PDE4C

Functionⁱ

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.1 Publication

Catalytic activityⁱ

Adenosine 3',5'-cyclic phosphate + H₂O = adenosine 5'-phosphate.

Cofactorⁱ

a divalent metal cation1 PublicationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.1 Publication

Activity regulationⁱ

Inhibited by rolipram.

Pathwayⁱ: 3',5'-cyclic AMP degradation

This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.
Proteins known to be involved in this subpathway in this organism are:

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A)

This subpathway is part of the pathway 3',5'-cyclic AMP degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	388	Proton donorBy similarity	1
Metal bindingⁱ	392	Divalent metal cation 1	1
Metal bindingⁱ	428	Divalent metal cation 1	1
Metal bindingⁱ	429	Divalent metal cation 1	1
Metal bindingⁱ	429	Divalent metal cation 2	1
Binding siteⁱ	429	cAMPBy similarity	1
Metal bindingⁱ	546	Divalent metal cation 1	1
Binding siteⁱ	546	cAMPBy similarity	1
Siteⁱ	549	Binds AMP, but not cAMPBy similarity	1
Binding siteⁱ	597	cAMPBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	388 – 392	cAMPBy similarity		5

GO - Molecular functionⁱ

3',5'-cyclic-AMP phosphodiesterase activity Source: Reactome
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cAMP catabolic process Source: UniProtKB-UniPathway
G protein-coupled receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	cAMP, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	3.1.4.53 2681
Reactomeⁱ	R-HSA-180024 DARPP-32 events R-HSA-418555 G alpha (s) signalling events
SIGNORⁱ	Q08493
UniPathwayⁱ	UPA00762;UER00747

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC:3.1.4.53) Alternative name(s): DPDE1 PDE21
Gene namesⁱ	Name:PDE4C Synonyms:DPDE1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105650.21
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8782 PDE4C
MIMⁱ	600128 gene
neXtProtⁱ	NX_Q08493

Keywords - Cellular componentⁱ

Cell projection, Cilium

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5143
Open Targets More...OpenTargetsⁱ	ENSG00000105650
PharmGKBⁱ	PA264

Chemistry databases

ChEMBLⁱ	CHEMBL291
Drug and drug target database More...DrugBankⁱ	DB00201 Caffeine DB05219 Crisaborole DB00651 Dyphylline DB05266 Ibudilast DB01088 Iloprost DB01791 Piclamilast DB01656 Roflumilast
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1302

Polymorphism and mutation databases

BioMutaⁱ	PDE4C
DMDMⁱ	20141263

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000198811	1 – 712	cAMP-specific 3',5'-cyclic phosphodiesterase 4CAdd BLAST		712

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	73	PhosphoserineBy similarity		1
Modified residueⁱ	641	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q08493
PaxDbⁱ	Q08493
PeptideAtlas More...PeptideAtlasⁱ	Q08493
PRIDEⁱ	Q08493
ProteomicsDBⁱ	58615 58616 [Q08493-2] 58617 [Q08493-3]

PTM databases

iPTMnetⁱ	Q08493
PhosphoSitePlusⁱ	Q08493

Expressionⁱ

Tissue specificityⁱ

Expressed in various tissues but not in cells of the immune system.

Gene expression databases

Bgeeⁱ	ENSG00000105650 Expressed in 240 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_PDE4C
ExpressionAtlasⁱ	Q08493 baseline and differential
Genevisibleⁱ	Q08493 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048975

HPAⁱ

HPA048975

Interactionⁱ

Subunit structureⁱ

Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SRI	P30626	3	EBI-10225541,EBI-750459

With

Entry

#Exp.

IntAct

Notes

SRI

P30626

3

EBI-10225541,EBI-750459

Protein-protein interaction databases

BioGridⁱ	111169, 1 interactor
IntActⁱ	Q08493, 8 interactors
STRINGⁱ	9606.ENSP00000347689

Chemistry databases

BindingDBⁱ

Q08493

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	317 – 323	Combined sources	7
Helixⁱ	324 – 326	Combined sources	3
Helixⁱ	334 – 340	Combined sources	7
Helixⁱ	345 – 356	Combined sources	12
Helixⁱ	359 – 362	Combined sources	4
Helixⁱ	367 – 379	Combined sources	13
Beta strandⁱ	385 – 389	Combined sources	5
Helixⁱ	390 – 404	Combined sources	15
Helixⁱ	407 – 409	Combined sources	3
Turnⁱ	410 – 412	Combined sources	3
Helixⁱ	415 – 427	Combined sources	13
Turnⁱ	428 – 431	Combined sources	4
Helixⁱ	435 – 437	Combined sources	3
Helixⁱ	456 – 467	Combined sources	12
Helixⁱ	468 – 470	Combined sources	3
Turnⁱ	476 – 479	Combined sources	4
Helixⁱ	482 – 497	Combined sources	16
Helixⁱ	501 – 503	Combined sources	3
Helixⁱ	504 – 516	Combined sources	13
Helixⁱ	531 – 546	Combined sources	16
Helixⁱ	549 – 551	Combined sources	3
Helixⁱ	554 – 569	Combined sources	16
Helixⁱ	600 – 603	Combined sources	4
Helixⁱ	605 – 616	Combined sources	12
Turnⁱ	617 – 620	Combined sources	4
Helixⁱ	621 – 630	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	Q08493
SMRⁱ	Q08493
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q08493

EvolutionaryTraceⁱ

Q08493

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	312 – 641	PDEasePROSITE-ProRule annotationAdd BLAST		330

Sequence similaritiesⁱ

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3689 Eukaryota ENOG410XRI7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118889
HOVERGENⁱ	HBG108239
KEGG Orthology (KO) More...KOⁱ	K13293
OMAⁱ	MCKTSLA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06CD
PhylomeDBⁱ	Q08493
TreeFamⁱ	TF314638

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00077 HDc, 1 hit
Gene3Dⁱ	1.10.1300.10, 1 hit
InterProⁱ	View protein in InterPro IPR003607 HD/PDEase_dom IPR023088 PDEase IPR002073 PDEase_catalytic_dom IPR036971 PDEase_catalytic_dom_sf IPR023174 PDEase_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00233 PDEase_I, 1 hit
PRINTSⁱ	PR00387 PDIESTERASE1
SMARTⁱ	View protein in SMART SM00471 HDc, 1 hit
PROSITEⁱ	View protein in PROSITE PS00126 PDEASE_I_1, 1 hit PS51845 PDEASE_I_2, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform PDE4C1 (identifier: Q08493-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENLGVGEGA EACSRLSRSR GRHSMTRAPK HLWRQPRRPI RIQQRFYSDP 
        60         70         80         90        100
DKSAGCRERD LSPRPELRKS RLSWPVSSCR RFDLENGLSC GRRALDPQSS 
       110        120        130        140        150
PGLGRIMQAP VPHSQRRESF LYRSDSDYEL SPKAMSRNSS VASDLHGEDM 
       160        170        180        190        200
IVTPFAQVLA SLRTVRSNVA ALARQQCLGA AKQGPVGNPS SSNQLPPAED 
       210        220        230        240        250
TGQKLALETL DELDWCLDQL ETLQTRHSVG EMASNKFKRI LNRELTHLSE 
       260        270        280        290        300
TSRSGNQVSE YISRTFLDQQ TEVELPKVTA EEAPQPMSRI SGLHGLCHSA 
       310        320        330        340        350
SLSSATVPRF GVQTDQEEQL AKELEDTNKW GLDVFKVAEL SGNRPLTAII 
       360        370        380        390        400
FSIFQERDLL KTFQIPADTL ATYLLMLEGH YHANVAYHNS LHAADVAQST 
       410        420        430        440        450
HVLLATPALE AVFTDLEILA ALFASAIHDV DHPGVSNQFL INTNSELALM 
       460        470        480        490        500
YNDASVLENH HLAVGFKLLQ AENCDIFQNL SAKQRLSLRR MVIDMVLATD 
       510        520        530        540        550
MSKHMNLLAD LKTMVETKKV TSLGVLLLDN YSDRIQVLQN LVHCADLSNP 
       560        570        580        590        600
TKPLPLYRQW TDRIMAEFFQ QGDRERESGL DISPMCDKHT ASVEKSQVGF 
       610        620        630        640        650
IDYIAHPLWE TWADLVHPDA QDLLDTLEDN REWYQSKIPR SPSDLTNPER 
       660        670        680        690        700
DGPDRFQFEL TLEEAEEEDE EEEEEGEETA LAKEALELPD TELLSPEAGP 
       710 
DPGDLPLDNQ RT

Length:712

Mass (Da):79,902

Last modified:March 27, 2002 - v2

Checksum:ⁱ1932116C9CE0322C

GO

Isoform PDE4C2 (identifier: Q08493-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-106: Missing.

« Hide

        10         20         30         40         50
MQAPVPHSQR RESFLYRSDS DYELSPKAMS RNSSVASDLH GEDMIVTPFA 
        60         70         80         90        100
QVLASLRTVR SNVAALARQQ CLGAAKQGPV GNPSSSNQLP PAEDTGQKLA 
       110        120        130        140        150
LETLDELDWC LDQLETLQTR HSVGEMASNK FKRILNRELT HLSETSRSGN 
       160        170        180        190        200
QVSEYISRTF LDQQTEVELP KVTAEEAPQP MSRISGLHGL CHSASLSSAT 
       210        220        230        240        250
VPRFGVQTDQ EEQLAKELED TNKWGLDVFK VAELSGNRPL TAIIFSIFQE 
       260        270        280        290        300
RDLLKTFQIP ADTLATYLLM LEGHYHANVA YHNSLHAADV AQSTHVLLAT 
       310        320        330        340        350
PALEAVFTDL EILAALFASA IHDVDHPGVS NQFLINTNSE LALMYNDASV 
       360        370        380        390        400
LENHHLAVGF KLLQAENCDI FQNLSAKQRL SLRRMVIDMV LATDMSKHMN 
       410        420        430        440        450
LLADLKTMVE TKKVTSLGVL LLDNYSDRIQ VLQNLVHCAD LSNPTKPLPL 
       460        470        480        490        500
YRQWTDRIMA EFFQQGDRER ESGLDISPMC DKHTASVEKS QVGFIDYIAH 
       510        520        530        540        550
PLWETWADLV HPDAQDLLDT LEDNREWYQS KIPRSPSDLT NPERDGPDRF 
       560        570        580        590        600
QFELTLEEAE EEDEEEEEEG EETALAKEAL ELPDTELLSP EAGPDPGDLP 

LDNQRT

Show »

Length:606

Mass (Da):67,791

Checksum:ⁱ3C42FC9F237333E1

GO

Isoform PDE4C3 (identifier: Q08493-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-81: MENLGVGEGA...LSWPVSSCRR → MQGPPAPAPV...RRFTVAHPLC

« Hide

        10         20         30         40         50
MQGPPAPAPV PGPGSPRGSP RGSPGLFRKL LVNQSIRLQR RFTVAHPLCF 
        60         70         80         90        100
DLENGLSCGR RALDPQSSPG LGRIMQAPVP HSQRRESFLY RSDSDYELSP 
       110        120        130        140        150
KAMSRNSSVA SDLHGEDMIV TPFAQVLASL RTVRSNVAAL ARQQCLGAAK 
       160        170        180        190        200
QGPVGNPSSS NQLPPAEDTG QKLALETLDE LDWCLDQLET LQTRHSVGEM 
       210        220        230        240        250
ASNKFKRILN RELTHLSETS RSGNQVSEYI SRTFLDQQTE VELPKVTAEE 
       260        270        280        290        300
APQPMSRISG LHGLCHSASL SSATVPRFGV QTDQEEQLAK ELEDTNKWGL 
       310        320        330        340        350
DVFKVAELSG NRPLTAIIFS IFQERDLLKT FQIPADTLAT YLLMLEGHYH 
       360        370        380        390        400
ANVAYHNSLH AADVAQSTHV LLATPALEAV FTDLEILAAL FASAIHDVDH 
       410        420        430        440        450
PGVSNQFLIN TNSELALMYN DASVLENHHL AVGFKLLQAE NCDIFQNLSA 
       460        470        480        490        500
KQRLSLRRMV IDMVLATDMS KHMNLLADLK TMVETKKVTS LGVLLLDNYS 
       510        520        530        540        550
DRIQVLQNLV HCADLSNPTK PLPLYRQWTD RIMAEFFQQG DRERESGLDI 
       560        570        580        590        600
SPMCDKHTAS VEKSQVGFID YIAHPLWETW ADLVHPDAQD LLDTLEDNRE 
       610        620        630        640        650
WYQSKIPRSP SDLTNPERDG PDRFQFELTL EEAEEEDEEE EEEGEETALA 
       660        670        680
KEALELPDTE LLSPEAGPDP GDLPLDNQRT

Show »

Length:680

Mass (Da):75,614

Checksum:ⁱE555883F32D17B64

GO

Isoform PDE4C4 (identifier: Q08493-4)

Sequence is not available

Length:–

Mass (Da):–

Isoform PDE4C5 (identifier: Q08493-5)

Sequence is not available

Length:–

Mass (Da):–

Isoform PDE4C6 (identifier: Q08493-6)

Sequence is not available

Length:–

Mass (Da):–

Isoform PDE4C7 (identifier: Q08493-7)

Sequence is not available

Length:–

Mass (Da):–

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q32MM7	Q32MM7_HUMAN	Phosphodiesterase Phosphodiesterase, EC 3.1.4.-	PDE4C	481	Annotation score:
B7Z6T1	B7Z6T1_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4C (cDNA FLJ50236, highly similar to cAMP-specific 3',5'-cyclic phosphodiesterase 4C)	PDE4C	231	Annotation score:
M0R1P5	M0R1P5_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	93	Annotation score:
V9GYP2	V9GYP2_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	82	Annotation score:
U3KPR3	U3KPR3_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	11	Annotation score:
U3KPR4	U3KPR4_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	89	Annotation score:
A0A2R9YJK9	A0A2R9YJK9_HUMAN	cAMP-specific 3',5'-cyclic phosphod... cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	11	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	204	K → N in AAD47053 (PubMed:10574328).Curated	1
Sequence conflictⁱ	204	K → N in AAD47054 (PubMed:10574328).Curated	1
Sequence conflictⁱ	211	D → Y in AAD47053 (PubMed:10574328).Curated	1
Sequence conflictⁱ	211	D → Y in AAD47054 (PubMed:10574328).Curated	1
Sequence conflictⁱ	339 – 340	EL → DV in CAA86601 (PubMed:7843419).Curated	2
Sequence conflictⁱ	444 – 446	NSE → K in AAC83047 (PubMed:15057824).Curated	3
Sequence conflictⁱ	446 – 447	EL → DV in CAA86601 (PubMed:7843419).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050473	131	S → L. Corresponds to variant dbSNP:rs10413646Ensembl.	1
Natural variantⁱVAR_050474	289	R → Q. Corresponds to variant dbSNP:rs34503849Ensembl.	1
Natural variantⁱVAR_034374	344	R → Q. Corresponds to variant dbSNP:rs2229228Ensembl.	1
Natural variantⁱVAR_061497	344	R → W. Corresponds to variant dbSNP:rs11879710Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004575	1 – 106	Missing in isoform PDE4C2. CuratedAdd BLAST		106
Alternative sequenceⁱVSP_004574	1 – 81	MENLG…SSCRR → MQGPPAPAPVPGPGSPRGSP RGSPGLFRKLLVNQSIRLQR RFTVAHPLC in isoform PDE4C3. CuratedAdd BLAST		81

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z46632 mRNA Translation: CAA86601.1 AF157816 , AF157811, AF157814, AF157815 Genomic DNA Translation: AAD47053.1 AF157816 , AF157812, AF157814, AF157815 Genomic DNA Translation: AAD47054.1 AF157816, AF157814, AF157815 Genomic DNA Translation: AAD47055.1 AK095384 mRNA Translation: BAG53036.1 AC005759 Genomic DNA Translation: AAC83047.1 CH471106 Genomic DNA Translation: EAW84677.1 L20968 mRNA Translation: AAA03591.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12373.1 [Q08493-1] CCDS42523.1 [Q08493-3] CCDS46016.1 [Q08493-2]
PIRⁱ	S71626
NCBI Reference Sequences More...RefSeqⁱ	NP_000914.2, NM_000923.5 [Q08493-1] NP_001092288.1, NM_001098818.3 [Q08493-3] NP_001092289.1, NM_001098819.3 [Q08493-2] NP_001317101.1, NM_001330172.1 [Q08493-1] XP_011526358.1, XM_011528056.2 [Q08493-2]
UniGeneⁱ	Hs.132584

Genome annotation databases

Ensemblⁱ	ENST00000262805; ENSP00000262805; ENSG00000105650 [Q08493-3] ENST00000447275; ENSP00000402091; ENSG00000105650 [Q08493-2] ENST00000594465; ENSP00000470210; ENSG00000105650 [Q08493-1] ENST00000594617; ENSP00000469696; ENSG00000105650 [Q08493-1]
GeneIDⁱ	5143
KEGGⁱ	hsa:5143
UCSC genome browser More...UCSCⁱ	uc002nii.5 human [Q08493-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q08493	Phosphodiesterase		HUMAN		821	UniRef100_Q08493
Phosphodiesterase (Fragment)		HUMAN		782
Isoform PDE4C2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4C		HUMAN		606

Protein	Similar proteins		Species	Score	Length	Source
Q08493	Phosphodiesterase		HUMAN		821	UniRef90_Q08493
Phosphodiesterase		PONAB		715
Phosphodiesterase		GORGO		713
Phosphodiesterase		PAPAN		713
Phosphodiesterase		CERAT		713
+61

Protein	Similar proteins		Species	Score	Length	Source
Q08493	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	)	HUMAN		809	UniRef50_Q08499
cAMP-specific 3',5'-cyclic phosphodiesterase 4D		RAT		803
Phosphodiesterase		NEOSC		811
Phosphodiesterase		ODORO		811
Phosphodiesterase		SAIBB		811
+613

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z46632 mRNA Translation: CAA86601.1 AF157816 , AF157811, AF157814, AF157815 Genomic DNA Translation: AAD47053.1 AF157816 , AF157812, AF157814, AF157815 Genomic DNA Translation: AAD47054.1 AF157816, AF157814, AF157815 Genomic DNA Translation: AAD47055.1 AK095384 mRNA Translation: BAG53036.1 AC005759 Genomic DNA Translation: AAC83047.1 CH471106 Genomic DNA Translation: EAW84677.1 L20968 mRNA Translation: AAA03591.1
CCDSⁱ	CCDS12373.1 [Q08493-1] CCDS42523.1 [Q08493-3] CCDS46016.1 [Q08493-2]
PIRⁱ	S71626
RefSeqⁱ	NP_000914.2, NM_000923.5 [Q08493-1] NP_001092288.1, NM_001098818.3 [Q08493-3] NP_001092289.1, NM_001098819.3 [Q08493-2] NP_001317101.1, NM_001330172.1 [Q08493-1] XP_011526358.1, XM_011528056.2 [Q08493-2]
UniGeneⁱ	Hs.132584

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LXU	model	-	A	306-649	[»]
	2QYM	X-ray	1.90	A	306-663	[»]
ProteinModelPortalⁱ	Q08493
SMRⁱ	Q08493
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111169, 1 interactor
IntActⁱ	Q08493, 8 interactors
STRINGⁱ	9606.ENSP00000347689

Chemistry databases

BindingDBⁱ	Q08493
ChEMBLⁱ	CHEMBL291
DrugBankⁱ	DB00201 Caffeine DB05219 Crisaborole DB00651 Dyphylline DB05266 Ibudilast DB01088 Iloprost DB01791 Piclamilast DB01656 Roflumilast
GuidetoPHARMACOLOGYⁱ	1302

PTM databases

iPTMnetⁱ	Q08493
PhosphoSitePlusⁱ	Q08493

Polymorphism and mutation databases

BioMutaⁱ	PDE4C
DMDMⁱ	20141263

Proteomic databases

EPDⁱ	Q08493
PaxDbⁱ	Q08493
PeptideAtlasⁱ	Q08493
PRIDEⁱ	Q08493
ProteomicsDBⁱ	58615 58616 [Q08493-2] 58617 [Q08493-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000262805; ENSP00000262805; ENSG00000105650 [Q08493-3] ENST00000447275; ENSP00000402091; ENSG00000105650 [Q08493-2] ENST00000594465; ENSP00000470210; ENSG00000105650 [Q08493-1] ENST00000594617; ENSP00000469696; ENSG00000105650 [Q08493-1]
GeneIDⁱ	5143
KEGGⁱ	hsa:5143
UCSCⁱ	uc002nii.5 human [Q08493-1]

Organism-specific databases

CTDⁱ	5143
DisGeNETⁱ	5143
EuPathDBⁱ	HostDB:ENSG00000105650.21
GeneCardsⁱ	ENSG00000285188 PDE4C
HGNCⁱ	HGNC:8782 PDE4C
HPAⁱ	HPA048975
MIMⁱ	600128 gene
neXtProtⁱ	NX_Q08493
OpenTargetsⁱ	ENSG00000105650
PharmGKBⁱ	PA264
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3689 Eukaryota ENOG410XRI7 LUCA
GeneTreeⁱ	ENSGT00760000118889
HOVERGENⁱ	HBG108239
KOⁱ	K13293
OMAⁱ	MCKTSLA
OrthoDBⁱ	EOG091G06CD
PhylomeDBⁱ	Q08493
TreeFamⁱ	TF314638

Enzyme and pathway databases

UniPathwayⁱ	UPA00762;UER00747
BRENDAⁱ	3.1.4.53 2681
Reactomeⁱ	R-HSA-180024 DARPP-32 events R-HSA-418555 G alpha (s) signalling events
SIGNORⁱ	Q08493

Miscellaneous databases

ChiTaRSⁱ	PDE4C human
EvolutionaryTraceⁱ	Q08493
GeneWikiⁱ	PDE4C
GenomeRNAiⁱ	5143
Protein Ontology More...PROⁱ	PR:Q08493
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105650 Expressed in 240 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_PDE4C
ExpressionAtlasⁱ	Q08493 baseline and differential
Genevisibleⁱ	Q08493 HS

Family and domain databases

CDDⁱ	cd00077 HDc, 1 hit
Gene3Dⁱ	1.10.1300.10, 1 hit
InterProⁱ	View protein in InterPro IPR003607 HD/PDEase_dom IPR023088 PDEase IPR002073 PDEase_catalytic_dom IPR036971 PDEase_catalytic_dom_sf IPR023174 PDEase_CS
Pfamⁱ	View protein in Pfam PF00233 PDEase_I, 1 hit
PRINTSⁱ	PR00387 PDIESTERASE1
SMARTⁱ	View protein in SMART SM00471 HDc, 1 hit
PROSITEⁱ	View protein in PROSITE PS00126 PDEASE_I_1, 1 hit PS51845 PDEASE_I_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDE4C_HUMAN
Accessionⁱ	Q08493Primary (citable) accession number: Q08493 Secondary accession number(s): B3KTC4 , Q9UN44, Q9UN45, Q9UN46, Q9UPJ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	March 27, 2002
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q08493 (PDE4C_HUMAN)

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cAMP-specific 3',5'-cyclic phosphodiesterase 4C

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Gene expression databases

Organism-specific databases

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Protein-protein interaction databases

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: 3',5'-cyclic AMP degradation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ