DPGDLPLDNQ RT
The sequence of this isoform differs from the canonical sequence as follows:
1-106: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-81: MENLGVGEGA...LSWPVSSCRR → MQGPPAPAPV...RRFTVAHPLC
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ32MM7 | Q32MM7_HUMAN | Phosphodiesterase | PDE4C | 481 | Annotation score: | ||
B7Z6T1 | B7Z6T1_HUMAN | 3',5'-cyclic-AMP phosphodiesterase | PDE4C | 231 | Annotation score: | ||
V9GYP2 | V9GYP2_HUMAN | 3',5'-cyclic-AMP phosphodiesterase | PDE4C | 82 | Annotation score: | ||
M0R1P5 | M0R1P5_HUMAN | cAMP-specific 3',5'-cyclic phosphod... | PDE4C | 93 | Annotation score: | ||
U3KPR4 | U3KPR4_HUMAN | cAMP-specific 3',5'-cyclic phosphod... | PDE4C | 89 | Annotation score: | ||
U3KPR3 | U3KPR3_HUMAN | cAMP-specific 3',5'-cyclic phosphod... | PDE4C | 11 | Annotation score: | ||
A0A2R9YJK9 | A0A2R9YJK9_HUMAN | cAMP-specific 3',5'-cyclic phosphod... | PDE4C | 11 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 204 | K → N in AAD47053 (PubMed:10574328).Curated | 1 | |
Sequence conflicti | 204 | K → N in AAD47054 (PubMed:10574328).Curated | 1 | |
Sequence conflicti | 211 | D → Y in AAD47053 (PubMed:10574328).Curated | 1 | |
Sequence conflicti | 211 | D → Y in AAD47054 (PubMed:10574328).Curated | 1 | |
Sequence conflicti | 339 – 340 | EL → DV in CAA86601 (PubMed:7843419).Curated | 2 | |
Sequence conflicti | 444 – 446 | NSE → K in AAC83047 (PubMed:15057824).Curated | 3 | |
Sequence conflicti | 446 – 447 | EL → DV in CAA86601 (PubMed:7843419).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050473 | 131 | S → L. Corresponds to variant dbSNP:rs10413646Ensembl. | 1 | |
Natural variantiVAR_050474 | 289 | R → Q. Corresponds to variant dbSNP:rs34503849EnsemblClinVar. | 1 | |
Natural variantiVAR_034374 | 344 | R → Q. Corresponds to variant dbSNP:rs2229228Ensembl. | 1 | |
Natural variantiVAR_061497 | 344 | R → W. Corresponds to variant dbSNP:rs11879710Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004575 | 1 – 106 | Missing in isoform PDE4C2. CuratedAdd BLAST | 106 | |
Alternative sequenceiVSP_004574 | 1 – 81 | MENLG…SSCRR → MQGPPAPAPVPGPGSPRGSP RGSPGLFRKLLVNQSIRLQR RFTVAHPLC in isoform PDE4C3. CuratedAdd BLAST | 81 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46632 mRNA Translation: CAA86601.1 AF157816 , AF157811, AF157814, AF157815 Genomic DNA Translation: AAD47053.1 AF157816 , AF157812, AF157814, AF157815 Genomic DNA Translation: AAD47054.1 AF157816, AF157814, AF157815 Genomic DNA Translation: AAD47055.1 AK095384 mRNA Translation: BAG53036.1 AC005759 Genomic DNA Translation: AAC83047.1 CH471106 Genomic DNA Translation: EAW84677.1 L20968 mRNA Translation: AAA03591.1 |
CCDSi | CCDS12373.1 [Q08493-1] CCDS42523.1 [Q08493-3] CCDS46016.1 [Q08493-2] |
PIRi | S71626 |
RefSeqi | NP_000914.2, NM_000923.5 [Q08493-1] NP_001092288.1, NM_001098818.3 [Q08493-3] NP_001092289.1, NM_001098819.3 [Q08493-2] NP_001317101.1, NM_001330172.1 [Q08493-1] XP_011526358.1, XM_011528056.2 [Q08493-2] |
Genome annotation databases
Ensembli | ENST00000262805; ENSP00000262805; ENSG00000105650 [Q08493-3] ENST00000447275; ENSP00000402091; ENSG00000105650 [Q08493-2] ENST00000594465; ENSP00000470210; ENSG00000105650 [Q08493-1] ENST00000594617; ENSP00000469696; ENSG00000105650 [Q08493-1] |
GeneIDi | 5143 |
KEGGi | hsa:5143 |
UCSCi | uc002nii.5, human [Q08493-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46632 mRNA Translation: CAA86601.1 AF157816 , AF157811, AF157814, AF157815 Genomic DNA Translation: AAD47053.1 AF157816 , AF157812, AF157814, AF157815 Genomic DNA Translation: AAD47054.1 AF157816, AF157814, AF157815 Genomic DNA Translation: AAD47055.1 AK095384 mRNA Translation: BAG53036.1 AC005759 Genomic DNA Translation: AAC83047.1 CH471106 Genomic DNA Translation: EAW84677.1 L20968 mRNA Translation: AAA03591.1 |
CCDSi | CCDS12373.1 [Q08493-1] CCDS42523.1 [Q08493-3] CCDS46016.1 [Q08493-2] |
PIRi | S71626 |
RefSeqi | NP_000914.2, NM_000923.5 [Q08493-1] NP_001092288.1, NM_001098818.3 [Q08493-3] NP_001092289.1, NM_001098819.3 [Q08493-2] NP_001317101.1, NM_001330172.1 [Q08493-1] XP_011526358.1, XM_011528056.2 [Q08493-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LXU | model | - | A | 306-649 | [»] | |
2QYM | X-ray | 1.90 | A | 306-663 | [»] | |
SMRi | Q08493 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111169, 9 interactors |
IntActi | Q08493, 9 interactors |
STRINGi | 9606.ENSP00000347689 |
Chemistry databases
BindingDBi | Q08493 |
ChEMBLi | CHEMBL291 |
DrugBanki | DB01427, Amrinone DB00201, Caffeine DB05219, Crisaborole DB00651, Dyphylline DB06246, Exisulind DB05266, Ibudilast DB01088, Iloprost DB01791, Piclamilast DB01656, Roflumilast DB09283, Trapidil |
DrugCentrali | Q08493 |
GuidetoPHARMACOLOGYi | 1302 |
PTM databases
iPTMneti | Q08493 |
PhosphoSitePlusi | Q08493 |
Genetic variation databases
BioMutai | PDE4C |
DMDMi | 20141263 |
Proteomic databases
EPDi | Q08493 |
jPOSTi | Q08493 |
MassIVEi | Q08493 |
PaxDbi | Q08493 |
PeptideAtlasi | Q08493 |
PRIDEi | Q08493 |
ProteomicsDBi | 58615 [Q08493-1] 58616 [Q08493-2] 58617 [Q08493-3] |
Protocols and materials databases
Antibodypediai | 27961, 216 antibodies |
Genome annotation databases
Ensembli | ENST00000262805; ENSP00000262805; ENSG00000105650 [Q08493-3] ENST00000447275; ENSP00000402091; ENSG00000105650 [Q08493-2] ENST00000594465; ENSP00000470210; ENSG00000105650 [Q08493-1] ENST00000594617; ENSP00000469696; ENSG00000105650 [Q08493-1] |
GeneIDi | 5143 |
KEGGi | hsa:5143 |
UCSCi | uc002nii.5, human [Q08493-1] |
Organism-specific databases
CTDi | 5143 |
DisGeNETi | 5143 |
GeneCardsi | ENSG00000285188 PDE4C |
HGNCi | HGNC:8782, PDE4C |
HPAi | ENSG00000105650, Tissue enhanced (tongue) ENSG00000285188, Tissue enhanced (gallbladder, intestine, pancreas) |
MIMi | 600128, gene |
neXtProti | NX_Q08493 |
OpenTargetsi | ENSG00000105650 |
PharmGKBi | PA264 |
VEuPathDBi | HostDB:ENSG00000105650.21 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3689, Eukaryota |
GeneTreei | ENSGT00940000162285 |
HOGENOMi | CLU_005940_5_3_1 |
OMAi | LQAENCN |
OrthoDBi | 904682at2759 |
PhylomeDBi | Q08493 |
TreeFami | TF314638 |
Enzyme and pathway databases
UniPathwayi | UPA00762;UER00747 |
BRENDAi | 3.1.4.53, 2681 |
PathwayCommonsi | Q08493 |
Reactomei | R-HSA-180024, DARPP-32 events R-HSA-418555, G alpha (s) signalling events |
SIGNORi | Q08493 |
Miscellaneous databases
BioGRID-ORCSi | 5143, 17 hits in 983 CRISPR screens |
ChiTaRSi | PDE4C, human |
EvolutionaryTracei | Q08493 |
GeneWikii | PDE4C |
GenomeRNAii | 5143 |
Pharosi | Q08493, Tclin |
PROi | PR:Q08493 |
RNActi | Q08493, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105650, Expressed in cerebellum and 247 other tissues |
ExpressionAtlasi | Q08493, baseline and differential |
Genevisiblei | Q08493, HS |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.1300.10, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR040844, PDE4_UCR IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS |
Pfami | View protein in Pfam PF18100, PDE4_UCR, 1 hit PF00233, PDEase_I, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
SMARTi | View protein in SMART SM00471, HDc, 1 hit |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDE4C_HUMAN | |
Accessioni | Q08493Primary (citable) accession number: Q08493 Secondary accession number(s): B3KTC4 Q9UPJ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | March 27, 2002 | |
Last modified: | April 7, 2021 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families